Article
Pharmacology & Pharmacy
Ferdane Danisman-Kalindemirtas, Husniye Birman, Selcan Karakus, Ayben Kilisliogu, Serap Erdem-Kuruca
Summary: In this study, novel drug-loaded nanocarriers were developed using nanotechnology, and their performance in drug delivery systems was evaluated. The nanocarriers showed spherical shape and uniform distribution and effectively released the drugs, exhibiting high cytotoxicity against breast cancer cells while being non-toxic to normal cells. This research highlights the potential of these nanomaterials in clinical drug delivery applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Mostafa Yusefi, Hui-Yin Chan, Sin-Yeang Teow, Pooneh Kia, Michiele Lee-Kiun Soon, Nor Azwadi Bin Che Sidik, Kamyar Shameli
Summary: The study synthesized layer-by-layer bionanocomposites from chitosan and rice straw cellulose encapsulated 5-Fluorouracil (CS-CF/5FU BNCs) with high biocompatibility and efficient drug release properties. The bionanocomposites showed promise in potential colorectal cancer treatment, demonstrating eco-friendly and innovative characteristics in nanodrug delivery.
Article
Pharmacology & Pharmacy
Susana Barbosa Ribeiro, Aurigena Antunes de Araujo, Maisie Mitchele Barbosa Oliveira, Alaine Maria dos Santos Silva, Arnobio Antonio da Silva-Junior, Gerlane Coelho Bernardo Guerra, Gerly Anne de Castro Brito, Renata Ferreira de Carvalho Leitao, Raimundo Fernandes de Araujo Junior, Vinicius Barreto Garcia, Roseane Carvalho Vasconcelos, Caroline Addison Carvalho Xavier de Medeiros
Summary: Oral mucositis, characterized by severe ulcers in the oral region from chemotherapy, lacks effective therapy. Dexamethasone-loaded nanoparticles showed therapeutic effects in a hamster model, reducing inflammation, oxidative stress, and modulating gene expression.
Article
Chemistry, Physical
Agnese Gagliardi, Nicola Ambrosio, Silvia Voci, Maria Cristina Salvatici, Massimo Fresta, Donato Cosco
Summary: For the first time, 5-Fluorouracil was successfully entrapped in sericin and zein blend nanosystems using an easy and economic approach. The resulting nanoblends exhibited small size, monodispersed population, high stability in serum, long-term storage stability, and the ability for freeze-drying. Furthermore, the blend systems showed improved drug loading capacity compared to zein nanosystems and allowed for gradual release of the drug. This study demonstrated the potential application of the nanoblend formulation in antitumor therapy by preserving the pharmacological activity of 5-Fluorouracil against cancer cells.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Oncology
Nkafu Bechem Ndemazie, Andriana Inkoom, Dexter Ebesoh, Raviteja Bulusu, Esther Frimpong, Jose Trevino, Bo Han, Xue Zhu, Edward Agyare
Summary: In this study, MFU was synthesized and characterized, showing potential anticancer activity against pancreatic cancer (PCa). The inhibitory concentration of MFU was significantly lower than that of Gemcitabine hydrochloride (GemHCl) in both cell lines, indicating its potential as a new therapeutic option for PCa.
Article
Biochemistry & Molecular Biology
Yu-Shi Liu, Jia-Wen Song, Wen-Xiao Zhong, Ming-Hao Yuan, Yu-Rou Guo, Cheng Peng, Li Guo, Yi-Ping Guo
Summary: This study successfully delivered curcumin and 5-fluorouracil simultaneously to tumor cells using dual drug-loaded liposomes, improving the therapeutic efficacy of the drugs and enabling real-time drug uptake monitoring.
Article
Biology
Norah M. Alhoshani, Norah S. Al-Johani, Nora Alkeraishan, Saud Alarifi, Saad Alkahtani
Summary: Colon cancer is a common malignancy and there is a need for improving the quality of life for patients. This study explored the role of lycopene as an adjuvant therapy with 5-fluorouracil (5-FU) in colon cancer cells. The findings showed that lycopene enhanced apoptosis, suppressed cell migration, and reduced cytotoxicity when combined with 5-FU treatment.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Medicine, Research & Experimental
Safiullah Khan, Muhammad Naeem Aamir, Asadullah Madni, Nasrullah Jan, Arshad Khan, Abdul Jabar, Hassan Shah, Muhammad Abdur Rahim, Ahsan Ali
Summary: The study successfully developed lipid polymer hybrid nanoparticles for delivering 5-fluorouracil, demonstrating sustained release and enhanced anti-cancer efficacy. The system shows potential for targeted chemotherapy delivery and minimizing toxic side effects.
Article
Biochemical Research Methods
Mohamed S. Hasanin, Mohamed El-Sakhawy, Hanaa Y. Ahmed, Samir Kamel
Summary: This study successfully prepared a nanocomposite that can be used in cancer therapy. The nanocomposite has low cytotoxicity and enhances the drug activity, reducing the side effects of long-term treatment.
BIOTECHNOLOGY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Mashael D. Alqahtani, May N. Bin Jumah, Abdulrahman Al-Hashimi, Ahmed A. Allam, Mostafa R. Abukhadra, Stefano Bellucci
Summary: In this study, natural bentonite clay was modified to enhance its drug loading capabilities for 5-fluorouracil. The modification process involved exfoliation of the clay into nanosheets and further functionalization with methanol. The modified carrier (Mth/EXBE) showed higher loading site density and faster drug release compared to the raw clay. Additionally, the cytotoxicity of 5-fluorouracil was significantly enhanced by the modified carriers.
Article
Engineering, Environmental
Peng He, Sha Yi, Jianzhong Zhang, Chengchao Chu, Xuqi Peng, Changhong Li, Xinfei Sun, Yang Zhang, Hongwei Cheng, Xia Xiong, Gang Liu
Summary: This study developed a novel formulation of 5-fluorouracil (5-Fu) called carrier-free pure 5-Fu nanoparticles (nano 5-Fu) for scar management. In vitro and in vivo tests showed that nano 5-Fu had superior efficacy in inactivating scar cells and longer retention time in soft tissues compared to free 5-Fu. Animal experiments and a first-in-human trial demonstrated that nano 5-Fu significantly reduced scar elevation, collagen fiber deposition, and microvessels, with excellent and stable efficacy and fewer side effects.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biophysics
Saeed A. AlQahtani, Gamaleldin Harisa, Abdullah H. Alomrani, Fars K. Alanazi, Mohamed M. Badran
Summary: NEs are utilized as carriers for 5-FU to target liver cancer cells, displaying favorable drug release effects and superior pharmacological efficacy compared to other formulations.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Polymer Science
Sanele Mngadi, Moganavelli Singh, Seipati Mokhosi
Summary: The study details the synthesis of Mg0.5Co0.5Fe2O4 ferrite nanoparticles functionalized with polyvinyl alcohol (PVA) and encapsulated with the anti-cancer drug 5-fluorouracil (5-FU). The functionalized nanoparticles displayed desirable physiochemical properties and exhibited high cytotoxicity in cancer cell lines, showing potential for targeted cancer treatment.
JOURNAL OF POLYMER ENGINEERING
(2021)
Article
Medicine, Research & Experimental
Mengying Hong, Dongdong Chen, Zhuping Hong, Kejun Tang, Yuanyuan Yao, Liubo Chen, Tingting Ye, Jing Qian, Yushen Du, Ren Sun
Summary: Martynoside (MAR) is a bioactive glycoside of Rehmannia glutinosa, traditionally used in Chinese medicine for treating chemotherapy-induced pancytopenia. It has been shown to protect bone marrow cells from chemotherapy-induced toxicity, improve the bone marrow microenvironment, and potentially counteract chemotherapy-induced myelosuppression in cancer patients.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Polymer Science
Ankur Pachauri, Havagiray Chitme, Sharad Visht, Vijay Chidrawar, Nawaj Mohammed, Basel A. Abdel-Wahab, Masood Medleri Khateeb, Mohammed Shafiuddin Habeeb, Mohamed A. A. Orabi, Marwa B. Bakir
Summary: The objective of this study was to develop a liposomal emulgel of 5FU with increased skin permeability and efficacy using clove oil and eucalyptus oil. The optimized formulation showed significant cytotoxicity against melanoma cells due to the improved skin permeability and reduced dose required for anti-skin cancer activity.
Article
Health Care Sciences & Services
Seema Mehdi, Kishor Manohar, Atiqulla Shariff, Nabeel Kinattingal, Shahid Ud Din Wani, Sultan Alshehri, Mohammad T. Imam, Faiyaz Shakeel, Kamsagara L. Krishna
Summary: Research suggests that including omega-3 fatty acids in the diet can reduce the risk of depression. This study evaluated the effectiveness of omega-3 fatty acid supplements in alleviating depressive symptoms in patients with mild to moderate depression. The results showed significant improvement in depressive symptoms within each treatment group, and the combination of omega-3 fatty acid supplement and an antidepressant was more effective than using either supplement or antidepressant alone.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Chemistry, Analytical
Prawez Alam, Faiyaz Shakeel, Mohammed H. Alqarni, Ahmed I. Foudah, Tariq M. Aljarba, Aftab Alam, Mohammed M. Ghoneim, Syed Mohammed Basheeruddin Asdaq, Sultan Alshehri, Muzaffar Iqbal
Summary: In this study, a stability-indicating greener high-performance thin-layer chromatography (HPTLC) technique was developed to determine cordycepin (CDN) in a laboratory-developed formulation. The proposed analytical technique showed accurate, rapid, simple, and stable CDN determination, with an AGREE score of 0.79 indicating outstanding greener characteristics. The method was suitable for the assay of CDN in the formulations.
Article
Chemistry, Analytical
Prawez Alam, Faiyaz Shakeel, Mohammed H. H. Alqarni, Ahmed I. I. Foudah, Tariq M. M. Aljarba, Mohammed M. M. Ghoneim, Syed Mohammed Basheeruddin Asdaq, Sultan Alshehri
Summary: This study developed a stability-indicating greener HPTLC densitometry assay for the quantification of flufenamic acid (FFA) in marketed products. The ecofriendly eluent system comprised of ethanol-water (70:30 v/v) and FFA was measured at 290 nm. The suggested analytical assay demonstrated linearity, accuracy, precision, selectivity, and stability-indication, with a greenness scale rating of 0.77 using AGREE methodology.
Editorial Material
Biochemistry & Molecular Biology
Faiyaz Shakeel
Article
Pharmacology & Pharmacy
Sultan Alshehri, Rehab Alshammari, Mohammad Alyamani, Rufaidah Dabbagh, Bander Almalki, Omamah Aldosari, Renad Alsowayigh, Amirah Alkudeer, Fatimah Aldosari, Jumana Sabr, Faiyaz Shakeel
Summary: This study explores the contribution of the local pharmaceutical industry to drug security in Saudi Arabia. The majority of drugs in the market are manufactured in Europe, followed by Saudi Arabia, China, and India. Most of the manufactured drugs are prescription drugs. The highest contributors to local drug security are Pharmaceutical Solution Industries (PSI), followed by TABUK Pharmaceutical Manufacturing CO., SPIMACO, JAMJOOM pharmaceutical company, Riyadh pharma, and Jazeera pharmaceutical industries.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Polymer Science
Prasanth Viswanadhan Vasantha, Sheri Peedikayil Sherafudeen, Mohamed Rahamathulla, Sam Thomarayil Mathew, Sandhya Murali, Sultan Alshehri, Faiyaz Shakeel, Prawez Alam, Ala Yahya Sirhan, Bhageerathy Anantha Narayana Iyer
Summary: The purpose of this study is to develop and evaluate mucoadhesive in situ nasal gel formulations of loratadine and chlorpheniramine maleate to improve drug bioavailability. Different permeation enhancers were studied for their influence on the nasal absorption of loratadine and chlorpheniramine from in situ nasal gels containing different polymeric combinations. Sodium taurocholate, Pluronic F127, and oleic acid showed significant enhancement in the nasal flux of loratadine, while oleic acid had the most pronounced effect on chlorpheniramine maleate permeation.
Article
Polymer Science
Bhakti Dhimmar, Rahul Pokale, Mohamed Rahamathulla, Umme Hani, Mohammad Y. Alshahrani, Sultan Alshehri, Faiyaz Shakeel, Prawez Alam, Riyaz Ali M. Osmani, Amit B. Patil
Summary: Luliconazole is used to design an alkaline pH-based antifungal spray solution for effective antifungal treatment. The solution is formulated using Eudragit RS 100, propylene glycol, water, sodium bicarbonate, and ethanol. The optimized formulation showed satisfactory drug release and compatibility with human skin, making it a promising option for topical antifungal treatments.
Article
Chemistry, Analytical
Nazrul Haq, Muzaffar Iqbal, Afzal Hussain, Faiyaz Shakeel, Ashfaq Ahmad, Ibrahim A. Alsarra, Mohamed Fahad AlAjmi, Asra Mahfooz, M. Ali Abouzadeh
Summary: The objective of this study was to investigate the potential of biodegradable agro-industrial waste materials as biosorbents in solid-phase extraction (SPE) technique for sample preparation. Waste coffee husk (CH) powder was collected, treated chemically, and used as an SPE adsorbent to extract pantoprazole from wastewater samples. The efficiency and regeneration capability of CH were comparable to a commercially available silica-based C18 SPE adsorbent. The developed biosorbent showed a recovery range of 93.0% to 102.0% with a %RSD of 3.72% to 12.7%.
Article
Chemistry, Analytical
Nazrul Haq, Faiyaz Shakeel, Mohammed M. Ghoneim, Syed Mohammed Basheeruddin Asdaq, Prawez Alam, Fahad Obaid Aloatibi, Sultan Alshehri
Summary: A rapid and sensitive HPLC method was used to quantify pterostilbene (PTT) in commercial capsule dosage form, solubility, and stability samples. The HPLC method utilized an RP C-18 column and a mobile phase of acetonitrile and water. PTT was detected at a wavelength of 254 nm. The HPLC method was found to be linear, accurate, precise, and sensitive, with a high determination coefficient. The method was successfully applied to determine PTT in commercial products, solubility, and stability samples.
Review
Biochemistry & Molecular Biology
Vishal Mathur, Ozair Alam, Nadeem Siddiqui, Mukund Jha, Ajay Manaithiya, Sandhya Bawa, Naveen Sharma, Sultan Alshehri, Prawez Alam, Faiyaz Shakeel
Summary: This article discusses various scaffolds that can be used to develop DPP-4 inhibitors for the treatment of type 2 diabetes mellitus (T2DM). The study highlights different scaffolds with high DPP-4 inhibition activity and explains the potential enhancement by substituting certain atoms. Docking experiments were performed on existing drugs and their interaction with specific residues was studied. The article also describes the synthesis schemes for commercially available DPP-4 inhibitors. Overall, the use of halogenated scaffolds for developing DPP-4 inhibitors is an area of increasing interest.
Article
Biochemistry & Molecular Biology
Faiyaz Shakeel, Nazrul Haq, Sultan Alshehri, Miteb Alenazi, Abdulrahman Alwhaibi, Ibrahim A. Alsarra
Summary: The solubility and solution thermodynamics of isotretinoin in DMSO and water mixtures were studied. The results showed that the solubility of ITN increased with temperature and DMSO mass fraction. The computational models also revealed good relationships between the experimental data. The study suggests that DMSO has great potential for solubilizing ITN in water.
Article
Biochemistry & Molecular Biology
Faiyaz Shakeel, Prawez Alam, Mohammed H. Alqarni, Nazrul Haq, Fatma M. Abdel Bar, Muzaffar Iqbal
Summary: A high-performance thin-layer chromatography (HPTLC) method with fluorescence detection was developed for measuring ergotamine (EGT) in commercially available tablets. The method utilized an eco-friendly eluent mixture and showed excellent linearity in the 25-1000 ng band(-1) range. The method was validated successfully and exhibited rapid, sensitive, and stability-indicating characteristics. Additionally, the method was rated highly for its "greenness" based on AGREE technology. The method also achieved successful separation of EGT degradation products and accurately measured EGT content in commercial products.
Article
Chemistry, Multidisciplinary
Ishtiaq Ahmad Chashoo, Shahid Ud Din Wani, Weekar Younus Raja, Zulfiqar Ali Bhat, Mohammad Ali, Sultan Alshehri, Prawez Alam, Mohammed M. Ghoneim, Syed Mohammed Basheeruddin Asdaq, Faiyaz Shakeel
Summary: This study aimed to identify and collect Sambucus wightiana and isolate and characterize its phytoconstituents using various methods. The methanolic extract of S. wightiana showed significant anti-hyperglycemic and antioxidant activity.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Editorial Material
Chemistry, Analytical
Faiyaz Shakeel
Article
Multidisciplinary Sciences
Nazrul Haq, Sultan Alshehri, Ibrahim A. Alsarra, Miteb Alenazi, Abdulrahman Alwhaibi, Faiyaz Shakeel
Summary: An environmentally friendly HPLC assay was designed and verified for the quantification of ITN in commercial products and solubility samples. The assay demonstrated high performance with excellent accuracy, precision, and sensitivity. The suggested approach proved to be applicable for regular testing of ITN in procured capsules and solubility samples, providing important information on its presence and solubility.
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
