Article
Agriculture, Dairy & Animal Science
Ana Rostaher, Yasser Morsy, Claude Favrot, Stefan Unterer, Manuela Schnyder, Michael Scharl, Nina Maria Fischer
Summary: This study compares the gut microbiota of allergic and healthy dogs and finds significant differences between the two groups. These results suggest that alterations in gut microbiota diversity and composition may be associated with canine atopic dermatitis (AD).
Article
Medicine, General & Internal
Yu-Jih Su, Sheng-Dean Luo, Chung-Yuan Hsu, Ho-Chang Kuo
Summary: This study compared gut microbiota differences between patients with eczema, hives, and allergic rhinitis, revealing significant differences in gut flora between skin allergy and nose allergy patients, indicating the existence of gut-skin and gut-nose axes. Certain Bacteroidales species may be a clinical link between gut flora and skin allergies.
Article
Medicine, General & Internal
Barbara Zapala, Tomasz Stefura, Magdalena Wojcik-Pedziwiatr, Radoslaw Kabut, Marta Balajewicz-Nowak, Tomasz Milewicz, Alicja Dudek, Anastazja Stoj, Monika Rudzinska-Bar
Summary: The study compared the gut microbiota composition between patients diagnosed with Parkinson's disease and those treated only with Levodopa to healthy controls, finding that PD patients have significantly different gut microbiota profiles.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Xiang Lu, Hao Wang, Jingqi Zhang, Kexin Jin, Ling Ma, Yan Wang, Shixing Yang, Xiaochun Wang, Quan Shen, Tianji Zhou, Hui Xu, Wen Zhang
Summary: The imbalance of gut microbiota affects the immune development and regulation of individuals, leading to immune dysregulation and the development of atopic dermatitis (AD). This study assessed the composition of the virome in the gut of AD patients and healthy controls, revealing differences in diversity between the two groups. Finds provide a new perspective for understanding the effect of the gut microecological environment on AD.
FRONTIERS IN MEDICINE
(2022)
Article
Pediatrics
Yue Liu, Xiaofan Du, Shujie Zhai, Xiaodong Tang, Cuiling Liu, Weihong Li
Summary: This scoping literature review explores the relationship between gut microbiota and atopic dermatitis (AD) in children. Current research indicates that disturbance of intestinal microbiota is closely associated with the occurrence and development of AD, and probiotics may play a role in the prevention and treatment of AD. However, there is still a lack of high-quality research on the efficacy and safety of probiotics in children with AD.
Article
Veterinary Sciences
Yaonan Li, Yanfang Lan, Shuang Zhang, Xiaoli Wang
Summary: This study investigated and compared gut microbial changes in horses during diarrhea. The results showed that the diversity and abundance of gut microbiota in diarrheic horses changed significantly. The dysbiosis of gut microbiota may be an important driving factor of diarrhea in horses.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Immunology
Ru-ping Hong, Yue-ying Hou, Xin-jie Xu, Ji-dong Lang, Yun-feng Jin, Xiao-feng Zeng, Xuan Zhang, Geng Tian, Xin You
Summary: This study examined the differences in gut microbiota and urinary organic acids between autistic children with and without atopic dermatitis. The results showed distinct characteristics in gut microbiota and urinary organic acid levels in the AD group, indicating the importance of gut microbiota in the development of AD in autistic children.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Nan Zhang, Danlei Mou, Tongzeng Li, Zhiyun Chen, Chunhua Ma, Lianchun Liang, Qiushui He
Summary: This study investigated the alteration and differences in gut and oropharynx microbiota between patients with mild and severe hand, foot, and mouth disease (HFMD). The results showed that compared to mild cases, severe HFMD exhibited decreased diversity and richness of gut microbiota. The bacterial profiles in the acute and convalescent phases were similar but differed from those in mild cases. Our findings suggest that severe HFMD is associated with impaired diversity of gut microbiota and inflammation-inducing bacteria in the gut and oropharynx.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Dermatology
Siqi Ye, Fenggen Yan, Haiyan Wang, Xiumei Mo, Junfeng Liu, Yu Zhang, Hongyi Li, Dacan Chen
Summary: The gut microbiota is increasingly recognized to be involved in atopic dermatitis. Differences in composition were observed between healthy controls and AD patients, suggesting potential for microbiota as diagnostic markers or targets for intervention in AD.
JOURNAL OF DERMATOLOGY
(2021)
Review
Nutrition & Dietetics
Alexandru Cosmin Pantazi, Cristina Maria Mihai, Adriana Luminita Balasa, Tatiana Chisnoiu, Ancuta Lupu, Corina Elena Frecus, Larisia Mihai, Adina Ungureanu, Mustafa Ali Kassim Kassim, Antonio Andrusca, Maria Nicolae, Viviana Cuzic, Vasile Valeriu Lupu, Simona Claudia Cambrea
Summary: The intestinal microbiota is a diverse and complex microecosystem that stabilizes by the age of three and plays a crucial role in human health, particularly in early childhood. Dysbiosis has been linked to the development of allergic diseases, such as atopic dermatitis, asthma, and food allergies. Next-generation sequencing methods have improved our understanding of the relationship between dysbiosis and allergic diseases. This review paper aims to synthesize the current knowledge on the development of the intestinal microbiota, its long-term impact on health, and the connection between dysbiosis and allergic diseases, as well as interventions for prevention and treatment.
Article
Immunology
Xiaomei Liu, Xue Pan, Hao Liu, Xiaoxin Ma
Summary: This study found significant differences in the diversity and composition of gut microbiota among female patients with IM, CC, and healthy controls. Abundance of cancer-related genes was significantly increased in IM and CC patients. Prevotella_7 may serve as a potential biomarker for distinguishing IM, CC, and controls.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Xiaoxiao Fan, Tianzi Zang, Jiamiao Dai, Ni Wu, Chloe Hope, Jinbing Bai, Yanqun Liu
Summary: This study investigated the relationship between maternal-offspring gut microbiota and the development of atopic dermatitis in infants and toddlers. The results showed that mothers of infants and toddlers with atopic dermatitis had higher abundance of certain bacteria during pregnancy, and the infants and toddlers themselves had higher abundance of certain bacteria at different time points. Additionally, the study found a lower abundance of a specific bacteria in mothers of infants and toddlers with atopic dermatitis. These findings support a correlation between gut microbiota and the development of pediatric atopic dermatitis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Armin Rashidi, Maryam Ebadi, Daniel J. Weisdorf, Massimo Costalonga, Christopher Staley
Summary: The study revealed that microbial communities in the mouth and distal gut are completely distinct, with no evidence of oral bacteria colonizing the gut. Finding the same bacteria in the mouth and stool may indicate the need for further clinical investigation for underlying pathologies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Leen Beller, Ward Deboutte, Sara Vieira-Silva, Gwen Falony, Raul Yhossef Tito, Leen Rymenans, Claude Kwe Yinda, Bert Vanmechelen, Lore Van Espen, Daan Jansen, Chenyan Shi, Mark Zeller, Piet Maes, Karoline Faust, Marc Van Ranst, Jeroen Raes, Jelle Matthijnssens
Summary: This study analyzed the virome and 16/18S gene data from 304 fecal samples of eight infants. The findings show that the gut virome is mainly composed of bacteriophages, which rapidly increase in abundance within the first few weeks after birth. The majority of phages are individual-specific, but there are also some common phages among infants. Bacterial hosts could be predicted for most of the phages, mainly infecting Firmicutes. Additionally, clinically asymptomatic eukaryotic viruses were detected, with an increase in infection rate after day-care entrance.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Microbiology
Jingjing Li, Yujia Chu, Wenwen Yao, Hui Wu, Jiang Feng
Summary: This study revealed differences in diet and gut microbial composition between lactating and non-lactating Asian particolored bats. Lactating bats consume a more diverse and protein-rich diet, with changes in the abundance of specific gut microbes to help them adapt to these dietary changes.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Endocrinology & Metabolism
Jaak Jurimae, Vita Karvelyte, Liina Remmel, Anna-Liisa Tamm, Priit Purge, Rita Gruodyte-Raciene, Sigitas Kamandulis, Katre Maasalu, Luis Gracia-Marco, Vallo Tillmann
Summary: The study compared sclerostin and preadipocyte factor-1 levels in rhythmic gymnasts, swimmers, and untrained controls, finding higher sclerostin levels in athletes. Sclerostin correlated with bone mineral values and predicted areal bone mineral density in gymnasts.
JOURNAL OF BONE AND MINERAL METABOLISM
(2021)
Article
Allergy
Linnea Reinert-Hartwall, Heli Siljander, Taina Harkonen, Tommi Vatanen, Jorma Ilonen, Onni Niemela, Kristiina Luopajarvi, Natalya Dorshakova, Sergei Mokurov, Aleksandr Peet, Vallo Tillmann, Raivo Uibo, Mikael Knip, Outi Vaarala, Jarno Honkanen
Summary: The study revealed that T helper cell signature cytokines are upregulated during the first 12 months of life, reflecting the natural development of adaptive immune responses; under normal circumstances, children have higher circulating levels of epidermal growth factor (EGF), which may play a protective role for children without IgE sensitization responses.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Inna Starskaia, Essi Laajala, Toni Gronroos, Taina Harkonen, Sini Junttila, Roosa Kattelus, Henna Kallionpaa, Asta Laiho, Veronika Suni, Vallo Tillmann, Riikka Lund, Laura L. Elo, Harri Lahdesmaki, Mikael Knip, Ubaid Ullah Kalim, Riitta Lahesmaa
Summary: This study used RRBS technology to investigate early-stage DNA methylation changes in type 1 diabetes, identifying differentially methylated regions associated with the disease and confirming some of the results. These preliminary results provide novel insights into the cell type-specific epigenetic regulation of genes, contributing to our understanding of type 1 diabetes pathogenesis at an early stage.
Correction
Multidisciplinary Sciences
Jelena Stsepetova, Kart Simre, Aili Tagoma, Oivi Uibo, Aleksandr Peet, Heli Siljander, Vallo Tillmann, Mikael Knip, Reet Mandar, Raivo Uibo
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Jelena Stsepetova, Kart Simre, Aili Tagoma, Oivi Uibo, Aleksandr Peet, Heli Siljander, Vallo Tillmann, Mikael Knip, Reet Mandar, Raivo Uibo
Summary: This study compared the microbiota composition and immune markers concentration in breast milk from mothers of children with genetic predisposition to celiac disease (CD) and mothers of unaffected children. The breast milk of mothers with genetically predisposed offspring who developed CD showed higher bacterial phylotype abundance and diversity, as well as a different bacterial composition. The immune markers were associated with specific bacterial genera and species, and may influence the risk for development of CD beyond early childhood.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Mari Lukka, Vallo Tillmann, Aleksandr Peet
Summary: The use of dual-wave boluses for evening meals based solely on the carbohydrate count did not improve time in range (TIR) in children with type 1 diabetes (T1D). However, it enabled significantly less correction boluses to achieve normal blood glucose levels in the morning compared to standard boluses.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Liisa Saare, Aleksandr Peet, Vallo Tillmann
Summary: The incidence of type 1 diabetes (T1D) is increasing worldwide. Our study found that children at genetic risk for T1D who were taller had a lower IGF-1/IGFBP-3 molar ratio, and children with diabetes-associated auto-antibodies (DAAB) tended to be taller and have a higher body mass index. The accelerator hypothesis for the increasing incidence of T1D may not solely be dependent on environmental factors, but could be partially genetically determined.
ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Sport Sciences
Marit Salus, Vallo Tillmann, Liina Remmel, Eve Unt, Evelin Maestu, Ulle Parm, Agnes Magi, Maie Tali, Jaak Jurimae
Summary: This study examined the effect of a supervised 12-week sprint interval training on cardiorespiratory fitness and body composition in adolescent boys with obesity. The results showed that the sprint interval training significantly increased cardiorespiratory fitness and decreased body fat percentage in these adolescent boys.
JOURNAL OF SPORTS SCIENCES
(2022)
Article
Environmental Sciences
Marit Salus, Vallo Tillmann, Liina Remmel, Eve Unt, Evelin Maestu, Ulle Parm, Agnes Magi, Maie Tali, Jaak Jurimae
Summary: This study found that supervised sprint interval training (SIT) effectively improves cardiometabolic health in adolescent boys with obesity, including increased cardiorespiratory fitness and decreased low-density cholesterol.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
Eva Mengel, Reeli Tamme, Liina Remmel, Priit Purge, Evelin Maestu, Jaak Jurimae, Vallo Tillmann
Summary: Increased insulin resistance during puberty may have a negative effect on the accumulation of lumbar spine bone mineral density independently of body composition parameters, potentially challenging adult bone quality.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Jaak Jurimae, Liina Remmel, Anna-Liisa Tamm, Priit Purge, Katre Maasalu, Vallo Tillmann
Summary: The aim of this investigation was to determine the associations of serum irisin and fibroblast growth factor-21 (FGF-21) with energy homeostasis and other hormones in highly trained adolescent rhythmic gymnasts. The results showed that serum irisin concentration was associated with energy expenditure and serum FGF-21 level with energy availability measures in lean adolescent athletes, while no relationships of irisin and FGF-21 with energy status measures were observed in lean nonathletic adolescents.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pediatrics
Marit Salus, Vallo Tillmann, Liina Remmel, Eve Unt, Evelin Mäestu, Ulle Parm, Agnes Mägi, Maie Tali, Jaak Jürimäe
Summary: The aim of this study was to investigate the effects of supervised cycling sprint interval training on serum osteocalcin, lipocalin-2 and sclerostin levels, and bone mineral characteristics among obese adolescent boys. After a 12-week intervention, there were significant improvements in bone mineral content and density in the SIT group. However, no significant differences were found in osteocalcin, lipocalin-2, and sclerostin levels between the two groups.
Meeting Abstract
Endocrinology & Metabolism
Mari Lukka, Vallo Tillmann, Aleksandr Peet
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Meeting Abstract
Endocrinology & Metabolism
Eva Mengel, Reeli Tamme, Liina Remmel, Priit Purge, Evelin Maestu, Jaak Jurimae, Vallo Tillmann
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Article
Endocrinology & Metabolism
Reeli Tamme, Jaak Jurimae, Evelin Maestu, Liina Remmel, Priit Purge, Eva Mengel, Vallo Tillmann
Summary: The study found a negative association between leptin to adiponectin ratio (LAR) in puberty and lumbar spine bone mineral density (BMD) and bone mineral apparent density (BMAD) at the age of 18.
