Article
Biochemistry & Molecular Biology
Jan Dudek, Ilona Kutschka, Christoph Maack
Summary: Cardiovascular stem cells are crucial for tissue regeneration and repair, with their differentiation process being influenced by metabolism and cellular redox state. Reactive oxygen species play a significant role in stem cell differentiation and tissue renewal, but can also contribute to cellular aging.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Tom Kretzschmar, Mohamed M. Bekhite, Jasmine M. F. Wu, Daniela Haase, Martin Foerster, Tina Mueller, Sandor Nietzsche, Martin Westermann, Marcus Franz, Markus H. Graeler, P. Christian Schulze
Summary: The study reveals that Doxorubicin increases ceramide levels, leading to cell death and fibrosis, and that inhibiting ceramide synthesis can partially reverse the associated damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Nicolas Mandel, Michael Buettner, Gernot Poschet, Rohini Kuner, Nitin Agarwal
Summary: Our study reveals that SUMOylation plays an essential neuroprotective role in sensory neurons in type 2 diabetes. Deletion of SUMOylation leads to an accelerated loss of thermal and mechanical sensation, increased nerve fiber loss, and elevated levels of reactive oxygen species (ROS). We also observed compromised detoxifying potential, impaired respiratory chain complexes, and reduced levels of protective lipids in sensory neurons upon deletion of SUMOylation.
Article
Pharmacology & Pharmacy
Jianyu Liu, Minghai Tang, Tao Li, Zhengying Su, Zejiang Zhu, Caixia Dou, Yan Liu, Heying Pei, Jianhong Yang, Haoyu Ye, Lijuan Chen
Summary: This study found that honokiol (HK) can improve post-myocardial infarction heart failure (post-MI HF) by increasing the expression of the cardioprotective protein Ucp3 and inhibiting reactive oxygen species (ROS) production. This provides a new therapeutic approach for heart failure.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Michael O. Isei, Don Stevens, Collins Kamunde
Summary: The research found that heart mitochondria show different responses to copper and thermal stress, and the consumption capacity of H2O2 is influenced by the type of substrate, temperature, and copper. The NADPH-dependent peroxidase system is the centerpiece of ROS scavenging in heart mitochondria, and copper has the ability to inhibit specific mitochondrial ROS scavenging pathways.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Matthew Reily-Bell, Andrew Bahn, Rajesh Katare
Summary: Research shows that ROS is one of the main causes of diabetic heart disease, and miRNAs play a crucial role in treating the disease. However, since miRNAs have multiple targets and exhibit different functions in different environments, a thorough understanding of their mechanisms is needed for successful application.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Cardiac & Cardiovascular Systems
Lindsay E. Volk, Constantine D. Mavroudis, Tiffany Ko, Thomas Hallowell, Nile Delso, Anna L. Roberts, Jonathan Starr, William Landis, Yuxi Lin, Marco Hefti, Ryan W. Morgan, Richard W. Melchior, Tami M. Rosenthal, Alexander Chappell, Douglas Fisher, Molly Dreher, Daniel J. Licht, Jonathan Chen, J. William Gaynor, Christopher E. Mascio, Todd J. Kilbaugh
Summary: The study found that using cardiopulmonary bypass during cardiac surgery can lead to decreased cerebral mitochondrial respiration even in the absence of local markers of ischemia. Exposure to 4 hours of cardiopulmonary bypass resulted in a significant increase in cerebral mitochondrial reactive oxygen species formation.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Review
Chemistry, Multidisciplinary
Zhan Zhang, Rinkoo Dalan, Zhenyu Hu, Jiong-Wei Wang, Nicholas Ws Chew, Kian-Keong Poh, Ru-San Tan, Tuck Wah Soong, Yunlu Dai, Lei Ye, Xiaoyuan Chen
Summary: Ischemic heart disease (IHD) is a leading cause of disability and death worldwide. Reactive oxygen species (ROS) play a key role in the progression of diabetes, hypertension, and hypercholesterolemia, which are independent risk factors for atherosclerosis and the development of IHD. Nanomedicines, as smart and multifunctional nanocarriers, are being extensively studied and explored for their synergistic therapeutic effects.
ADVANCED MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Thales M. H. Dourado, Victor O. Assis, Wanessa M. C. Awata, Marcela M. B. de Mello, Evelin C. Carnio, Michele M. Castro, Carlos R. Tirapelli
Summary: The effects of ethanol consumption on blood pressure involve vasoconstriction and activation of RAAS. This study found that MR pathway plays a role in ethanol-induced hypertension and vascular hypercontractility. Ethanol increased COX2 expression, ROS levels, and TXB2 production in blood vessels, which were prevented by MR blockade. The mechanism involves MR-triggered ROS generation, up-regulation of COX2, and overproduction of TXA2. MR blockade reversed the hyperreactivity induced by ethanol.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Patrizia Bottoni, Giulia Gionta, Roberto Scatena
Summary: Mitochondrial myopathies are a heterogeneous group of diseases caused by genetic mutations in proteins involved in mitochondrial oxidative metabolism. These myopathies show significant differences in their evolution, but some physiological and pathophysiological aspects of mitochondria reveal other potential molecular mechanisms that may play a significant role in their clinical progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Yanru Chen, Yin Wan, Wenqin Cai, Na Liu, Jiali Zeng, Chengmei Liu, Hong Peng, Guiming Fu
Summary: Ethanol stress inhibits the growth and esters production ability of P. anomala yeast, leading to cell membrane damage and excessive accumulation of ROS. These results are of great significance to the alcohol products brewing industry.
Article
Nanoscience & Nanotechnology
Zhiwei Huang, Yannan Shi, Hengcai Wang, Changju Chun, Longwang Chen, Kang Wang, Zhongqiu Lu, Yingzheng Zhao, Xinze Li
Summary: This study utilized chitosan-bilirubin nanoparticles to treat gastric ulcers through anti-inflammatory and antioxidant mechanisms, demonstrating their efficacy in in vitro and in vivo studies. The findings provide a novel approach for prophylaxis against or treatment of gastric ulcers.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Agronomy
Rupal Singh Tomar, Sunita Kataria, Anjana Jajoo
Summary: This article explores the recent research on signaling and mechanisms for salt tolerance in plants, focusing on the role of the salt overly sensitive system (SOS) and related antiporters proteins and mitogen-activated protein kinase cascades under salt stress. It also highlights the differential expression of various antioxidative enzymes in C3, C4 and CAM plants.
JOURNAL OF AGRONOMY AND CROP SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Anne Abot, Steven Fried, Patrice D. Cani, Claude Knauf
Summary: The role of reactive oxygen/nitrogen species as friend or foe messengers in the body is well studied, with their effects depending on concentration in tissues. The intestine, affected by oxidation and inflammation, plays a crucial role in diabetic symptoms. Controlling levels of intestinal reactive oxygen/nitrogen species is a complex balance with potential therapeutic implications.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Review
Endocrinology & Metabolism
Jan Dudek, Christoph Maack
Summary: Organs with high energy demands, like the heart, rely heavily on oxidative phosphorylation in mitochondria, a process that is influenced by the presence of cardiolipin. Deficiency in cardiolipin can lead to Barth syndrome, resulting in cardiomyopathy and other symptoms. Additionally, cardiolipin insufficiency can affect Krebs cycle activity and mitochondrial morphology.
JOURNAL OF INHERITED METABOLIC DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Kun He, Mengyi Xie, Weifeng Hong, Yonghe Li, Yaolin Yin, Xiaojin Gao, Yi He, Yu Chen, Chuan You, Jingdong Li
Summary: Centromere protein L (CENPL) is overexpressed in hepatocellular carcinoma (HCC) and is associated with poor patient prognosis. Upregulation of CENPL promotes tumor proliferation and glycolysis in HCC cells by activating the MEK1/2-ERK1/2 signaling pathway.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Yingzi Wang, Haozhong Huang, Huimin Weng, Chunsen Jia, Bin Liao, Yang Long, Fengxu Yu, Yongmei Nie
Summary: Talin protein plays a crucial role in transmitting mechanical forces by connecting the extracellular matrix to the cytoskeleton. It converts mechanical signals into biochemical signals and serves as diagnostic, therapeutic, and prognostic indicators in diseases.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Hema Saranya Ilamathi, Marc Germain
Summary: Mitochondria are the central metabolic hubs in cells, relying on proteins encoded by nuclear DNA and mitochondrial DNA (mtDNA) for their function. The maintenance and distribution of mtDNA are crucial for proper mitochondrial function and are associated with mitochondrial diseases. mtDNA is organized into nucleoids that dynamically move and interact with each other. The replication and distribution of mtDNA nucleoids are regulated by the complex interplay of mitochondrial dynamics, ER-mitochondria contact sites, and cytoskeletal networks.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
K. K. Sruthi, Sirisha Natani, Ramesh Ummanni
Summary: The overexpression of TPD52 is associated with the emergence of neuroendocrine prostate cancer (NEPC). TPD52 activates the NF-kappa B - STAT3 axis to induce neuroendocrine differentiation (NED) of prostate cancer cells. Therapeutic targeting of TPD52 is important for the treatment of prostate cancer.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Cui Li, Feifan Xiang, Yuqi Gong, Yi Fu, Ge Chen, Zhi Wang, Zhong Li, Daiqing Wei
Summary: Our study demonstrates the significant role of tumor-derived microparticles (T-MPs) in osteosarcoma metastasis and immune response. T-MPs promote macrophage polarization and stimulate migration and chemoresistance of osteosarcoma cells, thereby affecting the progression of osteosarcoma.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)