Article
Biotechnology & Applied Microbiology
Kamil Piwowarek, Edyta Lipinska, Elzbieta Hac-Szymanczuk, Vitaliy Kolotylo, Marek Kieliszek
Summary: Propionic acid bacteria are a valuable source of metabolites, and this study shows that both propionic acid and vitamin B12 can be sustainably produced through fermentation of residues.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Toxicology
Etienne Mondesert, Celine Eiden, Helene Peyriere, Aude Formoso, Lucas Corti, Jean-Paul Cristol, Stephanie Badiou
Summary: Misuse of inhaled nitrous oxide is a growing concern in France, as it affects the concentration of vitamin B-12 and leads to a range of clinical issues. Measurement of vitamin B-12, homocysteine, and methylmalonic acid concentrations can assist in diagnosing complex cases.
CLINICAL TOXICOLOGY
(2023)
Article
Clinical Neurology
Ulf Wike Ljungblad, Henriette Astrup, Lars Morkrid, Helle Borgstrom Hager, Morten Lindberg, Erik A. Eklund, Anne-Lise Bjorke-Monsen, Terje Rootwelt, Trine Tangeraas
Summary: This study aimed to identify risk factors and describe presenting symptoms and biochemical profiles in infants diagnosed with vitamin B12 deficiency. The results showed that spells, tremor, and irritability were common findings in early infant vitamin B12 deficiency. The administration of nitrous oxide during labor was proposed as a contributing risk factor to the development of early infant vitamin B12 deficiency.
PEDIATRIC NEUROLOGY
(2022)
Article
Hematology
Martine G. Caris, Remko S. Kuipers, Baruch E. Kiestra, Barry J. Ruijter, Robert K. Riezebos, Michiel Coppens, Hans L. Mooij
Summary: Recreational use of nitrous oxide (N2O) is associated with neurological complications and thromboembolisms. This study found a significant association between excessive N2O use and serious thrombotic events, accompanied by high homocysteine concentrations. The findings emphasize the need for increased awareness of the dangers of N2O use among both users and medical professionals.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Review
Toxicology
Michelle C. Paulus, Anjali M. Wijnhoven, Gerdinique C. Maessen, Shannon R. Blankensteijn, Marcel A. G. van der Heyden
Summary: Recreational use of nitrous oxide can lead to psychiatric symptoms, with hallucinations, delusions, and paranoia being the most commonly reported. Vitamin B12 supplementation is more frequently given to patients with accompanying neurological symptoms.
CLINICAL TOXICOLOGY
(2021)
Article
Toxicology
Courtney Temple, B. Zane Horowitz
Summary: This study reported four cases of subacute combined degeneration induced by recreational nitrous oxide abuse despite self-administered vitamin B12 supplementation.
CLINICAL TOXICOLOGY
(2022)
Article
Medicine, General & Internal
Mani Maheshwari, Hemanthkumar Athiraman
Summary: This case report highlights the severe neurologic symptoms caused by vitamin B12 deficiency in a young adult who used nitrous oxide recreationally. It emphasizes the importance of recognizing the harmful effects of recreational nitrous oxide use.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Pediatrics
Ulf Wike Ljungblad, Morten Lindberg, Erik A. Eklund, Ingjerd Saeves, Anne-Lise Bjorke-Monsen, Trine Tangeraas
Summary: This study aimed to investigate the risk factors for vitamin B12 deficiency in infants. The results indicated that the dose of nitrous oxide during labor was the strongest predictor for total homocysteine level in newborn screening dried blood spots.
Review
Pharmacology & Pharmacy
Darmiga Thayabaran, Daniel Burrage
Summary: Research has shown that the use of nitrous oxide can lead to toxicity associated with vitamin B12 deficiency, primarily affecting the haematological and neurological systems. Health warnings have been issued by experts due to its legal status as a recreational drug, making it crucial for clinicians to have an awareness and understanding of the pathophysiology and management of nitrous oxide toxicity.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuhan Zhang, Xiaolian Li, Ziqiang Wang, Yunshan Wang, Yuanyuan Ma, Zhiguo Su
Summary: The study on metabolic flux of Propionibacterium freudenreichii can optimize its fermentation process, increase the production of vitamin B-12 and propionic acid, providing a new strategy for industrial production.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2021)
Article
Clinical Neurology
B. J. Ruijter, M. J. de Mooij, J. E. Bruijnes, W. P. J. van Oosterhout, V. I. H. Kwa
Summary: This study reports a case series of excessive N2O users with neurological complications, including polyneuropathy, myelopathy, and encephalopathy. Testing for serum levels of vitamin B12, homocysteine, and methylmalonic acid may support the clinical diagnosis. Treatment should incorporate vitamin B12 supplementation and strategies to prevent relapses in N2O use.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Berenger Largeau, Arnaud Karam, Camille Potey, Anne-Sylvie Caous, Celine Tard, Louise Carton, Gregory Kuchcinski, Sophie Gautier, Sylvie Deheul, Regis Bordet
Summary: This study investigated the onset patterns of neurological disorders caused by nitrous oxide abuse and found that even low intermittent exposure could lead to neurological damage. There is no safe level of exposure to nitrous oxide in recreational settings.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Medicine, General & Internal
Bahadar S. Srichawla
Summary: The abuse of nitrous oxide, commonly through inhalation of whipped cream canisters, can lead to irreversible neurological deficits. The sale of these canisters, known as whippits, is unregulated in the United States, contributing to the increasing prevalence of abuse. The mechanism of injury is related to severe depletion of vitamin B-12.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Nutrition & Dietetics
Kazim Sahin, Cemal Orhan, Serdar Karatoprak, Mehmet Tuzcu, Patrick Brice Defo Deeh, Ibrahim Hanifi Ozercan, Nurhan Sahin, Merve Yilmaz Bozoglan, Sarah Sylla, Sara Perez Ojalvo, James R. Komorowski
Summary: This study aimed to investigate the impact of different doses of magnesium biotinate (MgB) on social behavior deficits, learning and memory alteration, and inflammatory markers in propionic acid (PPA)-exposed rats. The results showed that MgB supplementation improved behavioral and learning-memory disorders, reduced oxidative stress and inflammation indexes in the brain.
Article
Medical Laboratory Technology
Anders Abildgaard, Cindy Soendersoe Knudsen, Carsten Schriver Hoejskov, Eva Greibe, Tina Parkner
Summary: This study aimed to establish age-adjusted reference intervals for plasma B12 and serum/plasma MMA in the Danish population. The results showed that the concentrations of B12 and MMA are closely related to age and vary among different age groups. Therefore, it is suggested to use age-dependent cut-off values for screening B12 deficiency.
CLINICA CHIMICA ACTA
(2022)