期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 31, 期 -, 页码 45-50出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2014.08.001
关键词
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资金
- Esther A. and Joseph Klingenstein Fund
- Alfred P. Sloan Foundation
- NIMH [P30 MH089900]
- ONR [N00014-14-1-0322]
For decades, theta rhythms (similar to 5-10 Hz) have been thought to play a critical role in memory processing in the entorhinal-hippocampal network. However, recent evidence suggests that successful memory performance also requires coupling of similar to 30-100Hz gamma rhythms to particular phases of the theta cycle. Recent insights imply ways in which theta-gamma coupling may facilitate transfer of information throughout the entorhinal-hippocampal network. Activating gamma-modulated cell assemblies at a particular theta phase may allow the network to produce a more powerful output by ensuring that distributed cells fire closely in time. I hypothesize that such a mechanism would serve to facilitate either memory encoding or memory retrieval, depending on which type of gamma rhythms are recruited.
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