期刊
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
卷 55, 期 -, 页码 109-112出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijid.2017.01.002
关键词
dengue; pregnancy; vertical transmission; placenta
资金
- FAPERJ (Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro)
A histopathological and immunohistochemical study was conducted in placental tissues and retained products of conception from 24 patients with confirmed dengue infection during pregnancy. The immunohistochemical assay was positive for dengue virus in 19 placental and three ovular remnants analyzed. The light microscopic findings were signs of hypoxia, choriodeciduitis, deciduitis and intervillositis and the viral antigens were found in cytoplasmic of the trophoblast, villous stroma and decidua. Our results suggest that immunohistochemistry could be used as a laboratory confirmation method for dengue in pregnant women, especially in endemic areas when embedded material is the only material available. (C) 2017 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
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