期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 105, 期 -, 页码 1310-1314出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2017.07.152
关键词
Bioadhesion; Chitosan; Dermal; Hydrogel; Scars; Skin
Background: Skin delivery and transdermal delivery are key ambitions of the pharmaceutical and cosmetically researchers. Aim: The study aimed to chemically modify well-known polymeric gelling agents in order to boost their topical suitability by fostering their dermal adhesiveness. Methods: Conventional chitosan was modified via amide bound formation with sulfhydryl compound thioglycolic acid. Subsequently, preactivated chitosan conjugate was established by preactivation of chitosan-thioglycolic acid with mercaptonicotinamide being covalently attached via disulfide bond linkage. All conjugates were examined due to their dermal adhesiveness and controlled drug release properties. Results: Preactivated chitosan conjugates Exhibit 7.46-fold dermal adhesiveness on skin due to tensile adhesion strength. Furthermore a 1.9-fold controlled release of Rhodamine123 as model drug was determined in comparison to unmodified chitosan. Conclusion: Taken together, preactivated chitosan gels show a promising platform for topical application. (C) 2017 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据