Article
Environmental Sciences
Syed Mohammed Tareq, Armel Boutchuen, Shuvashish Roy, Dell Zimmerman, Gitapun Jur, Jejal Reddy Bathi, Soubantika Palchoudhury
Summary: The study utilized dynamic light scattering to analyze water samples from the Tennessee River, revealing the potential presence of nanomaterials. Complemented with scanning electron microscopy, the approach showed superiority in rapidly assessing nanomaterials in environmental water samples.
WATER RESOURCES RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Quim Tarres, Roberto Aguado, Justin O. Zoppe, Pere Mutje, Nuria Fiol, Marc Delgado-Aguilar
Summary: This study assesses a relatively simple method to estimate the dimensions of nanocellulose particles with an aspect ratio greater than 1. By combining dynamic light scattering and field-emission scanning electron microscopy, the method provides information on the hydrodynamic diameter and an acceptable approximation for the actual diameter, at least for bundles. The method can be useful as an alternative to high-resolution techniques, although it is not valid for the thinnest fibrils or single, small nanocrystals.
Article
Pharmacology & Pharmacy
Anna Jagusiak, Katarzyna Chlopas, Grzegorz Zemanek, Izabela Koscik, Irena Roterman
Summary: The research aims to design a new drug carrier system by analyzing the interactions between CR-Dox complexes and proteins, with the goal of improving the safety and efficacy of targeted drug delivery.
Article
Chemistry, Physical
Navdeep Rana, Aditya Prasad Roy, Dipanshu Bansal, Gopal Dixit
Summary: This study demonstrates that inelastic scattering methods, combined with theoretical simulation, can image lattice dynamics similar to time-resolved diffraction and imaging measurements. The proposed method is useful for imaging in-situ lattice dynamics under different environmental conditions, and will have a profound impact in cases where time-resolved diffraction within the pump-probe setup is not feasible.
NPJ COMPUTATIONAL MATERIALS
(2021)
Article
Chemistry, Physical
S. Merrad, M. Abbas, R. Brahimi, M. Trari
Summary: The deficient perovskite SrTiO3-delta synthesized by nitrate route was characterized by various techniques. It exhibited a large band gap and good photocatalytic performance for the degradation of Congo Red dye.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Nanoscience & Nanotechnology
Martin Kozak
Summary: We propose an all-optical technique for generating pulsed electron vortex beams in ultrafast electron microscopy. The technique is based on inelastic scattering of electrons at the ponderomotive potential of an optical traveling wave formed by two laser pulses at different frequencies. By transferring orbital angular momentum from a vortex beam optical pulse to the electron wave function, an electron vortex state can be created separated from the initial state in the energy domain.
Article
Chemistry, Physical
C. Maria Magdalane, G. Maria Assuntha Priyadharsini, K. Kaviyarasu, A. Irudaya Jothi, G. Gnanamani Simiyon
Summary: In this research, microwave improved porous CoFe2O4 and TiO2 doped CoFe2O4 nanostructures were designed using L-threonine as a fuel. The synthesized nanomaterials were characterized and investigated for their photocatalytic degradation abilities under visible light. The doping of titania resulted in smaller crystallite sizes for the nanostructures, and there was an observed association between the photocatalytic properties of CoFe2O4 and TiO2 doped CoFe2O4 in a solitary particle.
SURFACES AND INTERFACES
(2021)
Article
Polymer Science
Abbas Rezaei, Abolfazl Khanzadeh, Hossein Behniafar
Summary: In this study, PEG-based hydrophilic branches were grafted onto PCL-based hydrophobic chains to synthesize amphiphilic macromolecules with bioactive disulfide linkages. The structure of the PEG-grafted PCL chains was confirmed by spectroscopy techniques. The resulting micellar aggregates showed a spherical shape and had a critical micelle concentration of 7.1x10(-3) mg/mL. The size of the micelles was measured to be 150 nm with a low heterogeneity index of 0.18 using dynamic light scattering.
JOURNAL OF POLYMER RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
D. Rybkovskiy, V. O. Koroteev, A. Impellizzeri, A. A. Vorfolomeeva, E. Yu Gerasimov, A. Okotrub, A. Chuvilin, L. G. Bulusheva, C. P. Ewels
Summary: The missing 1D-phosphorus allotrope, red phosphorus chains, is identified to form inside tip-opened single-walled carbon nanotubes. Comprehensive experimental and theoretical studies reveal the presence of linear P8]P2 chains and fibrous cross-linked double-chains of red phosphorus in intermediate diameter cavities. These findings provide a comprehensive understanding of the diameter dependence of confined 1D-phosphorus allotropes.
Article
Food Science & Technology
Jhonatan Rafael de Oliveira Bianchi, Bruna Elisa Reis Paz, Larissa Germano Fonseca, Rebeca Lima Carvalho, Jose Carlos Magalhaes, Karina Azevedo Pacheco, Andersen Escobar Schlogl, Daniela Leite Fabrino, Edson Romano Nucci, Jane Selia dos Reis Coimbra, Igor Jose Boggione Santos
Summary: Protein nanostructures can be used to enhance the properties of food formulations. This study explores the ideal conditions for producing and altering alpha-lactalbumin nanostructured aggregates, focusing on improvements in foaming, emulsification, techno-functional properties, cytotoxicity, and antibacterial activity compared to native alpha-lactalbumin. The changes in protein structure were observed in the alpha-helix and beta-sheet. The size of the nanostructures was 163.84 nm with a polydispersity index of 0.29. The nanostructures exhibited enhanced techno-functional properties and were non-toxic and harmless to bacteria. This study provides valuable insights for the application of alpha-lactalbumin nanostructured aggregates in the food industry.
JOURNAL OF FOOD SCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Mohamed A. M. Alsafy, Manal A. Seif, Samir A. A. El-Gendy, Mohamed El-Beskawy, Mohamed El Dakroury
Summary: The research examined the ultrastructure of the oropharyngeal cavity floor in the red porgy fish using various microscopic techniques. The fish has specialized teeth in the lower jaw, with different heights and shapes. The tongue has distinct ridges and grooves and is adorned with pointed papillae. The teeth and tongue structure of the red porgy reflect its carnivorous behavior.
MICROSCOPY AND MICROANALYSIS
(2023)
Article
Public, Environmental & Occupational Health
Gottlieb Georg Lindner, Claus-Peter Drexel, Katrin Saelzer, Tobias B. Schuster, Nils Krueger
Summary: The study summarizes the literature on the presence and structure of biogenic amorphous silica (BAS) in nature. It is found that BAS is ubiquitous and has a similar structure to synthetic amorphous silica (SAS). Many food products containing BAS are beneficial to health, which is important for discussions on the safety of using SAS in specific applications.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Chemistry, Analytical
Kaimin Gao, Hong Lian, Chengfeng Xue, Jing Zhou, Xiaomei Yan
Summary: Protein aggregation is a major challenge in biopharmaceuticals, affecting therapeutic efficacy and reducing shelf life. This study presents a new method of using a laboratory-built nano-flow cytometer (nFCM) to count and size protein aggregates as small as 40 nm. The results show that therapeutic proteins contain billions to trillions of particles per milliliter in the size range of 40 to 200 nm.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Ryan Lane, Anouk H. G. Wolters, Ben N. G. Giepmans, Jacob P. Hoogenboom
Summary: We developed a 3D image acquisition and reconstruction pipeline that integrates widefield fluorescence microscopy with scanning electron microscopy, overcoming the limitations of slow acquisition rates and difficulty in providing targeted biological information. By using cathodoluminescent markers, we achieved high precision EM-FM overlay. Our proof-of-concept on immunolabelled serial sections of tissues demonstrated expedited acquisition times and reduced data burden.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Jennyfer Zapata-Farfan, Morteza Hasanzadeh Kafshgari, Sergiy Patskovsky, Michel Meunier
Summary: Culture-based diagnosis of bacterial diseases is time-consuming and can lead to antibiotic resistance or bacterial mutation. A molecular-level diagnostic technique that is widely available and requires no complex analysis or expensive equipment is of great interest. In this study, a promising analytical approach using nanoplasmonic biomarkers is presented, which can accurately detect pathogenic bacteria. These biomarkers, possessing greater photostability and biocompatibility, serve as selective markers and amplifying agents in optical biomedical detection. The proposed system shows potential for rapid diagnostic tests as point-of-care devices in emergency departments, clinics, and public hospitals.
Review
Biochemistry & Molecular Biology
Gulam Rabbani, Ejaz Ahmad, Abrar Ahmad, Rizwan Hasan Khan
Summary: Microbial lipases are excellent biocatalysts that can catalyze various reactions in both aqueous and non-aqueous media. This review focuses on microbial lipases from different sources (psychrophiles, mesophiles, and thermophiles), highlighting the structural diversity in temperature adaptation and industrial applications. Understanding the molecular mechanisms of temperature adaptation in lipases is of great interest, as extremophilic lipases are widely used in biotransformation reactions with higher yields and unique products.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Suliman Khan, William C. Cho, Laila Abdulmohsen Jaragh-Alhadad, Rahil Tarharoudi, Samir Haj Bloukh, Zehra Edis, Soyar Sari, Mojtaba Falahati, Timo L. M. ten Hagen, Rizwan Hasan Khan, Qian Bai
Summary: It has been recognized that inorganic nanoparticles (NPs) have diverse biomedical characteristics and can interact with biological macromolecules, leading to antibacterial, anticancer, and antioxidant effects. Studying DNA damage in bacterial and cancer cells is crucial for developing biocompatible therapeutic nano-platforms derived from inorganic NPs. This paper provides an overview of biophysical techniques used to study DNA-NP interactions and explores the mechanistic aspects of the interaction between different inorganic NPs and calf thymus DNA (CT-DNA). Furthermore, the molecular interactions between inorganic NPs and DNA are discussed in relation to their anticancer and antibacterial properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Gad Elsayed Mohamed Salem, Shaimaa M. Azzam, Mona A. F. Nasser, Tamer El Malah, Hanan M. Abd El-Latief, Rizwan Hasan Khan, Suchana Chavanich, Hend Mohamed Anwar
Summary: This study focuses on evaluating the anti-inflammatory and antioxidant effects of Bacterial Protease (BP) and 4,4'-(2,5-dimethoxy-1,4-phenylene) bis (1-(3-ethoxy phenyl)-1H-1,2,3-triazole) (DPET) in treating early-stage liver fibrosis induced by thioacetamide (TAA). The results showed that treatment with BP can improve the severe effects of TAA on the liver, restore tissue architecture, and have the potential to alleviate liver fibrosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Syed Moasfar Ali, Faisal Nabi, Mohammad Furkan, Malik Hisamuddin, Sadia Malik, Syed Mohammad Zakariya, Irum Rizvi, Vladimir N. Uversky, Rizwan H. Khan
Summary: Protein misfolding and amyloid fibril formation are linked to various conformational diseases. Luteolin, a natural flavonoid, has been found to inhibit the aggregation of human insulin, indicating its potential therapeutic role in neuroinflammation. Molecular simulation and spectroscopic techniques confirmed the inhibitory effect of luteolin on the aggregation process.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Syed Moasfar Ali, Faisal Nabi, Malik Hisamuddin, Irum Rizvi, Azeem Ahmad, Md Nadir Hassan, Pradipta Paul, Ali Chaari, Rizwan H. Khan
Summary: Protein misfolding in amyloidosis is linked to various pathophysiological conditions. Inhibition of toxic aggregates or disaggregation of preformed fibrils is an important strategy in preventing these diseases. Natural compounds, such as luteolin, have been shown to prevent amyloid fibril formation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Suliman Khan, William C. Cho, Arif Hussain, Sadaf Azimi, Mohammad Mahdi Nejadi Babadaei, Samir Haj Bloukh, Zehra Edis, Mesha Saeed, Timo L. M. ten Hagen, Hosein Ahmadi, Mahsa Ale-Ebrahim, Laila Abdulmohsen Jaragh-Alhadad, Rizwan Hasan Khan, Mojtaba Falahati, Xiaoju Zhang, Qian Bai
Summary: In biological systems, nanoparticles (NPs) have complex interactions with proteins, including the formation of protein corona and structural changes. These interactions depend on both the physicochemical properties of NPs and the stability of protein molecules. This review discusses the direct bio-chemical and biophysical interactions between NPs and blood proteins, specifically transferrin. The study explores the effects of NP properties on protein structure, transferrin stability, and its applications in drug delivery systems for cancer therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Mohd Aamir Qureshi, Mohd Amir, Rizwan Hasan Khan, Javed Musarrat, Saleem Javed
Summary: This study investigates the binding efficiency of Aflatoxin B-1 (AFB(1)) with Human Serum Albumin (HSA) using multi-spectroscopic approaches. The results reveal that AFB(1) can bind to HSA and alter its structure and conformation, providing insight into the toxic effect of this mycotoxin.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Aishah M. Alsibaee, Haya I. Aljohar, Mohamed W. Attwa, Ali S. Abdelhameed, Adnan A. Kadi
Summary: Fenebrutinib is an orally available Bruton tyrosine kinase inhibitor currently in phase III clinical trials for B-cell tumors and autoimmune disorders. In-silico and in-vitro experiments were carried out to identify the metabolites and reactive intermediates of Fenebrutinib. The results provide insights into the adverse effects of Fenebrutinib and guidance for the synthesis of safer drugs.
Article
Cell Biology
Edward J. Calabrese, Naomi Osakabe, Rosanna Di Paola, Rosalba Siracusa, Roberta Fusco, Ramona 'Amico, Daniela Impellizzeri, Salvatore Cuzzocrea, Tilman Fritsch, Ali S. Abdelhameed, Uwe Wenzel, Claudio Franceschi, Vittorio Calabrese
Summary: This commentary provides a novel synthesis on the concept of hormesis, which proposes that adaptive responses to low levels of stress can enhance health and protect against degenerative diseases and aging. It emphasizes the quantitative limits of biological plasticity and the importance of integrating anti-oxidant, anti-inflammatory, and cellular repair responses. The hormetic dose response defines the capacity for adaptation and protection in biological systems.
AGEING RESEARCH REVIEWS
(2023)
Article
Chemistry, Physical
Sadia Malik, Faisal Nabi, Mohammad Khursheed Siddiqi, Aiman Masroor, Malik Hisamuddin, Tajalli Ilm Chandel, Nabeela Majid, Rizwan Hasan Khan
Summary: This study confirms the inhibitory effect of lipophilic FAEE on insulin fibrillation, which can cross the blood brain barrier and stabilize the monomeric state of insulin, thereby preventing the extension of fibrillation.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Materials Science, Biomaterials
Nabeela Majid, Mohammad Khursheed Siddiqi, Md. Nadir Hassan, Sadia Malik, Seema Khan, Rizwan Hasan Khan
Summary: The aggregation of soluble proteins into insoluble fibrils is a key factor in the development of amyloid-associated disorders. In this study, the anti-diabetic drug chlorpropamide was found to effectively inhibit the aggregation of human lysozyme in vitro, reducing its cytotoxicity. Additionally, chlorpropamide was found to not only inhibit fibrillation but also stabilize the protein in its native state.
BIOMATERIALS ADVANCES
(2023)
Article
Biochemistry & Molecular Biology
Moyad Shahwan, Nageeb Hassan, Akram Ashames, Mohammed Alrouji, Fahad Alhumaydhi, Waleed Al Abdulmonem, Abdullatif Bin Muhsinah, Mohammad Furkan, Rizwan Hasan Khan, Anas Shamsi, Akhtar Atiya
Summary: This study aimed to find a potential SphK1 inhibitor through virtual screening and identified a compound with high potential. The stability of the compound and its binding with SphK1 were evaluated through various molecular dynamics and analysis methods. The results provide a platform for the discovery and development of new anticancer therapeutics targeting SphK1.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Anas Shamsi, Mohammad Furkan, Rizwan Hasan Khan, Mohd Shahnawaz Khan, Moyad Shahwan, Dharmendra Kumar Yadav
Summary: This study deciphers the binding mechanism between rutin and human transferrin, and suggests that rutin can be used for the treatment of neurodegenerative diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Medicine, General & Internal
Naomi Osakabe, Sergio Modafferi, Maria Laura Ontario, Francesco Rampulla, Vincenzo Zimbone, Maria Rita Migliore, Tilman Fritsch, Ali S. Abdelhameed, Luigi Maiolino, Gabriella Lupo, Carmelina Daniela Anfuso, Elisabetta Genovese, Daniele Monzani, Uwe Wenzel, Edward J. Calabrese, R. Martin Vabulas, Vittorio Calabrese
Summary: There is significant interest in finding effective strategies to prevent and slow the onset of hearing loss. Research suggests that protective dietary supplements, such as polyphenols, can help protect cochlear neural stem cells from aging and noise-related damage. These studies also show that polyphenols exhibit a biphasic dose-response pattern, with low doses having beneficial effects and high doses potentially becoming ineffective or harmful. Furthermore, polyphenols targeting the Nrf2 pathway show promise in reducing oxidative stress and inflammation, thus preventing degeneration of auditory hair cells and XIII cranial/auditory nerve cells.
MEDICINA-LITHUANIA
(2023)
Article
Biochemistry & Molecular Biology
Akhtar Atiya, Abdullatif Bin Muhsinah, Mohammed Alrouji, Fahad A. Alhumaydhi, Waleed Al Abdulmonem, Mohammad A. Aljasir, Sharaf E. Sharaf, Mohammad Furkan, Rizwan Hasan Khan, Moyad Shahwan, Anas Shamsi
Summary: In this study, compounds with structural similarity to LCS-1 were screened and analyzed for their interaction with SOD1. Two potential SOD1 inhibitors were identified for further exploration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
