期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 13, 期 5, 页码 660-668出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.19194
关键词
Andrographolide; angiogenesis; miR-21-5p; TIMP3
资金
- National Natural Science Foundation of China [31471290]
- Natural Science Foundation of Guangdong Province, China [2014A030313582, 2016A030313601]
- Science and Technology Planning Project of Guangdong Province, China [2013B021800082, 2015A030302083]
- Science and Technology Foundation of Guangzhou, China [201510010076]
- Pearl River S&T Nova Program of Guangzhou, China [201610010045]
- Training Program for Excellent Young Teachers in Guangdong Province, China [YQ2015100]
Angiogenesis provides nutrients and oxygen to promote tumor growth and affords a channel that facilitates tumor cell entry into the circulation. Andrographolide (Andro) possess anti-tumor activity; however, its direct effect on angiogenesis still needs to be clarified. In this study, our experiments revealed that Andro significantly inhibited vascular growth in chick embryo chorioallantoic membrane (CAM) and yolk sac membrane (YSM) models. Meanwhile, tumor angiogenesis was also suppressed by Andro. Additionally, we found that cell proliferation, migration and tube formation of vascular endothelial cells was inhibited by Andro treatment in vitro. The effect was primarily mediated through inhibition of miR-21-5p expression and further targeting of TIMP3. This work provides evidence that Andro directly inhibits angiogenesis and might be an effective anti-angiogenic therapeutic drug for cancer treatment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据