Article
Biochemistry & Molecular Biology
Max Petitjean, Jose Ramon Isasi
Summary: In this study, three different polysaccharides were crosslinked with or without beta-cyclodextrin using citric acid in different ratios to create 'green' hydrogel matrices with favorable swelling behavior for sorption. The amount of beta-cyclodextrin groups is not the only factor affecting sorption capability, as the polysaccharides themselves also play a role based on their characteristic functional groups, chain conformation, and degrees of swelling. The Hill equation provided the best fit for analyzing sorption capabilities of a model sorbate, offering insights into the interaction mechanisms.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Food Science & Technology
Olajide Emmanuel Adedeji, Ji-Young Choi, Gi Eon Park, Hye Jee Kang, Mariam Omowunmi Aminu, Ju Hyun Min, Chiemela Enyinnaya Chinma, Kwang-Deog Moon, Young Hoon Jung
Summary: In this study, a bioink for 3D printing was developed using locust bean gum (LBG) and cellulose microfibers (CMFs) in an interpenetrating hydrogel. The addition of LBG increased flow behavior index, viscoelasticity, and gel strength in the hydrogel matrix. The CMFs/LBG hydrogel maintained high shape stability after printing, showing promise for use as a bioink in various applications.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2022)
Article
Chemistry, Applied
Dominika Grala, Krzysztof Biernacki, Cristina Freire, Iwona Kuzniarska-Biernacka, Hileia K. S. Souza, Maria P. Goncalves
Summary: This study investigated novel bio-based films containing Locust Bean Gum (LBG) and Chitosan (CH) or Chitosan nanoparticles (CHNPs)/natural deep eutectic solvents (NADES). The films were prepared by a semi-continuous knife-coating process. The characterization results showed that the films were transparent, uniform, and without cracks or pores. The addition of CHNPs reduced the apparent viscosity of LBG solution and the presence of NADES provided more flexible films with less mechanical and barrier resistance.
FOOD HYDROCOLLOIDS
(2022)
Article
Chemistry, Multidisciplinary
Meenakshi Tanwar, Archna Rani, Rajinder Gupta
Summary: The study explores the application of carboxymethylated locust bean gum for the development of a pH and temperature responsive matrix for controlled delivery of an anti-diabetic drug. The drug-loaded hydrogel exhibits non-Fickian diffusion, with a higher release rate at pH 7.4.
Article
Chemistry, Applied
Xinya Wang, H. Douglas Goff, Steve W. Cui
Summary: Yellow mustard gum (YMG) is a natural stabilizer that improves the texture, quality, and shelf life of food products. When mixed with kappa-carrageenan or locust bean gum (LBG), significant synergistic interactions were observed, resulting in stronger hydrogels compared to their individual gums. The gel characteristics and gelation behaviors of the mixtures were different, with YMG-kappa-carrageenan forming a firm and elastic gel and YMG-LBG forming an adhesive and paste-like gel.
FOOD HYDROCOLLOIDS
(2022)
Article
Chemistry, Applied
Faezeh Khoobbakht, Sadaf Khorshidi, Fereshte Bahmanyar, Seyede Marzieh Hosseini, Nafise Aminikhah, Mehdi Farhoodi, Leila Mirmoghtadaie
Summary: This study investigated the structural, mechanical, and rheological properties of a compound hydrogel using agar/locust bean/xanthan gum (ALX). The results showed that the addition of locust bean gum (LBG) and xanthan gum (XG) to agar could significantly improve the springiness and reduce the hardness of agar hydrogel, making it a promising alternative to high-bloom gelatin.
FOOD HYDROCOLLOIDS
(2024)
Article
Chemistry, Applied
Adam O'Connell, Francisco M. Goycoolea, Alessandro Gulotta, Peter Holmqvist, Peter Schuetz, Johan Mattsson
Summary: Locust bean gum (LBG) is widely used in various industries, and understanding its solution behaviour is crucial for formulation design. This study investigated the structure and dynamics of LBG in aqueous solution using different techniques. It was found that steady state shear rheology mainly probes the dispersed LBG fraction, while scattering response is dominated by supramolecular LBG aggregates. Three viscosity-concentration regimes were identified, with scaling behaviour consistent with predictions for neutral flexible polymers. Our study provides comprehensive insight into the structure and dynamics of aqueous LBG solutions, paving the way for a better understanding and control of LBG-based formulations.
FOOD HYDROCOLLOIDS
(2023)
Article
Engineering, Chemical
Jwala Patel, N. S. Hari Narayana Moorthy, Sabyasachi Maiti
Summary: This investigation developed semi-interpenetrating polymer network hydrogel particles using Moi gum and carboxymethyl xanthan gum, and found promising drug release performance and preclinical anti-diabetic activity.
POLYMER ENGINEERING AND SCIENCE
(2022)
Article
Polymer Science
Hui Zhang, Zhun Yan, Fan Xie, Yanjun Tian, Lianzhong Ai
Summary: The synergistic interaction and gelling kinetics between xanthan gum (XG) and locust bean gum (LBG) were evaluated at different mass ratios. The mixture of XG/LBG 3:7 showed the strongest gel structure and the densest entanglements. This study provides insights for designing novel food structures using XG-LBG blends.
Review
Biochemistry & Molecular Biology
Max Petitjean, Jose Ramon Isasi
Summary: Locust bean gum (LBG) is a vegetable galactomannan extracted from carob tree seeds and commonly used as a thickening agent in the food industry. It has unique properties due to its synergistic behavior with other biopolymers and can be easily modified or crosslinked. LBG and its derivatives find applications in various fields such as food, encapsulation, drug delivery, packaging, batteries, and catalyst supports. The use of LBG contributes to the development of greener products as it is biodegradable and non-toxic.
Article
Environmental Sciences
Fredrick Nwude Eze, Titilope John Jayeoye, Roseline Chika Eze
Summary: This research aimed to construct a plasmonic Ag-nanocomposite for the optical detection of Fe2+ in aqueous solution. The nanocomposite was successfully synthesized using a green chemistry route with locust bean gum and Phyllanthus reticulatus anthocyanin. It exhibited small size, good dispersion, stability, and prominent SPR absorption peak. The nanocomposite showed high selectivity for Fe2+ and displayed a concentration dependent increase in color and SPR absorption band intensity. The detection limit for Fe2+ was much lower than the guideline limit in drinking water. The results demonstrate a facile and eco-friendly approach for synthesizing plasmonic Ag-nanocomposites and its potential as a probe for monitoring Fe2+ in aqueous environment.
ENVIRONMENTAL RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Sreekanth Reddy Obireddy, Wing-Fu Lai
Summary: In this study, a new type of nanocomposites was designed as a carrier for controlled delivery of bioactive agents. The nanocomposites showed pH-responsive behavior, reactive oxygen species (ROS)-generating capacity, and cell type-dependent toxicity. This research demonstrates the high potential of the nanocomposites for use in bioactive agent delivery and their potential as pH-responsive carriers for therapeutic applications.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Applied
Adam O'Connell, Yadira Gonzalez-Espinosa, Francisco M. Goycoolea, Peter Schuetz, Johan Mattsson
Summary: In this study, we characterised locust bean gum (LBG) using asymmetric flow field-flow fractionation (AF4) and light scattering techniques. Our results showed the presence of both aggregated and well-dispersed fractions in LBG, and we were able to provide structural information for both fractions. Our findings demonstrate the suitability of AF4 for LBG characterisation, with potential application to other similar galactomannans and associating polymer systems.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Applied
Keding Li, Yuqing Lei, Jun Liao, Yong Zhang
Summary: The graphene oxide/locust bean gum aerogels synthesized in ice crystal template showed excellent adsorption properties for Rhodamine-B and Indigo Carmine, with promising potential in removing water-soluble RhB from wastewater.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Eliadna de Lemos Vasconcelos Silva, Antonia Carla de Jesus Oliveira, Livia Maria Coelho de Carvalho Moreira, Edson C. Silva-Filho, Almir Goncalves Wanderley, Monica Felts de La Roca Soares, Jose Lamartine Sores-Sobrinho
Summary: In this study, a nanoparticulate system using acetylated cashew gum (ACG) and chitosan was developed for oral administration of insulin. The results showed that the nanoparticles had good biocompatibility and effective oral insulin release.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Education, Scientific Disciplines
Aniruddha Mukherjee, Kalyan K. Sen, Sugato Banerjee
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
(2017)
Article
Pharmacology & Pharmacy
Aniruddha Mukherjee, Bina K. Mehta, Kalyan K. Sen, Sugato Banerjee
INDIAN JOURNAL OF PHARMACOLOGY
(2018)
Review
Pharmacology & Pharmacy
Sritoma Banerjee, Kalyan Kumar Sen
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2018)
Article
Chemistry, Applied
Bibek Laha, Rimpa Goswami, Sabyasachi Maiti, Kalyan Kumar Sen
CARBOHYDRATE POLYMERS
(2019)
Article
Biophysics
Bibek Laha, Sanjib Das, Sabyasachi Maiti, Kalyan Kumar Sen
COLLOIDS AND SURFACES B-BIOINTERFACES
(2019)
Review
Pharmacology & Pharmacy
Sreejan Manna, Sougata Jana
Summary: Marine polysaccharides have attracted interest as biomaterials for drug delivery applications due to their low cytotoxicity and potential health benefits. This review provides an overview of marine polysaccharides, their classification based on biological sources, and their applications in tissue-specific drug delivery.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Pharmacology & Pharmacy
Sougata Jana, Rakesh Pramanik, Amit Kumar Nayak, Kalyan Kumar Sen
Summary: This study developed diclofenac sodium-loaded carboxymethyl tamarind gum-gellan gum IPN microbeads using ionic gelation technique. The microbeads showed excellent drug entrapment and sustained release of diclofenac sodium over 8 hours, following the Korsmeyer-Peppas model. In vivo pharmacodynamic results demonstrated the sustained anti-inflammatory effect of these microbeads.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Sreejan Manna, Dadala Dhanalakshmi, Manas Bhowmik, Sougata Jana, Subrata Jana
Summary: In this study, matrix-type transdermal patches of glibenclamide were developed using a combination of hydrophilic and hydrophobic polymers. The patches showed sustained release of the drug and may serve as a better alternative to conventional oral delivery of glibenclamide.
FRONTIERS IN MATERIALS
(2022)
Review
Materials Science, Biomaterials
Sreejan Manna, Arnab Seth, Prajna Gupta, Gouranga Nandi, Ria Dutta, Subrata Jana, Sougata Jana
Summary: Chitosan has gained attention as a biomaterial carrier in pharmaceutical and biomedical research due to its nontoxic behavior, biodegradability, and biocompatibility. Chemical modifications of chitosan derivatives, such as trimethyl chitosan and thiolated chitosan, have improved its efficacy as a drug carrier and are widely studied for controlled and target-specific drug delivery. Chitosan derivatives also have applications in wound healing, hyperthermia therapy, tissue engineering, and bioadhesives.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Engineering, Biomedical
Sreejan Manna, Prajna Gupta, Gouranga Nandi, Sougata Jana
Summary: In addition to oral delivery, transdermal delivery systems have become more acceptable to patients in recent decades. Novel techniques such as microneedle patches, transdermal films, and hydrogel formulations have been employed for transdermal drug targeting. Natural polysaccharides, with their ability to form hydrogels and other rheological behavior, are attractive options for transdermal use. Alginate, an anionic polysaccharide originated from marine sources, is widely used in pharmaceutical, cosmetics, and food industries due to its excellent biodegradability, biocompatibility, and mucoadhesive properties. Due to its favorable properties for transdermal drug delivery systems (TDDS), the application of alginate has been increasing in recent times. This review summarizes the source and properties of alginate, as well as several transdermal delivery techniques, including the application of alginate for respective transdermal systems.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Review
Chemistry, Applied
Sandip Karmakar, Sreejan Manna, Sourav Kabiraj, Sougata Jana
Summary: The field of ocular drug delivery presents a challenge to pharmaceutical researchers. Alginate, a naturally occurring polysaccharide, has been extensively investigated in drug delivery as it can increase ocular residence time through ion-sensitive in situ gelation, while also being non-toxic and biodegradable.
FOOD HYDROCOLLOIDS FOR HEALTH
(2022)
Proceedings Paper
Materials Science, Multidisciplinary
Sougata Jana, Kalyan Kumar Sen
MATERIALS TODAY-PROCEEDINGS
(2019)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)