期刊
INTERNATIONAL JOURNAL OF CANCER
卷 142, 期 3, 页码 460-469出版社
WILEY
DOI: 10.1002/ijc.31010
关键词
ovarian cancer; case-control studies; menstrual pain; inflammation
类别
资金
- U.S. Army Medical Research and Materiel Command [DAMD17-01-1-0729]
- National Health & Medical Research Council of Australia [199600, 400281, 1043134]
- Cancer Council of New SouthWales
- Cancer Foundation of Western Australia [AUS]
- U.S. National Institutes of Health [R01-CA063678, R01-CA074850, R01-CA080742, R01-CA112523, R01-CA87538, R01-CA58598, N01-CN-55424, N01-PC-67001, K07-CA080668, R01-CA95023, P50-CA159981, R01- CA61107, R01-CA54419, P50-CA105009, T32 CA009001-38, R01-CA76016]
- Department of Defense [DAMD17-02-1-0669, W81XWH-10-1-02802, DAMD17-02-1-0666, P01CA17054, P30CA14089, R01CA61132, N01PC67010, R03CA113148, R03CA115195, N01CN025403]
- Danish Cancer Society, Copenhagen, Denmark [94 222 52]
- Mermaid I project
- California Cancer Research Program [00-01389V-20170, 2II0200]
- Cancer Council of Victoria
- Cancer Council of Queensland
- Cancer Council of South Australia
- Cancer Council of Tasmania
Menstrual pain, a common gynecological condition, has been associated with increased risk of ovarian cancer in some, but not all studies. Furthermore, potential variations in the association between menstrual pain and ovarian cancer by histologic subtype have not been adequately evaluated due to lack of power. We assessed menstrual pain using either direct questions about having experienced menstrual pain, or indirect questions about menstrual pain as indication for use of hormones or medications. We used multivariate logistic regression to calculate the odds ratio (OR) for the association between severe menstrual pain and ovarian cancer, adjusting for potential confounders and multinomial logistic regression to calculate ORs for specific histologic subtypes. We observed no association between ovarian cancer and menstrual pain assessed by indirect questions. Among studies using direct question, severe pain was associated with a small but significant increase in overall risk of ovarian cancer (OR=1.07, 95% CI: 1.01-1.13), after adjusting for endometriosis and other potential confounders. The association appeared to be more relevant for clear cell (OR=1.48, 95% CI: 1.10-1.99) and serous borderline (OR=1.31, 95% CI: 1.05-1.63) subtypes. In this large international pooled analysis of case-control studies, we observed a small increase in risk of ovarian cancer for women reporting severe menstrual pain. While we observed an increased ovarian cancer risk with severe menstrual pain, the possibility of recall bias and undiagnosed endometriosis cannot be excluded. Future validation in prospective studies with detailed information on endometriosis is needed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据