Article
Cell Biology
Zhigang Li, Yilei Meng, Chang Liu, Huan Liu, Wenze Cao, Chang Tong, Min Lu, Li Li, Luying Peng
Summary: Myocardial dysfunction is a significant manifestation in sepsis, with Kcnh2 potentially playing a protective role in sepsis-induced cardiac dysfunction by regulating FAK/AKT-FOXO3A signaling pathway to block LPS-induced myocardium apoptosis.Survival outcome in Kcnh2(+/-) septic rats was markedly deteriorated, compared with Kcnh2(+/+) rats. Activation of AKT or knockdown of FOXO3A attenuated the pathological manifestations mediated by Kcnh2 defect.
CELL PROLIFERATION
(2021)
Article
Cardiac & Cardiovascular Systems
Menglin Liu, Zhen Wang, Jishou Zhang, Di Ye, Menglong Wang, Yao Xu, Mengmeng Zhao, Yongqi Feng, Xiyi Lu, Heng Pan, Wei Pan, Cheng Wei, Dan Tian, Wenqiang Li, Jingjun Lyu, Jing Ye, Jun Wan
Summary: This study investigated the role of IL-12p40 in LPS-induced cardiac dysfunction and its mechanisms. The findings showed that IL-12p40 deletion exacerbated LPS-induced cardiac injury and dysfunction by regulating the NF-kappa B and MAPK signaling pathways and involving monocytes. Moreover, adoptive transfer of IL-12p40-positive monocytes alleviated LPS-induced cardiac dysfunction. Therefore, IL-12p40 plays a protective role in sepsis-induced cardiac dysfunction.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Yan Cao, Zhengyu Liu, Wenfeng Ma, Chen Fang, Yanfang Pei, Yingxia Jing, Jie Huang, Xiaotong Han, Weiwei Xiao
Summary: This study used metabolomic profiling to distinguish between septic patients with and without cardiac dysfunction, and identified kynurenic acid and gluconolactone as potential biomarkers for cardiac dysfunction, as well as kynurenic acid and galactitol as prognostic markers for survivors and non-survivors in the cardiac dysfunction group.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pharmacology & Pharmacy
Zhen Wang, Menglin Liu, Di Ye, Jing Ye, Menglong Wang, Jianfang Liu, Yao Xu, Jishou Zhang, Mengmeng Zhao, Yongqi Feng, Shuwan Xu, Wei Pan, Zhen Luo, Dan Li, Jun Wan
Summary: The study revealed an upregulation of Il12a in septic patients, while Il12a deletion exacerbated sepsis-induced cardiac dysfunction and injury mainly by affecting macrophage activity and the NF-κB signaling pathway. The findings suggest Il12a as a potential target for treating sepsis-induced cardiac dysfunction.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Hong Zhang, Xiaofei Wu, Yanyan Tao, Guoyu Lu
Summary: This study investigated the cardioprotective role of berberine in sepsis-induced cardiac dysfunction by upregulating the Akt/eNOS pathway. Berberine improved ventricular function and decreased plasma myocardial injury markers, inflammatory factors and oxidative stress levels. However, the cardioprotective effects of berberine were counteracted by L-NAME, an NOS inhibitor.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Cell Biology
Guy Nadel, Zhong Yao, Ehud Wainstein, Izel Cohen, Ido Ben-Ami, Amir Schajnovitz, Galia Maik-Rachline, Zvi Naor, Benjamin A. Horwitz, Rony Seger
Summary: This study identifies the mechanism for the unique inactivation of AKT following the activation of GqPCRs. The main regulator of this process is the phosphatase PP2A, which operates with the non-canonical regulatory subunit IGBP1. The results demonstrate a stimulated shift of PP2Ac from PI3K to AKT, leading to the repression of the PI3K/AKT pathway.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Biochemistry & Molecular Biology
Alice Chiara Manetti, Aniello Maiese, Marco Di Paolo, Alessandra De Matteis, Raffaele La Russa, Emanuela Turillazzi, Paola Frati, Vittorio Fineschi
Summary: miRNAs are single-strand ribonucleic acids that can be used as biomarkers in sepsis, affecting cardiac dysfunction. Research suggests that miRNAs may be used as biomarkers for early sepsis-induced cardiac dysfunction or as new drug targets, aiding clinicians in detecting, preventing, and treating cardiac damage early.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Zhengyu Liu, Hongwei Pan, Yixiong Zhang, Zhaofen Zheng, Weiwei Xiao, Xiuqin Hong, Fang Chen, Xiang Peng, Yanfang Pei, Jingjing Rong, Jin He, Lianhong Zou, Jia Wang, Jie Zhong, Xiaotong Han, Yan Cao
Summary: The study demonstrates that G-Rg1 inhibits sepsis-induced cardiac dysfunction and mitochondrial dysfunction by activating the Akt/GSK-3 beta pathway through P2X7 receptors.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ao Wei, Jingjing Liu, Dihua Li, Yanmin Lu, Lei Yang, Yuzhen Zhuo, Wencong Tian, Hongliang Cong
Summary: The study demonstrated that syringaresinol (SYR) exerts a protective effect on sepsis-induced cardiac dysfunction through the ER/SIRT1/NLRP3/GSDMD pathway. These findings provide a new insight into the treatment of sepsis-induced cardiac dysfunction.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Immunology
Chiara Verra, Shireen Mohammad, Gustavo Ferreira Alves, Elisa Porchietto, Sina Maren Coldewey, Massimo Collino, Christoph Thiemermann
Summary: This study found that activation of the JAK/STAT pathway is associated with cardiac dysfunction and multiple-organ failure in a mouse model of trauma-induced sepsis. Treatment with the JAK1/JAK2 inhibitor baricitinib can inhibit the activation of these pathways and protect mice from sepsis-induced cardiac injury and multiple-organ failure.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Hanzhi Ling, Yufan Lin, Weilei Bao, Nannan Xu, Liping Chen, Lin Zhao, Chuanlong Liu, Yecheng Shen, Danlu Zhang, Yuqiang Gong, Qiuqi Gao, Jianguang Wang, Shengwei Jin
Summary: The study found that Erythropoietin (EPO) has protective effects in septic gut damage, improving survival rate, reducing inflammatory responses, and ameliorating intestinal damage. EPO treatment also reversed gut microbiota dysbiosis caused by sepsis. Additionally, IL-17 F was identified as a potential therapeutic target for sepsis-induced gut damage.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Zhen Qi, Renrong Wang, Rongheng Liao, Song Xue, Yongyi Wang
Summary: Neferine can protect the heart from lipopolysaccharide-induced damage, improve cardiac function, increase survival rate, and alleviate apoptosis and oxidative stress by activating the PI3K/AKT/mTOR signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Gen Chen, Ning An, Jingling Shen, Huinan Chen, Yunjie Chen, Jia Sun, Zhicheng Hu, Junhui Qiu, Cheng Jin, Shengqu He, Lin Mei, Yanru Sui, Wanqian Li, Peng Chen, Xueqiang Guan, Maoping Chu, Yang Wang, Litai Jin, Kwonseop Kim, Xiaokun Li, Weitao Cong, Xu Wang
Summary: This study reveals that FGF18 has a cardioprotective effect by maintaining redox homeostasis through the FYN/Nox4 signaling axis. It is found that overexpression of FGF18 can alleviate hypertrophy, decrease oxidative stress, attenuate cardiomyocyte apoptosis, and ameliorate fibrosis and cardiac function in pressure overload-induced pathological cardiac hypertrophy.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Lei Li, Ling Chen, Fang Lin, Jinsong Mu, Dan Wang, Wei Zhang, Lai Mi, Yuling Qin, Yuesu Zhou
Summary: The study revealed significantly elevated levels of IL-6, IL-10, and IL-17 in patients with acute-on-chronic liver failure combined with sepsis, while IL-4 remained unchanged. These findings suggest a potential correlation between inflammatory factors and the development of coagulation dysfunction and sepsis in liver failure patients. The results provide new insights and strategies for delaying deterioration in clinical practice.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Zhe Cheng, Dingyi Lv, Minghao Luo, Ruiyu Wang, Yongzheng Guo, Xiyang Yang, Longxiang Huang, Xingbing Li, Chang Li, Fei-Fei Shang, Bi Huang, Jian Shen, Suxin Luo, Jianghong Yan
Summary: The study found that tubeimoside I (TBM) can alleviate sepsis-induced cardiac dysfunction (SICD) and exerts its effects through SIRT3. Additionally, SIRT3 plays an essential role in the cardioprotective effects of TBM.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Letter
Cardiac & Cardiovascular Systems
Daisuke Morisawa, Shinichi Hirotani, Makiko Oboshi, Koichi Nishimura, Hisashi Sawada, Akiyo Eguchi, Yoshitaka Okuhara, Toshihiro Iwasaku, Yoshiro Naito, Toshiaki Mano, Haruki Okamura, Tohru Masuyama
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2016)