Review
Immunology
Philipp R. R. Esser, Michael Huber, Stefan F. F. Martin
Summary: Maintaining homeostasis is crucial for organismal health. The innate immune system and the unfolded protein response play important roles in inflammation and inflammatory diseases, including allergic contact dermatitis. This review explores the interplay between the innate immune system and cellular stress responses, focusing on the unfolded protein response.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
S. Leng, W. Xu, L. Wu, L. Liu, J. Du, F. Yang, D. Huang, L. Zhang
Summary: Apical periodontitis is an inflammatory condition caused by immunological reaction to invading bacteria. NLRP3 plays a crucial role in the pathogenesis of this condition by disturbing the balance between Treg and Th17 cells. The dysregulation of NLRP3 exacerbates periapical inflammation and bone resorption.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Materials Science, Multidisciplinary
Zhaoxuan Zhu, Qianhui Ma, Xiangfei Meng, Yuxue Pan, Yanhua Li, Jia Wang, Yue Liu, Ping Yang
Summary: This study investigated the morphodynamic changes of interstitial cells, especially Telocytes (TCs), in the skin during the development and treatment of Allergic Contact Dermatitis (ACD) using histological and microscopic scientific methods. The results demonstrated that TCs were mainly present around dermal collagen fibers, perivascular, and skin appendages, and their absence during ACD development and recovery causes dermal interstitial cell dysregulation. The study also revealed the anatomical relationships between TCs, immune cells, and follicular stem cells. Overall, the study provides morphodynamic evidence for ACD development and recovery and offers potential cytological ideas for ACD treatment.
MICROSCOPY AND MICROANALYSIS
(2023)
Article
Immunology
Zsofia Penzes, Shahrzad Alimohammadi, Dorottya Horvath, Attila Olah, Balazs Istvan Toth, Attila Bacsi, Attila Gabor Szollosi
Summary: Extracts and compounds from hemp are gaining popularity in the treatment of various diseases, with topical formulations for dermatological conditions leading the way. This study investigates the effects of different phytocannabinoids on human dendritic cells, and shows that CBD achieves its anti-inflammatory effect by reprogramming cells during long-term treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
B. Shoshana Zha, Ludovic Desvignes, Tawania J. Fergus, Amber Cornelius, Tan-Yun Cheng, D. Branch Moody, Joel D. Ernst
Summary: In the early stages of tuberculosis infection, the interactions between different strains of Mycobacterium tuberculosis and lung leukocytes can shape the adaptive immune responses.
Review
Immunology
Edries Yousaf Hajam, Patricia Panikulam, Chung-Ching Chu, Haarshadri Jayaprakash, Amitabha Majumdar, Colin Jamora
Summary: As the interface between the body and the environment, the skin not only acts as a physical barrier, but also as an immunologically active organ. Regulatory T cells (T-regs) play a crucial role in maintaining homeostasis, clearing pathogens, and promoting wound healing. Recent studies have uncovered non-lymphoid functions of cutaneous T-regs, suggesting that they have executive control over various biological activities in the skin. These findings highlight the importance of T-regs and their potential role in future discoveries in the field of regenerative medicine.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Lei Zhao, Xi Yang
Summary: The interaction between dendritic cells and NKT cells is crucial for host defense against infections, as they can modulate each other's immune responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kanako Nakayama, Hiroe Tetsu, Taku Nishijo, Takuo Yuki, Masaaki Miyazawa
Summary: Allergic contact dermatitis (ACD) and atopic dermatitis (AD) are common inflammatory diseases. This study investigated the commonality of findings across haptens and mechanisms focused on dendritic cells (DCs) in AD. The results revealed that attenuated contact hypersensitivity (CHS) responses in AD may be hapten-independent and the tolerogenic phenotype of hapten-bearing DCs can contribute to reduced T-cell proliferation and CHS responses.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Zheng Liu, Zhan Fan, Jinxin Liu, Jialu Wang, Mengli Xu, Xinlin Li, Yilun Xu, Yafang Lu, Chenlu Han, Zhihong Zhang
Summary: An immunomodulatory approach based on lipid nanoparticles carrying alpha-helical configurational melittin is developed to treat allergic contact dermatitis and atopic dermatitis by suppressing T cell-mediated inflammatory reactions.
Review
Immunology
Arnolda Jakovija, Tatyana Chtanova
Summary: The skin, as the body's largest organ, serves as a barrier to pathogens and the first line of immune defense. In the event of skin injury, a series of events contribute to wound repair, including inflammation, tissue formation, and tissue remodeling. Immune cells in the skin work alongside non-immune cells to clear pathogens, debris, and guide tissue regeneration. Disruption to the wound repair process can lead to chronic inflammation and non-healing wounds, which can promote skin cancer development by hijacking the wound healing response.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Zhengwang Sun, Ravi Vattepu, Songfa Zhang
Summary: Skin acts as the outermost barrier protecting the body against external invasion, with immune cell migration and chemokines playing crucial roles in restoring and maintaining skin homeostasis. The complex dynamics of the immune ecosystem in the skin require coordination between innate and adaptive immune cells, while abnormal chemokine-chemokine receptor interactions can lead to and exacerbate skin inflammation in conditions such as contact hypersensitivity, atopic dermatitis, and psoriasis.
Review
Immunology
Risa Tamagawa-Mineoka
Summary: The skin acts as a physical barrier and toll-like receptors (TLRs) play a role in both infectious and non-infectious inflammatory diseases. In atopic dermatitis (AD), skin barrier dysfunction allows stimuli to penetrate the skin and activate the innate immune system, leading to inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Oceane Paris, Franck J. D. Mennechet, E. J. Kremer
Summary: This study investigated the interaction between ILCs and adaptive immune response. The researchers found that ILCs uptake HAdVs, leading to phenotypic maturation and cytokine secretion. Moreover, the complex of neutralizing antibodies and host defense proteins altered the cytokine profile generated by ILCs, potentially impacting the efficacy of adenovirus-based vaccines.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Xin Tian, Qiongxiao Huang, Jingyao Liang, Jianqin Wang, Jing Zhang, Yan Yang, Qianru Ye, Suling He, Junlong Li, Zhouwei Wu, Yumei Liu
Summary: The dysregulation of skin microflora and Staphylococcus aureus infection in patients with AD have become research hotspots. Staphylococcus aureus infection can cause inflammatory damage in keratinocytes, leading to a vicious cycle.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Review
Multidisciplinary Sciences
Tamia A. Harris-Tryon, Elizabeth A. Grice
Summary: The human skin acts as a protective barrier and plays a crucial role in our overall health. The microbiota colonization on the skin plays a significant role in maintaining the skin's barrier function and protecting against pathogens. Understanding the host-microbiota interactions can provide insights into the development and management of skin disorders.
