期刊
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
卷 12, 期 11, 页码 10381-10389出版社
ESG
DOI: 10.20964/2017.11.02
关键词
Electrochemical immunosensor; Enzyme-free; Au-Ag; Alpha fetoprotein; Clinic detection
资金
- Jilin province department K - Ras autoantibodies and MEN1 gene methylation in the study of the role of the liver cancer) [2016Q009]
This study presented the enzyme-free determination of alpha fetoprotein (AFP) using a new electrochemical immunosensor. Our proposed immunosensor consisted of a sandwich system involving catalytic Au-Ag nanocrystals. The determination of AFP in the absence of an enzyme was achieved through the generation of signals by the remarkable Au-Ag alloy-induced catalysis of hydrogen peroxide reduction and the increase in sensitivity by enhanced charge transfer. Our developed immunosensor exhibited a linear range as broad as 0.05-30 ng/mL and a limit of detection (LOD) as low as 0.007 ng/mL. This immunosensor was found to be sensitive for clinical determination due to its simplicity and the involvement of catalytic Au-Ag nanoparticles.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据