Article
Biochemistry & Molecular Biology
Alessandro Pierri, Giulia Gagno, Alessandra Fluca, Davide Radaelli, Diana Bonuccelli, Laura Giusti, Michela Bulfoni, Antonio P. Beltrami, Aneta Aleksova, Stefano D'Errico
Summary: There is increasing evidence of cardiac involvement in COVID-19 cases, with a wide range of clinical manifestations. Acute myocarditis is a rare but frightening complication of SARS-CoV-2 infection, and most reports lack histological confirmation of cardiac injury. This case report provides microscopic and genetic evidence suggesting direct cardiac involvement compatible with fulminant myocarditis in a young lady who died suddenly after testing positive for SARS-CoV-2.
Article
Veterinary Sciences
Emily A. Gavic, Sarah E. Achen, Phillip R. Fox, Eduardo J. Benjamin, Jonathan Goodwin, Tamilselvam Gunasekaran, Karsten E. Schober, Sonja S. Tjostheim, John Vickers, Jessica L. Ward, Duncan S. Russell, Mark Rishniw, Sarah A. Hamer, Ashley B. Saunders
Summary: This study describes the clinical presentation and outcome of dogs diagnosed with Trypanosoma cruzi infection in nonendemic areas and surveys veterinary cardiologists in North America for Chagas disease awareness. Results indicate the potential for encountering T cruzi infection in dogs in nonendemic areas and emphasize the need for raising awareness about Chagas disease in North America.
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
James McKinney, Kim A. Connelly, Paul Dorian, Anne Fournier, Jack M. Goodman, Nicholas Grubic, Saul Isserow, Nathaniel Moulson, Francois Philippon, Andrew Pipe, Paul Poirier, Taryn Taylor, Jane Thornton, Mike Wilkinson, Amer M. Johri
Summary: The COVID-19 pandemic has had significant health, financial, and societal impacts, leading to the cancellation of organized sporting events and increased focus on protecting athletes from infection-related harm. Athletes with suspected or confirmed COVID-19 infection are advised to refrain from exercise for 7 days post symptoms resolution before gradually returning to activity, with medical assessment recommended for those showing new cardiac symptoms or reduced fitness levels.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ibrahim El-Battrawy, Katharina Koepsel, David Tenbrink, Boldizsar Kovacs, Tobias C. Dreher, Christian Blockhaus, Michael Gotzmann, Norbert Klein, Thomas Kuntz, Dong-In Shin, Hendrik Lapp, Stephanie Rosenkaimer, Mohammad Abumayyaleh, Nazha Hamdani, Ardan Muammer Saguner, Jacqueline Kowitz, Julia W. Erath, Firat Duru, Andreas Muegge, Ibrahim Akin, Assem Aweimer, Thomas Beiert
Summary: This study shows that the use of wearable cardioverter-defibrillator (WCD) may be beneficial for the treatment of patients with myocarditis. Prior ventricular arrhythmia may be a better predictor of risk than a reduced left ventricular ejection fraction <35% in this population.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Psychiatry
Brandi L. Bellissima, Alisha Vara, Nuala Helsby, Fintan Garavan, Malcolm D. Tingle
Summary: The study conducted a retrospective review of patients initiating clozapine in the Auckland District Health Board (ADHB) region, finding an incidence of clozapine-associated myocarditis and cardiomyopathy at 3.8% and 1.3% respectively over a two-year period.
PSYCHIATRY RESEARCH
(2021)
Article
Medicine, General & Internal
Matteo Antonio Sacco, Ludovico Abenavoli, Fabrizio Cordasco, Francesco Maria Galassi, Elena Varotto, Pietrantonio Ricci, Isabella Aquila
Summary: This article reports a case of sudden death in a woman, with autopsy and histopathological investigations revealing lymphocytic myocarditis. The patient's clinical history showed that she had visited the hospital a few days earlier for joint pain and low-grade fever.
CLINICAL CASE REPORTS
(2022)
Letter
Cardiac & Cardiovascular Systems
D. Patriki, N. Baltensperger, J. Berg, L. T. Cooper, C. K. Kissel, J. Kottwitz, M. Lovrinovic, R. Manka, F. Scherff, C. Schmied, F. C. Tanner, T. F. Luescher, Bettina Heidecker
Summary: This study prospectively followed 30 patients with newly diagnosed myocarditis for 12 months, finding that the risk of cardiac events one year after diagnosis appeared to be low after resuming exercise after 3 months. No cardiac events or worsening LVEF were noted during the 6- and 12-month follow-up period.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Carlos de las Cuevas, Manuel Arrojo-Romero, Can-Jun Ruan, Georgios Schoretsanitis, Emilio J. J. Sanz, Jose de Leon
Summary: Clozapine-induced myocarditis in children has been studied using PubMed and the World Health Organization's Vigibase database. The findings indicate that myocarditis can occur in children due to clozapine and the risk is higher in the first 30 days of up-titration. The data from Vigibase showed a significant disproportionality in the occurrence of clozapine-induced myocarditis.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Babken Asatryan, Angeliki Asimaki, Andrew P. Landstrom, Mohammed Y. Khanji, Katja E. Odening, Leslie T. Cooper, Francis E. Marchlinski, Anna R. Gelzer, Christopher Semsarian, Tobias Reichlin, Anjali T. Owens, C. Anwar A. Chahal
Summary: Arrhythmogenic cardiomyopathy (ACM) is primarily caused by genetic defects in proteins of the cardiac intercalated disc, with wide phenotype variability. Inflammation and immune responses are considered aggravators of cardiac myocyte damage, and play a role in the pathogenesis of ACM.
Review
Psychiatry
Mark Vickers, Vinay Ramineni, Eva Malacova, Lars Eriksson, Kirsten McMahon, Vikas Moudgil, James Scott, Dan Siskind
Summary: This study conducted a systematic review and meta-analysis to identify potential risk factors for clozapine-induced myocarditis and cardiomyopathy. The results showed that concurrent use of sodium valproate increased the odds of clozapine-induced myocarditis, while other factors, including quetiapine, lithium, and selective serotonin reuptake inhibitors, were not significantly associated with increased risk. Conflicting results were found for increasing age and higher clozapine dose as risk factors for myocarditis. No risk factors for cardiomyopathy were identified in the literature.
ACTA PSYCHIATRICA SCANDINAVICA
(2022)
Article
Cardiac & Cardiovascular Systems
Amrit S. Lota, Mark R. Hazebroek, Pantazis Theotokis, Rebecca Wassall, Sara Salmi, Brian P. Halliday, Upasana Tayal, Job Verdonschot, Devendra Meena, Ruth Owen, Antonio de Marvao, Alma Iacob, Momina Yazdani, Daniel J. Hammersley, Richard E. Jones, Riccardo Wage, Rachel Buchan, Fredrik Vivian, Yakeen Hafouda, Michela Noseda, John Gregson, Tarun Mittal, Joyce Wong, Jan Lukas Robertus, A. John Baksi, Vassilios Vassiliou, Ioanna Tzoulaki, Antonis Pantazis, John G. F. Cleland, Paul J. R. Barton, Stuart A. Cook, Dudley J. Pennell, Pablo Garcia-Pavia, Leslie T. Cooper, Stephane Heymans, James S. Ware, Sanjay K. Prasad
Summary: The study investigated the frequency and clinical consequences of genetic variants associated with dilated cardiomyopathy (DCM) and arrhythmogenic cardiomyopathy (ACM) in patients with acute myocarditis. The findings suggest that these genetic variants have clinical implications for treatment, risk stratification, and family screening in patients with acute myocarditis.
Article
Cardiac & Cardiovascular Systems
Pierre Ollitrault, Mayane Al Khoury, Yann Troadec, Yoann Calcagno, Laure Champ-Rigot, Virginie Ferchaud, Arnaud Pellissier, Damien Legallois, Paul Milliez, Fabien Labombarda
Summary: This study evaluated the association between recurrent acute myocarditis (RAM) episodes and the later diagnosis of genetic arrhythmogenic cardiomyopathy (ACM). The results showed that RAM episodes were related to the occurrence of genetic ACM, suggesting that RAM episodes might represent the early inflammatory phases of the disease. Therefore, including RAM episodes in the ACM diagnosis criteria may facilitate early diagnosis and potential therapeutic interventions.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Basel A. Abdel-Wahab, Safaa Yousef Salem, Hala Mostafa Mohammed, Nashwa Ahmed Mohammed, Helal F. Hetta
Summary: Clozapine is effective for treating resistant schizophrenia, but can cause myocarditis in psychiatric patients. Beta-blockers are helpful in managing myocarditis. Propranolol demonstrated a protective effect against Clozapine-induced myocarditis, involving Vimentin and Connexin-43 proteins.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Andres F. Miranda-Arboleda, Luis Gerardo Gonzalez-Barrera, Kiera Liblik, Juan Farina, Ezequiel Jose Zaidel, Clara Saldarriaga, Zier Zhou, Reem Al-Rawi, Jose Patricio Lopez-Lopez, Jorge P. Juarez-Lloclla, Shyla Gupta, Dorairaj Prabhakaran, R. Krishna Kumar, Alvaro Sosa-Liprandi, Adrian Baranchuk
Summary: Sudden cardiac death is responsible for 6% of global mortality and 25% of cardiovascular deaths. Besides the known diseases, neglected tropical diseases have also been found to be associated with SCD, potentially leading to fatal arrhythmias in patients.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
George Markousis-Mavrogenis, George Poulos, Theodoros Dimitroulas, Aikaterini Giannakopoulou, Clio Mavragani, Vasiliki Vartela, Dionysia Manolopoulou, Genovefa Kolovou, Paraskevi Voulgari, Petros P. Sfikakis, George D. Kitas, Sophie I. Mavrogeni
Summary: In patients with non-sustained ventricular tachycardia and preserved ejection fraction, cardiovascular magnetic resonance identified different arrhythmogenic substrates in those with and without autoimmune rheumatic diseases. Patients with autoimmune rheumatic diseases exhibited predominantly non-ischaemic cardiac fibrosis patterns, with evidence of diffuse inflammatory and ischaemic changes. Tissue characterisation indices were significant even after accounting for potential confounding factors.
Article
Cardiac & Cardiovascular Systems
Shazia Shehzad Abbas, Tazeen Majeed, Balakrishnan R. Nair, Peta M. Forder, Natasha Weaver, Julie E. Byles
Summary: The study revealed that some atrial fibrillation patients did not receive any medication, while most of those who did received a combination therapy. Various medication patterns were identified, with patients likely to stick to the same pattern in the long-term. It emphasized the importance of initial patient assessment and stroke risk score evaluation in determining atrial fibrillation treatment to avoid potential complications.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
(2021)
Article
Cardiac & Cardiovascular Systems
Usaid K. Allahwala, Peter A. Cistulli, Avedis Ekmejian, Nadeem Mughal, Hasthi U. Dissanayake, Michael Ward, James C. Weaver, Ravinay Bhindi
Summary: In patients with a chronic total occlusion, documented obstructive sleep apnea (OSA) is independently associated with more robust coronary collaterals and lower mortality. The cardioprotective implications of intermittent hypoxia in OSA, as well as treatment effect, require further investigation.
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Article
Health Care Sciences & Services
Shazia S. Abbas, Tazeen Majeed, Natasha Weaver, Balakrishnan R. Nair, Peta M. Forder, Julie E. Byles
Summary: This study estimated and compared SF-6D utility scores for older women with atrial fibrillation (AF), revealing higher health utility for women living in regional and remote areas and using oral anticoagulants. Factors negatively associated with health utility included difficulty managing living expenses, low physical activity, disability, history of stroke, and history of arthritis.
QUALITY OF LIFE RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Usaid K. Allahwala, Hosen Kiat, Avedis Ekmejian, Nadeem Mughal, Levi Bassin, Michael Ward, James C. Weaver, Ravinay Bhindi
Summary: The study found that in patients with a chronic total occlusion (CTO), the presence of robust coronary collaterals is not associated with prognosis, while patients who undergo surgical or percutaneous coronary revascularization have a better prognosis compared to those who only receive medical management. Further research into the optimal revascularization strategy for CTO is needed.
Article
Cardiac & Cardiovascular Systems
Michael McGee, Stuart Sugito, Mohammed S. Al-Omary, Darren Hartnett, Tharindu Senanayake, Kristy Hales, Tazeen Majeed, Doan T. M. Ngo, Patrick Oakley, James W. Leitch, Aaron L. Sverdlov, Andrew J. Boyle
Summary: The study found that Aboriginal and Torres Strait Islander patients admitted with heart failure are typically younger, more likely to live in rural areas, and have a higher burden of comorbidities. However, after adjusting for age and comorbidities, indigenous status does not predict worse outcomes.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Avedis A. Ekmejian, Ravinay Bhindi, Gemma A. Figtree
Article
Multidisciplinary Sciences
Tanmay Bagade, Kailash Thapaliya, Erica Breuer, Rashmi Kamath, Zhuoyang Li, Elizabeth Sullivan, Tazeen Majeed
Summary: Infertility affects millions of people globally, but little is known about its impact on mental health. This study used data from the Australian Longitudinal Study on Women's Health to investigate the mental health impacts of infertility on women. The findings showed that infertility has a significant impact on women's mental health, even after it is resolved.
SCIENTIFIC REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Belinda M. Brucki, Tanmay Bagade, Tazeen Majeed
Summary: Since March 2020, Victoria, Australia has experienced six lockdowns, totaling 264 days, making it the city with the longest cumulative lockdown in the world. This Health Impact Assessment focuses on gender disparities, specifically women's mental health, as indicated by increased levels of psychological distress during the lockdowns.
Article
Cardiac & Cardiovascular Systems
Avedis Ekmejian, Hari Sritharan, Dinesh Selvakumar, Venkateshka Venkateshka, Usaid Allahwala, Michael Ward, Ravinay Bhindi
Summary: This meta-analysis investigated the outcomes of diabetic and non-diabetic patients in whom revascularization was deferred based on negative FFR. The study found that diabetes was associated with an increased risk of cardiovascular events, unplanned revascularization, all-cause mortality, and cardiovascular mortality compared to non-diabetic patients.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Avedis Ekmejian, Usaid Allahwala, Michael Ward, Ravinay Bhindi
Summary: Invasive coronary physiology is used by interventional cardiologists to guide the management of coronary artery disease. The readings of invasive coronary physiology can be influenced and confounded by various factors, both within and beyond the coronary tree. This review article aims to summarize the impact of these factors on invasive coronary physiology and distinguish factors that contribute to ischemia from confounding factors. The potential for mis-classification of ischemic status is highlighted, and targets for future research are identified to improve the precision of physiology-guided management of coronary artery disease. (Am Heart J 2023;257:51-61.)
AMERICAN HEART JOURNAL
(2023)
Article
Medicine, General & Internal
Tazeen Majeed, Erica Breuer, Layla Edwards, Marc Remond, Jo Taylor, Reem Zeki, Stephen Hampton, Luke Grant, Juanita Sherwood, Eileen Baldry, Elizabeth Sullivan
Summary: This study aims to develop expert consensus on the nomenclature and best-practice principles of programmes and services for people transitioning from prison into the community. A modified Delphi process will be conducted involving online surveys and meetings. The final list of nomenclature and best-practice statements will be disseminated after approval from experts.
Article
Cardiac & Cardiovascular Systems
Avedis Ekmejian, Daniel Brieger, Aditya Bhat, Hari Sritharan, Daniel Nour, Usaid Allahwala, Michael Ward, Ravinay Bhindi
Summary: Variations in myocardial supply area and hydrostatic pressure gradients result in a higher likelihood of positive fractional flow reserve (FFR) in the left anterior descending (LAD) compared with the circumflex (Cx) and right coronary artery (RCA). However, the same FFR threshold for deferral of revascularization is applied to all arteries, without evidence of equivalent outcomes. This study assessed the vessel-specific outcomes of deferred revascularization for the 3 major coronary arteries based on FFR > 0.8.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Avedis Ekmejian, Nadeem Mughal, Dinesh Selvakumar, Usaid Allahwala, Michael Ward, Peter Hansen, Gemma Figtree, Stephen Vernon, Ravinay Bhindi
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Hari Sritharan, Kunwardeep Bhatia, Bipeen Gautam, Nadeem Mughal, Avedis Ekmejian, Usaid Allahwala, Ravinay Bhindi, Peter Hansen
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Joanne Eng-Frost, Lewis Murray, Scott Lorensini, Rajinder Singh Harjit-Singh
Summary: Purulent bacterial pericarditis (PBP) is a highly lethal infection of the pericardial space. This article presents a case of cardiac tamponade and subsequent constrictive pericarditis due to Actinomyces meyeri PBP, which was successfully managed with intravenous antibiotics and pericardiectomy.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2022)