Article
Biochemistry & Molecular Biology
Yang Yu, Xiaoyi Zheng, Xiuying Liu, Jiulong Zhao, Shige Wang
Summary: An injectable PCP hydrogel was developed to reduce post-operative infection and prevent tumor recurrence. The hydrogel effectively killed tumor cells and bacteria, and exhibited anti-bacterial and anti-tumor properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Shamim Ashkezari, Maryam Sadat Abtahi, Zahra Sattari, Mohammad Tavakkoli Yaraki, Fatemeh Hosseini, Raheleh Inanloo Salehi, Elham Afzali, Saeedeh Hajihosseini, Neda Mousavi-Niri
Summary: Niosomes loaded with sultamicillin tosylate and inorganic nanoparticles (zinc oxide or silver nanoparticles) were synthesized and characterized. Carboxymethyl chitosan was used to enhance the antimicrobial and anti-biofilm activities. The optimized niosome showed good stability and high potential for biomedical applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Polymer Science
Tanpong Chaiwarit, Sarana Rose Sommano, Pornchai Rachtanapun, Nutthapong Kantrong, Warintorn Ruksiriwanich, Mont Kumpugdee-Vollrath, Pensak Jantrawut
Summary: Polymeric nanoparticles, specifically CMCS-Ca2+ nanoparticles, loaded with clindamycin HCl demonstrated potential for modifying the drug release of small hydrophilic antibiotics. Ultrasonication with experimental design was utilized to produce these nanoparticles, and it was discovered that the size of nanoparticles had an inverse relationship with the drug content as well as the release rate.
Article
Biochemistry & Molecular Biology
Sante Di Gioia, Giuseppe Fracchiolla, Stefania Cometa, Filippo Maria Perna, Andrea Francesca Quivelli, Giuseppe Trapani, Valeria Daniello, Concetta Nobile, Md Niamat Hossain, Adriana Trapani, Massimo Conese
Summary: In this study, two novel macromolecular conjugates were synthesized and characterized for their stability, release rate, formation of polymeric nanoparticles, antioxidant activity, and cytocompatibility. The results showed that the conjugates exhibited good stability at high temperatures, with the O-carboxymethyl chitosan-DA conjugate having a faster release rate. The formation of polymeric nanoparticles was observed using TEM and Photon correlation spectroscopy. Additionally, the conjugates showed antioxidant activity and were found to be non-toxic to neuroblastoma cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Biomaterials
Mengyu Yao, Qingxia Zou, Wenwu Zou, Zhenze Xie, Zhihao Li, Xiujuan Zhao, Chang Du
Summary: The study developed a bifunctional tissue engineering scaffold with anti-tumor and bone repair properties using a combination of hydroxyapatite, poly(dopamine), and carboxymethyl chitosan. The scaffold showed enhanced osteogenic properties and effective suppression of tumor growth in both in vitro cell experiments and in vivo tumor models in nude mice. The scaffolds with poly(dopamine) were able to promote osteogenic differentiation of bone marrow stromal cells and suppress tumor cell proliferation through a direct photothermal effect.
BIOMATERIALS SCIENCE
(2021)
Article
Chemistry, Applied
Yilin Wang, Wenjie Wang, Xiaoming Wang, Hao Wu, Weifeng Zhao, Changsheng Zhao
Summary: This study develops low-immunogenicity CM nanoparticles for MRI-guided photothermal therapy using CMC and KMnO4. In vitro and in vivo experiments demonstrate excellent hemocompatibility and low immunogenicity of the proposed nanomaterials, along with outstanding photothermal properties for successful MRI-guided PTT.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Atefe Sadeghi Lari, Payam Zahedi, Hedayatollah Ghourchian, Alireza Khatibi
Summary: This study successfully synthesized novel crosslinked carboxymethyl chitosan nanoparticles using microfluidics and demonstrated their potential application in diabetes therapy. In the rat experiments, it was found that metformin hydrochloride loaded in these nanoparticles significantly increased body weight and reduced blood glucose levels, with effects on pancreatic islets and beta cells similar to healthy conditions.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Multidisciplinary
Rizwan Ahmed, Noor ul ain Hira, Zhinan Fu, Mingwei Wang, Adeel Halepoto, Santosh Khanal, Shahid Iqbal, Hidayatullah Mahar, Martien Abraham Cohen Stuart, Xuhong Guo
Summary: Nanoscale polyelectrolyte complex materials have been extensively studied for their potential applications in protocell, drug carriers, imaging, and catalysis. By utilizing reactive flash nanoprecipitation (RFNP), a more homogeneous mixing and preparation process for these materials has been achieved, resulting in stable nanoscale complexes with controllable size and narrow size distribution. The method allows for continuous and tunable production of these complexes, showing promise for practical translation in the future.
Article
Biochemistry & Molecular Biology
Zewen Shi, Fang Yang, Qian Pang, Yiwei Hu, Haijian Wu, Xueqiang Yu, Xianjun Chen, Lin Shi, Bowen Wen, Rui Xu, Ruixia Hou, Dan Liu, Qingjiang Pang, Yabin Zhu
Summary: With the development of minimally invasive orthopedics, injectable materials for bone repair are attracting more attention. In this study, a hydrogel called FHCS was designed and fabricated, which showed thermo-responsiveness, degradability, and injectability. The FHCS hydrogel enhanced the ALP activity and extracellular matrix calcification of MC3T3-E1 cells, promoting new bone formation and maturation in a rat calvarial bone defect model. The upregulation of osteogenic genes and proteins through the BMP/Smad signaling pathway suggested promising applications for the FHCS-5 hydrogel in non-loading bone regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Fisheries
Zhensheng Wang, Xingchen Huo, Yanqi Zhang, Yang Gao, Jianguo Su
Summary: This study demonstrates that nanoparticle CMCS-20a loaded with carboxymethyl chitosan (CMCS) has a good preventive effect on bacterial diseases in aquaculture. CMCS-20a can effectively kill bacteria and reduce the influence of external factors, it is almost non-toxic to fish cells, and can increase the activity of important antibacterial substances in the serum. Furthermore, CMCS-20a can improve fish survival rate by regulating inflammation responses, reducing bacterial burdens, and alleviating tissue lesions.
Article
Polymer Science
Huan-Jun Lu, Jian-Ke Cen, Yu Ren, Mei-Xian Li
Summary: This study aimed to design a nanoparticle delivery system using ginsenoside Rh2-conjugated O-carboxymethyl chitosan and explore its anti-nociceptive effects. The results showed that the nanoparticle could effectively reduce inflammatory pain and had a longer analgesic effect, indicating its potential medicinal application.
Review
Biotechnology & Applied Microbiology
Jixuan Zheng, Jinting Jiang, Yicheng Pu, Tingrui Xu, Jiantong Sun, Qiang Zhang, Ling He, Xiao Liang
Summary: This article provides a comprehensive review of recent advancements in the field of nanomedicines targeting tumor-associated macrophages (TAMs). Strategies to inhibit macrophage recruitment, suppress TAM survival, and transform TAM phenotypes are discussed as potential therapeutic avenues. Various approaches, including the use of ligands, immunoglobulins, and short peptides, are explored to enhance the targeting capacity of nanomedicines.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jinhu Liu, Weiwei Mu, Tong Gao, Yuxiao Fang, Na Zhang, Yongjun Liu
Summary: Liver cancer, particularly hepatocellular carcinoma, is a leading cause of cancer-related deaths, and its incidence is increasing globally. Nano drug delivery systems have displayed great potential in cancer treatment. Achieving high drug accumulation and effective release at the tumor site are crucial for improving therapeutic efficacy. In this study, CD13-targeted mesoporous silica nanoparticles coated with NGR-peptide-modified pegylated carboxymethyl chitosan were developed as drug carriers for doxorubicin (DOX). These nanostructures demonstrated responsive release of DOX in acidic environments and efficient internalization through NGR-mediated uptake in vitro. In vivo, they successfully delivered DOX to tumor tissues with prolonged accumulation times and exhibited significant tumor inhibition. This research provides a promising strategy for using DOX/MSN-CPN as a nano-platform for targeted drug delivery in hepatocellular carcinoma treatment.
Article
Biochemistry & Molecular Biology
Chengpeng Li, Xiaoyan Luo, Lefan Li, Ying Cai, Xinhuang Kang, Puwang Li
Summary: In this study, a method for improving the loading of citral in nanofibers was proposed and used to develop an anti-infection dressing. The dressing showed good antibacterial performance and hemocompatibility, and could promote cell proliferation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Meihan Fang, Jialu Wang, Sheng Fang, Xiaobo Zuo
Summary: Gliadin-carboxymethyl chitosan composite nanoparticles (GC NPs) co-encapsulated with natamycin (Nata) and theaflavins (TFs) were added to carboxymethyl chitosan (CMCS) films as an antioxidant, antifungal, and structural enhancer. The stability of GC NPs dispersion was maintained by electrostatic repulsion. Coencapsulation of TFs improved the photostability of Nata and the antioxidant activity of the NPs dispersion. The addition of Nata/TFs-GC NPs improved the properties and activities of CMCS films.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)