期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 26, 期 -, 页码 34-41出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2015.01.023
关键词
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资金
- Japan Society for the Promotion of Science (JSPS) [21000005]
- Japan Science and Technology Agency (JST) Core Research for Evolutional Science and Technology (CREST) of Molecular Technology and Platform for Drug Discovery, Informatics, and Structural Life Science from MEXT, Japan
- Life Science Research Fund of Takeda Science Foundation
- JSPS [P14065]
Naturally occurring macrocyclic peptides represent a unique class of compounds that exhibit various biological activities ranging from antibiotics to immunosuppressant. Although the discovery of such macrocyclic peptides had relied on their isolation from living organisms, recent advances in ribosomal peptide synthesis and in display techniques made it possible to use artificially generated nnacrocyclic peptide libraries for selection of ligands for biologically relevant proteins. In this review, we discuss the technologies and their applications for the discovery of peptide ligands.
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