期刊
INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS
卷 19, 期 11, 页码 991-1000出版社
BEGELL HOUSE INC
DOI: 10.1615/IntJMedMushrooms.2017024498
关键词
food safety; gestational diabetes mellitus; Lentinus edodes; medicinal mushrooms; reproductive toxicology
资金
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [FAPESP-2015/24566-9, FAPESP-2013/05765-5]
- Financiadora de Estudos e Projetos [FINEP-01.10.0659.00]
- Programa de Suporte a Pos-Graduacao de Instituicoes de Ensino Particulares (PROSUP/CAPES)
- Programa de Bolsas de Iniciacao Cientifica da Universidade de Sorocaba (PROBIC-UNISO)
- Post Graduate Program in Pharmaceuticals Sciences from University of Sorocaba, Sorocaba, SP, Brazil
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [15/24566-9] Funding Source: FAPESP
This study evaluated the protective effect of Lentinus edodes in rats with streptozotocin-induced gestational diabetes mellitus (STZ-GDM) when administered orally. The rats received from the 1st to the 19th day of gestation daily doses of 100 or 200 mg/kg of lyophilized and reconstituted L. edodes; the animals in the saline control group and diabetic control group received a saline solution (DS). Gestational diabetes mellitus was induced by streptozotocin (80 mg/kg, administered intraperitoneally) on the fourth day of pregnancy; blood glucose > 180 mg/dL was considered to indicate STZ-GDM. L. edodes reduced catalase in plasma. We also observed reduced glucose in plasma, urea, triglycerides, and aspartate aminotransferase. There was a decrease in preimplantation loss when compared with the DS group. The doses of L. edodes used here had a protective effect on the preimplantation parameters in STZ-GDM. However, the mushroom was not able to reverse the deleterious effects caused by streptozotocin throughout the evolution of pregnancy.
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