Article
Chemistry, Medicinal
Mingqiang Wang, Yanzhen Li, Jianhui Su, Jingyan Bai, Zhongxiang Zhao, Zhanghua Sun
Summary: This study found that 4-GDB can alleviate colonic injury, reduce inflammation, and improve colonic barrier function by regulating cAMP/PKA/CREB and NF-kappa B pathways. This suggests that 4-GDB may be a potential agent for treating ulcerative colitis.
PHYTOTHERAPY RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Arun Reddy Ravula, Suraj Benerji Teegala, Shanker Kalakotla, Jagadeesh Prasad Pasangulapati, Venkatesan Perumal, Hemanth Kumar Boyina
Summary: Fisetin, as a potential molecule for treating neurodegenerative diseases, is believed to positively impact neurobehavioral and cognitive abnormalities. It has shown various health benefits in clinical models of neurodegenerative diseases and is thought to have the potential to treat these diseases through multiple mechanisms.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Plant Sciences
Jeong-Oog Lee, So-Hyeon Hwang, Ting Shen, Ji Hye Kim, Long You, Weicheng Hu, Jae Youl Cho
Summary: PPT enhances skin barrier function and hydration by promoting the expression of filaggrin, transglutaminase, claudin, hyaluronic acid synthase, and activating Src/AKT/NF-kappa B and MAPK signaling pathways.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Immunology
Zhiyan Zhou, Ranhui Xi, Jiaxin Liu, Xian Peng, Lei Zhao, Xuedong Zhou, Jiyao Li, Xin Zheng, Xin Xu
Summary: The study identified multiple subtypes of taste receptors in human gingival fibroblasts and highlighted TAS2R16's role in inhibiting pro-inflammatory responses by regulating NF-kappa B signaling. This provides a new target and paradigm for the treatment of periodontitis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lei Xu, Yangfan Ye, Zeqiang Tao, Tian Wang, Yutian Wei, Wanzhi Cai, Xin Wan, Pengzhan Zhao, Wei Gu, Bin Gu, Liuchao Zhang, Yufei Tian, Ning Liu, Yiming Tu, Jing Ji
Summary: This study elucidated the role of MLPH in GBM radiation resistance, showing that MLPH promotes radiotherapy resistance by regulating the NF-kappa B pathway. Additionally, O-GlcNAcylation of MLPH protects it from degradation and stabilizes its presence in cells. These findings provide insights into a potential mechanism of GBM radiation resistance and suggest a therapeutic strategy for GBM treatment.
Article
Medicine, Research & Experimental
Francisca B. M. Sousa, Gabriella Pacheco, Ana P. Oliveira, Lucas A. D. Nicolau, Andre L. F. Lopes, Hygor Ferreira-Fernandes, Giovanny R. Pinto, Jand V. R. Medeiros
Summary: The study demonstrated that hydrogen sulfide (H2S) can protect against cholera toxin (CT) by preserving villus and crypt morphology in mice. This protective effect is likely achieved at least in part by reducing the activity of NF-kappa B and PGE2.
Article
Immunology
Xuerui Zhang, Banghui Zhu, Lin Li, Jiahong Xu, Yuheng Han, Jing Zhang, Zichun Hua
Summary: This study discovered that FADD plays a significant role in the development of TCRαβ(+) IELs, but not TCRγδ(+) IELs. The dephosphorylation of FADD is crucial for cell activation in TCRαβ(+)CD8(+) T cells and the dephosphorylated FADD promotes high NF-kappa B activation in TCR-dependent cell expansion. Additionally, FADD(S191A) induces abnormal IEL populations and increases the incidence and severity of colitis.
Article
Food Science & Technology
Hyeon-Hwa Nam, Li Nan, Byung-Kil Choo
Summary: Dill seeds, commonly used as a seasoning, have shown therapeutic potential in treating indigestion and inflammation. Studies have demonstrated their anti-inflammatory effects in vitro and in rats with reflux esophagitis, indicating their potential for prevention and therapy of gastroesophageal diseases.
Article
Biotechnology & Applied Microbiology
Jia Liang, RuoXiao Zhuang, XueYao Sun, Feng Zhang, Bin Zou
Summary: Apremilast exerts a protective effect against IL-13-induced inflammatory response and mucin production in hNECs by inhibiting the activity of AP-1 and NF-kappa B.
Article
Medicine, Research & Experimental
Liping Cao, Zhenghong Li, Zhizhou Yang, Mengmeng Wang, Wei Zhang, Yi Ren, Liang Li, Junxian Hu, Zhaorui Sun, Shinan Nie
Summary: Ferulic acid showed significant protective effects in murine ALI and cellular ALI models, reducing inflammation and improving histopathological changes. FA exerts its effects by modulating the GSK-3 beta/NF-kappa B/CREB pathway to protect the liver.
Article
Cell Biology
Wenfei Pan, Limei Deng, Haitao Wang, Vivien Ya-Fan Wang
Summary: The NF-kappa B family of dimeric transcription factors regulate various biological functions. A study has revealed that the atypical I kappa B protein, Bcl3, plays a crucial role in enhancing the population of the p52:p52 homodimer within the NF-kappa B family. Bcl3 competes with other NF-kappa B subunits for efficient p52:p52 homodimer formation, leading to the upregulation of target genes involved in cell proliferation, migration, and inflammation. The aberrant activation of Bcl3 and p52 contributes to cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Dianbo Long, Yiyang Xu, Guping Mao, Ruobing Xin, Zengfa Deng, Hongyi Liao, Zhiwen Li, Zhi Yang, Baoxi Yu, Zhijian Yang, Aishan He, Ziji Zhang, Yan Kang
Summary: tRNA-derived fragments (tRFs) have been shown to play important roles in cell metabolism by regulating gene expression. This study investigates the role of tRFs in the cellular metabolism of the anterior cruciate ligament (ACL). The findings reveal that TRF365 regulates ACL cell metabolism by targeting IKBKB.
CELL DEATH DISCOVERY
(2022)
Article
Behavioral Sciences
Badrah S. Alghamdi, Fahad S. Alshehri
Summary: The study revealed the potential of melatonin in modulating morphine addiction by affecting gene expression levels such as GLT-1, BDNF, NF-kappa B, and CREB.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Plant Sciences
Hong-Ying Yang, Weidong Yao, Pei-Zhi Huang, Hui Xu, Qian Ma, Xiaoming Chen, Jian-Jun Chen, Kun Gao
Summary: This study isolated three unreported ent-abietane-type norditerpene lactones, named euphohelides A-C (1-3), from the whole plants of Euphorbia helioscopia L. The structures of euphohelides A-C were established using spectroscopic methods, computational ECD, and X-ray crystallographic analyses. Euphohelide A (1) is a novel 2-nor-ent-abietane lactone with a unique 5/6/6/5 tetracyclic system.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Cell Biology
Yaru Bao, Ju Hun Oh, Chan Woo Kang, Cheol Ryong Ku, Yoon Hee Cho, Eun Jig Lee
Summary: Olfactory marker protein (OMP) plays a regulatory role in olfactory transduction and is expressed in adipose tissue. Loss of OMP function inhibits adipogenesis by affecting adipocyte differentiation, leading to decreases in body weight, adipose tissue mass, and adipogenic gene expression.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Otorhinolaryngology
Yueng-Hsiang Chu, Wen-Sen Lai, Yuan-Yung Lin, Shao-Cheng Liu, Jih-Chin Lee
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2020)
Article
Medicine, Research & Experimental
Kuen-Tze Lin, Shih-Yu Lee, Shao-Cheng Liu, Chih-Cheng Tsao, Sheng-Der Hsu, Wu-Chien Chien, Chi-Hsiang Chung, Wei-Kuo Chang, Yuan-Wu Chen, Chun-Shu Lin
Article
Cell Biology
Chih-Ming Huang, Chin-Sheng Huang, Tung-Nien Hsu, Mao-Suan Huang, Iat-Hang Fong, Wei-Hwa Lee, Shao-Cheng Liu
Article
Multidisciplinary Sciences
Chung-Feng Jeffrey Kuo, Chih-Hsiang Kao, Sifundvolesihle Dlamini, Shao-Cheng Liu
SCIENTIFIC REPORTS
(2020)
Article
Clinical Neurology
Chung-Feng Jeffrey Kuo, Chun-Shu Lin, Cheng-Hsien Chuang, Chung-Shen Lin, Feng-Shiang Chiu, Shao-Cheng Liu
NATURE AND SCIENCE OF SLEEP
(2020)
Article
Oncology
Shao-Cheng Liu, Yang-Che Wu, Chih-Ming Huang, Ming-Shou Hsieh, Ting-Yi Huang, Chin-Sheng Huang, Tung-Nien Hsu, Mao-Suan Huang, Wei-Hwa Lee, Chi-Tai Yeh, Chun-Shu Lin
Summary: The study found that BTK is highly expressed in CCRT-resistant OSCC, leading to poor overall survival. Inhibiting BTK may help reduce the cancer stem cell-like characteristics of OSCC cells.
Article
Integrative & Complementary Medicine
Che-Jui Lee, Hsin-Chien Chen, Cheng-Ping Shih, Yuan-Yung Lin, Chao-Yin Kuo, Shao-Cheng Liu
Summary: The study showed that combined acupuncture, HBOT, and conventional steroid therapy can improve hearing in ISSNHL patients, with the S-H-A group showing better hearing improvement outcomes and more favorable hearing recovery grades compared to the other treatment groups. Acupuncture is a safe and nonpharmacologic treatment option that can be considered as an initial treatment strategy in such a clinical scenario.
JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
(2021)
Article
Multidisciplinary Sciences
Chung Feng Jeffrey Kuo, Wen-Sen Lai, Jagadish Barman, Shao-Cheng Liu
Summary: A computer-aided diagnostic system was developed for the detection of laryngeal lesions based on objective criteria, using distinct features of image contour and hue and geometric analysis to automatically screen and segment clear images from laryngoscopic videos. The system showed high accuracy in detecting various laryngeal lesions, demonstrating the feasibility of using hue and geometric features of the larynx as signs to assist physicians in diagnosing such lesions.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Shao-Cheng Liu, Oluwaseun Adebayo Bamodu, Kuang-Tai Kuo, Iat-Hang Fong, Chih-Cheng Lin, Chi-Tai Yeh, Shyi-Gen Chen
Summary: The study showed that ADSCs can promote an increase in levels of miR-29b and miR-21, leading to the activation and proliferation of dermal fibroblasts and extracellular matrix (ECM) remodeling, thereby enhancing cutaneous wound healing.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Medicine, General & Internal
Chung Feng Jeffrey Kuo, Jagadish Barman, Shao-Cheng Liu
Summary: This study introduced a laser projection device that can assist in the analysis of laryngeal mucosa changes before and after surgery under general anesthesia. The device utilizes image processing techniques to quantify post-extubation laryngeal variation and determine parameters such as vocal fold length and glottic area. The results showed significant differences between the control group and the intubation group, especially in the interarytenoid region. The equipment and processing used in the study can help clinicians diagnose postoperative laryngeal inflammation in a simpler and less invasive way.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Medicine, General & Internal
Pei-Rong Lee, Chung Feng Jeffrey Kuo, Shao-Cheng Liu
Summary: This study presents a method for analyzing airway mucosal changes using a laser projection device and compares pre-operative and post-operative parameters of the larynx. The results showed higher measurements in post-operative images, decreased glottic area, and increased vocal width. Additionally, the post-operative retropalatal depth and CSAOI significantly increased but slightly reduced in the 12th week.
FRONTIERS IN MEDICINE
(2022)
Article
Mathematics
Chung-Feng Jeffrey Kuo, Shao-Cheng Liu
Summary: The aim of this study is to develop an automatic segmentation algorithm based on paranasal sinus CT images, which realizes automatic identification and segmentation of the sinus boundary and its inflamed proportions, as well as the reconstruction of normal sinus and inflamed site volumes. The algorithm achieved significant improvements in both sinus segmentation and classification.
Article
Mathematics
Chung Feng Jeffrey Kuo, Zheng-Xun Yang, Wen-Sen Lai, Shao-Cheng Liu
Summary: This study presents the development of a computer tomography (CT) system for automatic segmentation and quantitative analysis of the pulmonary bronchus. The proposed system can automatically detect the location of the pulmonary airway and identify multiple generations of bronchi with high accuracy and automation.
Article
Radiology, Nuclear Medicine & Medical Imaging
Chung-Feng Jeffrey Kuo, Yu-Shu Liao, Jagadish Barman, Shao-Cheng Liu
Summary: This study proposed a volume-based modified LM score (VMLMs) to evaluate the volume of inflammatory disease and found that VMLMs had a stronger correlation with clinical symptoms. The methods showed improved sinus classification and segmentation compared to state-of-the-art networks and were able to differentiate sex dimorphism and age correlation. Patients who underwent surgery had significantly higher TLMs and VMLMs, and VMLMs had excellent predictive capability for postoperative symptom improvement.
Article
Pharmacology & Pharmacy
Shao-Cheng Liu, Chin-Sheng Huang, Chih-Ming Huang, Ming-Shou Hsieh, Mao-Suan Huang, Iat-Hang Fong, Chi-Tai Yeh, Chih-Cheng Lin
Summary: Isoorientin attenuates the stemness and epithelial-mesenchymal transition potential of OSCC cells by inhibiting the JAK/STAT3 and Wnt/β-catenin signaling pathways. It also enhances the cytotoxic effects of cisplatin against OSCC and inhibits the tumorigenicity and growth of OSCC in vivo through the disruption of Wnt/β-catenin/STAT3 signaling.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)