Review
Oncology
Simona Pompili, Antonella Vetuschi, Roberta Sferra, Alfredo Cappariello
Summary: This article discusses the issue of drug resistance in cancer treatment, arguing that resistance is closely related to multiple mechanisms, including the expression of transporter proteins, mutations in oncogenes and transcription factors, and the role of extracellular vesicles.
FRONTIERS IN ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
Adeeb Shehzad, Salman Ul Islam, Raheem Shahzad, Salman Khan, Young Sup Lee
Summary: Cell-to-cell interactions within the tumor microenvironment play a crucial role in cancer promotion, development, and malignant transformation. Extracellular vesicles (EVs), including exosomes and microvesicles, mediate the transportation of regulatory molecules between cells and to distant sites, contributing to the formation of premetastatic niches and the progression of malignancies. EVs have potential applications in disease diagnosis, prognosis, and therapeutics in the field of cancer research.
PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Cell Biology
Manideep C. Pachva, Horton Lai, Andy Jia, Melanie Rouleau, Poul H. Sorensen
Summary: Ewing sarcoma is a highly aggressive cancer, with poor prognosis for patients with metastatic disease. Intercellular communication within the tumor microenvironment is crucial for cancer cells to establish immunosuppressive and cancer-permissive environments. Additional research on this communication mechanism may lead to new therapeutic strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Aisling Forder, Chi-Yun Hsing, Jessica Trejo Vazquez, Cathie Garnis
Summary: Communication between cancer cells and stromal cells through extracellular vesicles plays a key role in promoting metastasis. Tumor-secreted EVs induce a pro-tumorigenic phenotype in non-malignant cells of the stroma, driving metastasis through various mechanisms. Targeting these EV-mediated signaling pathways may have therapeutic potential for developing biomarkers and novel treatment strategies.
Review
Biotechnology & Applied Microbiology
Yi Liao, Qian Yi, Jinglong He, Dixi Huang, Jianyi Xiong, Wei Sun, Weichao Sun
Summary: Osteosarcoma is the most common primary malignant bone tumor, mainly affecting teenagers. Extracellular vesicles (EVs) released by tumor cells and cells in the tumor microenvironment play important roles in osteosarcoma tumorigenesis, development, metastasis, drug resistance, and communication. EVs deliver bioactive molecules to recipient cells, contributing to intercellular communication, cellular homeostasis, and pathological progression. This review discusses the involvement of EVs in osteosarcoma and proposes their potential for diagnosis and treatment.
Article
Pharmacology & Pharmacy
Qi Zhang, Linbo Jin, Quanxin Jin, Qiang Wei, Mingyuan Sun, Qi Yue, Huan Liu, Fangfang Li, Honghua Li, Xiangshan Ren, Guihua Jin
Summary: The study found that DHA has inhibitory effects on the proliferation, migration, and metastasis of melanoma, and can also impact immune cells in the tumor microenvironment. This suggests that DHA may serve as a potential treatment for melanoma.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Misung Park, Dohee Kim, Sunghyub Ko, Ayoung Kim, Kyumin Mo, Hyunho Yoon
Summary: Breast cancer is the most common malignancy in women worldwide, and metastasis is the leading cause of high mortality. Currently, breast cancer is often discovered or diagnosed after metastasis has occurred, resulting in poor prognosis. Understanding the mechanisms and nature of breast cancer metastasis can facilitate the development of targeted therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Xiaoxing Wang, Defa Huang, Jiyang Wu, Zhengzhe Li, Xiaomei Yi, Tianyu Zhong
Summary: This review systematically describes the potential mechanisms of small extracellular vesicles (sEVs) in tumor development and discusses their role in colorectal cancer (CRC) metastasis. Understanding these mechanisms can improve early diagnosis and treatment of CRC metastasis.
Review
Immunology
Yukang Lu, Mengting Zhang, Jiajun Zhou, Xiulan Liu, Lanfeng Wang, Xinyi Hu, Yiping Mao, Rongfa Gan, Zhiping Chen
Summary: This review provides an overview of recent studies on the role of extracellular vesicles (EVs) in the progression of renal cell carcinoma (RCC), including their involvement in tumor cell interaction with M2 macrophages, mediating immune tolerance, and acting as communication messengers in the tumor microenvironment. The review also discusses the potential use of engineered sEVs or EV tumor vaccines, mesenchymal stem cell EV therapy, and reduction of tumor-derived EV secretion in RCC treatment. Overall, the review highlights the importance of EVs in RCC and their potential as a pathway for future treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Ye Zeng, Yan Qiu, Wenli Jiang, Bingmei M. Fu
Summary: The glycocalyx plays a crucial role in the development of the tumor microenvironment, while extracellular vesicles (EVs) are important components that regulate the microenvironment. EVs can modify the glycocalyx by carrying specific components, facilitating the development of the tumor microenvironment.
Review
Cell Biology
Xinyi Hu, Yukang Lu, Jiajun Zhou, Lanfeng Wang, Mengting Zhang, Yiping Mao, Zhiping Chen
Summary: Colorectal cancer is a prevalent malignant tumor with high mortality and incidence rates. Small extracellular vesicles (sEVs) play a significant role in the communication and progression of cancer cells. Regulatory RNAs have emerged as potential biomarkers for the diagnosis and prognosis of colorectal cancer, influencing various cancer-related processes. This review highlights the importance of sEVs as biomarkers in colorectal cancer diagnosis and suggests their potential application in treatment, emphasizing the need for further research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Oncology
Yujuan Huang, Masamitsu Kanada, Jiaxiang Ye, Yayan Deng, Qian He, Zhengyang Lei, Yong Chen, Yongqiang Li, Peiwu Qin, Jinyan Zhang, Jiazhang Wei
Summary: This review summarizes the latest progress in the exploration of exosome-mediated cell-cell communication implicated in tumor microenvironment (TME) remodeling and underlying mechanisms. It focuses on the role of cell-cell interactions mediated by tumor cell-derived exosomes in promoting invasion and metastasis, and their potential as a therapeutic intervention target against distant metastasis. The clinical translational significance of tumor-derived exosomes for early diagnosis, efficacy, and progression evaluations is also discussed.
Review
Biochemistry & Molecular Biology
Theresa Akoto, Sharanjot Saini
Summary: Prostate cancer is a life-threatening disease among men globally, with metastasis being the major cause of mortality. Cell-to-cell communication plays a crucial role in the progression and metastasis of prostate cancer, with exosomes/extracellular vesicles demonstrating significant involvement in signaling pathways related to metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Zhengke Zhi, Qiaochu Sun, Weibing Tang
Summary: Extracellular vesicles (EV) are vesicular structures with phospholipid bilayer, found in biological fluids and the extracellular microenvironment. They play a crucial role in intercellular communication by delivering lipids, proteins, and RNAs to recipient cells. Tissue derived extracellular vesicles (Ti-EVs), distinct from those derived from biofluids and cell culture, provide us with more accurate and enriched information about the tissue microenvironment, participating directly in the crosstalk between various cell types within the microenvironment. The study of Ti-EVs is increasing as they have the potential to accurately reflect the occurrence and development of human diseases.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Immunology
Yongmin Li, Fei Liu
Summary: Extracellular vesicles (EVs) play a crucial role in cell-to-cell communication as small particles secreted by various cell types. They have become attractive candidates for treating tumors, including melanoma, due to their involvement in multiple physiological and pathological processes. Targeting the tumor microenvironment (TME) through EVs-based therapy has emerged as a cutting-edge strategy for inhibiting melanoma progression and enhancing anti-tumor immunity. This review aims to summarize and discuss the therapeutic role of EVs that target TME components in melanoma, providing insights into promising clinical strategies for melanoma treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Rodrigo B. Aires, Alexandre A. de S. M. Soares, Ana Paula M. Gomides, Andre M. Nicola, Andrea Teixeira-Carvalho, Dayde Lane M. da Silva, Eliana T. de Gois, Flavia D. Xavier, Francielle P. Martins, Gabriela P. J. Santos, Heidi Luise Schulte, Isabelle S. Luz, Laila S. Espindola, Laurence R. do Amaral, Liza F. Felicori, Luciana A. Naves, Maira R. M. de Carvalho, Matheus de S. Gomes, Otavio T. Nobrega, Patricia Albuquerque, Wagner Fontes, Ciro M. Gomes, Patricia S. Kurizky, Cleandro P. Albuquerque, Olindo A. Martins-Filho, Licia Maria H. da Mota
Summary: Thromboelastometry parameters are useful in differentiating the coagulation profile between severe and non-severe COVID-19 patients, which is important for therapeutic intervention.
Article
Medicine, General & Internal
Bruno Nobre Lins Coronado, Felipe Bruno Santos da Cunha, Raphaela Menezes de Oliveira, Otavio de Toledo Nobrega, Carlos Andre Ornelas Ricart, Wagner Fontes, Marcelo Valle de Sousa, Marcos Pereira de avila, Aline Maria Araujo Martins
Summary: This study aims to evaluate the protein profiles of the aqueous humor of patients with age-related macular degeneration (AMD) and identifies potential biomarkers associated with the development of neovascularization.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemical Research Methods
Daiane Gonzaga Ribeiro, Ana Paula Zotta Mota, Ivonaldo Reis Santos, Fabricio Barbosa Monteiro Arraes, Priscila Grynberg, Wagner Fontes, Mariana de Souza Castro, Marcelo Valle de Sousa, Maria Eugenia Lisei-de-Sa, Maria Fatima Grossi-de-Sa, Octavio Luiz Franco, Angela Mehta
Summary: In this study, proteins and genes involved in nematode resistance in cowpea were identified through proteomic and transcriptomic analysis. Key processes such as the activation of R genes, production of protease inhibitors, and maintenance of the actin cytoskeleton were found to be important for cowpea resistance to nematodes.
JOURNAL OF PROTEOMICS
(2022)
Article
Chemistry, Analytical
Francielli C. C. Melo, Renata P. Alves, Anderson L. Valle, Fabiana de A. A. Santos, Ana Carolina S. Dias, Isabela M. B. Goulart, Eduardo G. A. Oliveira, Guedmiller S. Oliveira, Luciano P. Rodrigues, Luiz R. Goulart
Summary: This research explores the use of 4-dimethylaminoantipyrine (4-DMAA)-mediated interfacing as a general indicator in electrochemical immunoassays, demonstrating its broad application for the specific diagnosis of four infectious diseases.
Article
Cell Biology
Lara Vecchi, Sara Teixeira Soares Mota, Mariana Alves Pereira Zoia, Isabella Castro Martins, Jessica Brito de Souza, Tiago Goss Santos, Adriano de Oliveira Beserra, Victor Piana de Andrade, Luiz Ricardo Goulart, Thaise Goncalves Araujo
Summary: Annexin A1 and interleukin-6 are both overexpressed in breast cancer tissue, indicating a correlation between the two. The activation of the AnxA1/FPR1 autocrine axis plays a crucial role in the IL-6 signaling pathway and has an impact on the tumor microenvironment.
Article
Agriculture, Dairy & Animal Science
Simone Sommerfeld, Antonio Vicente Mundim, Rogerio Reis Silva, Jessica Santos Queiroz, Maisa Paschoal Rios, Fabiana Oliveira Notario, Alessandra Aparecida Medeiros Ronchi, Marcelo Emilio Beletti, Rodrigo Rodrigues Franco, Foued Salmen Espindola, Luiz Ricardo Goulart, Belchiolina Beatriz Fonseca
Summary: This study aimed to verify whether chicken embryos of different ages have specific responses to viruses and drugs, and emphasizes the importance of standardization in using the model.
Article
Biochemistry & Molecular Biology
Alinne T. F. Silva, Claudia M. Rodrigues, Izabella C. C. Ferreira, Leticia L. D. Santos, Donizeti W. Santos, Thaise G. Araujo, Paula P. L. Canto, Carlos E. Paiva, Luiz R. Goulart, Yara C. P. Maia
Summary: In this study, we analyzed the presence of circulating tumor cells (CTCs) in the blood to identify markers for the diagnosis and monitoring of breast cancer. By determining the transcriptional levels and flow cytometry profiles, we developed a method that shows high sensitivity and specificity for breast cancer detection and therapy monitoring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Veterinary Sciences
Fabiana de Almeida Araujo Santos, Patricia Tiemi Fujimura, Emilia Rezende Vaz, Ana Cristina Honorato de Castro, Ana Graci Brito-Madurro, Vivian Alonso-Goulart, Luciana Machado Bastos, Belchiolina Beatriz Fonseca, Anna Monteiro Correia Lima, Luiz Ricardo Goulart
Summary: This study demonstrates the effectiveness of mimetic epitopes of B. abortus in developing new platforms for diagnosing brucellosis. Additionally, a fast test based on an electrochemical sensor using graphite modified with poly-3-hydroxyphenylacetic acid is proposed.
VETERINARY RESEARCH COMMUNICATIONS
(2023)
Article
Public, Environmental & Occupational Health
Felipe Andres Cordero da Luz, Camila Piqui Nascimento, Eduarda da Costa Marinho, Pollyana Junia Felicidade, Rafael Mathias Antonioli, Rogerio Agenor de Araujo, Marcelo Jose Barbosa Silva
Summary: Men with non-reproductive cancers have lower survival rates compared to women, but this difference is not solely explained by the incidence of more aggressive and advanced cancers in men.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Virology
Marlonni Maurastoni, Tathiana Sa F. Antunes, Emanuel F. M. Abreu, Simone G. Ribeiro, Angela Mehta, Marcio M. Sanches, Wagner Fontes, Elliot W. Kitajima, Fabiano T. Cruz, Alexandre M. C. Santos, Jose A. Ventura, Ana C. M. M. Gomes, F. Murilo Zerbini, Patricia Sosa-Acosta, Fabio C. S. Nogueira, Silas P. Rodrigues, Francisco J. L. Aragao, Anna E. Whitfield, Patricia M. B. Fernandes
Summary: Papaya sticky disease is caused by papaya meleira virus (PMeV) and papaya meleira virus 2 (PMeV2). Two major proteins were identified in the purified virus. A potential interaction between the viral proteins and the 50S ribosomal protein L17 (AtRPL17) was discovered, suggesting the importance of virus-host interactions in the disease.
Article
Multidisciplinary Sciences
Felipe Andres Cordero da Luz, Camila Piqui Nascimento, Eduarda da Costa Marinho, Pollyana Junia Felicidade, Rafael Mathias Antonioli, Rogerio Agenor de Araujo, Marcelo Jose Barbosa Silva
Summary: Surgery has a significant impact on staging prostate cancer, especially regarding lymph node metastasis. Comparative studies on patients who underwent prostatectomy revealed that the number of lymph node metastasis plays an important prognostic role.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Reynaldo Magalhaes Melo, Jaques Miranda Ferreira de Souza, Thomas Christopher Rhys Williams, Wagner Fontes, Marcelo Valle de Sousa, Carlos Andre Ornelas Ricart, Luis Henrique Ferreira do Vale
Summary: This study provides the first top-down proteome analysis of C. glutamicum, characterizing its proteoforms and post-translational modifications. The presence of various PTMs in proteoforms suggests their potential role in regulating biotechnologically relevant processes in this bacterium.
SCIENTIFIC REPORTS
(2023)
Article
Plant Sciences
Daiane Gonzaga Ribeiro, Ana Carolina Mendes Bezerra, Ivonaldo Reis Santos, Priscila Grynberg, Wagner Fontes, Mariana de Souza Castro, Marcelo Valle de Sousa, Maria Eugenia Lisei-de-Sa, Maria Fatima Grossi-de-Sa, Octavio Luiz Franco, Angela Mehta
Summary: The co-occurrence of biotic and abiotic stresses severely affects crop performance and productivity in agricultural areas. The present study aimed to identify proteins involved in the resistance of cowpea to nematode and drought stresses. Proteomic analysis revealed key processes, such as hormonal signaling regulation, pathogenesis-related proteins production, and downregulation of photosynthetic activity.
Article
Oncology
Rogerio Agenor de Araujo, Felipe Andres Cordero da Luz, Eduarda da Costa Marinho, Camila Piqui Nascimento, Thais Rezende Mendes, Etelvina Rocha Tolentino Mosca, Lara de Andrade Marques, Patricia Ferreira Ribeiro Delfino, Rafael Mathias Antonioli, Ana Cristina Araujo Lemos da Silva, Maria Luiza Goncalves dos Reis Monteiro, Morun Bernardino Neto, Marcelo Jose Barbosa Silva
Summary: In this prospective study, researchers aimed to improve the prognostic stratification of Luminal B breast cancer patients. They found that the expression of serum chemokines in Luminal B subtype patients can better predict prognosis and risk of metastasis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Kellen Cristina Torres Costa, Vanessa Santana Vieira Santos, Emilia Rezende Vaz, Sarah Natalie Cirilo Gimenes, Lucas Ian Veloso Correia, Jessica Brito de Souza, Fabiana de Almeida Araujo Santos, Veridiana de Melo Rodrigues, Luiz Ricardo Goulart, Vivian Alonso Goulart
Summary: This study aimed to select PLA2 inhibitor mimetic peptides with anti-inflammatory activity using phage display technology. The selected peptide, C2PD, played a pivotal role in modulating IL-6, IL-1β, and IL-10 cytokines in inflammatory cells. C2PD showed a significant reduction in PLA2 activity and down-regulated IL-6 and IL-1β release in PBMC, while up-regulated IL-10 responses.
