Article
Medicine, General & Internal
Chin-Shern Lau, Ya Li Liang, Soon Kieng Phua, Gillian Murtagh, Imo E. Hoefer, Ron H. Stokwielder, Milica Kosevich, Jennifer Yen, Jaganathan Sickan, Christos Varounis, Tar-Choon Aw
Summary: This study evaluated the performance of the Abbott NT-proBNP assay compared to the Roche NT-proBNP immunoassay at two sites. Precision, linearity, and sensitivity studies were conducted, and a regression analysis was performed. The results showed excellent agreement between the two assays, with slight bias in the Roche assay. The age groups recommended for acute heart failure diagnosis by ESC/AHA were also applicable to the Abbott assay.
Article
Cardiac & Cardiovascular Systems
Jr James L. Januzzi, Faiez Zannad, Stefan D. Anker, Javed Butler, Gerasimos Filippatos, Stuart J. Pocock, Joao Pedro Ferreira, Naveed Sattar, Subodh Verma, Ola Vedin, Janet Schnee, Tomoko Iwata, Dan Cotton, Milton Packer
Summary: This study found that empagliflozin treatment reduced the risk of heart failure or renal events regardless of baseline NT-proBNP concentration in patients with heart failure.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Biology
Aidonis Rammos, Aris Bechlioulis, Petros Kalogeras, Chris J. Watson, Pietro Salvo, Tommaso Lomonaco, Olga Kardakari, Evanthia E. Tripoliti, Yorgos Goletsis, Dimitris I. Fotiadis, Christos S. Katsouras, Lampros K. Michalis, Katerina K. Naka
Summary: This study found that saliva NT-proBNP correlates with serum values in patients with acute decompensated HF, but cannot differentiate between HF and other causes of dyspnea.
Article
Medical Laboratory Technology
Ling Li, Alexander G. Semenov, Evgeniya E. Feygina, Chenchen Yang, Nan Wang, Chao Chen, Xinghai Hu, Xiaoqin Ni, Zhenlu Zhang
Summary: The study compared the diagnostic accuracy of two NT-proBNP assays and found that the clinical value of total NT-proBNP for HF diagnosis was similar to the non-glycosylated subfraction of NT-proBNP. The lower percentage of non-glycosylated NT-proBNP to total NT-proBNP in non-HF patients suggests that total NT-proBNP might be more sensitive in individuals without current or prior symptoms of HF.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Walter Schmitt, Hauke Ruehs, Rolf Burghaus, Christian Diedrich, Sulav Duwal, Thomas Eissing, Dirk Garmann, Michaela Meyer, Bart Ploeger, Joerg Lippert
Summary: The study demonstrates that NT-proBNP can serve as a surrogate for clinical outcomes in HF trials, with a well-described relationship between NT-proBNP concentration and clinical events using an E-max model. Quantitative analysis provided insights into potential risks and risks associated with clinical events. Model-based predictions solely based on NT-proBNP measurements match final trial results, and early NT-proBNP measurements enable shorter yet reliable HF trials.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Cardiac & Cardiovascular Systems
Se-Eun Kim, Dong-Hyuk Cho, Jang Young Kim, Seok-Min Kang, Myeong-Chan Cho, Hae-Young Lee, Dong-Ju Choi, Eun-Seok Jeon, Byung-Su Yoo
Summary: NT-proBNP levels are an important prognostic factor for both de novo heart failure (DNHF) and acute decompensated chronic heart failure (ADHF), with patients with ADHF consistently having higher risks compared to those with DNHF at the same NT-proBNP level for 1-year all-cause mortality.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Michele Senni, Jose Lopez-Sendon, Alain Cohen-Solal, Piotr Ponikowski, Richard Nkulikiyinka, Cecilia Freitas, Vanja Miodrag Vlajnic, Lothar Roessig, Burkert Pieske
Summary: The treatment response to vericiguat in heart failure patients is influenced by baseline NT-proBNP levels, with patients with higher NT-proBNP values potentially not benefiting from the treatment.
Article
Chemistry, Analytical
Qian Luo, Xiaomin Qian, Xiaona Mi, Yifeng Tu
Summary: A new type of immunosensor based on a gold nanoparticles/aminozeolitic imidazolate framework-67 nanocomposite was developed for the detection of NT-proBNP, a biomarker for heart failure. The immunosensor showed excellent response and sensitivity, with a broad linear range and low detection limit. It also demonstrated good specificity, stability, and reproducibility, making it suitable for detecting NT-proBNP in real blood samples.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Cardiac & Cardiovascular Systems
Paul W. Armstrong, Yinggan Zheng, Richard W. Troughton, Lars H. Lund, Jian Zhang, Carolyn S. P. Lam, Cynthia M. Westerhout, Robert O. Blaustein, Javed Butler, Adrian F. Hernandez, Lothar Roessig, Christopher M. O'Connor, Adrian A. Voors, Justin A. Ezekowitz
Summary: This study assessed the effect of vericiguat on changes in NT-proBNP levels and its relationship with clinical outcomes. The results showed that vericiguat treatment led to a significant decline in NT-proBNP levels, which was associated with a relative improvement in the primary outcome of cardiovascular death or heart failure hospitalization.
JACC-HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Juan Caro-Codon, Juan R. Rey, Antonio Buno, Angel M. Iniesta, Sandra O. Rosillo, Sergio Castrejon-Castrejon, Laura Rodriguez-Sotelo, Luis A. Martinez, Irene Marco, Carlos Merino, Lorena Martin-Polo, Jose M. Garcia-Veas, Marcel Martinez-Cossiani, Luis Gonzalez-Valle, Alicia Herrero, Esteban Lopez-de-Sa, Jose L. Merino
Summary: Research has shown that NT-proBNP levels are frequently elevated in COVID-19 patients and are strongly associated with prognosis.
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Antoni Bayes-Genis, Kieran F. Docherty, Mark C. Petrie, James L. Januzzi, Christian Mueller, Lisa Andreson, Biykem Bozkurt, Javed Butler, Ovidiu Chioncel, John G. F. Cleland, Ruxandra Christodorescu, Stefano Del Prato, Finn Gustafsson, Carolyn S. P. Lam, Brenda Moura, Rodica Pop-Busui, Petar Seferovic, Maurizio Volterrani, Muthiah Vaduganathan, Marco Metra, Giuseppe Rosano
Summary: Diagnosing heart failure is often difficult due to non-specific symptoms. This document explores the use of NT-proBNP as a biomarker for diagnosing heart failure in different clinical scenarios. Validated cut-points are provided for ruling in or ruling out acute and de novo heart failure. The concept of 'heart stress' is introduced, and a simple acronym FIND-HF is proposed for early diagnosis of heart failure.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Medicine, General & Internal
Rafael de la Espriella, Antoni Bayes-Genis, Pau Llacer, Patricia Palau, Gema Minana, Enrique Santas, Mauricio Pellicer, Miguel Gonzalez, Jose Luis Gorriz, Vicent Bodi, Juan Sanchis, Julio Nunez
Summary: This study evaluated the impact of glomerular filtration rate (eGFR) on the predictive value of NT-proBNP and CA125 in patients with AHF. The results showed that CA125 outperformed NT-proBNP in predicting 1-year mortality in patients with severely reduced eGFR, while their predictive abilities were similar in other eGFR categories.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Medical Laboratory Technology
Kwaku D. Tawiah, Caroline E. Franks, Jessica Tang, Avihu Gazit, Dennis J. Dietzen, Christopher W. Farnsworth
Summary: This study investigated the concordance and correlation between BNP and NT-proBNP in pediatric patients. The results showed a positive correlation and moderate concordance between BNP and NT-proBNP. Age group and cardiac pathology had some impact on the concordance.
CLINICAL BIOCHEMISTRY
(2022)
Article
Medicine, General & Internal
Pau Llacer, Mari Angeles Gallardo, Patricia Palau, Mari Carmen Moreno, Carla Castillo, Cristina Fernandez, Rafael de la Espriella, Anna Mollar, Enrique Santas, Gema Minana, Luis Manzano, Antoni Bayes-Genis, Julio Nunez
Summary: The study assessed the association between CA125 and NT-proBNP with congestion parameters in patients with AHF. Results showed that CA125 was positively associated with peripheral edema, pleural effusion, and elevated IVC levels, while NT-proBNP was associated with pleural effusion and IVC diameter. CA125 had a higher discriminatory capacity in identifying peripheral edema and pleural effusion compared to NT-proBNP.
Article
Medical Laboratory Technology
Morgan Lundgren, Peter Ridefelt, Mathias Karlsson, Anna Norling, Anders Larsson
Summary: NT-proBNP is commonly used to rule out heart failure, but there is limited standardization between manufacturers, leading to different treatment of patients. A common calibrator and reference materials are needed to address this issue.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Geriatrics & Gerontology
Artaza Gilani, Sheena E. Ramsay, Paul Welsh, Olia Papacosta, Lucy T. Lennon, Peter H. Whincup, S. Goya Wannamethee
Summary: The study found that vitamin D deficiency is associated with an increased risk of orthostatic hypotension, while vitamin D insufficiency is not. Future research should further investigate whether treating vitamin D deficiency can improve postural blood pressure.
Article
Medical Laboratory Technology
Roshni Joshi, Goya Wannamethee, Jorgen Engmann, Tom Gaunt, Deborah A. Lawlor, Jackie Price, Olia Papacosta, Tina Shah, Therese Tillin, Peter Whincup, Nishi Chaturvedi, Mika Kivimaki, Diana Kuh, Meena Kumari, Alun D. Hughes, Juan P. Casas, Steve E. Humphries, Aroon D. Hingorani, A. Floriaan Schmidt
Summary: This study measured 14 triglyceride-containing lipoprotein subfraction metabolites using nuclear magnetic resonance in a general population sample, establishing reference interval ranges. The results showed that triglyceride subfraction concentrations increased with age and body mass index, were higher in smokers, and in individuals with cardiovascular disease or type 2 diabetes. These findings emphasize the importance of appropriate reference interval ranges for clinical decision making regarding the role of triglycerides in cardiovascular disease.
ANNALS OF CLINICAL BIOCHEMISTRY
(2021)
Article
Nutrition & Dietetics
Eftychia Kotronia, Heather Brown, A. Olia Papacosta, Lucy T. Lennon, Robert J. Weyant, Peter H. Whincup, S. Goya Wannamethee, Sheena E. Ramsay
Summary: The study found associations between poor oral health and diet quality in older individuals, with persistent poor diet quality increasing the risk of tooth loss and oral health problems. Older individuals with oral health issues tended to have poorer diets and consume fewer nutrient-rich foods.
BRITISH JOURNAL OF NUTRITION
(2021)
Article
Medicine, Research & Experimental
Douglas G. J. McKechnie, A. Olia Papacosta, Lucy T. Lennon, Paul Welsh, Peter H. Whincup, S. Goya Wannamethee
Summary: The study found that inflammatory biomarkers are associated with natriuretic peptide activity and may explain the link between inflammation and incident heart failure (HF). Higher baseline inflammatory markers were related to an increased risk of developing HF, but this relationship weakened after adjustment for NT-proBNP levels.
BIOMARKERS IN MEDICINE
(2021)
Correction
Nutrition & Dietetics
Eftychia Kotronia, Heather Brown, A. Olia Papacosta, Lucy T. Lennon, Robert J. Weyant, Peter H. Whincup, S. Goya Wannamethee, Sheena E. Ramsay
BRITISH JOURNAL OF NUTRITION
(2021)
Article
Peripheral Vascular Disease
Artaza Gilani, Raffaele De Caterina, Olia Papacosta, Lucy T. Lennon, Peter H. Whincup, S. Goya Wannamethee
Summary: The study found that excessive orthostatic changes in blood pressure were associated with the risk of incident heart failure in older men. Both orthostatic hypotension and orthostatic hypertension increased the risk of HF, with the systolic component of orthostatic hypotension being more predictive than the diastolic component.
Article
Geriatrics & Gerontology
Douglas G. J. McKechnie, A. Olia Papacosta, Lucy T. Lennon, Sheena E. Ramsay, Peter H. Whincup, S. Goya Wannamethee
Summary: The study found that IL-6 and hs-cTnT were associated with incident frailty, while CRP and NT-proBNP showed no significant association. Top tertiles of CRP, IL-6, hs-cTnT, and NT-proBNP were correlated with mortality prior to follow-up.
Article
Public, Environmental & Occupational Health
Rachel Kimble, Gillian McLellan, Lucy T. Lennon, A. Olia Papacosta, John C. Mathers, S. Goya Wannamethee, Peter H. Whincup, Shenna E. Ramsay
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Geriatrics & Gerontology
Douglas G. J. McKechnie, Meera Patel, A. Olia Papacosta, Lucy T. Lennon, Elizabeth A. Ellins, Julian P. J. Halcox, Sheena E. Ramsay, Peter H. Whincup, S. Goya Wannamethee
Summary: The study found that myocardial injury biomarkers are associated with frailty in older men. Inflammation is associated with frailty in men without cardiovascular disease. Carotid artery stiffness is associated with frailty in men without cardiovascular disease, independently of these biomarkers.
Article
Endocrinology & Metabolism
Robyn J. Tapp, Christopher G. Owen, Sarah A. Barman, David P. Strachan, Roshan A. Welikala, Paul J. Foster, Peter H. Whincup, Alicja R. Rudnicka
Summary: The study found clear associations between retinal microvascular architecture and cardiometabolic risk factors in patients with diabetes, indicating potential preclinical disease processes and suggesting impaired autoregulation due to hyperglycemia may play a pivotal role in the development of diabetes-related microvascular complications.
Article
Geriatrics & Gerontology
Rachel Kimble, Gillian McLellan, Lucy T. Lennon, Anna Olia Papacosta, Robert J. Weyant, Yvonne Kapila, John C. Mathers, Sasiwarang Goya Wannamathee, Peter H. Whincup, Sheena E. Ramsay
Summary: Poor oral health is associated with decline in physical function in later life, indicating a potential risk factor for frailty and disability in older adults.
LANCET HEALTHY LONGEVITY
(2022)
Meeting Abstract
Medicine, General & Internal
Kathryn J. Bush, Anna Olia Papacosta, Lucy Lennon, Judith Rankin, Peter Hynes Whincup, Sasiwarang Goya Wannamethee, Sheena Esther Ramsay
Meeting Abstract
Public, Environmental & Occupational Health
Rachel Kimble, Gillian McLellan, Lucy T. Lennon, A. Olia Papacosta, John C. Mathers, Peter H. Whincup, S. Goya Wannamethee, Sheena E. Ramsay
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2022)
Meeting Abstract
Public, Environmental & Occupational Health
Pauline Sobiesuo, Heather Brown, Rachel Kimble, Lucy T. Lennon, A. Olia Papacosta, Peter H. Whincup, S. Goya Wannamethee, Sheena E. Ramsay
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2022)
Article
Cardiac & Cardiovascular Systems
S. Goya Wannamethee, Olia Papacosta, Lucy Lennon, Aroon Hingorani, Peter Whincup
Summary: The study found that taller stature in older men is associated with an increased risk of atrial fibrillation, leading to a higher risk of heart failure. On the other hand, shorter stature is also associated with a higher risk of heart failure, which cannot be explained by known cardiovascular disease risk factors.
IJC HEART & VASCULATURE
(2021)