期刊
INTERNATIONAL JOURNAL FOR PARASITOLOGY
卷 47, 期 10-11, 页码 597-600出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2017.04.001
关键词
Toxoplasma gondii; Coccidia; Merozoite; TgGRA11B; Dense granule; Parasitophorous vacuole
类别
资金
- National Institutes of Health EuPathDB Driving Biological Discoveries Scheme
- Swiss Government Excellence Postdoctoral Scholarship from the Swiss Confederation
The apicomplexan, Toxoplasma gondii, infects all warm-blooded animals as intermediate hosts but only felids as definitive hosts. Dense granule proteins are critical for the survival of Toxoplasma within host cells but, whilst these proteins have been studied intensively in tachyzoites, little is known about their expression in the coccidian stages in the cat intestine. Transcriptomic profiling indicates that two putative dense granule proteins, TgGRA11A and TgGRA11B, are expressed uniquely in merozoites. Immunofluorescent microscopy of Toxoplasma-infected cat intestine and tachyzoites engineered to express TgGRA11B, reveals that it is a dense granule protein that traffics into the parasitophorous vacuole and its membrane. (C) 2017 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.
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