Article
Microbiology
Shumei Huang, Shuang Wang, Yan Li, Ming Fang, Zengqiang Kou, Baoli Chen, Liuchen Xu, Zhenwang Bi, Hao Xu, Xiaohui Chi, Zhenqiang Bi
Summary: This study found that colistin-resistant Escherichia coli, most of which are multi-drug resistant strains, is common and highly transmissible among healthy residents in rural areas in China. Interventions should be implemented to prevent the spread of colistin-resistant Escherichia coli through health education and tighter regulation of antibiotics.
MICROBIOLOGICAL RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Jialiang Mai, Zhuwei Liang, Zhile Xiong, Chao Zhang, Hao Cai, Shuwen Yao, Xiantang Chen, Bingshao Liang, Fei Gao, Zhuohong Huang, Fangjun Lan, Shuyan Liu, Zhenwen Zhou
Summary: The study investigated the sequence type and prevalence of Escherichia coli (E. coli) harboring the mcr-1 gene in the gut flora of children in southern China. The results showed that the mcr-1 gene can be horizontally transmitted within species, highlighting the importance of monitoring bacteria that carry the mcr-1 gene in children.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Article
Infectious Diseases
Xiucai Zhang, Chao Fang, Junfeng Zhang, Wang Hua, Rong He, Mingming Zhou
Summary: This study reveals that the main mechanisms of carbapenem and colistin co-resistance in E. coli strains are encoded by blaNDM and mcr1.1 genes, while mgrB mutations also contribute to colistin resistance. Additionally, the study identifies the coexistence of blaNDM-5, blaCTX-M-65, blaOXA-10, blaTEM-1, and mcr1.1 genes in a ST156 E. coli strain, as well as identifies a ST457 E. coli strain carrying blaTEM-1, blaNDM-9, blaCTX-M-199, and mcr1.1 gene.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Infectious Diseases
Elsa de la Cadena, Mateo Mahecha, Ana Maria Velandia, Juan Carlos Garcia-Betancur, Laura J. J. Rojas, Jessica Porras, Christian Pallares, Maria Virginia Villegas
Summary: We discovered the presence of the mcr-1 gene in a low percentage of colistin-resistant Escherichia coli isolates from Colombian hospitals. Whole genome sequencing revealed the presence of multiple resistance genes and different sequence types in the five isolates carrying mcr-1. The spread of mcr-1 in E. coli in this geographic region seems to be limited and has not affected high-risk clones like ST131.
Article
Microbiology
Ping Cheng, Yuqi Yang, Sai Cao, Haibin Liu, Xiaoting Li, Jichao Sun, Fulei Li, Muhammad Ishfaq, Xiuying Zhang
Summary: The study found a high prevalence of mcr-1-positive colistin-resistant E. coli in food animals, showing extensive antimicrobial resistance, strong transferability, and impact on host fitness.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Multidisciplinary Sciences
Abdulaziz Alqasim
Summary: Gram-negative bacteria (GNB) pose a significant health threat globally, with increasing antimicrobial resistance leading to the need for colistin treatment. Saudi Arabia's annual mass religious gatherings heighten the risk of infectious disease transmission. While colistin remains effective locally, high resistance has been observed among major GNB, and the role of mass gatherings in triggering colistin resistance is concerning.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2021)
Letter
Immunology
Cong Shen, Lan-Lan Zhong, Zhijuan Zhong, Yohei Doi, Jianzhong Shen, Yang Wang, Furong Ma, Mohamed Abd El-Gawad El-Sayed Ahmed, Guili Zhang, Yong Xia, Cha Chen, Guo-Bao Tian
Summary: China banned the use of colistin in livestock fodders in response to the spread of the colistin resistance gene mcr-1. A time-series analysis of inpatient colonization data from 2011-2019 accurately revealed fluctuations in mcr-1 among inpatients in response to the ban.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Baoli Chen, Bjorn Berglund, Shuang Wang, Stefan Borjesson, Zhenqiang Bi, Maud Nilsson, Hong Yin, Beiwen Zheng, Yonghong Xiao, Zhenwang Bi, Lennart E. Nilsson
Summary: This study investigated the occurrence and characteristics of carbapenem-resistant Enterobacteriaceae (CRE) in fecal samples from healthy individuals in 12 villages in Shandong Province, China. The results showed a rapid increase in CRE carriage from 2.4% to 13.4% from 2015 to 2017, with the majority of isolates being Escherichia coli carrying NDM-type carbapenemases. The worsening epidemiological situation highlights the need for further monitoring and interventions in the region.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Infectious Diseases
Muhammad Yasir, A. Keith Turner, Sarah Bastkowski, Martin Lott, Emma R. Holden, Andrea Telatin, Andrew J. Page, Mark A. Webber, Ian G. Charles
Summary: Colistin is an antibiotic used for treating human infections caused by multidrug-resistant pathogens. Colistin resistance is a growing problem, and this study identified the overexpression of the basSR two-component system and other genes as important factors in colistin susceptibility.
Article
Engineering, Multidisciplinary
Yuqing Zhou, Refath Farzana, Somsavanh Sihalath, Sayaphet Rattanavong, Manivanh Vongsouvath, Mayfong Mayxay, Kirsty Sands, Paul N. Newton, David A. B. Dance, Brekhna Hassan, Timothy R. Walsh
Summary: This study investigated the molecular epidemiology of mobile colistin resistance (mcr) in Laos, finding variations in the prevalence of MCRPEC and their resistance profiles. The distribution and dissemination of plasmids were identified as important factors influencing the spread of mcr.
Article
Biochemistry & Molecular Biology
Hui-Hua Zheng, Chao Yu, Xin-Yue Tang, Chong-Tao Du, Guang-Hong Xie
Summary: This study analyzed the colistin resistance of oral and intestinal microbiota from dog origins in mainland China, and found that Escherichia coli strains from dogs showed severe antibiotic resistance, especially to three common antibiotics in a clinic. This study provides guidance for the use of antibiotics and draws attention to antibiotic resistance in veterinary clinical treatment for animals in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Infectious Diseases
Fabio P. Sellera, Luciano C. B. A. Da Silva, Nilton Lincopan
Summary: The COVID-19 pandemic has deepened the relationships between humans and companion animals, leading to an increase in the use of antibiotics and biocides worldwide. Data from global surveillance studies show a linear trend in increasing carbapenem resistance among Gram-negative pathogens in companion animals, with humans potentially acquiring carbapenemase-producing bacteria through contact with infected animals or contaminated environments. The rapid spread of WHO critical priority carbapenemase-producing pathogens in companion animals presents a One Health challenge for the post-pandemic world.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Fen Wan, Linna Xu, Zhi Ruan, Qixia Luo
Summary: The study found that the PmrB L14R amino acid substitution leads to colistin resistance in Escherichia coli, and the two-component system EvgS/EvgA plays a significant role in the global regulation of colistin resistance.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Veterinary Sciences
Cui-Yi Liao, Balamuralikrishnan Balasubramanian, Jin-Ju Peng, Song-Ruo Tao, Wen-Chao Liu, Yi Ma
Summary: The study evaluated antimicrobial resistance of Escherichia coli in aquaculture farms of Zhanjiang, China by analyzing 90 strains isolated from water, soil, and sediment samples. These strains showed high resistance to multiple antimicrobial drugs and carried various resistance genes. Strengthening rational use of antimicrobial drugs, especially amide alcohol drugs, is crucial to controlling antimicrobial resistance in Zhanjiang's aquaculture industry.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Cong Liu, Peng Wang, Yu Dai, Yu Liu, Yanying Song, Lanping Yu, Chenglian Feng, Mengda Liu, Zhijing Xie, Yingli Shang, Shuhong Sun, Fangkun Wang
Summary: The extensive use of antibiotics has led to antimicrobial resistance and multi drug resistance in Escherichia coli, posing challenges for bacterial treatment and public health. Monitoring the resistance of E. coli throughout the broiler fattening period is crucial for the poultry industry and public health.
Review
Critical Care Medicine
Siddarth Daniels David, Anna Aroke, Nobhojit Roy, Harris Solomon, Cecilia Stalsby Lundborg, Martin Gerdin Warnberg
Summary: Trauma has a significant impact on disability-adjusted life-years globally, particularly in low- and middle-income countries. It affects employment opportunities, social participation, social support, and quality of life among survivors. Research has primarily focused on specific subsets of trauma patients, limiting the overall understanding of outcomes in different populations and settings. This systematic review aims to provide an overview of knowledge on return-to-work, participation, social support, and quality of life in trauma patients up to one year after discharge.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Environmental Sciences
Krushna Chandra Sahoo, Rachna Soni, Madhanraj Kalyanasundaram, Surya Singh, Vivek Parashar, Ashish Pathak, Manju R. Purohit, Yogesh Sabde, Cecilia Stalsby Lundborg, Kristi Sidney Annerstedt, Salla Atkins, Kamran Rousta, Vishal Diwan
Summary: This study explored the motivation, opportunity, and ability of urban community members in waste segregation. The findings revealed that household members have the motivation to segregate waste but fear the consequences of improper sorting. Waste segregation is gaining acceptance as a social norm, and convenient facilities and social support systems contribute to waste segregation. The study emphasizes the importance of motivation, opportunity, and ability in managing sustainable waste segregation practices.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biotechnology & Applied Microbiology
Ananyo Jyoti Misra, Aradhana Basu, Arpan Ghosh, Habeeb A. P. Rahman, Nitika Tiwari, Amrita Mishra, Cecilia Stalsby Lundborg, Suraj K. Tripathy
Summary: The emergence of multidrug resistance (MDR) in waterborne bacteria poses a catastrophic threat to global public health. This study investigates the effectiveness of Zinc Oxide-Kaolinite nanocomposites (ZnO-K) coated on sodium alginate beads (ZnO/K@alginate) for photocatalytic disinfection (PCD) of multidrug-resistant Staphylococcus haemolyticus and Escherichia coli under visible-light emitting diode (LED). The results show that ZnO-K NC has higher efficiency compared to other photocatalysts and traditional disinfection techniques. The study suggests that hydrogen peroxide may play a key role in the PCD of targeted bacteria. The ZnO/K@alginate beads can be reused for multiple cycles, indicating potential real-world application in limiting nosocomial infections.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2022)
Article
Engineering, Environmental
A. P. Habeeb Rahman, Pranjal, Susanta Kumar Beher, Amrita Mishra, Cecilia Stalsby Lundborg, Suraj K. Tripathy
Summary: Bacterial adaptation to external stress and its evolution to antibiotic resistance poses a risk to the health sector. Conventional wastewater treatment may disseminate antibiotic resistance, but new technologies are emerging. This study found that stress-adapted bacteria survived SPC treatment for a longer time compared to unadapted bacteria.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Environmental
Vivek Parashar, Surya Singh, Manju R. Purohit, Ashok J. Tamhankar, Dharmpal Singh, Madhanraj Kalyanasundaram, Cecilia Stalsby Lundborg, Vishal Diwan
Summary: Increasing generation and indiscriminate disposal of wastewater pose risks to human and animal health. Constructed wetlands, as a low-cost and easy-to-operate alternative treatment system, can effectively remove pollutants from wastewater. This study examined the use of constructed wetlands for treating hospital wastewater and found that Typha latifolia was particularly efficient in removing antibiotic resistant bacteria.
WATER ENVIRONMENT RESEARCH
(2022)
Article
Environmental Sciences
Bhumika Jena, Swati Sucharita Singh, Susanta Kumar Behera, Smrutirekha Mishra, Sankha Chakrabortty, Dayanidhi Meher, Bansidhar Mulia, Suraj K. Tripathy, Ramesh Kumar, Byong-Hun Jeon, Cecilia Stalsby Lundborg, Amrita Mishra
Summary: Globally, Methicillin-Resistant Staphylococcus aureus bacteraemia is a common bloodstream infection associated with complications and high mortality. This study demonstrates the biosynthesis of Ag nanoparticles using a phytochemical agent from Urginea indica bulb extract. The synthesized nanoparticles show potential antibacterial and anti-biofilm activity against S. aureus and MRSA. They also exhibit biocompatibility and future clinical potential against Staphylococcus infections.
ENVIRONMENTAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Xiankun Chen, Wei Jiang, Mariano Salazar, Huiying Zhu, Zehuai Wen, Xixi Chen, Cecilia Stalsby Lundborg
Summary: This study explores the experiences of Chinese patients with chronic heart failure who undertook Baduanjin exercise at home as part of a pilot trial. The findings suggest that Baduanjin could be an effective cardiac rehabilitation exercise modality for these patients, especially in a home-based setting. Factors such as improvement in practice, motivation from training benefits, trust in Baduanjin, personal attitudes toward health, flexibility in practice times, and social support were important for maintaining good exercise adherence.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Engineering, Environmental
Pranjal, Soujanya Ghosh, A. P. Habeeb Rahman, Sankha Chakrabortty, Shirsendu Banerjee, Ramesh Kumar, Amrita Mishra, Byong-Hun Jeon, Cecilia Stalsby Lundborg, Suraj K. Tripathy
Summary: A systematic study was conducted to understand the bactericidal mechanism of ultrasound assisted Fenton reaction (Sono-Fenton) against multidrug resistant Acinetobacter baumannii. The study found that SF achieved approximately 99% inactivation efficiency against A. baumannii within 90 minutes under weak acidic conditions. The combination of ultrasound and H2O2 was found to be more efficient, and the generation of multiple reactive oxygen species (ROS) may have led to the membrane damage of the bacteria.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Infectious Diseases
Ioana Ghiga, Anna Sidorchuk, Emma Pitchforth, Cecilia Stalsby Lundborg, Anna Machowska
Summary: This systematic review synthesizes the evidence on the value of community-based behavior change interventions to improve antibiotic use. The findings show positive emerging evidence of the benefits of such interventions, especially multifaceted ones. Combining education with persuasion may be more effective than solely educational interventions. However, standardized approaches are needed in study design and outcome measurements.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Review
Veterinary Sciences
Ali Mostafaei, Hamid Akbari, Cecilia Stalsby Lundborg, Neda Kabiri, Nafiseh Vahed, Sakineh Hajebrahimi, Leila Doshmangir
Summary: Actions to preserve effective antibacterial agents and eliminate transmission of resistant organisms are crucial to prevent a catastrophic postantibiotic era. This systematic review gathered and appraised texts and expert opinions to determine effective strategies to tackle bacterial resistance worldwide. The findings emphasize the importance of strengthening surveillance, developing guidelines, improving public awareness, enhancing hygiene, improving prescribing patterns, enhancing laboratory capacity, promoting innovation and research, and strengthening coordination.
VETERINARY MEDICINE AND SCIENCE
(2023)
Letter
Pharmacology & Pharmacy
Saibal Das, Shambo Samrat Samajdar, Shatavisa Mukherjee, Sougata Sarkar, Sumalya Sen, Ashish Pathak, Cecilia Stalsby Lundborg, Sandhiya Selvarajan, Santanu Kumar Tripathi, Jyotirmoy Pal, Nandini Chatterjee, Shashank R. Joshi
INTERNATIONAL JOURNAL OF PHARMACY PRACTICE
(2023)
Article
Environmental Sciences
Nada Hanna, Ashok J. Tamhankar, Cecilia Stalsby Lundborg
Summary: Environmental contamination with antibiotic residues is a significant concern. This study developed a prioritisation system for antibiotics based on their integrated environmental and human health risks, to implement eco-pharmacovigilance and develop targeted policies.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Environmental Sciences
Nada Hanna, Ashok J. Tamhankar, Cecilia Stalsby Lundborg
Summary: This study aimed to determine the antibiotic residue levels that are likely to select for resistance and the relative contributions from different aquatic sources in the WHO Western Pacific region and the WHO South-East Asia region. The highest risk for the development of resistance was observed in tap or drinking water with ciprofloxacin in these regions.
LANCET PLANETARY HEALTH
(2023)
Article
Primary Health Care
Ioana Ghiga, Emma Pitchforth, Cecilia Stalsby Lundborg, Anna Machowska
Summary: This qualitative study conducted semi-structured interviews with 12 family doctors in Romania to explore their perceptions of antibiotic resistance. The findings revealed differences in their perceptions and highlighted the lack of patient education and awareness as a major driver of antibiotic consumption. Potential interventions, particularly focused on patient education, were identified to address this issue.
Article
Engineering, Environmental
Ananyo Jyoti Misra, Aradhana Basu, Susanta Kumar Behera, Amita Mishra, Cecilia Stalsby Lundborg, Suraj K. Tripathy
Summary: A working prototype of a point-of-use water disinfection device using reusable photo catalytic beads under visible light is demonstrated. The device effectively disinfects antibiotic-resistant Salmonella enterica serovar and other waterborne bacteria. The treated water does not have a noticeable impact on animal health, indicating the bio-safety of the process. This device is suitable for rural populations and individuals in remote areas.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Review
Infectious Diseases
Allison M. Hitchcock, Wesley D. Kufel, Keri A. Mastro Dwyer, Eric F. Sidman
Summary: Lenacapavir is a novel HIV-1 treatment option for patients with multidrug-resistant (MDR) HIV-1 infection. It has a favorable pharmacokinetic profile and has shown good tolerability and efficacy in clinical trials.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)
Article
Infectious Diseases
Roberta Gagliardini, Alessandro Tavelli, Stefano Rusconi, Sergio Lo Caputo, Vincenzo Spagnuolo, Maria Mercedes Santoro, Andrea Costantini, Alessandra Vergori, Franco Maggiolo, Andrea Giacomelli, Giulia Burastero, Giordano Madeddu, Eugenia Quiros Roldan, Antonella d'Arminio Monforte, Andrea Antinori, Alessandro Cozzi-Lepri
Summary: This study evaluated multiple treatment failures to modern antiretroviral therapy in HIV-infected individuals and found that approximately 4% of them were difficult to treat. The difficult to treat group, compared to the non-difficult to treat group, was characterized by older age, higher prevalence of AIDS, lower CD4+ cell count, and higher risk of treatment failure.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)
