Article
Biochemistry & Molecular Biology
Ramsha Hafeez, Zakia Kanwal, Muhammad Akram Raza, Shafqat Rasool, Saira Riaz, Shahzad Naseem, Shifa Rabani, Imran Haider, Naushad Ahmad, Suliman Yousef Alomar
Summary: Green-synthesized metallic nanoparticles from plant extracts show potential antibacterial activity with reduced toxicity to animal cells and hosts. This study demonstrated that the application of these nanoparticles, specifically silver nanoparticles synthesized from Citrullus colocynthis and Psidium guajava, improved the survival rate and promoted recovery in Labeo rohita infected with Aeromonas hydrophila. Hematological, histological, oxidative stress, and cytokine analysis indicated positive effects of the nanoparticles on various bio-indicators and immune response in infected fish.
Article
Chemistry, Multidisciplinary
Shafqat Rasool, Asima Tayyeb, Muhammad Akram Raza, Hanfa Ashfaq, Sadia Perveen, Zakia Kanwal, Saira Riaz, Shahzad Naseem, Nadeem Abbas, Naushad Ahmad, Suliman Yousef Alomar
Summary: This study investigated the biomedical potential of eco-friendly Citrullus colocynthis-mediated silver nanoparticles (Cc-AgNPs), revealing their antibacterial efficacy against multidrug-resistant pathogenic bacteria and their antiproliferative and antilipidemic activities against breast cancer cells.
Article
Plant Sciences
Bushra Hafeez Kiani, Qudsia Ajmal, Nosheen Akhtar, Ihsan-ul Haq, Mostafa A. Abdel-Maksoud, Abdul Malik, Mohammed Aufy, Nazif Ullah
Summary: Green synthesis of zinc oxide nanoparticles from Citrullus colocynthis extracts showed antimicrobial, cytotoxic, antidiabetic, and antioxidant properties. The bioactivity of the plant suggests its potential therapeutic use. The nanoparticles can also be used for in vivo assessment of a nano-directed drug delivery system.
Article
Agricultural Engineering
Umar Nawaz Khan, Abid Inayat, Ghulam Mujtaba Shah, Hassan M. A. Hassan, Magdi E. A. Zaki, Abdulaziz A. Alanazi, Adel A. El-Zahhar, Shama Noureen, Syed Mustansar Abbas
Summary: The present study focuses on the green synthesis of MgO nanocatalyst using a novel fruit extract and its application in biodiesel production from tea seed oil. The synthesized biodiesel showed excellent fuel properties and can be used as an alternative fuel source for internal combustion engines.
BIOMASS & BIOENERGY
(2022)
Article
Chemistry, Physical
Arif Nazir, Shakeel Alam, Norah Alwadai, Mazhar Abbas, Ismat Bibi, Abid Ali, Naveed Ahmad, Maryam Al Huwayz, Munawar Iqbal
Summary: In this study, copper nanoparticles were synthesized using leaves extract of Citrullus colocynthis as a reducing agent. The synthesized nanoparticles exhibited promising photocatalytic and antibacterial activities, as well as significant antioxidant potential. The results highlight the potential of green synthesis for the fabrication of Cu NPs with desirable properties.
ZEITSCHRIFT FUR PHYSIKALISCHE CHEMIE-INTERNATIONAL JOURNAL OF RESEARCH IN PHYSICAL CHEMISTRY & CHEMICAL PHYSICS
(2023)
Review
Polymer Science
Fahad M. Aldakheel, Marwa M. El Sayed, Dalia Mohsen, Mohammed H. Fagir, Dalia K. El Dein
Summary: Wound healing is a complex biological process, and nanotechnology, particularly the use of silver nanoparticles (AgNPs), has gained attention for its potential in enhancing this process. AgNPs offer advantages such as easy synthesis and high surface area, which make them efficient for topical drug administration and wound healing. Green synthesis methods utilizing natural sources have been found to be eco-friendly. Characterization techniques such as UV-Vis spectroscopy, FT-IR, SEM, TEM, and XRD are employed to confirm the specific properties of AgNPs. This review highlights the potential of green-synthesized AgNPs loaded in Polyacrylamide hydrogel for advanced wound healing therapies.
Article
Chemistry, Medicinal
Hua-Wei Lv, Qiao-Liang Wang, Song -Wei Li, Meng -Di Zhu, Zhong-Bo Zhou, Chang -Chun Chen, Sheng-Qiang Tong, Hong Wang, Xing-Nuo Li
Summary: A phytochemical investigation of Citrullus colocynthis fruits led to the discovery of 21 structurally diverse cucurbitane triterpenoids, including 9 new compounds. The absolute configurations of these compounds were determined through quantum chemical electronic circular dichroism calculations, CD exciton chirality method, and single-crystal X-ray crystallography. Some of these compounds exhibited inhibitory activities against acetylcholinesterase and cytotoxicity against PACA, A431, and HepG2 cells.
Article
Chemistry, Physical
Mubsher Mazher, Muhammad Ishtiaq, Bilqeesa Hamid, Shiekh Marifatul Haq, Atiya Mazhar, Faiza Bashir, Mussaddaq Mazhar, Eman A. Mahmoud, Ryan Casini, Abed Alataway, Ahmed Z. Dewidar, Hosam O. Elansary
Summary: Modern nanotechnology is being widely studied in various fields. The present research focused on the synthesis, characterization, stability, biocompatibility, and in vitro bioactivities of calcium oxide nanoparticles (CaONPs) synthesized using Citrullus colocynthis ethanolic fruit extracts. The greenly synthesized nanoparticles showed great stability and had bioactivity and biosafety when combined with C. colocynthis fruit extracts. The CaONPs released consistently and had significant effects on Micrococcus luteus and the reduction of free radicals.
Article
Engineering, Electrical & Electronic
Azeez Abdullah Barzinjy, Banaz Shahab Haji, Hassan Fouad
Summary: This study synthesized silver nanoparticles with unique properties using a biological approach and utilized them to prepare high-standard thin films for photovoltaic devices.
JOURNAL OF NANOELECTRONICS AND OPTOELECTRONICS
(2022)
Review
Biochemistry & Molecular Biology
Xiaotian Cheng, Minni Qin, Rongrong Chen, Yunxia Jia, Qing Zhu, Guangtong Chen, Andong Wang, Bai Ling, Weiwei Rong
Summary: Citrullus colocynthis (L.) Schrad. (Cucurbitaceae) is a plant widely found in desert areas around the world. Its fruit bodies are known for their potential as nutraceuticals, as well as medicinal and pharmaceutical uses. The plant has been used for various purposes, including treating asthma, bronchitis, cancer, colic, common cold, cough, diabetes, dysentery, and jaundice. The fruit has been extensively studied for its biological activities, including insecticidal, antitumor, and antidiabetic effects, and contains various bioactive compounds such as essential oils, fatty acids, glycosides, alkaloids, and flavonoids. This review summarizes the scientific evidence for the insecticidal, cytotoxic, and antidiabetic effects of C. colocynthis.
Article
Biochemistry & Molecular Biology
Bismillah Mubeen, Mahvish Ghulam Rasool, Inam Ullah, Rabia Rasool, Syed Sarim Imam, Sultan Alshehri, Mohammed M. Ghoneim, Sami I. Alzarea, Muhammad Shahid Nadeem, Imran Kazmi
Summary: The synthesis of gold nanoparticles using Citrullus colocynthis seed extract was successfully achieved, with characterization techniques verifying their formation and potential applications.
Article
Polymer Science
Roya Binaymotlagh, Alessandra Del Giudice, Silvano Mignardi, Francesco Amato, Andrea Giacomo Marrani, Francesca Sivori, Ilaria Cavallo, Enea Gino Di Domenico, Cleofe Palocci, Laura Chronopoulou
Summary: This study investigated the synthesis of peptide-based hydrogel composites containing photo-generated silver nanoparticles (AgNPs) and the effects of honey on their properties. The results showed that honey increased the swelling ability and mechanical stability of the hydrogel. Additionally, the presence of honey enhanced the antibacterial activity of AgNPs in the hydrogel.
Article
Biochemistry & Molecular Biology
Xiao Han, Zilu Lv, Fangli Ran, Lin Dai, Chenyu Li, Chuanling Si
Summary: This study demonstrates a green and simple design strategy for piezoresistive pressure sensors based on nanocomposite hydrogel, using hybrid organic-inorganic nanoparticles synthesized from alkaline lignin and silver nanoparticles. The novel nanomaterial effectively enhances the compressibility, pressure sensitivity, and signal response stability of the hydrogel.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Malik Shoaib Ahmad, Nayab Shah, Zeeshan Akbar, Tajwali Khan, Arslan Ali
Summary: The purification of peroxidase enzyme from Citrullus colocynthis root was successfully achieved in a two-step process, resulting in maximum purity. The enzyme was extracted in a high salt buffer and partially purified using a Q-Sepharose anion exchange column, followed by final purification with a HighLoad 16/600 Superdex G-75 column. SDS gel electrophoresis confirmed the presence of a single band at approximately 35 kDa, and mass spectrometric analysis using an ESI-QTOF spectrometer further identified the enzyme. This study will contribute to the isolation and commercial applications of this enzyme in biotechnology.
NATURAL PRODUCT RESEARCH
(2023)
Article
Plant Sciences
Merajuddin Khan, Mujeeb Khan, Khaleel Al-hamoud, Syed Farooq Adil, Mohammed Rafi Shaik, Hamad Z. Alkhathlan
Summary: Seeds of Citrullus colocynthis extracted with different solvents showed significant antimicrobial and anticancer activities. Hexane extracts exhibited the highest antimicrobial activity, while all extracts showed anticancer activity against tested cell lines except for the chloroform extracts against HepG2 cells.
Review
Chemistry, Multidisciplinary
Pooyan Makvandi, Sidra Iftekhar, Fabio Pizzetti, Atefeh Zarepour, Ehsan Nazarzadeh Zare, Milad Ashrafizadeh, Tarun Agarwal, Vinod V. T. Padil, Reza Mohammadinejad, Mika Sillanpaa, Tapas Kumar Maiti, Giuseppe Perale, Ali Zarrabi, Filippo Rossi
Summary: The inert nature of most commercial polymers and nanomaterials limits their applications in various industrial fields, which can be solved by surface modifications to improve physicochemical and biological properties. Polymer functionalization allows for specific moieties and conjugate molecules to be grafted onto surfaces, enhancing material performances. Further research is needed on cell-polymer interactions, nanosafety, and industrial scale manufacturing to fully understand the advantages and challenges of polymer functionalization.
ENVIRONMENTAL CHEMISTRY LETTERS
(2021)
Review
Engineering, Biomedical
Danial Khorsandi, Amir Fahimipour, Payam Abasian, Sepehr Sadeghpour Saber, Mahla Seyedi, Sonya Ghanavati, Amir Ahmad, Andrea Amoretti De Stephanis, Fatemeh Taghavinezhaddilami, Anna Leonova, Reza Mohammadinejad, Majid Shabani, Barbara Mazzolai, Virgilio Mattoli, Franklin R. Tay, Pooyan Makvandi
Summary: 3D and 4D printing technologies enable precise and expedited manufacturing of a wide range of objects, including those used in dentistry such as surgical drill guides, crowns, bridges, and implants. This review highlights the available 3D printing technologies and materials in dentistry, as well as recent applications to show the progress in this field.
ACTA BIOMATERIALIA
(2021)
Review
Oncology
Milad Ashrafizadeh, Hossein Rafiei, Reza Mohammadinejad, Tahereh Farkhondeh, Saeed Samarghandian
Summary: Despite advancements in diagnostic tools and anti-tumor drugs, the survival time of gastric cancer patients has not significantly increased. Studies have shown that signaling pathways such as Wnt, Nrf2, MAPK, and PI3K/Akt are involved in GC invasion, with long non-coding RNAs and microRNAs playing a role in GC malignancy. Resveratrol exhibits high anti-tumor activity and has the potential to target various signaling pathways to induce apoptotic cell death and inhibit migration and metastasis of GC cells.
CANCER CELL INTERNATIONAL
(2021)
Review
Pharmacology & Pharmacy
Sepideh Mirzaei, Hojjat Samareh Fekri, Farid Hashemi, Kiavash Hushmandi, Reza Mohammadinejad, Milad Ashrafizadeh, Ali Zarrabi, Manoj Garg
Summary: Venom peptides are an important source of bioactive compounds with anti-tumor activities. They can induce cancer cell death, enhance chemotherapy and radiotherapy efficacy, and mitigate cancer cell migration through suppression of angiogenesis and epithelial-to-mesenchymal transition. Moreover, nanoparticles have been used to enhance the bioavailability and targeted delivery of venom peptides, leading to elevated anti-tumor activity and potential application in cancer therapy.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Cell Biology
Milad Ashrafizadeh, Masoud Najafi, Nasim Kavyiani, Reza Mohammadinejad, Tahereh Farkhondeh, Saeed Samarghandian
Summary: Melatonin, a hormone produced by the pineal gland, plays a crucial role in regulating physiological activities such as sleep and circadian rhythm. It possesses various pharmacological activities, including antioxidant, anti-inflammatory, and protective effects on the liver, heart, and nervous system. Studies have shown that melatonin exerts therapeutic efficacy in treating cancer and diabetes by affecting multiple molecular pathways.
Review
Chemistry, Multidisciplinary
Vijay Sagar Madamsetty, Shima Tavakol, Saeid Moghassemi, Arezoo Dadashzadeh, John D. Schneible, Iman Fatemi, Abdolsamad Shirvani, Ali Zarrabi, Fereshteh Azedi, Ali Dehshahri, Abbas Aghaei Afshar, Kian Aghaabbasi, Abbas Pardakhty, Reza Mohammadinejad, Prashant Kesharwani
Summary: Breast cancer is a highly deadly neoplastic disease with limited efficacy in existing treatment methods, prompting a search for new remedies. Nanotechnology has shown promise in the field, particularly with chitosan as a potential carrier for anticancer drugs. Further research is ongoing to explore the therapeutic and diagnostic applications of chitosan in breast cancer treatment.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Cell Biology
Elizaveta Belyaeva, Rajesh Kumar Kharwar, Ilya Ulasov, Irina Karlina, Petr Timashev, Reza Mohammadinejad, Arbind Acharya
Summary: Autophagy is a crucial self-regulating mechanism in cells, allowing them to maintain homeostasis under conditions of stress or nutrient deprivation, and is also considered a form of cell death. Recent studies have identified autophagy as a potential mechanism in the treatment of malignant glioma, however, the molecular mechanisms involving autophagy-related proteins require further investigation.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Engineering, Chemical
Kavithraashree Arumugam, Rosfarizan Mohamad, Siti Efliza Ashari, Joo Shun Tan, Mohd Shamzi Mohamed
Summary: Calcium carbonate precipitation is a sedimentary carbonate phenomenon induced by microorganisms in an ecosystem saturated with calcium ions. Certain microalgae species can produce cementitious CaCO3 deposits. This study evaluated the biomineralization capability of eight microalgae and found that Synechocystis sp. ATCC 27178 had the highest calcium ion removal rate under specific conditions.
ASIA-PACIFIC JOURNAL OF CHEMICAL ENGINEERING
(2022)
Article
Plant Sciences
Mahshid Moballegh Nasery, Mohammad Varzandeh, Saghar Pahlavanneshan, Neda Mohamadi, Solmaz Sarhadi, Hojjat Samareh Fekri, Reza Mohammadinejad, Kwang Seok Ahn
Summary: This review examines the role of curcumin in the treatment of adenocarcinomas in multiple organs and describes key molecular pathways involved. It also discusses the synthesis of curcumin analogs for enhanced cytotoxicity and bioavailability, and the production of curcumin-loaded nanoparticles. The literature search demonstrates the effectiveness of curcumin in modulating antitumor signaling pathways and improving therapeutic efficacy against adenocarcinoma cells. Further investigation in clinical settings is warranted.
PHYTOCHEMISTRY LETTERS
(2022)
Article
Polymer Science
Ali Dehshahri, Bahman Khalvati, Zahra Taheri, Farshad Safari, Reza Mohammadinejad, Abolfazl Heydari
Summary: This study evaluated the transfection efficiency and cytotoxicity of N-[(2-hydroxy-3-trimethylammonium)propyl] chitosan salt (HTCS) as a gene carrier. HTCS was synthesized and used for the delivery of the interleukin-12 (IL-12) gene plasmid. The results showed that HTCS could effectively condense the IL-12 plasmid into polyplexes and demonstrated higher hIL-12 production compared to CS and polyethylenimine polyplexes in cell transfection experiments.
Review
Materials Science, Biomaterials
Vijay Sagar Madamsetty, Reza Mohammadinejad, Ilona Uzieliene, Noushin Nabavi, Ali Dehshahri, Jomarien Garcia-Couce, Shima Tavakol, Saeid Moghassemi, Arezoo Dadashzadeh, Pooyan Makvandi, Abbas Pardakhty, Abbas Aghaei Afshar, Ali Seyfoddin
Summary: Dexamethasone (DEX) is widely used to treat various diseases, but its poor solubility limits its clinical usage. Efficient DEX-loaded nanoformulations have been developed to mitigate its side effects and promote scientific research. Various nanoparticles have been used to selectively deliver drugs without damaging healthy cells or organs.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Agriculture, Dairy & Animal Science
Hidayat Mohd Yusof, Nor'Aini Abdul Rahman, Rosfarizan Mohamad, Uswatun Hasanah Zaidan, Anjas Asmara Samsudin
Summary: Traditionally, higher levels of inorganic zinc (Zn) were added to broiler chicken diets to meet optimal body requirements, but this can lead to heavy metal contamination. Nanomaterial ZnO NPs have unique properties that increase nutrient utilization and improve broiler physiological function and production. This study found that dietary biosynthesized ZnO NPs increased Zn absorption in broiler chickens, improved tibia bone development, and enhanced antioxidative status in serum and liver tissue.
Review
Materials Science, Biomaterials
Hafez Jafari, Pejman Ghaffari-Bohlouli, Seyyed Vahid Niknezhad, Ali Abedi, Zohreh Izadifar, Reza Mohammadinejad, Rajender S. Varma, Amin Shavandi
Summary: This review focuses on the application of tannic acid in biomaterials engineering, discussing its interactions with other substances and providing fundamental criteria for using tannic acid in the design and fabrication of hydrogel biomaterials for tissue healing and regeneration.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Biotechnology & Applied Microbiology
Siti Nur Hazwani Oslan, Siti Nurbaya Oslan, Rosfarizan Mohamad, Joo Shun Tan, Abdul Hafidz Yusoff, Patricia Matanjun, Ruzaidi Azli Mohd Mokhtar, Rossita Shapawi, Nurul Huda
Summary: Haematococcus lacustris is considered the most promising microalgae for producing natural astaxanthin, with high antioxidant activity and economic potential. Although synthetic astaxanthin currently dominates the market, extracting it from this microalga remains expensive due to bioprocess difficulties and high cultivation costs.
FERMENTATION-BASEL
(2022)
Article
Biotechnology & Applied Microbiology
Muhammad Hariadi Nawawi, Khairul Izdihar Ismail, Norazliza Sa'ad, Rosfarizan Mohamad, Paridah Md Tahir, Ainun Zuriyati Asa'ari, Wan Zuhainis Saad
Summary: An effective statistical tool, response surface methodology (RSM) using central composite design (CCD), was used to increase the production of xylanase and pectinase by Bacillus amyloliquefaciens ADI2 in submerged fermentation (SmF). The optimized CCD model resulted in significantly higher xylanase and pectinase production compared to the one factor at a time (OFAT) approach. The production of concurrent enzymes of xylanase and pectinase showed a ratio of 1:1.3.
FERMENTATION-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
