期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 101, 期 -, 页码 474-480出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2017.03.106
关键词
Salecan; Hydrogel; Quaternary ammonium salt; Drug delivery; Biomaterials
资金
- National Natural Science Foundation of China [51573078]
- Fundamental Research Funds for the Central Universities [30920130121013]
Salecan is a biological macromolecular and biocompatible polysaccharide that has been investigated for recent years. Herein, we report a novel cationic hydrogel fabricated by graft-polymerizing 3(methacryloylamino)propyl-trimethylammonium chloride (MAPTAC) onto salecan chains. The obtained hydrogels were transparent, solid-elastic, macro-porous, ion-sensitive, and non-cytotoxic. The swelling ratios increased with salecan content, while mechanical strength does the opposite. Moreover, drug delivery test was studied as a potential application. Diclofenac sodium (DS) and insulin were selected as model drugs. Interestingly, in drug loading process, DS molecules exhibited highly affinity to these cationic hydrogels. Almost all the DS molecules in loading solution were absorbed and spread into the hydrogel. For drug release profiles, insulin-loaded hydrogel showed an initial rapid release and a sustained release. As a comparison, DS-loaded hydrogel exhibited a more sustained release profile. Results suggested salecan-g-PMAPTAC hydrogel could be a good candidate for anionic drug loading and delivery. (C) 2017 Elsevier B.V. All rights reserved.
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