期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 96, 期 -, 页码 675-686出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2016.12.078
关键词
Polysaccharides; Carboxymethyl cellulose; Biopolymer
资金
- CAPES [PROEX-433/2010, PROINFRA2010-2014]
- FAPEMIG [PPM-00202-13, BCN-TEC 30030/12]
- CNPq [PQ1B-306306/2014-0, UNIVERSAL-457537/2014-0, PIBIC-2014/2015]
- FINEP [CTINFRA-PROINFRA 2008/2010]
In this study, it is reported the use of sodium carboxymethyl cellulose (CMCel) as a multifunctional biocompatible polysaccharide for the direct synthesis of fluorescent alloyed-ZnCdS quantum dot (QD) nanoconjugates via aqueous 'green process at room temperature. The nanoconjugates were extensively characterized by spectroscopical (NMR, FFIR, UV-vis, PL) and morphological techniques (DLS, TEM) for accessing their structural and physicochemical properties associated with X-ray photoelectron spectroscopy (XPS) for surface and interface analysis. The results proved the hypothesis of formation of core-shell nanostructures composed by the semiconductor ZnCdS QD core and the organic biocompatible ligand CMCeI shell. Moreover, CMCeI chemical functional groups played a pivotal role for controlling the size of water-soluble colloidal nanocrystals (2r = 4-5 nm) and hydrodynamic diameters (<15 nm) evidenced by metal complexation and interactions at the nanointerfaces. Additionally, these nanoconjugates were cytocompatible and luminescent for bioimaging human osteosarcoma cancer cells. Thus, these novel polysaccharide-based fluorescent bioconjugates offer promising perspectives as nanoplatforms for cancer cell bioimaging and diagnosis purposes. (C) 2016 Elsevier B.V. All rights reserved.
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