Review
Medicine, Research & Experimental
Mariana Carolina Di Santo, Cecilia Luciana D'Antoni, Ana Paula Dominguez Rubio, Agustina Alaimo, Oscar Edgardo Perez
Summary: Plant-based polyphenols are natural compounds found in fruits and vegetables, known for their nutraceutical and pharmacological activities. However, their photosensitivity, low bioavailability, rapid metabolism, and short biological half-life present major limitations for their use, which can be overcome by encapsulating polyphenols into chitosan-tripolyphosphate based nanoparticles.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Engineering, Chemical
Dmitriy Berillo, Aknazar Arysbek
Summary: This study demonstrates the effective removal of silver nanoparticles (AgNPs) using a chitosan-based cryogel, which has potential applications in agriculture, water treatment, and industrial plants. The adsorbent is economically viable, has high affinity toward metal nanoparticles, is biodegradable and biocompatible, and displays good removal efficiency of nanoparticles.
Article
Materials Science, Textiles
Fitri Khoerunnisa, Mita Nurhayati, Fitri Dara, Regita Rizki, Muhamad Nasir, Hafiz Aji Aziz, Hendrawan Hendrawan, Ng Eng Poh, Chariya Kaewsaneha, Pakorn Opaprakasit
Summary: Chitosan (CS) nanoparticles with antibacterial properties were successfully synthesized using the ionic gelation method with tripolyphosphate (TPP) as a crosslinking agent. The resulting CS-TPP nanoparticles showed significant antibacterial efficacy under optimized conditions, demonstrating their potential as valuable antibacterial agents.
FIBERS AND POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Hemant Mittal, Ali Al Alili, Pranay P. Morajkar, Saeed M. Alhassan
Summary: The study synthesized graphene oxide crosslinked nanocomposites hydrogels of chitosan and carboxymethyl cellulose as versatile adsorbents for both cationic and anionic dyes contaminated wastewater. The adsorption process was well explained using pseudo-second-order and Langmuir models, with excellent regeneration capacity demonstrated for continuous cycles of adsorption-desorption. The synthesized CS/CMC-NCH showed great potential for effective treatment of dye-contaminated wastewater.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Renato Nunes, Ana Sofia Serra, Aiva Simaite, Angela Sousa
Summary: Nucleic acid vaccines are a fast, safe, cost-effective, and efficient technology for combating viral infections. Developing methods to protect, carry, and deliver nucleic acids is crucial for ensuring their effectiveness.
Article
Food Science & Technology
Sepideh Soleymanfallah, Zhaleh Khoshkhoo, Seyed Ebrahim Hosseini, Mohammad Hossein Azizi
Summary: Grape extract encapsulated in chitosan nanoparticles showed significant antioxidant activity. The nanoparticles exhibited satisfactory encapsulation efficiency and loading capacity at an appropriate chitosan/extract weight ratio. The encapsulation process enhanced the antioxidant activity of the grape extract.
FOOD SCIENCE & NUTRITION
(2022)
Article
Chemistry, Multidisciplinary
Rahmi, Muhammad Iqhrammullah, Ulfa Audina, Husni Husin, Haya Fathana
Summary: A film adsorbent OC/Chi-EDTA was prepared from OPEFB-based charcoal through a simple phase inversion technique, showing advantageous properties for Cd (II) adsorptive removal. The material exhibited high tensile strength, adsorption capacity, and thermal stability, with successful adsorption mechanisms of electrostatic attraction and complexation for Cd (II) uptake.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2021)
Article
Environmental Sciences
Chandi Patra, E. Suganya, Senthilkumar Sivaprakasam, G. Krishnamoorthy, Selvaraju Narayanasamy
Summary: Chitosan was successfully fabricated as a potential adsorbent for anionic synthetic dyes, showing high adsorption capacity for Bromophenol blue, Direct blue 6, and Congo red. The adsorption process was found to be influenced by factors such as initial pH, dosage, temperature, and initial concentration of dye species. Competitive Langmuir isotherm model verified antagonistic behavior among different dyes in multi-adsorptive systems over the chitosan surface. The thermodynamics of the sorbate-sorbent interaction were favorable, with minimal interference from co-existing metal cations and anionic salts.
Review
Biochemistry & Molecular Biology
Daniele C. da Silva Alves, Bronach Healy, Luiz A. de Almeida Pinto, Tito R. Sant'Anna Cadaval, Carmel B. Breslin
Summary: Chitosan and its composites show great potential as environmentally friendly adsorbents for removing contaminants such as heavy metal ions, dyes, and organic molecules. These materials exhibit promising performance in adsorption applications and continue to be researched for further development.
Article
Biochemistry & Molecular Biology
Honglin Zhu, Sunni Chen, Hanyi Duan, Jie He, Yangchao Luo
Summary: Chitosan (CS)/carboxymethyl cellulose (CMC) porous hydrogels crosslinked by epichlorohydrin and with polyethylene glycol (PEG) as a pore-forming agent were synthesized for removal of anionic (Congo red, CR) and cationic (methylene blue, MB) dyes from aqueous solutions. The addition of PEG significantly increased the adsorption of CR and MB, with optimal performance observed for hydrogels prepared with 2% CS and 2% CMC (CS2/CMC2). The adsorption processes followed pseudosecond-order and pseudo-first-order kinetics models for CR and MB, respectively. Freundlich and Langmuir models were suitable for describing the adsorption isotherms of CR and MB, respectively. The thermodynamic study confirmed that the adsorption of CR and MB by the hydrogels was spontaneous, with CR adsorption being endothermic and MB adsorption being exothermic.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Elham Alehosseini, Hoda Shahiri Tabarestani, Mohammad Saeed Kharazmi, Seid Mahdi Jafari
Summary: Chitosan nanoparticles (CSNPs) have high performance and unique properties, making them widely applicable in the food, pharmaceutical, and cosmetic sectors. This research synthesized CSNPs using the ionic gelation method and optimized the synthesis conditions. The concentration of chitosan, sodium tripolyphosphate, and the ratio between them influenced the size and zeta potential of the nanoparticles. The optimized CSNPs can be used as efficient carriers and stabilizers.
Article
Environmental Sciences
Saptarshi Roy, Md. Ahmaruzzaman
Summary: Water pollution is a severe problem that threatens the sustainability of human and other life forms. Ionic liquids have shown potential as sustainable materials in wastewater treatment and have achieved effective results. This review explores the application of Ionic liquid-based nano adsorbents in the removal of organic compounds, dyes, and heavy metal ions, discussing the factors influencing the adsorption process and the mechanisms involved.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Article
Biochemistry & Molecular Biology
A. Vijaya Bhaskar Reddy, Rehan Rafiq, Aqeel Ahmad, Abdulhalim Shah Maulud, Muhammad Moniruzzaman
Summary: In this study, a imidazolium based cross-linked polymer was synthesized and its efficiency for removing two widely used ionic dyes from aqueous systems was demonstrated. The synthesized polymer was characterized and the optimal adsorption conditions and kinetics models were determined. The possible adsorption mechanism between the polymer adsorbent and the dyes was proposed.
Article
Biochemistry & Molecular Biology
Li Xiao, Hanbin Shan, Yi Wu
Summary: Epichlorohydrin-modified chitosan-Schiff base composite (CS/24Cl/ECH) was characterized using FT-IR, XRD, DSC, and SEM. The removal efficiency of Pb(II) ions from aqueous solution was investigated. The maximum adsorption capacity of Pb(II) ions was found to be 170 mg/g. The adsorption mechanism involved chemical coordination between Pb(II) ions and the active sites on the surface of CS/24Cl/ECH composite. CS/24Cl/ECH also showed excellent recyclability and potential for adsorption of other heavy metal ions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Environmental Sciences
Mahmuda Akter, Noriko Hirase, Md. Tajuddin Sikder, Md. Mostafizur Rahman, Toshiyoki Hosokawa, Takeshi Saito, Masaaki Kurasaki
Summary: Lead (Pb) is a highly toxic heavy metal that can enter the biological system through the food chain, and lead ion (Pb (II)) can be released into the environment from natural and anthropogenic sources. Among various remediation techniques, adsorption is considered effective for its economic and versatile properties. The study showed that the CS-AC-PVA composite beads have better adsorption capacity for Pb (II) compared to lone CS, AC, and CS-AC beads, with a 44% increase compared to CA-AC beads. The adsorption capacity of CS-AC-PVA beads for Pb (II) was highest at 25 degrees C, following the Freundlich isotherm model with increasing concentrations and decreasing temperatures. This demonstrates the potential of CS-AC-PVA composite beads as an adsorbent for environmental remediation of Pb (II) from aqueous solutions.
WATER AIR AND SOIL POLLUTION
(2021)
Article
Nanoscience & Nanotechnology
Dhanasekaran Thangavelu, Yuanfu Chen, Padmanaban Annamalai, Manigandan Ramadoss, Vengidusamy Narayanan
Summary: A novel Ag@polymer/NiAl LDH nanohybrid was synthesized by a simple hydrolysis method and demonstrated as an efficient bifunctional electrocatalyst for the electrochemical detection of 4-nitrophenol and oxygen evolution reaction.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Pharmacology & Pharmacy
Subramanian Mutheeswaran, Antony Mariappan, Kamaraj Ragavendran, Vedapuri Porchezhiyan, Poovan Elankani, Naif Abdullah Al-Dhabi, Mariadhas Valan Arasu, Savarimuthu Ignacimuthu
Summary: An ethnobotanical survey was conducted in Sathuragiri hills, India, revealing 139 medicinally useful plant species. The study highlighted the importance of Fabaceae, Euphorbiaceae, and Apocynaceae families, which contained numerous important medicinal plants. Dermatological ailments, gastrointestinal problems, joint pain, fever, and poisonous bites were among the important diseases treated by these species. The study emphasized the need for conservation of these medicinal plants and local knowledge.
ADVANCES IN TRADITIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
M. R. Lima Mirabel Louis, Vedham Pushpa Rani, Padma Krishnan, Appadurai Daniel Reegan, Kedike Balakrishna, Savarimuthu Ignacimuthu, Soosaimanickam Maria Packiam, Rajan Maheswaran, Osamu Shirota
Summary: This study presents the larvicidal activities of three active constituents from the methanolic extract of unripe fruit peel of Persea americana against three mosquito species. The three compounds showed the highest larvicidal activity against Anopheles stephensi, and also exhibited certain larvicidal activity against Aedes aegypti and Culex quinquefasciatus.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Immunology
Arokia Vijaya Anand Mariadoss, Kandasamy Saravanakumar, Anbazhagan Sathiyaseelan, Kumar Vishven Naveen, Myeong-Hyeon Wang
Summary: This study established a cost-effective and environmentally friendly method to synthesize selenium nanoparticles using Artemisia annua and encapsulated them with starch for enhanced antibacterial activity. The results showed that the modified nanoparticles had stronger antimicrobial activity, which could be used to treat infections caused by multidrug-resistant pathogens.
MICROBIAL PATHOGENESIS
(2022)
Article
Biochemistry & Molecular Biology
Shajahan Azeez, Anbazhagan Sathiyaseelan, Ezekiel Raj Jeyaraj, Kandasamy Saravanakumar, Myeong-Hyeon Wang, Venkatesan Kaviyarasan
Summary: Producing chitosan from fungi, specifically Cunninghamella echinulata, has potential due to its high glucosamine content. Chitosan isolates derived from this fungi have distinctive physicochemical properties and biocompatibility.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kumar Vishven Naveen, Kandasamy Saravanakumar, Anbazhagan Sathiyaseelan, Myeong-Hyeon Wang
Summary: The current study evaluated the metabolite abundance, inhibitory activity on alpha-amylase and alpha-glucosidase, antioxidant activity, and antibacterial activity of ethyl acetate extract (EAE) from Penicillium lanosum (PL) and Penicillium radiatolobatum (PR). EAE-PR showed higher extract yield and phenolic/flavonoid content. It exhibited significant inhibitory effects on alpha-amylase and scavenged ABTS+ radicals. Moreover, it demonstrated higher antibacterial activity and cytoprotective effects on stressed cells compared to EAE-PL.
Article
Electrochemistry
S. Munusamy, Ramesh Poonchi Sivasankaran, K. Sivaranjan, P. Sabhapathy, V. Narayanan, Faruq Mohammad, Suresh Sagadevan
Summary: This study investigated the electrochemical sensing behavior of a GaN-PANI-PPy hybrid composite for mebendazole (MBZ). The synthesized MBZ drug was detected using a GaN-PANI-PPy modified glassy carbon electrode, showing linear responses in the concentration range of 3 x 10-7 - 9 x 10-8 M with a sensitivity of 3.02 mu A/mu M cm-2. The prepared GaN-PANI-PPy electrode exhibited good reproducibility, long-term stability, and anti-interference ability, making it suitable for the electrochemical sensing detection of MBZ in liquid samples such as anti-helthiminic drug milk.
ELECTROCHIMICA ACTA
(2023)
Article
Entomology
Muzafar Riyaz, Rauf Ahmad Shah, Ignacimuthu Savarimuthu, Sivasankaran Kuppusamy
Summary: This study sequenced the mitogenomes of two species from the family Erebidae and found that despite different lengths, their gene orders were identical, and both genomes contained 13 protein-coding genes, 22 tRNA genes, 2 rRNA genes, and an A+T-rich region. Phylogenomic analysis revealed that the superfamily Noctuoidea has a well-supported monophyletic relationship with Notodontidae, Erebidae, Nolidae, Euteliidae, and Noctuidae, and L. dorsigera should be classified within the subfamily Toxocampinae instead of Erebinae.
EUROPEAN JOURNAL OF ENTOMOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xin Zhang, Kandasamy Saravanakumar, Anbazhagan Sathiyaseelan, Soyoung Park, Myeong-Hyeon Wang
Summary: Antibiotics-loaded zirconium dioxide nanoparticles (ZrO2 NPs) were developed using Cirsium setidens extract (CSE), and they exhibited enhanced antibacterial activity. The ZrO2 NPs synthesized with CSE had an average particle size of 54.67 +/- 3.89 d. nm, showing a monoclinic and tetragonal crystalline structure. The ZrO2-Amp NPs showed higher inhibitory activity against Bacillus cereus and Escherichia coli than ZrO2-Ery NPs. Biological assays confirmed the low cytotoxicity of antibiotics-loaded ZrO2 NPs to NIH3T3 cells, chick chorioallantoic membrane (CAM), and red blood cells (RBC).
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yingshan Jin, Yuting Lu, Anbazhagan Sathiyaseelan, Kandasamy Saravanakumar, Xin Zhang, Myeong-Hyeon Wang
Summary: Multidrug-resistant (MDR) pathogens are a major concern globally, and nanomaterials and phyto-compounds are being explored as novel antibacterial agents to target them. This study aimed to develop and characterize Paeoniflorin loaded silica oxide nanoparticles (Pae-SiO2 NPs) for increased effectiveness against MDR bacteria. The Pae-SiO2 NPs showed strong antibacterial effects on Staphylococcus aureus and Bacillus cereus, with low toxicity to human embryonic kidney cells and red blood cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Plant Sciences
S. Antony Ceasar, S. Ignacimuthu
Summary: Genome editing tools based on CRISPR/Cas system have the potential to solve agricultural issues and improve food production. The use of genetic engineering in agriculture has allowed for the introduction of specific traits in crops, while CRISPR/Cas system offers a more precise technique for targeted modification of genes in the host plant genome. The delivery of CRISPR reagents has the potential to overcome limitations with traditional transformation methods and produce transgene-free plants. The CRISPR/Cas system is expected to play a key role in future crop breeding.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Rauf Ahmad Shah, Muzafar Riyaz, Savarimuthu Ignacimuthu, Kuppusamy Sivasankaran
Summary: In this study, the complete mitogenomes of Sympis rufibasis, Lacera noctilio, Oxyodes scrobiculata, Mocis undata, and Artena dotata were newly sequenced using next-generation sequencing methods. The analysis of these mitogenomes revealed a common gene order and characteristics unique to Noctuoidea moths. Additionally, the phylogenetic analyses provided insights into the tribe and subfamily relationships within the Erebidae.
BIOCHEMICAL GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Kumar Vishven Naveen, Anbazhagan Sathiyaseelan, Sumana Mandal, Kiseok Han, Myeong-Hyeon Wang
Summary: This study aimed to extract intracellular polysaccharides (IPS-1 and IPS-2) from endophytic Penicillium radiatolobatum and compare their physicochemical and bioactive attributes. IPS-2 showed higher antioxidant activities and inhibited the viability of prostate cancer cells (PC-3) via apoptosis. The findings suggest that P. radiatolobatum could be a potent source of polysaccharides with promising antioxidant and anticancer activity.
Article
Biotechnology & Applied Microbiology
Kiseok Han, Soyoung Park, Anbazhagan Sathiyaseelan, Myeong-Hyeon Wang
Summary: In this study, eight strains of Enterococcus faecium were isolated from soybean paste, a traditional Korean fermented food, and their probiotic properties were evaluated. The results demonstrated that all strains survived in simulated human gastrointestinal conditions, exhibited auto-aggregation and hydrophobicity, and showed significant co-aggregation ability with Salmonella enterica and Staphylococcus aureus. However, they were resistant to Gentamycin. The bacterial cell-free supernatant exhibited antibacterial activity and the strains showed potent antioxidant activity.
FERMENTATION-BASEL
(2023)
Article
Nutrition & Dietetics
Anbazhagan Sathiyaseelan, Xin Zhang, Myeong-Hyeon Wang
Summary: In this study, nanoemulsions (NEMs) loaded with Melaleuca alternifolia oil (tea tree oil) rich in antibacterial and antioxidant molecules were prepared using chitosan (CS) and encapsulated by sodium alginate (SA) microspheres for antibacterial wound dressing. The CS-TTO NEMs with an average particle size of 89.5 nm were prepared by an oil-in-water emulsion technique. The SA-CS-TTO microspheres with an average particle size of 0.76 +/- 0.10 μm were confirmed through SEM analysis. The presence of TTO in CS NEMs and SA encapsulation was shown by FTIR analysis. The study concluded that the SA-CS-TTO microspheres could serve as an antibacterial and antioxidant wound dressing, as they released TTO in a sustained manner, inhibited bacterial pathogens, and exhibited antioxidant potential.
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
