Review
Oncology
Marina Oldenburg, Nadine Ruechel, Stefan Janssen, Arndt Borkhardt, Katharina L. Goessling
Summary: The concept of holobionts emphasizes the complex interactions between a host and other species, which, if disturbed may lead to disease and premature aging. The impact of chemotherapy on the microbiome and long-term dysbiosis in survivors of acute lymphoblastic leukemia requires further research.
Article
Medicine, Research & Experimental
Yizhen Li, Wentao Yang, Meenakshi Devidas, Stuart S. Winter, Chimene Kesserwan, Wenjian Yang, Kimberly P. Dunsmore, Colton Smith, Maoxiang Qian, Xujie Zhao, Ranran Zhang, Julie M. Gastier-Foster, Elizabeth A. Raetz, William L. Carroll, Chunliang Li, Paul P. Liu, Karen R. Rabin, Takaomi Sanda, Charles G. Mullighan, Kim E. Nichols, William E. Evans, Ching-Hon Pui, Stephen P. Hunger, David T. Teachey, Mary Relling, Mignon L. Loh, Jun J. Yang
Summary: Genetic alterations in the RUNX1 gene are associated with various blood disorders, especially those of the megakaryocyte and myeloid lineages. Germline RUNX1 variants have different effects on B-ALL and T-ALL, with the latter showing severe damaging effects. Additionally, JAK3 mutation is a common somatic genomic abnormality in T-ALL with germline RUNX1 variants.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cell Biology
Yuting Zhu, Xiaopeng Ma, Heng Zhang, Yijun Wu, Meiyun Kang, Yongjun Fang, Yao Xue
Summary: The study revealed that circADD2 is down-regulated in ALL, and its overexpression inhibits cell proliferation while promoting apoptosis. circADD2 functions by directly sponging miR-149-5p.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Andrej Lissat, Claudia van Schewick, Ingo G. Steffen, Ayumu Arakawa, Jean-Pierre Bourquin, Birgit Burkhardt, Guenter Henze, Georg Mann, Christina Peters, Lucie Sramkova, Cornelia Eckert, Arend von Stackelberg, Christiane Chen-Santel
Summary: The study focused on children with extramedullary relapse of acute lymphoblastic leukemia, identifying specific clinical features and poor prognosis. Individualized treatment based on patient-specific factors is necessary, and localized therapy may be beneficial in selected cases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Maria Kourti, Michalis Aivaliotis, Emmanouel Hatzipantelis
Summary: Acute lymphoblastic leukemia (ALL) is the most common cancer in children, and risk-directed therapy based on clinical, biologic and genetic features has played a significant role in its treatment. Despite improvement in survival rates, ALL remains a leading cause of cancer-related deaths. Proteomics is a cutting-edge technology that aims to understand the impact of the proteome on leukemia subtypes and identify new biomarkers and targets for therapy.
Article
Oncology
Marco Severgnini, Mariella D'Angio, Silvia Bungaro, Giovanni Cazzaniga, Ingrid Cifola, Grazia Fazio
Summary: In this study, RNA-seq technology was used to comprehensively profile the transcriptional landscape of childhood BCP-ALL cases. The analysis revealed a subset of conjoined genes (CGs) that were exclusively expressed in leukemic cases, suggesting a potential novel mechanism of transcriptional regulation in childhood leukemia and potential leukemia-specific biomarkers.
Article
Oncology
Yifan Zhai, Qiuqiong Tang, Douglas D. Fang, Jing Deng, Kaixiang Zhang, Qixin Wang, Yan Yin, Chengcheng Fu, Sheng -Li Xue, Na Li, Feng Zhou, Dajun Yang
Summary: This study aimed to determine if novel anticancer agents targeting BCL-2 and MDM2 could overcome venetoclax resistance. The combination of lisaftoclax and alrizomadlin exhibited synergistic antitumor effects and overcame venetoclax resistance mediated by various mechanisms, including BCL-2 mutations. These findings provide a theoretical basis for the clinical application of this treatment combination in patients with resistant diseases.
CLINICAL CANCER RESEARCH
(2023)
Article
Clinical Neurology
Rui Li, Ji-Hong Tang, Bing-Bing Zhang, Xiao-Yan Shi, Yuan-Yuan Dai, Rui Qu
Summary: The clinical characteristics of epileptic seizures in children with acute lymphoblastic leukemia (ALL) during treatment were analyzed. Epileptic seizures mainly occurred in the induction remission period, maintenance treatment period, and after bone marrow transplantation. The common causes were MTX-related demyelinating encephalopathy and reversible posterior encephalopathy syndrome (PRES). Convulsion was the first symptom. Early neuroimaging and EEG examination are important for early diagnosis and treatment.
FRONTIERS IN NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Yao Xue, Jing Chen, Siyuan Gao, Xiaowen Zhai, Ningling Wang, Ju Gao, Yu Lv, Mengmeng Yin, Yong Zhuang, Hui Zhang, Xiaofan Zhu, Xuedong Wu, Chi Kong Li, Shaoyan Hu, Changda Liang, Runming Jin, Hui Jiang, Minghua Yang, Lirong Sun, Kaili Pan, Jiaoyang Cai, Jingyan Tang, Xianmin Guan, Yongjun Fang
Summary: Tumor lysis syndrome (TLS) is a common and fatal complication of childhood hematologic malignancies, with age, white blood cell count, and tumor type being risk factors for TLS occurrence. Hyperphosphatemia and hypocalcemia are common in TLS children with hyperleukocytosis, and significant differences in levels of potassium, calcium, phosphorus, and uric acid were observed in different groups of TLS patients. Older age, infant, a higher level of white blood cells, and T-ALL were identified as risk factors for TLS occurrence.
SCIENTIFIC REPORTS
(2021)
Article
Hematology
Sofie Gottschalk Hojfeldt, Kathrine Grell, Jonas Abrahamsson, Bendik Lund, Kim Vettenranta, Olafur G. Jonsson, Thomas L. Frandsen, Benjamin O. Wolthers, Hanne Vibeke Marquart, Goda Vaitkeviciene, Kristi Lepik, Mats Heyman, Kjeld Schmiegelow, Birgitte Klug Albertsen
Summary: Truncation of asparaginase treatment due to toxicity or silent inactivation may increase relapse risk in children with acute lymphoblastic leukemia, highlighting the importance of therapeutic drug monitoring and appropriate adjustment of therapy.
Review
Oncology
Lilly Velentza, Farasat Zaman, Lars Savendahl
Summary: GCs are widely used in the treatment of childhood ALL but their long-term use is associated with bone-related morbidities. Unfortunately, there is currently no efficient treatment for bone health impairment in patients and survivors. The review aims to discuss how GCs impact bone health in pediatric ALL and efforts made to minimize these side effects.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Review
Oncology
Unai Illarregi, Jaione Telleria, Nerea Bilbao-Aldaiturriaga, Elixabet Lopez-Lopez, Javier Ballesteros, Idoia Martin-Guerrero, Angela Gutierrez-Camino
Summary: Childhood acute lymphoblastic leukemia is a heterogeneous disease with multiple molecular subtypes, and long non-coding RNAs (lncRNAs) have the potential to serve as novel diagnostic, classification, and treatment response markers to improve survival rates and refine patient classification.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Kinga Panuciak, Emilia Nowicka, Angelika Mastalerczyk, Joanna Zawitkowska, Maciej Niedzwiecki, Monika Lejman
Summary: Recent years have seen significant progress in the treatment of B-cell acute lymphoblastic leukemia (ALL), with improved conventional therapy schemes and the development of new treatment forms. The 5-year survival rates now exceed 90% in pediatric patients. However, at the molecular level, there are still many variations that need to be analyzed in more detail, including aneuploidy, which is among the most common genetic changes in B-cell ALL. Our work will focus on summarizing the current state of knowledge on aneuploidy and its correlates with the treatment of B-cell ALL patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Mary H. Ward, Jessica M. Madrigal, Rena R. Jones, Melissa C. Friesen, Roni T. Falk, David Koebel, Catherine Metayer
Summary: Based on the California Childhood Leukemia Study, this research evaluated the relationship between residential pesticide use and the risk of childhood acute lymphoblastic leukemia (ALL). The study found that glyphosate concentrations in house dust were associated with occupational pesticide exposure, nearby agricultural use, treatment for lawn weeds and bees/wasps, and sampling season. However, increasing glyphosate concentrations were not associated with an increased ALL risk. This study highlights the potential risk of young children being exposed to pesticides in residential settings and the need for further research.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Shamil Urazbakhtin, Anastasia Smirnova, Anastasiya Volakhava, Elena Zerkalenkova, Maria Salyutina, Michael Doubek, Hana Jelinkova, Nelly Khudainazarova, Egor Volchkov, Laima Belyaeva, Ekaterina Komech, Sarka Pavlova, Yuri Lebedev, Karla Plevova, Yulia Olshanskaya, Alexander Komkov, Ilgar Mamedov
Summary: Retroelements have been proposed to play a role in cancerogenesis and different cancer types are characterized by varying levels of tumor-specific RE insertions. Recent study found that acute lymphoblastic leukemia and childhood acute leukemias have low levels of RE insertional activity, and no new tumor-specific RE insertions were identified in the acute leukemia samples tested. Additionally, increased transcription levels of active L1 copies were found, but this was not sufficient for a significant elevation of L1 retrotranspositional activity in leukemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Katrine Praetorius, Stine Kjaer Urhoj, Anne-Marie Nybo Andersen
Summary: The aim of this study was to investigate the association between parental socio-economic position and the onset of type 1 diabetes in offspring. Analysis of individual data from the entire Danish population showed no clear pattern in type 1 diabetes risk according to parental educational attainment or household income.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Julie Bergeron, Luise Cederkvist, Isabel Fortier, Naja Hulvej Rod, Per Kragh Andersen, Anne-Marie Nybo Andersen
Summary: This study found that maternal life stress and emotional distress during pregnancy are associated with gestational age at birth, and pregnancy-related stress is the main driver of this association.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Isabel Fortier, Tina W. Wey, Julie Bergeron, Angela Pinot de Moira, Anne-Marie Nybo-Andersen, Tom Bishop, Madeleine J. Murtagh, Milica Miocevic, Morris A. Swertz, Esther van Enckevort, Yannick Marcon, Michaela. Th. Mayrhofer, Jos Pedro Ornelas, Sylvain Sebert, Ana Cristina Santos, Artur Rocha, Rebecca C. Wilson, Lauren E. Griffith, Paul Burton
Summary: Optimizing research on the developmental origins of health and disease involves harmonizing and integrating existing cohort study data to achieve comparability and reusability. This is crucial for comparison and validation across different studies.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Article
Obstetrics & Gynecology
Trine Damsted Rasmussen, Sarah Fredsted Villadsen, Anne Vinkel Hansen, Laust H. Mortensen, Claus Thorn Ekstrom, Signe Smith Jervelund, Anne-Marie Nybo Andersen
Summary: This study evaluated the impact of the MAMAACT antenatal care intervention on perinatal health outcomes and reducing ethnic and social disparities in Denmark. The intervention, which included training for midwives, dialogue meetings, and health education materials, did not improve the overall composite perinatal mortality and morbidity outcome. Contextual factors, such as organizational barriers in antenatal care, may have hindered the effectiveness of the intervention.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Pharmacology & Pharmacy
Trine Lauritzen, John Munkhaugen, Kari Peersen, Oscar Kristiansen, Elise Sverre, Shane D. Nebauer, Maja Villseth, Anders M. Andersen, Anja Camilla Svarstad, Elena Prunes Jensen, Stein Bergan, Einar Husebye, Nils Tore Vethe
Summary: Self-perceived statin-associated muscle symptoms (SAMS) are common but mostly not related to the drug itself. The study aimed to determine the correlation between atorvastatin metabolites in blood and skeletal muscle, and if genetic variants of statin transporters influence this relationship. Muscle symptoms were examined in patients with coronary disease during treatment with atorvastatin 40 mg/day and placebo. The study found strong correlations between muscle and blood plasma concentrations of atorvastatin metabolites, suggesting that blood measurements can reflect muscle tissue exposure. The relationship between atorvastatin metabolites in blood and SAMS warrants further investigation.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Public, Environmental & Occupational Health
Mathilde Klinte, Asmund Hermansen, Anne-Marie Nybo Andersen, Stine Kjaer Urhoj
Summary: Parental cancer and income loss during childhood have a negative impact on the child's socioeconomic position in early adulthood, with an increased risk of low education and lower income at age 30 years for those who experienced both.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2023)
Article
Obstetrics & Gynecology
Anne K. Ortqvist, Maria C. Magnus, Anna J. M. Aabakke, Stine Kjaer Urhoj, Anne Vinkel Hansen, Anne-Marie Nybo Andersen, Lone Krebs, Karin Pettersson, Siri E. Haberg, Olof Stephansson
Summary: This study aimed to explore the characteristics of pregnant women admitted to the ICU with severe COVID-19, including maternal factors, pregnancy outcomes, vaccination status, and virus variants. The results showed that unvaccinated pregnant women of non-Scandinavian origin and lower socioeconomic status were at higher risk of ICU admission. Additionally, pregnant women admitted to the ICU for COVID-19 had a higher risk of adverse pregnancy outcomes.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Correction
Environmental Sciences
Jonathan Groot, Amelie Keller, Marie Pedersen, Torben Sigsgaard, Steffen Loft, Anne-Marie Nybo Andersen
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Marie Pedersen, Shuo Liu, Jiawei Zhang, Zorana Jovanovic Andersen, Jorgen Brandt, Esben Budtz-Jorgensen, Klaus Bonnelykke, Lise Marie Frohn, Anne-Marie Nybo Andersen, Matthias Ketzel, Jibran Khan, Leslie Stayner, Bert Brunekreef, Steffen Loft
Summary: This study found that early-life exposure to ambient air pollution increases the risk of childhood asthma.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2023)
Article
Public, Environmental & Occupational Health
Frederikke Lihme, Saima Basit, Lucca Katrine Sciera, Anne-Marie Nyboe Andersen, Henning Bundgaard, Jan Wohlfahrt, Heather A. Boyd
Summary: A study found that parents of daughters with preeclampsia have an increased risk of cardiovascular disease. The risk was 1.19 times higher in parents with one daughter with preeclampsia compared to parents without daughters with preeclampsia.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Angela Pinot De Moira, Neil Pearce, Marie Pedersen, Anne-Marie Nybo Andersen
Summary: This study explored factors that may modify associations of early-life animal exposure with asthma and allergic disease, and found that type of animal, source of exposure, parental history of asthma or allergy, and timing of exposure can modify these associations. It is important to consider these factors when assessing the risks associated with early-life animal exposure.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Multidisciplinary Sciences
Johan L. L. Vinther, Claus T. T. Ekstrom, Thorkild I. A. Sorensen, Luise Cederkvist, Deborah A. A. Lawlor, Anne-Marie Nybo Andersen
Summary: Preterm birth is associated with smaller body dimensions at birth with unclear impact on BMI and height in later life. A prospective cohort study on Danish singletons born between 1996 and 2003 showed that the BMI difference between preterm and term children decreased with age, becoming insignificant in adolescence. Though the height difference decreased during childhood, preterm individuals remained slightly shorter than term peers in adolescence.
SCIENTIFIC REPORTS
(2023)
Article
Nursing
Trine Damsted Rasmussen, Anne-Marie Nybo Andersen, Claus Thorn Ekstrom, Signe Smith Jervelund, Sarah Fredsted Villadsen
Summary: The MAMAACT intervention aims to reduce ethnic and social disparities in stillbirth and infant death by improving communication between pregnant women and midwives. This study evaluates the effect of the intervention on pregnant women's health literacy and complication management, and finds that while it improves women's certainty of how to respond to complication signs, it does not improve their health literacy levels.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2023)