Article
Plant Sciences
Yue Li, Lei Zhang, Pan Ren, Yang Yang, Sinai Li, Xiaomei Qin, Meng Zhang, Mingxue Zhou, Weihong Liu
Summary: Our study demonstrates that Qing-Xue-Xiao-Zhi formula (QXXZF) has a significant inhibitory effect on the development of atherosclerosis in ApoE(-/-) mice fed a high-fat and high-choline diet, with decreased atherosclerotic plaques, plasma lipid levels, and serum TMAO content. Additionally, QXXZF effectively reduces foam cell formation and promotes reverse cholesterol transport in macrophages, influencing cholesterol metabolism by inhibiting the TLR4-mediated NF-kappa B axis. These findings provide new insights into the anti-atherosclerotic mechanisms of QXXZF.
Article
Biochemistry & Molecular Biology
Wenjuan Mu, Shuwen Qian, Yanjue Song, Lijie Yang, Saisai Song, Qiqi Yang, Hao Liu, Yang Liu, Dongning Pan, Yan Tang, Qi-Qun Tang
Summary: Loss of bone morphogenetic protein 4 (BMP4) in perivascular adipose tissue (PVAT) leads to reduced brown adipocyte-characteristic gene expression and increased endothelial inflammation, exacerbating atherosclerosis in ApoE-/- mice. Conversely, overexpression of BMP4 in adipose tissues promotes browning of PVAT and protects against atherosclerosis. These findings highlight the importance of organ crosstalk between PVAT and blood endothelial cells in the development of atherosclerosis.
Article
Biochemistry & Molecular Biology
Xiaoqing Guo, Bowei Li, Cheng Wen, Feng Zhang, Xuying Xiang, Lei Nie, Jiaojiao Chen, Ling Mao
Summary: Disordered lipid accumulation in the arterial wall is a hallmark of atherosclerosis. This study investigated the role of triggering receptor expressed on myeloid cells 2 (TREM2) in atherosclerosis using animal models and cell cultures. The results showed that TREM2 promotes the development of atherosclerosis by promoting foam cell formation in vascular smooth muscle cells and macrophages through regulating the expression of the scavenger receptor CD36. These findings suggest that TREM2 may be a potential therapeutic target for the treatment of atherosclerosis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Pathology
Aline Gottlieb, Som Dev, Lauren DeVine, Kathleen L. Gabrielson, Robert N. Cole, James P. Hamilton, Svetlana Lutsenko
Summary: Wilson disease is caused by inactivation of the copper transporter ATP7B and diet has an impact on liver phenotype in Wilson disease patients. Despite elevated hepatic copper levels, liver inflammation was reduced in high calorie diet conditions, causing changes in cellular pathways.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Review
Physiology
Wei Zhang, Linyong Xu, Ling Zhu, Yifan Liu, Siwei Yang, Mingyi Zhao
Summary: Lipid droplets (LDs) are organelles related to cell metabolism, composed of polar lipids and proteins on the surface with neutral lipids in the core. LDs play a pivotal role in various physiological and pathological processes, including antitumor immunity, anti-infective immunity, and metabolic immune diseases. Additionally, the interaction between LDs and immune cells is analyzed in atherosclerosis and Mycobacterium tuberculosis infection.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Environmental Sciences
Quanlong Hong, Lin Ling, Wenli Huang, Yilan Liu, Yafen Zhuo, Zhenzhen Hong, Bing Wu, Yi Zhang
Summary: The study shows that overexpression of RNCR3 in patients with atherosclerosis increases cell proliferation and inflammatory cytokine secretion, while the level of miR-185-5p is lower in their serum. Additionally, there is a negative correlation between miR-185-5p and RNCR3 expression in the serum of these patients.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Physiology
Zhi Ouyang, Jian Zhong, Junyi Shen, Ye Zeng
Summary: Atherosclerosis is an inflammatory disease initiated by endothelial activation, in which various components like lipoprotein, cholesterol, extracellular matrix, and immune and non-immune cells accumulate and form plaques on the arterial wall. Foam cells, previously believed to be derived from macrophages or smooth muscle cells, play a crucial role in the occurrence, development, and rupture of atherosclerotic plaques. The distribution of atherosclerotic plaques is not random, but concentrated at the bend and bifurcation of the arterial tree. Mechanical stress affects the development and rupture of atherosclerotic plaques, and this review discusses the advances in understanding foam cell formation, plaque regulation, and lipid metabolism regulation by mechanical forces in atherosclerosis.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Pu-Lin Liang, Qian-Wen Liang, Pei-Wen He, Xue-Lian Chen, Ya Xu, Hai-Sheng Tu, Liang Zhang, Xiao-Hui Qiu, Jing Zhang, Zhi-Hai Huang, Wen Xu
Summary: This study investigated the regulatory effects of three polymethoxyflavones on foam cell formation and explored the molecular mechanisms. The results showed that these flavones can alleviate inflammation, inhibit oxidized low-density lipoprotein uptake and foam cell formation, and promote cholesterol efflux mediated by high-density lipoprotein.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Genetics & Heredity
GenYi Qu, Lu Liu, Lai Yi, Cheng Tang, Guang Yang, Dan Chen, Yong Xu
Summary: A risk coefficient model of long non-coding RNAs (lncRNAs) associated with lipid metabolism was established using model algorithms to predict the prognosis in patients with clear cell renal cell carcinoma (ccRCC) and to understand cancer lipid metabolism and sensitivity to immune-targeting drugs.
FRONTIERS IN GENETICS
(2023)
Review
Endocrinology & Metabolism
Ping Ling, Xueying Zheng, Sihui Luo, Junbo Ge, Suowen Xu, Jianping Weng
Summary: ASCVD is the largest cause of morbidity and mortality worldwide, with lipid-lowering therapies as the current major cornerstone of its management. However, some patients do not respond to standard therapies and remain at high risk of ASCVD.
DIABETES OBESITY & METABOLISM
(2021)
Article
Medicine, Research & Experimental
Xin-Yu Yang, Hang Yu, Jie Fu, Hui-Hui Guo, Pei Han, Shu-Rong Ma, Li-Bin Pan, Zheng-Wei Zhang, Hui Xu, Jia-Chun Hu, Hao-Jian Zhang, Meng-Meng Bu, Xian-Feng Zhang, Wei Yang, Jing-Yue Wang, Jing-Yu Jin, Hui-Cong Zhang, Dong-Rui Li, Jin-Yue Lu, Yuan Lin, Jian-Dong Jiang, Qian Tong, Yan Wang
Summary: In this study, the efficacy of hydroxyurea in treating atherosclerosis in high-fat diet-fed ApoE-/-mice was investigated. It was found that hydroxyurea effectively reduced serum cholesterol levels and modulated the composition of gut microbiota. Furthermore, the expression of NPC1L1 in small intestinal epithelial cells was significantly reduced after hydroxyurea treatment, affecting cholesterol absorption.
Article
Immunology
Zeping Zhang, Boyan Zhang, Xianzhe Jiang, Yue Yu, Yimeng Cui, Hailing Luo, Bing Wang
Summary: This study found that hyocholic acid supplementation alleviated kidney lipid deposition and reduced kidney weight. The activation of bile acid receptors and the alteration of immune response and fibrosis-related genes contributed to the reduction of renal cholesterol accumulation. This study revealed the important role of hyocholic acid in alleviating kidney lipid accumulation and inflammatory response.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Marisa Fernandes das Neves, Joana R. Batuca, Jose Delgado Alves
Summary: Inflammation and immune dysfunction play crucial roles in the development of atherosclerosis. Low HDL levels are associated with both atherosclerosis and autoimmune rheumatic diseases, suggesting a potential link between the two. HDL modulates immune responses by affecting cholesterol transport and lipid raft disruption, predominantly showing anti-inflammatory effects despite some pro-inflammatory actions.
Article
Biochemistry & Molecular Biology
Evgeniya Shcherbinina, Tatiana Abakumova, Daniil Bobrovskiy, Ilia Kurochkin, Ksenia Deinichenko, Elena Stekolshchikova, Nickolay Anikanov, Rustam Ziganshin, Pavel Melnikov, Ekaterina Khrameeva, Maria Logacheva, Timofei Zatsepin, Olga Sergeeva
Summary: Long non-coding RNAs play an important role in glucose and lipid metabolism. The murine lncRNA Falcor/LL35, a functional analog of human DEANR1/linc00261, is involved in the regulation of glycolysis and lipid biosynthesis. The depletion of LL35 affects the Notch and NF-kappa B signaling pathways, leading to decreased proliferation and migration of hepatocytes.
Article
Pharmacology & Pharmacy
Yifei Chen, Fangpu Yu, Yu Zhang, Mengmeng Li, Mingxue Di, Weijia Chen, Xiaolin Liu, Yun Zhang, Mei Zhang
Summary: Tongxinluo (TXL) is a traditional Chinese medication that plays a key role in the formation and progression of atherosclerotic plaques by inhibiting lipid deposition through enhancing autophagy in macrophages. It also reverses the inhibitory effect of class I histone deacetylases on the expression of Beclin-1.
FRONTIERS IN PHARMACOLOGY
(2021)
