Article
Cardiac & Cardiovascular Systems
A. C. A. Azevedo, M. V. L. Barros, L. G. Klaboe, T. Edvardsen, H. S. Costa, G. M. M. Paixao, O. R. Santos Junior, M. C. P. Nunes, M. O. C. Rocha
Summary: The study confirms the association between myocardial mechanical dispersion (MD) and ventricular arrhythmogenicity in patients with Chagas cardiomyopathy (CCM). Increased MD is linked to higher density and complexity of ventricular extrasystoles (VES) in CCM patients.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Adriana Soares Xavier de Brito, Renata Junqueira Moll-Bernardes, Martha Valeria Tavares Pinheiro, Gabriel Cordeiro Camargo, Fabio Paiva Rossini Siqueira, Renee Sarmento Oliveira, Adriana Pereira Glavam, Sergio Altino de Almeida, Marcelo Teixeira de Holanda, Luiz Henrique Conde Sangenis, Fernanda de Souza Nogueira Sardinha Mendes, Paulo Henrique Rosado-de-Castro, Andrea Silvestre de Sousa
Summary: This study found that autonomic denervation, myocardial hypoperfusion, fibrosis, and ventricular arrhythmia are associated in patients with Chagas heart disease (CHD). These imaging parameters can be used for risk stratification and implementation of preventive strategies for sudden cardiac death (SCD) in early CHD patients.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Review
Microbiology
Mariana Citlalli De Alba-Alvarado, Elia Torres-Gutierrez, Olivia Alicia Reynoso-Ducoing, Edgar Zenteno-Galindo, Margarita Cabrera-Bravo, Yolanda Guevara-Gomez, Paz Maria Salazar-Schettino, Norma Rivera-Fernandez, Martha Irene Bucio-Torres
Summary: This review analyzes the mechanisms involved in cardiac damage in Chagas disease, which is an active field of study. The factors underlying the progression of lesions following Trypanosoma cruzi infection and the persistence of its antigens and host response, leading to the development of clinically observable cardiac damage, are examined.
Review
Cardiac & Cardiovascular Systems
Ziqi Tan, Shan Huang, Kaibo Mei, Menglu Liu, Jianyong Ma, Yuan Jiang, Wengen Zhu, Peng Yu, Xiao Liu
Summary: In this study, a systematic review and meta-analysis were conducted to investigate the prevalence and associated death of ventricular arrhythmia and sudden cardiac death (SCD) in patients with COVID-19. The findings showed that ventricular arrhythmia was common in COVID-19 patients, with a high prevalence and an increased risk of death. Elevated levels of cardiac troponin T and European populations were associated with a higher occurrence of ventricular arrhythmia. Clinicians should be vigilant and monitor for ventricular arrhythmias in COVID-19 patients, particularly in severe cases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Heather M. M. Giacone, Henry Chubb, Anne M. M. Dubin, Kara S. S. Motonaga, Scott R. R. Ceresnak, William R. R. Goodyer, Debra Hanisch, Anthony V. V. Trela, Nicole Boramanand, Erin Lencioni, Derek Boothroyd, Anna Graber-Naidich, Gail Wright, Christiane Haeffele, Seth A. A. Hollander, Doff B. B. McElhinney, Michael Ma, Frank L. L. Hanley, Sharon Chen
Summary: This study assessed the incidence of ventricular arrhythmias (VAs) in Fontan patients and their implications on transplant-free survival. The results showed that 11% of patients were diagnosed with VA, and VA was highly associated with the risk of transplant or death. Older age at Fontan and a history of right ventricular to pulmonary artery conduit were risk factors for VA. A diagnosis of VA in Fontan patients should lead to increased clinical surveillance.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Maykon Tavares de Oliveira, Andre Schmidt, Maria Claudia da Silva, Eduardo Antonio Donadi, Joao Santana da Silva, Jose Antonio Marin-Neto
Summary: The study revealed that the blood parasite load in patients with CCC is highly variable and appears to be directly linked to the reduction of LVEF, an important prognostic indicator in CCC patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Regis Guieu, Michele Brignole, Jean Claude Deharo, Pierre Deharo, Giovanna Mottola, Antonella Groppelli, Franck Paganelli, Jean Ruf
Summary: The concept of receptor reserve as an adaptive mechanism in cardiovascular disease is relatively new, with spare receptors suspected to be present when weak activation leads to maximal effects. Adenosine, an ATP derivative, impacts the cardiovascular system through its four receptors, with particular roles in heart rhythm and vasodilation. The presence of spare adenosine receptors and their implications in cardiovascular physiopathology are explored, along with the role of the adenosinergic system in long-term potentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cardiac & Cardiovascular Systems
Jorge Romero, Alejandro Velasco, Cristiano F. Pisani, Isabella Alviz, David Briceno, Juan Carlos Diaz, Domenico Giovanni Della Rocca, Andrea Natale, Maria de Lourdes Higuchi, Mauricio Scanavacca, Luigi Di Biase
Summary: Chagas disease, caused by Trypanosoma cruzi, has seen increased incidence outside Latin America due to global migration. Chronic Chagas cardiomyopathy often presents with arrhythmias, posing a major challenge for clinical electrophysiologists. Innovative approaches, such as bilateral cervicothoracic sympathectomy and bilateral renal denervation, have been described to improve outcomes in patients with refractory ventricular arrhythmias.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Marwan M. Refaat, Charbel Gharios, M. Vinayaga Moorthy, Farah Abdulhai, Roger S. Blumenthal, Miran A. Jaffa, Samia Mora
Summary: The study found that high-grade PVCs occurring during recovery were associated with long-term risk of cardiovascular mortality in asymptomatic individuals, whereas PVCs occurring only during exercise were not associated with increased risk.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Immunology
Melissa S. Nolan, David Aguilar, Arunima Misra, Sarah M. Gunter, Tim Erickson, Rodion Gorchakov, Hilda Rivera, Susan P. Montgomery, Kristy O. Murray
Summary: This study identified a high prevalence of underdiagnosed Trypanosoma cruzi infection and discrepant results in clinical diagnostic assays among Latinx cardiac patients in the United States. It suggests that laboratory screening for T. cruzi infection would benefit this population.
EMERGING INFECTIOUS DISEASES
(2021)
Review
Immunology
Eduardo G. Bruneto, Miguel M. Fernandes-Silva, Cristina Toledo-Cornell, Silvia Martins, Joao M. B. Ferreira, Valeria R. Correa, Joicely M. da Costa, Ana Yece das N. Pinto, Dilma do S. M. de Souza, Maria Carmelinda G. Pinto, Jose Albuquerque de F Neto, Alberto N. Ramos, James H. Maguire, Odilson M. Silvestre
Summary: Orally-transmitted acute Chagas disease is emerging as a significant public health problem, with considerable lethality in the first year after infection but a declining mortality rate over the years. Symptomatic cases have a similar lethality rate to those from other routes of infection.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Carla Cofino-Fabres, Robert Passier, Verena Schwach
Summary: Heart rhythm disorders and arrhythmias have a significant impact on society and individuals' quality of life. Current therapies only manage symptoms, highlighting the need for innovative test models and platforms to understand the underlying disease mechanisms of arrhythmias. This review outlines the key features of atrial fibrillation (AFib), the most common cardiac arrhythmia, including epidemiology, risk factors, therapies, and discusses the limitations and opportunities of current models for cardiac arrhythmia research, such as animal models and in vitro models using human pluripotent stem cell-derived cardiomyocytes.
Article
Biochemistry & Molecular Biology
Jaime Balderas-Villalobos, J. M. Lourdes Medina-Contreras, Christopher Lynch, Rajiv Kabadi, Janee Hayles, Rafael J. Ramirez, Alex Y. Tan, Karoly Kaszala, Montserrat Samso, Jose F. Huizar, Jose M. Eltit
Summary: Frequent premature ventricular contractions (PVCs) in a large animal model of PVC-induced cardiomyopathy (PVC-CM) resulted in eccentric cardiac hypertrophy and reduced ejection fraction. The molecular mechanisms and markers of this hypertrophic remodeling were explored. Pathological hypertrophy markers were unaltered, while prohypertrophic and antiapoptotic pathways were activated in the PVC-CM group.
Review
Cell Biology
Marta Okninska, Michal Maczewski, Urszula Mackiewicz
Summary: Cardiovascular diseases, especially sudden cardiac death triggered by ventricular arrhythmia, have a significant impact on global mortality. This study highlights the influence of age and sex on the susceptibility to life-threatening arrhythmias during acute coronary syndrome (ACS). The research indicates that changes in the aging process, such as increased fibrosis and alterations in electrophysiological parameters, have pro-arrhythmic significance, particularly in male individuals.
AGEING RESEARCH REVIEWS
(2022)
Article
Multidisciplinary Sciences
Natalia Velasquez-Ortiz, Giovanny Herrera, Carolina Hernandez, Marina Munoz, Juan David Ramirez
Summary: This article presents a systematic review of the literature from the past 20 years to provide an update on the distribution of DTUs for Chagas disease in the Americas and collects ecoepidemiological information. The study found that this disease is widespread throughout the continent and that researchers use a wide range of genetic markers and methods to study the parasite.
