期刊
CURRENT OPINION IN IMMUNOLOGY
卷 32, 期 -, 页码 54-60出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2014.12.003
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资金
- Ministere de l'Education Nationale de la Recherche et de Technologie fellowship
- Sidaction
- ATIP-Avenir program, Agence Nationale de Recherche sur le SIDA (ANRS)
- Ville de Paris Emergence program, European FP7 Marie Curie Actions [268311]
- LABEX DCBIOL [ANR-10-IDEX0001-02 PSL*, ANR-11-LABX-0043]
- LABEX VRI
- ACTERIA Foundation
- Fondation Schlumberger pour l'Education et la Recherche (FSER)
- European Research Council [309848 HIVINNATE]
The ability to sense infections is primordial to preserve organisms. Immune cells express pathogen sensors that induct innate and adaptive immune responses. Understanding how HIV-1 infection defeats these responses in most individuals remains an outstanding challenge. Since HIV-1 targets immune cells, innate immune sensors are remarkably positioned at the nexus of viral replication and immunity. Here, we discuss recent studies that have revealed innate sensing mechanisms of HIV-1 infection in plasnnacytoid dendritic cells, monocyte-derived dendritic cells, monocyte-derived macrophages, and CD4+ T cells. These studies help understand how HIV-1 avoids antiviral innate immune sensors and how it induces pathogenic processes. Ultimately, this may contribute to therapy and vaccines.
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