Article
Cell & Tissue Engineering
Ya-Dong Li, Yan-Jia Luo, Ling Xie, Dalton S. Tart, Ryan N. Sheehy, Libo Zhang, Leon G. Coleman, Xian Chen, Juan Song
Summary: Patients with Alzheimer's disease (AD) show memory loss, depression, and anxiety, along with impaired adult hippocampal neurogenesis (AHN). This study demonstrates that optogenetic stimulation of the hypothalamic supramammillary nucleus (SuM) enhances AHN in AD mouse models, improving memory and emotion deficits. Activation of SuM-enhanced adult-born neurons (ABNs) triggers synaptic plasticity and microglia phagocytosis, providing insights into the signaling mechanisms involved.
Article
Neurosciences
Guohua Wang, Canmao Wang, He Chen, Limei Chen, Juan Li
Summary: The study reveals that sustained hyperactivity of 6-8-week-old new mature aDGCs induces anxiety-like behaviors and disrupts spatial memory, as well as activates mature DG neurons and inhibits immature aDGCs. Additionally, mice displaying anxiety-like behaviors due to chronic stress also show increased activity in 6-8-week-old aDGCs.
NEUROBIOLOGY OF STRESS
(2021)
Article
Multidisciplinary Sciences
Brenna Hourigan, Spencer D. Balay, Graydon Yee, Saloni Sharma, Qiumin Tan
Summary: New neurons continuously arise in the adult hippocampus, but little is known about the factors regulating neuronal differentiation, migration, and dendrite maturation. Our study reveals a previously unrecognized role of the transcriptional repressor protein CIC in adult hippocampal neurogenesis, as its loss impedes neuronal lineage development and disrupts dendritic arborization and migration of adult-born neurons.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Dong Sun, Leena Milibari, Jin-Xiu Pan, Xiao Ren, Ling-Ling Yao, Yang Zhao, Chen Shen, Wen-Bing Chen, Fu-Lei Tang, Daehoon Lee, Jun-Shi Zhang, Lin Mei, Wen-Cheng Xiong
Summary: The research identified the critical functions of Ocn-Cre(+) dDG neurons in suppressing anxiety-like behaviors and promoting adult DG neurogenesis, likely through the activation of BDNF.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Nicholas P. Vyleta, Jason S. Snyder
Summary: Studies suggest that adult-born neurons display slow development of LTP at LPP synapses, but gradually increase over a period of 3-4 months, indicating a presynaptic mechanism. This new form of neuron plasticity may be relevant for maintaining cognitive function in aging.
Article
Neurosciences
Sang-Yoon Kim, Woochang Lim
Summary: Young immature granule cells (imGCs) appear in the hippocampal dentate gyrus through adult neurogenesis. These imGCs exhibit two competing properties: high excitability and low excitatory innervation.
COGNITIVE NEURODYNAMICS
(2023)
Article
Clinical Neurology
Risa Yamazaki, Dianru Wang, Anna De Laet, Renato Maciel, Claudio Agnorelli, Sebastien Cabrera, Sebastien Arthaud, Paul-Antoine Libourel, Patrice Fort, Hyunsook Lee, Pierre-Herve Luppi
Summary: The study aimed to investigate the reactivation of neurons in the hippocampus and supramammillary nucleus during wakefulness and paradoxical sleep. The results showed different activated neurons in these regions during wakefulness and paradoxical sleep, and the activation of granule cells in the infrapyramidal blade of the DG during paradoxical sleep. Further research is needed to determine the role of these granule cells in memory reactivation during paradoxical sleep.
Article
Clinical Neurology
Risa Yamazaki, Dianru Wang, Anna De Laet, Renato Maciel, Claudio Agnorelli, Sebastien Cabrera, Sebastien Arthaud, Paul-Antoine Libourel, Patrice Fort, Hyunsook Lee, Pierre-Herve Luppi
Summary: The study aimed to determine whether the same neurons were reactivated in the hippocampus and the supramammillary nucleus when mice were exposed to different periods of wakefulness and paradoxical sleep. The results showed that different neurons were activated during wakefulness and paradoxical sleep in the two brain regions, with granule cells of the infrapyramidal blade of the DG specifically activated during paradoxical sleep. Further experiments are needed to confirm if these granule cells are involved in memory engrams during paradoxical sleep.
Article
Cell Biology
Matias Mugnaini, Mariela F. Trinchero, Alejandro F. Schinder, Veronica C. Piatti, Emilio Kropff
Summary: Optogenetic activation experiments in mice reveal that young adult-born granule cells play a unique role in remodeling spatial maps in the hippocampus, while mature adult-born granule cells do not have this ability.
Article
Biology
Nicholas P. Vyleta, Jason S. Snyder
Summary: Adult-born granule neurons in the hippocampus exhibit enhanced excitability and plasticity during immature stages, which is believed to contribute to their unique roles in learning and memory. Our findings reveal hyper-excitability in the presynaptic terminals of mossy fibers onto CA3 pyramidal neurons, and suggest rapid functionality in immature neurons. Electrophysiological recordings in mouse hippocampal slices demonstrate faster maturation of action potential waveforms in the presynaptic bouton of adult-born granule neurons compared to the soma.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Liying Chen, Yingwei Xu, Heming Cheng, Zhongxia Li, Nanxi Lai, Menghan Li, Yeping Ruan, Yang Zheng, Fan Fei, Cenglin Xu, Jiao Ma, Shuang Wang, Yan Gu, Feng Han, Zhong Chen, Yi Wang
Summary: This study found that adult-born dentate granule cells (abDGCs) born at a critical period after epileptogenic insult can influence the duration of seizures. Activation or inhibition of these cells can significantly extend or curtail seizure duration, providing new insights for precise treatment of epilepsy.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Neurosciences
Jiao Ma, Zhechun Hu, Huimin Yue, Yujian Luo, Chao Wang, Xuan Wu, Yan Gu, Lang Wang
Summary: In this study, the researchers found that the metabotropic glutamate receptor 2 (GRM2) is highly expressed in hippocampal dentate granule cells (DGCs) and plays a crucial role in regulating their development and functional integration. Lack of GRM2 leads to developmental defects and impaired cognitive functions in the hippocampus. Interestingly, knocking down GRM2 resulted in the excessive activation of the MEK/ERK1/2 pathway, which was ameliorated by inhibiting MEK.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Muhammad N. Arshad, Alejandro Pinto, Henriette van Praag, Janice R. Naegele
Summary: Adult neurogenesis in the rodent hippocampus is affected by seizures and can lead to hyperexcitable circuits. Transplantation of GABAergic interneurons from the medial ganglionic eminence (MGE) into the dentate gyrus (DG) of mice with temporal lobe epilepsy (TLE) can reduce seizures and form inhibitory connections with adult-born granule cells (GCs). This study found that TLE increased excitatory inputs onto adult-born GCs, but mice with MGE grafts showed reduced excitatory inputs and increased GABAergic interneuron innervation of GCs, suggesting that MGE grafts can prevent epilepsy-associated changes in adult-born GC connectivity.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Biology
Stephen Johnston, Sarah L. Parylak, Stacy Kim, Nolan Mac, Christina Lim, Iryna Gallina, Cooper Bloyd, Alexander Newberry, Christian D. Saavedra, Ondrej Novak, J. Tiago Goncalves, Fred H. Gage, Matthew Shtrahman
Summary: The study demonstrated that neural progenitor cells and immature dentate granule cells in the adult murine hippocampus are highly sensitive to rAAV-induced cell death, which is dose-dependent and nearly complete at experimentally relevant viral titers. rAAV-induced cell death is rapid and persistent, with no evidence of recovery of adult neurogenesis at 3 months post-injection.
Article
Biochemical Research Methods
Alvaro Carrier-Ruiz, Yuki Sugaya, Deependra Kumar, Pablo Vergara, Iyo Koyanagi, Sakthivel Srinivasan, Toshie Naoi, Masanobu Kano, Masanori Sakaguchi
Summary: Adult-born neurons in the dentate gyrus play a crucial role in memory consolidation, particularly during sleep. This study presents a method for Ca2+ imaging of ABN activity using a miniaturized fluorescent microscope and sleep recordings, with detailed descriptions and tips provided for surgery and data processing challenges. For a comprehensive guide on the protocol, readers are encouraged to refer to Kumar et al. (2020).
Article
Neurosciences
Mariela F. Trinchero, Muriel Koehl, Malik Bechakra, Pauline Delage, Vanessa Charrier, Noelle Grosjean, Elodie Ladeveze, Alejandro F. Schinder, D. Nora Abrous
Article
Multidisciplinary Sciences
Emilio Kropff, James E. Carmichael, May-Britt Moser, Edvard I. Moser
Article
Neurosciences
Silvio G. Temprana, Lucas A. Mongiat, Sung M. Yang, Mariela F. Trinchero, Diego D. Alvarez, Emilio Kropff, Damiana Giacomini, Natalia Beltramone, Guillermo M. Lanuza, Alejandro F. Schinder
Article
Biology
Maria Belen Pardi, Mora Belen Ogando, Alejandro F. Schinder, Antonia Marin-Burgin
Article
Mathematical & Computational Biology
Maria Constantinou, Soledad Gonzalo Cogno, Daniel H. Elijah, Emilio Kropff, John Gigg, Ines Samengo, Marcelo A. Montemurrol
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
(2016)
Article
Anatomy & Morphology
Marine Krzisch, Silvio G. Temprana, Lucas A. Mongiat, Jan Armida, Valentin Schmutz, Mari A. Virtanen, Jacqueline Kocher-Braissant, Rudolf Kraftsik, Laszlo Vutskits, Karl-Klaus Conzelmann, Matteo Bergami, Fred H. Gage, Alejandro F. Schinder, Nicolas Toni
BRAIN STRUCTURE & FUNCTION
(2015)
Article
Physics, Multidisciplinary
Melisa B. Maidana Capitan, Emilio Kropff, Ines Samengo
Article
Cell Biology
Miguel M. Carvalho, Nouk Tanke, Emilio Kropff, Menno P. Witter, May-Britt Moser, Edvard Moser
Article
Neurosciences
Emilio Kropff, James E. Carmichael, Edvard I. Moser, May-Britt Moser
Summary: The study found that theta rhythm frequency is linearly related to positive acceleration but not to negative acceleration or speed, making it unsuitable for computing displacement or other kinematic variables. Temporally precise variations in theta frequency may serve as a mechanism for accelerating entorhinal-hippocampal computations during movement acceleration.
Article
Engineering, Environmental
Andrea L. Pineda Rojas, Sandra M. Cordo, Ramiro Saurral, Jose L. Jimenez, Linsey C. Marr, Emilio Kropff
Summary: Studies have shown that humidity has a significant impact on the variation of COVID-19 positive cases, showing a negative-slope linear relationship, with the highest predictive power in winter months.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Correction
Engineering, Environmental
Zhe Peng, Andrea L. Pineda Rojas, Emilio Kropff, William Bahnfleth, Giorgio Buonanno, Stefanie J. Dancer, Jarek Kurnitski, Yuguo Li, Marcel G. L. C. Loomans, Linsey C. Marr, Lidia Morawska, William Nazaroff, Catherine Noakes, Xavier Querol, Chandra Sekhar, Raymond Tellier, Trisha Greenhalgh, Lydia Bourouiba, Atze Boerstra, Julian W. Tang, Shelly L. Miller, Jose L. Jimenez
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Engineering, Environmental
Z. Peng, A. L. Pineda Rojas, E. Kropff, W. Bahnfleth, G. Buonanno, S. J. Dancer, J. Kurnitski, Y. Li, M. G. L. C. Loomans, L. C. Marr, L. Morawska, W. Nazaroff, C. Noakes, X. Querol, C. Sekhar, R. Tellier, T. Greenhalgh, L. Bourouiba, A. Boerstra, J. W. Tang, S. L. Miller, J. L. Jimenez
Summary: Some infectious diseases, including COVID-19, can undergo airborne transmission. Two indicators of infection risk are proposed, which combine key factors that control airborne disease transmission indoors. COVID-19 outbreaks show a clear trend consistent with airborne infection and enable recommendations to minimize transmission risk.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Matias Mugnaini, Diana Polania, Yannina Diaz, Marcelo Ezquer, Fernando Ezquer, Robert M. J. Deacon, Patricia Cogram, Emilio Kropff
Summary: Octodon degus serves as a potential model for studying aging and late-onset Alzheimer's disease. The similarities in hippocampal function and behavior between Octodon degus and laboratory rodents provide a framework for investigating hippocampal dysfunction associated with aging and disease in this species.
SCIENTIFIC REPORTS
(2022)