Article
Oncology
Dimitrios Nasioudis, Melissa K. Frey, Eloise Chapman-Davis, Thomas A. Caputo, Kevin M. Holcomb
Summary: A surveillance only strategy for patients with stage I malignant ovarian germ cell tumors is associated with excellent survival outcomes for patients with grade 2 or 3 immature teratoma or mixed germ cell tumors. Patients with yolk sac tumors who received chemotherapy had better overall survival compared to those who did not receive chemotherapy.
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2021)
Article
Medicine, General & Internal
Shih-Hsiang Chen, Chia-Jui Du, Jin-Yao Lai, Tsung-Yen Chang, Chao-Ping Yang, Iou-Jih Hung, Tang-Her Jaing, Yung-Ching Ming, Chuen Hsueh
Summary: This study analyzed data from 15 children with malignant sacrococcygeal germ cell tumors (MSGCTs) in Taiwan. Some patients were found to have sacrococcygeal tumors present at birth. All patients presented with a bulging mass at the buttock region and normal alpha-fetoprotein levels. The main treatment approach was primary excision of the tumor.
Article
Pediatrics
Brent R. Weil, Barrie S. Rich, Arin L. Madenci, Kathryn C. Stambough, Nicholas Schmoke, Alyssa Peace, Jennifer L. Bruny, Frederick J. Rescorla, Bryan J. Dicken, Jennifer E. Dietrich, Deborah F. Billmire
Summary: The appropriate operation is crucial for patients with suspected ovarian germ cell tumors, as it aims to provide optimal therapy and minimize the risks of treatment toxicities. Key elements of the operative procedure include complete tumor resection and intraperitoneal staging.
SEMINARS IN PEDIATRIC SURGERY
(2023)
Article
Obstetrics & Gynecology
Deborah Billmire, Bryan Dicken, Frederick Rescorla, Jonathan Ross, Jin Piao, Li Huang, Mark Krailo, Farzana Pashankar, Lindsay Frazier
Summary: The study assessed the preoperative imaging appearance of pediatric malignant ovarian germ cell tumors, with 83.5% showing a mixed cystic and solid appearance. The presence of associated benign teratoma was common among the patients.
JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY
(2021)
Review
Oncology
Hitomi Sakaguchi-Mukaida, Shinya Matsuzaki, Yutaka Ueda, Satoko Matsuzaki, Mamoru Kakuda, Misooja Lee, Satoki Deguchi, Mina Sakata, Michihide Maeda, Reisa Kakubari, Tsuyoshi Hisa, Seiji Mabuchi, Shoji Kamiura
Summary: This systematic review examines the effectiveness of neoadjuvant chemotherapy (NACT) for women with malignant ovarian germ cell tumors (MOGCT). The results indicate that NACT is used in approximately 40% of advanced MOGCT cases with a response rate of 95.8%. The uterine preservation rate is around 70% and the cumulative resumed menstruation rate is 100%. Comparisons with primary debulking surgery show similar overall survival, disease-free survival, recurrence rate, and adverse event rate from chemotherapy.
Article
Pathology
Khaleel Al-Obaidy, Sean R. Williamson, Nathan Shelman, Muhammad T. Idrees, Thomas M. Ulbright
Summary: Rare hepatoid teratomas (HTs) in testicular germ cell tumor patients present distinct histological features and immunohistochemical profiles compared to hepatoid yolk sac tumor (HYST) and hepatocellular carcinoma (HCC).
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Margaretha A. Skowron, Mara Kotthoff, Felix Bremmer, Katja Ruhnke, Fatma Parmaksiz, Annika Richter, Stefan Kueffer, Kirsten Reuter-Jessen, Stella Pauls, Anja Stefanski, Philipp Stroebel, Kai Stuehler, Daniel Nettersheim
Summary: This study identified a novel CLDN6-ADC for targeting germ cell tumors (GCT) and discovered pharmacological inhibitors that block FGF, VGF, PDGF, mTOR, CHEK1, AURKA, or PARP signaling for the treatment of refractory yolk-sac tumors (YST). Furthermore, the study shed light on the mechanisms of therapy resistance in YST.
MOLECULAR MEDICINE
(2023)
Article
Clinical Neurology
Alexander G. Weil, Natalie Mathews, Jean-Pierre Farmer, Christine St Martin, Steffen Albrecht, Nada Jabado, Roy W. R. Dudley
Summary: The authors presented two cases of NGGCT in neonates, one with mixed malignant germ cell tumor and the other with pure YST. These tumors were successfully treated with either complete tumor resection or subtotal tumor resection with chemotherapy, resulting in event-free survival exceeding 5 years for both patients without the need for radiation therapy. The cases highlight the importance of radical surgery and successful treatment of neonatal YST, and emphasize the rare non-midline location of these tumors and the need to consider YSTs and mixed NGGCTs with YST components in the differential diagnosis of non-midline hemispheric or skull base tumors in newborns.
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2021)
Article
Oncology
Ting-Huan Huang, Giun-Yi Hung, Te-Fu Weng, Fu-Mien Wang, Chih-Ying Lee, Dong-Tsamn Lin, Bow-Wen Chen, Kai-Hsin Lin, Kang-Hsi Wu, Hsi-Che Liu, Jiann-Shiuh Chen, Shiann-Tarng Jou, Jen-Yin Hou, Yung-Li Yang, Shih-Hsiang Chen, Hsiu-Hao Chang, Shyh-Shin Chiou, Pei-Chin Lin, Rong-Long Chen, Chih-Cheng Hsiao, Hsiu-Ju Yen, Chao-Ping Yang, Te-Kau Chang, Meng-Yao Lu, Chao-Neng Cheng, Jiunn-Ming Sheen, Yu-Mei Liao, Min-Yu Su, Ting-Chi Yeh
Summary: This study retrospectively analyzed the prognostic factors and treatment outcomes of primary malignant mediastinal germ cell tumors (GCTs) in Taiwanese children. The results showed that surgical treatment was associated with better outcomes, while advanced disease stage and choriocarcinoma histology subtype were associated with poorer outcomes. Additionally, there was no difference in treatment outcomes between cisplatin-based and carboplatin-based chemotherapy.
Article
Pathology
Yao Li, Xiang Huang, Xue Meng, Yuqing Luo, Shuai Luo, Jinjing Wang
Summary: This report presents a rare case of primary mixed extragonadal germ cell tumor in the shoulder. The patient underwent surgery and chemotherapy, and showed no signs of recurrence during follow-up. The importance of further research on this rare disease to develop effective treatment strategies is emphasized.
DIAGNOSTIC PATHOLOGY
(2023)
Article
Medicine, Research & Experimental
Tian Wang, Bo Wang, Shi-xuan Wang, Ming-fu Wu
Summary: Yolk sac tumors typically affect young females and are mostly unilateral, with distant metastasis and localized disease being common presentations. Postmenopausal women have a worse prognosis compared to premenopausal women.
CURRENT MEDICAL SCIENCE
(2021)
Article
Pathology
Andres M. Acosta, Khaleel Al-Obaidy, Lynette M. Sholl, Brendan C. Dickson, Neal Lindeman, Michelle S. Hirsch, Katrina Collins, Christopher D. Fletcher, Muhammad T. Idrees
Summary: This study found that 60% of SYST tumors in TGCTs carry rare somatic oncogenic mutations, and the presence of these mutations is associated with aggressive clinical progression. High-grade SYST tumors have a higher risk of disease-specific death compared to low-grade tumors, and the presence of somatic mutations increases the risk of disease-specific mortality.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Review
Medicine, General & Internal
Taiki Isaji, Kenichiro Iwami, Fuminori Ato, Tadashi Watanabe, Emiko Takahashi, Shigeru Miyachi
Summary: Yolk sac tumor (YST) is a rare brain tumor that mainly affects patients under 30 years old, with the most common sites being the pineal and suprasellar regions. YSTs in the medulla oblongata are extremely rare and can be difficult to diagnose due to their uncommon growth patterns. They have a poor prognosis, but this case study presents a 50-year-old woman who remained tumor-free during an 18-month follow-up.
Article
Pathology
Sheila E. Segura, Robert H. Young, Esther Oliva, Thomas M. Ulbright
Summary: This study describes 21 cases of nonpure germinomatous gonadal germ cell tumors, most of which are associated with gonadoblastoma and disorders of sex development. These tumors are typically mixed, with yolk sac tumor and germinoma being the most common components. The high occurrence of yolk sac tumors with glandular and hepatoid morphologies suggests a possible association with gonadoblastoma and disorders of sex development.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Review
Pathology
Vladimir Samal, Tomas Jirasek, Vit Paldus, Igor Richter, Ondrej Hes
Summary: This case report presents a rare case of urachal yolk sac tumor with glandular and hepatoid structures in a male patient presenting with macroscopic hematuria. Immunohistochemistry confirmed the presence of these structures, supporting the diagnosis.
DIAGNOSTIC PATHOLOGY
(2022)
Article
Oncology
Lauriane Lemelle, Antoine Moya-Plana, Benoit Dumont, Brice Fresneau, Anne Laprie, Line Claude, Sophie Deneuve, Camille Cordero, Gaelle Pierron, Vincent Couloigner, Sophie Bernard, Liesbeth Cardoen, Nerve J. Brisse, Nina Jehanno, Lucy Metayer, Paul Freneaux, Sylvie Helfre, Frederic Kolb, Juliette Thariat, Yves Reguerre, Daniel Orbach
Summary: NUT carcinoma is an aggressive tumor with poor prognosis. It is often underdiagnosed and difficult to treat. Conventional combination chemotherapy with local therapy is currently the main treatment strategy, but new targeted drugs show promise as alternatives.
BULLETIN DU CANCER
(2022)
Article
Multidisciplinary Sciences
Daniel Bejarano-Quisoboni, Nathalie Pelletier-Fleury, Rodrigue Allodji, Brigitte Lacour, Pascale GrosClaude, Helene Pacquement, Francois Doz, Delphine Berchery, Claire Pluchart, Piere-Yves Bondiau, Julie Nys, Angela Jackson, Charlotte Demoor-Goldschmidt, Agnes Dumas, Cecile Thomas-Teinturier, Giao Vu-Bezin, Dominique Valteau-Couanet, Nadia Haddy, Brice Fresneau, Florent de Vathaire
Summary: Childhood cancer survivors in France face a substantial economic burden, with higher healthcare expenditures among female survivors and those with central nervous system primary cancer.
Article
Oncology
Asmaa Janah, Charlotte Demoor-Goldschmidt, Florent De Vathaire, Nicolas Bougas, Jacqueline Clavel, Claire Poulalhon, Brigitte Lacour, Vincent Souchard, Angela Jackson, Leonie Casagranda, Claire Berger, Rodrigue Allodji, Nadia Haddy, Chiraz El Fayech, Brice Fresneau, Agnes Dumas
Summary: This study assesses the risk perceptions of childhood cancer survivors (CCS) related to COVID-19 and their forgoing of health care. The results show that approximately 60% of survivors believe that COVID-19 could have severe consequences for their health, and 30% of respondents seeking care declared they had forgone at least one medical appointment in 2020. Forgoing medical appointments was more common among survivors who reported a deterioration in their financial situation and those who felt more at risk of being infected.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Clinical Neurology
Alexandru Szathmari, Pierre-Aurelien Beuriat, Alexandre Vasiljevic, Pierre Leblond, Cecile Faure-Conter, Line Claude, Federico Di Rocco, Carmine Mottolese
Summary: This study analyzed the data of 151 pediatric patients with pineal tumors treated in Lyon, France from 1997 to 2020. The results showed that benign tumors had a good prognosis with complete surgical removal, while pinealoblastomas had a poor prognosis, and papillary tumors required complete removal for the best chance of survival.
CHILDS NERVOUS SYSTEM
(2023)
Article
Oncology
Victoria Corvest, Perrine Marec-Berard, Cyril Lervat, Helene Pacquement, Maud Toulmonde, Jean-Claude Gentet, Valerie Laurence, Morgane Cleirec, Ludovic Mansuy, Emmanuelle Bompas, Marie-Pierre Castex, Sophie Taque, Bruno Filhon, Marie-Dominique Tabone, Cecile Verite, Natacha Entz-Werle, Laure Saumet, Gregory Guimard, Morgane Pondrom, Christine Chevreau, Jennifer Flandrin, Lise Duranteau, Christine Rousset-Jablonski, Laurence Brugieres, Marta Jimenez, Marie-Cecile Le Deley, Nathalie Gaspar, Brice Fresneau
Summary: The study showed that cyclophosphamide is as effective as ifosfamide in the consolidation treatment of standard-risk Ewing sarcoma. However, using VAI (vincristine-dactinomycin-ifosfamide) regimen may increase the risk of kidney toxicity.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Cecile Faure-Conter, Daniel Orbach, Helene Sudour-Bonnange, Cecile Verite, Ludovic Mansuy, Angelique Rome, Cecile Dumesnil, Estelle Thebaud, Marleen Renard, Frederic Hameury, Aude Flechon, Ellen Blanc, Frederique Dijoud, Brice Fresneau, Sylvie Chabaud
Summary: The TGM13-NS protocol, which aims to decrease the chemotherapy burden while maintaining a high survival rate, showed promising results in patients with non-seminomatous germ cell tumours. However, the IR2 group may require more intensive chemotherapy.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Oncology
Ana-Raluca Mihalcea, Nathalie Garnier, Cecile Faure-Conter, Nicolas Rama, Cecile Renard, Sarah Benezech, Yves Bertrand, Christine Fuhrmann, Carine Domenech
Summary: Infection is a leading cause of death in cancer patients, and the emergence of multidrug resistant bacteria complicates treatment. This study aimed to document the evolution of multidrug resistant bacteria in a tertiary center in Lyon, France. The incidence of multidrug resistant bacteria increased over the years, highlighting the need for awareness and further studies in other centers to prevent dangerous infections in immunocompromised children.
Article
Biochemistry & Molecular Biology
Maria Grazia Andreassi, Nadia Haddy, Mats Harms-Ringdahl, Jonica Campolo, Andrea Borghini, Francois Chevalier, Jochen M. Schwenk, Brice Fresneau, Stephanie Bolle, Manuel Fuentes, Siamak Haghdoost
Summary: The Health Effects of Cardiac Fluoroscopy and Modern Radiotherapy (photon and proton) in Pediatrics (HARMONIC) is a five-year project funded by the European Commission with the aim of improving understanding of long-term ionizing radiation risks for pediatric patients. This paper provides a detailed overview of the project's rationale, design, and methods for the biological aspect, with objectives to understand the molecular pathways and identify potential biomarkers involved in long-term health risks. Biological samples will be collected at three time points, and state-of-the-art analytical methods will be used to assess biomarker levels and explore proteomics and miRNA transcriptomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Pierre Leblond, Emmanuelle Tresch-Bruneel, Alicia Probst, Nadege Neant, Caroline Solas, Arthur Sterin, Thomas Boulanger, Isabelle Aerts, Cecile Faure-Conter, Anne-Isabelle Bertozzi, Pascal Chastagner, Natacha Entz-Werle, Emilie De Carli, Marie-Cecile Le Deley, Gauthier Bouche, Nicolas Andre
Summary: This study tested the repurposing of two non-anticancer drugs to provide less toxic therapeutic options for children with gliomas. The recommended phase II dose of fluvastatin in combination with celecoxib for children with gliomas is 6mg/kg/day, with a fixed daily dose of celecoxib depending on weight. This combination may be explored as a maintenance treatment in low-grade glioma patients to delay tumor recurrence.
Article
Oncology
Pierluigi Calo, Nicolas Pianton, Alexandre Basle, Alexandre Vasiljevic, Marc Barritault, Pierre Aurelien Beuriat, Cecile Faure-Conter, Pierre Leblond
Summary: Currently, there is no clear consensus on the best treatment for children with optic pathway gliomas (OPG). Different chemotherapy regimens have been proposed, but none have proven superiority in terms of progression-free survival (PFS). Recent publications have suggested that the combination of bevacizumab and irinotecan may be effective, although irinotecan has shown digestive side effects. This retrospective study evaluated the efficacy of bevacizumab used as a single agent in children with OPG, and found promising results in terms of tumor response rate and disease control.
Article
Oncology
Stefania Chounta, Rodrigue Allodji, Maria Vakalopoulou, Mahmoud Bentriou, Duyen Thi Do, Florent De Vathaire, Ibrahima Diallo, Brice Fresneau, Thibaud Charrier, Vincent Zossou, Stergios Christodoulidis, Sarah Lemler, Veronique Letort Le Chevalier
Summary: Childhood cancer survivors are at risk of experiencing late effects due to treatment complications, including Valvular Heart Disease (VHD) caused by radiation leakage during radiotherapy. This study explores the use of machine learning algorithms to accurately predict the risk of late VHD in survivors. The results show that the use of dosiomics features significantly improves the predictive capability of the models, especially in the sub-population with spatially heterogeneous dose distribution.
Article
Oncology
Robin Coppin, Helene Martelli, Cyrus Chargari, Helene Sudour-Bonnange, Daniel Orbach, Cecile Verite, Marlene Pasquet, Laure Saumet, Christophe Piguet, Catherine Patte, Florent Guerin, Cecile Faure-Conter, Brice Fresneau
Summary: Childhood vaginal malignant germ cell tumors (MGCTs) have a favorable prognosis with risk-adapted chemotherapy and local treatment of post-chemotherapy residuum, preferably by conservative surgery with partial vaginectomy. Brachytherapy can be an alternative when conservative surgery is not possible or in cases of incomplete resection with residual viable cells.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Mathieu Chicard, Yasmine Iddir, Julien Masliah Planchon, Valerie Combaret, Valery Attignon, Alexandra Saint-Charles, Didier Frappaz, Cecile Faure-Conter, Kevin Beccaria, Pascale Varlet, Birgit Geoerger, Sylvain Baulande, Gaelle Pierron, Yassine Bouchoucha, Francois Doz, Olivier Delattre, Joshua J. Waterfall, Franck Bourdeaut, Gudrun Schleiermacher
Summary: We demonstrated that cell-free DNA extracted from CSF can be used for whole exome sequencing in pediatric embryonal brain tumors, with informative results in 83% of samples. Clonal heterogeneity was identified in most cases compared to primary tumor tissue sequencing. Nucleosome footprinting at transcription start sites of genes of interest enabled the inference of gene expression. These findings pave the way for the use of CSF cfDNA in molecular diagnosis and disease monitoring.
Meeting Abstract
Oncology
Arnault Tauziede-Espariat, Lea Guerrini-Rousseau, Alexandre Perrier, Jacob Torrejon, Flavia Bernardi, Mathilde Filser, Pascale Varlet, Emilie De Carli, Anne Pagnier, Pierre Leblond, Cecile Faure-Conter, Francois Doz, Anne-Isabelle Bertozzi, Ludovic Mansuy, Marjolaine Willems, Gilles Palenzuela, Natacha Entz-Werle, Christine Bourneix, Lauren Hasty, Olivier Delattre, Thomas Blauwblomme, Kevin Beccaria, Alice Metais, Olivier Ayrault, Fabrice Chretien, Franck Bourdeaut, Christelle Dufour, Julien Masliah-Planchon
Meeting Abstract
Oncology
Gabriele Calaminus, Brigitte Bison, Cecile Faure Conter, Didier Frappaz, Andreas Peyrl, Nicolas U. Gerber, Jans-Enno Mueller, Thankamma Ajithkumar, Giovanni Morana, Justin Cross, Torsten Pietsch, Colin Smith, Kristin Solem, Irenne Devenney, Maria Luisa Garre, Herve Brisse, Martin Zimmermann, Rolf-Dieter Kortmann, Claire Alapetite, James Nicholson