Article
Environmental Sciences
Yuri Dornelles Zebral, Patricia Gomes Costa, Marta Marques de Souza, Adalto Bianchini
Summary: The study tracked the environmental impacts of the Mariana dam collapse, one of the worst environmental disasters in Brazilian history, using trace-element accumulation in avian blood and feathers as a monitoring tool. The results showed strong spatial and temporal variations in inorganic contamination levels in birds, with the first collection event showing higher contamination levels compared to the second. Bioaccumulation was more severe in the Doce River mouth and southern area. Furthermore, elevated levels of Pb, Hg, As and Cd in birds from the first expedition indicated potential health impacts.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Water Resources
E. M. Tanvir, Shakil Mahmood, Md Nazrul Islam, Mahbuba Khatun, Rizwana Afroz, Shaikh Shohidul Islam, Sabrina Afrin, Md Ibrahim Khalil, Muhammed Alamgir Zaman Chowdhury, Jack C. Ng, Karen M. Whitfield, P. Nicholas Shaw
Summary: The study investigated the urinary concentrations of metals and metalloids in primary school-aged children in different industrialized areas of Dhaka, Bangladesh, finding that children in these areas were exposed to higher levels of environmental pollutants compared to control children. Specifically, higher concentrations of manganese in urine and drinking water samples in the textile area suggest an elevated risk of adverse health effects for exposed children, with potential correlations between copper concentrations in drinking water and urine samples indicating a possible source of exposure. The study highlights the current situation of metals and metalloid pollution in industrialized areas, where children may face higher risks of health problems caused by heavy metals.
EXPOSURE AND HEALTH
(2022)
Article
Environmental Sciences
Mikhail S. Ermolin, Alexandr I. Ivaneev, Natalia N. Fedyunina, Petr S. Fedotov
Summary: Volcanic activity is a main source of natural nanoparticles, with toxic metals/metalloids in volcanic ash nanoparticles potentially being one or two orders of magnitude higher than in bulk samples. The fate and behavior of these toxic elements depend on their binding type to nanoparticles, indicating a need to distinguish element species adsorbed onto pyroclastic nanoparticles from individual nanophases of metal/metalloid oxides or salts. This study utilizes single particle inductively coupled plasma mass spectrometry to analyze nanoparticles from Kamchatka volcanoes, revealing that the nanospeciation of various elements is dependent on both element type and volcano source.
Article
Environmental Sciences
Aldo E. Calogero, Maria Fiore, Filippo Giacone, Maria Altomare, Paola Asero, Caterina Ledda, Giulietta Romeo, Laura M. Mongioi, Chiara Copat, Maria Giuffrida, Enzo Vicari, Salvatore Sciacca, Margherita Ferrante
Summary: The study found that environmental exposure to lead and cadmium contributes to a decline in human semen quality, while selenium may have beneficial effects. Measurements of metals/metalloids in the seminal fluid may be more predictive of semen quality than conventional blood measurements.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
M. Semih Bingoel, Emre Comakli, Mudahir Ozgul, Muhammet Altun, Tugba Comakli
Summary: This study investigated the concentrations of heavy metals in naturally grown plants and roadside soil along the European route e80 highway in Turkiye. The findings suggest that plant leaves can be used as a monitoring technique to track the changes in heavy metal concentrations along highways.
ENVIRONMENTAL EARTH SCIENCES
(2023)
Review
Plant Sciences
Matthias Wiggenhauser, Rebekah E. T. Moore, Peng Wang, Gerd Patrick Bienert, Kristian Holst Laursen, Simon Blotevogel
Summary: This work critically reviews stable isotope fractionation of various metals and metalloids in plants, providing basic principles and methodologies for non-traditional isotope analyses. The study finds that different biological and physico-chemical processes drive isotope fractionation in plants, and both biotic and abiotic factors can influence the process.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Environmental Sciences
Jairo Buitrago Cortes, Philippe Sarazin, Denis Dieme, Jonathan Cote, Capucine Ouellet, Naima El Majidi, Michele Bouchard
Summary: This research aimed to assess the actual dose of metal components absorbed by apprentice welders in a learning environment and establish the nature and level of exposure to welding fumes and their metallic components. The study found higher levels of manganese, iron, and nickel in urine and manganese in hair during the Shielded Metal Arc Welding (SMAW) module, while there was no significant difference for the other elements.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Ciprian Mihai Cirtiu, Mathieu Valcke, Michelle Gagne, Marie-Helene Bourgault, Celine Narame, Souleymane Gadio, Patrick Poulin, Pierre Ayotte
Summary: This study investigated the baseline biological exposure of the Nunavik population to rare earth elements and other chemicals before potential mining development. While most rare earth elements were not detected in the samples, elements like arsenic, antimony, chromium, and cobalt were detected in 100% of the samples, with concentrations higher than the general Canadian population in some cases.
Article
Environmental Sciences
Andy Schmied, Aline Murawski, Marike Kolossa-Gehring, Peter Kujath
Summary: A method utilizing inductively coupled plasma-tandem mass spectrometry was developed and validated for multi-element analyses of human urine samples. The method's combination of simple sample preparation and state-of-the-art technique allows high-throughput and lowest limits of quantification up to 1 ng/L. The method's performance was demonstrated by successful participation in international interlaboratory comparison programs, showing its suitability for measuring the general population's exposure to various metals and metalloids.
Article
Green & Sustainable Science & Technology
Michaela Zeiner, Viktor Sjoberg, Heidelore Fiedler
Summary: This study presents a widespread distribution of elements in fresh and salt surface water by analyzing samples from 22 countries and three continents. Significant differences were found between countries and water types. Correlations were also observed between organic contaminants and V and As.
Article
Biochemistry & Molecular Biology
Cathleen L. Doherty, Brian T. Buckley
Summary: ICP-MS is an indispensable standard technique with adaptability across disciplines, from analyzing environmental contamination to deep-Earth processes. Continuing advancements, including improved auxiliary applications, have revolutionized the precision and range of analysis, enabling effective interdisciplinary crossover.
Article
Environmental Sciences
Zorimar Rivera-Nunez, Pahriya Ashrap, Emily S. Barrett, Deborah J. Watkins, Amber L. Cathey, Carmen M. Velez-Vega, Zaira Rosario, Jose F. Cordero, Akram Alshawabkeh, John D. Meeker
Summary: Metal(loid)s may act as endocrine disruptors by altering prenatal hormone levels, with potential effects depending on specific windows of exposure during pregnancy. Essential metal(loid)s such as manganese and cobalt may also contribute to adverse maternal and fetal outcomes. Future studies are needed to further investigate these associations, as the study of metal(loid)s as endocrine disruptors is still in its early stages of epidemiological research.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Kirstin Hester, Ellen Kirrane, Timothy Anderson, Nichole Kulikowski, Jane Ellen Simmons, David M. Lehmann
Summary: This study aims to identify and characterize the epidemiological and experimental data on the relationship between environmental metals exposure and neurodegenerative diseases, and highlight important knowledge gaps and future research directions.
ENVIRONMENT INTERNATIONAL
(2022)
Review
Environmental Sciences
Maciej Marcin Durkalec, Agnieszka Nawrocka, Ignacy Kitowski, Aleksandra Filipek, Bartosz Sell, Miroslawa Kmiecik, Piotr Jedziniak
Summary: The golden eagle and white-tailed eagle in Poland have been found to accumulate different environmental contaminants, including toxic elements. Analysis of liver samples revealed interspecific and regional differences in the levels of certain trace elements. Despite most elements being below the suggested thresholds for adverse health effects, the presence of hepatic lead in some individuals suggests an ongoing threat to the health of Polish eagles.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Eliza Matuszewska, Agnieszka Klupczynska, Krzysztof Maciolek, Zenon J. Kokot, Jan Matysiak
Summary: Bee products contain essential nutrients but may also have harmful heavy metals, requiring quality testing. Due to variability in elemental content based on environmental factors, standards regulating acceptable levels of inorganic pollutants are necessary.
Review
Biochemistry & Molecular Biology
Frederic J. Tessier, Eric Boulanger, Michael Howsam
Summary: The Maillard reaction is a major chemical reaction responsible for most yellow-to-brown colors and aromas in cooked foods, leading to the formation of structurally-modified amino acids. High or chronic exposure to dietary AGEs may be potentially detrimental to human health, prompting research in food safety to focus on the metabolic transit of AGEs.
GLYCOCONJUGATE JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Olivia May, Laure Yatime, Nicolas S. Merle, Florian Delguste, Mike Howsam, Marie Daugan, Charles Paul-Constant, Muriel Billamboz, Alina Ghinet, Steve Lancel, Jordan D. Dimitrov, Eric Boulanger, Lubka T. Roumenina, Marie Frimat
Summary: The interaction between RAGE and heme with micromolar affinity could potentially promote proinflammatory and prothrombotic signaling in vivo. This suggests that this interaction may play a role in heme-overload conditions.
Article
Agriculture, Dairy & Animal Science
X. Yu, N. Leconte, S. Mejean, G. Garric, S. Even, G. Henry, F. J. Tessier, M. Howsam, T. Croguennec, G. Gesan-Guiziou, D. Dupont, R. Jeantet, A. Deglaire
Summary: The study aimed to investigate innovative minimal processing routes for the production of first-age infant formula powder while ensuring microbial safety with minimal protein denaturation. Three IF powders were produced using different heat treatments, with the powder produced without heat treatment showing the lowest protein denaturation extent. This study demonstrates the feasibility of producing bacteriologically safe infant formula with a high content of native proteins at a semi-industrial scale.
JOURNAL OF DAIRY SCIENCE
(2021)
Letter
Critical Care Medicine
Morgan Caplan, Michael Howsam, Raphael Favory, Sebastien Preau
ANNALS OF INTENSIVE CARE
(2021)
Article
Environmental Sciences
Mireille Matrat, Murielle Gain, Corinne Haioun, Fabien Le Bras, Catherine Nisse, Franck Morschhauser, Benedicte Clin, Isabelle Baldi, Catherine Verdun-Esquer, Robert Garnier, Herve Laborde-Casterot, Fabrice Herin, Yolande Esquirol, Pascal Andujar, Milia Belacel, Christos Chouaid, Claire Chauvet, Gerard Lasfargues, Jean-Claude Pairon
Summary: The questionnaire developed in this study showed high sensitivity and specificity in identifying patients with non-Hodgkin lymphoma who may have been affected by environmental or occupational exposure. 15% of the subjects were invited to apply for compensation for occupational disease, mainly due to exposure to pesticides and solvents.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Nutrition & Dietetics
Lucie Marousez, Norbert Sprenger, Marie De Lamballerie, Sarahi Jaramillo-Ortiz, Lea Tran, Edwina Micours, Frederic Gottrand, Michael Howsam, Frederic J. Tessier, Delphine Ley, Jean Lesage
Summary: This study evaluated the impact of HHP processing on human milk components and found that HHP treatment preserves HMOs and avoids the formation of Maillard reaction products. In contrast, Holder pasteurization significantly increased the levels of Maillard reaction products.
CLINICAL NUTRITION
(2022)
Review
Medical Laboratory Technology
Sarahi Jaramillo Ortiz, Michael Howsam, Elisabeth H. van Aken, Joris R. Delanghe, Eric Boulanger, Frederic J. Tessier
Summary: Nails have been widely studied as a source of biomarkers for diseases, offering the potential to study biological processes over a longer time scale. They are easy to collect and store, containing information on circulating molecules and elements that reflect the subject's metabolic history.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Ariane Leroyer, Harry Gomajee, Romain Leroy, Muriel Mazzuca, Bruno Leleu, Catherine Nisse
Summary: This study investigated the risk of excess cancer mortality in employees of a lead and zinc smelter in northern France. The results showed that employees who worked for 15 to 29 years had an increased risk of cancer mortality. Occupational exposures were found to be associated with different types of cancer.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Romain Magny, Nicolas Auzeil, Bertrand Lefrere, Bruno Megarbane, Pascal Houze, Laurence Labat
Summary: Identification of xenobiotics and their metabolites in poisoned patients is challenging. This study used a liquid chromatography approach coupled with high-resolution mass spectrometry and molecular network analysis to successfully identify tramadol metabolites in urine and plasma. The use of both positive and negative ion modes allowed for the identification of previously unreported metabolites and clustering of phase II metabolites. The combined use of positive and negative ion modes in molecular network analysis is a suitable and robust tool for identifying a broad range of metabolites in poisoned patients.
Article
Biochemistry & Molecular Biology
Nicolas Beauval, Ariane Leroyer, Michael Hisbergues, Delphine Allorge, Patrice Maboudou, Mike Howsam, Catherine Nisse
Summary: This study evaluated the impact of long-term frozen storage on the urinary concentration of 10 trace elements. The results showed that concentrations of arsenic, cadmium, lead, thallium, zinc, and possibly manganese did not undergo major modifications during storage. However, the use of plastic containers may contaminate the samples with antimony. Technological evolution over time may also affect the accuracy of results, particularly for lower concentrations.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2022)
Article
Biochemical Research Methods
Pauline Thiebot, Nada Maaziz, Chrystelle Oppon, Laetitia Bertolo, Romain Magny, Lucie Chevillard, Bruno Megarbane, Pascal Houze, Laurence Labat
Summary: A rapid, sensitive and specific LC-HRMS method was developed for the identification and quantification of ricinine in plasma. Micro-solid-phase elution was used to extract ricinine from 100 μL of plasma, eliminating the evaporation step and reducing extraction time. The method was validated according to European Medicines Agency guidelines and showed good linearity, precision, and accuracy. The method allows rapid and reliable identification of ricin-exposed victims in cases of terrorist attacks or poisonings, as demonstrated by the report of three intoxication cases.
BIOMEDICAL CHROMATOGRAPHY
(2023)
Article
Biochemistry & Molecular Biology
Pascal Houze, Ilona Borowski, Eugenie Bito, Romain Magny, Athina Morcos, Sebastian Voicu, Bruno Megarbane, Laurence Labat
Summary: In toxicology, chromatographic methods coupled to HR/MS are commonly used for screenings, with the development of methods for alternative samples such as Volumetric Adsorptive Micro-Sampling. The optimized extraction procedure using Mitra (TM) allowed the confirmation of 87 compounds in spiked whole blood, with identification limits below 12.5 ng center dot mL(-1) for 82.2% of the investigated drugs. The novel screening approach showed a satisfying concordance in the analysis of poisoned patients' samples.
Article
Pharmacology & Pharmacy
Lea Darnaud, Clement Delage, Youssef Daali, Anne-Priscille Trouvin, Serge Perrot, Nihel Khoudour, Nadia Merise, Laurence Labat, Bruno Etain, Frank Bellivier, Celia Lloret-Linares, Vanessa Bloch, Emmanuel Curis, Xavier Decleves
Summary: Drug-metabolizing enzymes and drug transporters play crucial roles in drug pharmacokinetics and response. The cocktail-based phenotyping approach involves administering multiple probe drugs to evaluate the activities of CYP and transporter simultaneously. This study determined the range of phenotyping indices in healthy volunteers and classified patients with therapeutic issues based on CYP and P-gp activities.
Article
Biochemistry & Molecular Biology
Romain Magny, Bruno Megarbane, Pauline Guillaud, Lucie Chevillard, Nicolas Auzeil, Pauline Thiebot, Sebastian Voicu, Isabelle Malissin, Nicolas Deye, Laurence Labat, Pascal Houze
Summary: Metabolomics in clinical toxicology aims to identify and semi-quantify a wide range of endogenous and exogenous metabolites. In this study, a three-step workflow was developed to investigate the metabolic impact of the antidepressant drug venlafaxine in a poisoned patient. Targeted quantitative and untargeted semi-quantitative metabolomic analyses were performed to determine the plasma kinetics of venlafaxine and its metabolites, and correlations between the metabolomic data and endogenous metabolites were explored. This preliminary study is a first step towards the application of toxicometabolomics in clinical toxicology and provides a useful workflow for identifying toxicity biomarkers.
Article
Biology
Alexandre Pierre, Claire Bourel, Raphael Favory, Benoit Brassart, Frederic Wallet, Frederic N. N. Daussin, Sylvain Normandin, Michael Howsam, Raphael Romien, Jeremy Lemaire, Gaelle Grolaux, Arthur Durand, Marie Frimat, Bruno Bastide, Philippe Amouyel, Eric Boulanger, Sebastien Preau, Steve Lancel
Summary: Sepsis is a life-threatening infection that leads to muscle weakness, which impairs short- and long-term prognoses. This study investigated the impact of an energy deficit on skeletal muscle during the early stages of sepsis. The results showed that a sepsis-like energy deficit did not explain the muscle fiber atrophy and mitochondrial dysfunction observed in sepsis, but led to specific metabolic adaptations not found in sepsis.
Article
Public, Environmental & Occupational Health
Dewan Muhammad Shoaib, Tanvir Ahmed, Kazy Farhat Tabassum, Mehedi Hasan, Fazle Sharior, Mahbubur Rahman, Makfie Farah, Md Azizur Rahman, Alauddin Ahmed, James B. Tidwell, Mahbub-Ul Alam
Summary: An intervention was implemented in Bangladesh during COVID-19 to reduce occupational health risks for waste and sanitation workers. The intervention involved training and distribution of personal protective equipment (PPE). The study found that the intervention improved workers' knowledge, attitude, and practice regarding PPE usage.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Andreas Kortenkamp, Olwenn Martin, Eleni Iacovidou, Martin Scholze
Summary: The European Food Safety Authority's downward revision of the Health-based Guidance Value for bisphenol A (BPA) has led to disagreements with other regulatory agencies, particularly the German Federal Institute for Risk Assessment. The differing views between EFSA and BfR are driven by their respective selection of endpoints and study evaluation systems, as well as their acceptance or refusal of immunotoxic effects as a basis for establishing a Health-based Guidance Value.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Shizhen He, Bjorn Lundberg, Jenny Hallberg, Susanna Klevebro, Goran Pershagen, Kristina Eneroth, Erik Melen, Matteo Bottai, Olena Gruzieva
Summary: Early life air pollution exposure and abnormal inflammation-related protein profiles may interact synergistically towards lower lung function in infants.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Paulien Cleys, Emilie Hardy, Yu Ait Bamai, Giulia Poma, Adam Cseresznye, Govindan Malarvannan, Paul T. J. Scheepers, Susana Viegas, Simo P. Porras, Tiina Santonen, Lode Godderis, Jelle Verdonck, Katrien Poels, Carla Martins, Maria Joao Silva, Henriqueta Louro, Inese Martinsone, Lasma Akulova, An van Nieuwenhuyse, Martien Graumans, Selma Mahiout, Radu Corneliu Duca, Adrian Covaci
Summary: The aim of this study was to assess the exposure of e-waste workers to phthalates and alternative plasticizers. The results showed that e-waste workers had higher urinary concentrations of phthalates and metabolites compared to non-occupationally exposed controls. However, no significant differences were found between pre-and post-shift concentrations in the e-waste workers.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Karolina Bralewska
Summary: This review study examines the concentrations of various air pollutants in fire stations, identifies the limitations and strengths of existing research, identifies research gaps and challenges, and suggests potential solutions for reducing firefighter exposure to air pollution at fire stations.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
