DNA damage response and hematological malignancy

Acute lymphoblastic leukemia and lymphoma in the context of constitutional mismatch repair deficiency syndrome

(2016) Tim Ripperger et al.   European Journal of Medical Genetics

BRCA1, PARP1 and γH2AX in acute myeloid leukemia: Role as biomarkers of response to the PARP inhibitor olaparib

(2015) Isabella Faraoni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Constitutional mismatch repair deficiency syndrome: clinical description in a French cohort

(2015) N Lavoine et al.   JOURNAL OF MEDICAL GENETICS

Synthetic lethal targeting of oncogenic transcription factors in acute leukemia by PARP inhibitors

(2015) Maria Teresa Esposito et al.   NATURE MEDICINE

ATM-dependent DNA damage-response pathway as a determinant in chronic myelogenous leukemia

(2013) Masatoshi Takagi et al.   DNA REPAIR

Ataxia Telangiectasia-mutated- and Rad3-related Protein Regulates the DNA Damage-induced G2/M Checkpoint through the Aurora A Cofactor Bora Protein

(2013) Bo Qin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The genomic landscape of hypodiploid acute lymphoblastic leukemia

(2013) Linda Holmfeldt et al.   NATURE GENETICS

A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance

(2011) Tobias Menzel et al.   EMBO REPORTS

Aurora-B Mediated ATM Serine 1403 Phosphorylation Is Required for Mitotic ATM Activation and the Spindle Checkpoint

(2011) Chunying Yang et al.   MOLECULAR CELL

Assessing ‘radiosensitivity’ with kinetic profiles of γ-H2AX, 53BP1 and BRCA1 foci

(2011) Nathan T. Martin et al.   RADIOTHERAPY AND ONCOLOGY

Bloom's Syndrome. XII. Report from the Registry for 1987

(2010) James German et al.   CLINICAL GENETICS

Bcr/Abl Interferes with the Fanconi Anemia/BRCA Pathway: Implications in the Chromosomal Instability of Chronic Myeloid Leukemia Cells

(2010) Antonio Valeri et al.   PLoS One

Transcriptional Regulation by P53

(2010) R. Beckerman et al.   Cold Spring Harbor Perspectives in Biology

Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes

(2009) T. J. Gaymes et al.   HAEMATOLOGICA

BCR/ABL kinase interacts with and phosphorylates the RAD51 paralog, RAD51B

(2009) A Slupianek et al.   LEUKEMIA

BCR/ABL downregulates DNA-PKCS-dependent and upregulates backup non-homologous end joining in leukemic cells

(2009) Tomasz Poplawski et al.   MOLECULAR BIOLOGY REPORTS

Poly(ADP-ribose) polymerase inhibitor ABT-888 potentiates the cytotoxic activity of temozolomide in leukemia cells: influence of mismatch repair status and O6-methylguanine-DNA methyltransferase activity

(2009) T. M. Horton et al.   MOLECULAR CANCER THERAPEUTICS