Article
Urology & Nephrology
Cornelia Then, Christian Herder, Holger Then, Barbara Thorand, Cornelia Huth, Margit Heier, Christa Meisinger, Annette Peters, Wolfgang Koenig, Wolfgang Rathmann, Michael Roden, Michael Stumvoll, Haifa Maalmi, Thomas Meitinger, Andreas Lechner, Juergen Scherberich, Jochen Seissler
Summary: sUmod was inversely associated with biomarkers of subclinical inflammation in older participants of the KORA F4 study. The association of sUmod with IL-6 differed between women and men.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Microbiology
Haoyu Lang, Huijuan Duan, Jieni Wang, Wenhao Zhang, Jun Guo, Xue Zhang, Xiaosong Hu, Hao Zheng
Summary: This study explores the role of honeybee gut microbiota in the host's immune system and shows that certain bacterial species can protect honeybees from pathogen invasion. The analysis reveals that specific strains of Gilliamella and Lactobacillus induce immune responses and stimulate the production of antibacterial proteins. Comparative genomic analysis suggests that the unique surface-layer proteins of Lactobacillus strains play a crucial role in regulating the host's immune system.
MICROBIOLOGY SPECTRUM
(2022)
Review
Pharmacology & Pharmacy
Jacob McCright, Ann Ramirez, Mayowa Amosu, Arnav Sinha, Amanda Bogseth, Katharina Maisel
Summary: This article discusses strategies using nanomaterials to locally target the GI tract and its mucosal immune system to regulate inflammation and disease outcomes.
Article
Food Science & Technology
Kun-Ho Seo, Hyeon Gyu Lee, Ju Young Eor, Hye Jin Jeon, Wallace Yokoyama, Hyunsook Kim
Summary: The combination of postbiotic lactic bacteria cellular components and prebiotic wine grape seed flour can help improve gut microbiota imbalance and obesity caused by a high-fat diet. This combination has a significant impact on the composition of gut bacteria and adipocyte gene expression, which is beneficial for preventing obesity and obesity-related diseases.
FOOD RESEARCH INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Harpreet Kaur, Syed Azmal Ali
Summary: Probiotics play an important role in maintaining gut health and preventing diseases through their interaction and modulation of the gut immune system.
Article
Microbiology
Ji Youn Yoo, Sarah Sniffen, Kyle Craig McGill Percy, Veera Bramhachari Pallaval, Bojjibabu Chidipi
Summary: Atherosclerosis, a major cause of cardiovascular disease, can be influenced by alterations in the gut microbiota composition, leading to gut dysbiosis. This dysbiosis activates immune processes and systemic inflammation, contributing to the development of atherosclerotic cardiovascular disease (ACVD). The gut microbiota produces metabolites, such as trimethylamine (TMA) and short-chain fatty acids (SCFAs), that can either promote or decrease atherogenesis. Understanding the relationship between the gut microbiota and the host immune system could provide insights into ACVD development, prognostic factors, and potential treatments.
Review
Immunology
Po-Tsang Lee, Fernando Y. Yamamoto, Chen-Fei Low, Jiun-Yan Loh, Chou-Min Chong
Summary: The gastrointestinal immune system plays a crucial role in regulating the symbiotic host-microbiome interactions and maintaining immune homeostasis. Fish gastrointestinal immune system has specialized gut-associated lymphoid tissues that establish tolerance towards commensal gut microbiome while mounting immune responses against enteric pathogens. Understanding the intestinal immune system is essential for developing oral vaccines and immunostimulants in aquaculture.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Kang Tang, Jing Tang, Jinfeng Zeng, Wei Shen, Min Zou, Chi Zhang, Qianru Sun, Xiaoyan Ye, Chunwei Li, Caijun Sun, Siyang Liu, Guozhi Jiang, Xiangjun Du
Summary: The HUMPPI-2022 network provides insights into the network topology and functional characteristics of immune-related genes and virus-human interactions, shedding light on their roles in the human immune system and viral pathogenesis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Nutrition & Dietetics
Ravindra Pal Singh, Aditi Bhardwaj
Summary: The human gastrointestinal tract contains a complex and dynamic microbial community, which has a significant impact on host physiology under normal and disease conditions. Diet plays a major role in shaping the gut microbiota throughout life. Intestinal microbial communities are vital for maintaining immune and metabolic homeostasis and protecting against pathogens. Certain inflammatory diseases and infections have been linked to alterations in gut bacterial composition. Beta-glucans, a type of glucose polymer, have various structures and can modulate the immune system by binding to specific receptors on immune cells. How these properties affect molecular mechanisms and biological functions is still not well understood. This review provides a comprehensive understanding of the structures and functions of beta-glucans in modulating the gut microbiota and immune system.
FRONTIERS IN NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Javier Calleja-Conde, Victor Echeverry-Alzate, Kora-Mareen Buhler, Pedro Duran-Gonzalez, Jose Angel Morales-Garcia, Lucia Segovia-Rodriguez, Fernando Rodriguez de Fonseca, Elena Gine, Jose Antonio Lopez-Moreno
Summary: The human gut houses a diverse population of microorganisms called microbiota which play a key role in maintaining immune and metabolic homeostasis. Factors like diet and alcohol can influence the composition of gut bacteria, with alcohol consumption disrupting the intestinal barrier integrity and leading to a compromised mucosal immunity. This disruption allows bacteria to enter the blood tissue and affect organs like the liver and brain, contributing to the link between alcohol consumption, gut microbiota, and the immune system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Ruqaiyyah Siddiqui, Sutherland K. Maciver, Naveed Ahmed Khan
Summary: The gut microbiome of reptiles, along with their robust immune system, may contribute to their longevity and overall hardiness. Current research focuses on the composition of the reptilian gut microbiome, the interaction between the immune system and gut microbiome, antimicrobial peptides, reptilian resistance to infectious diseases and cancer. Preliminary studies have shown that reptiles possess gut flora with anticancer and antibacterial properties, as well as produce novel gut bacterial metabolites and antimicrobial peptides. Understanding the mechanisms between the gut microbiome and immune system may lead to the development of new therapies.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Microbiology
Jiayan Chen, Weijie Lv, Xueli Zhang, Tianyou Zhang, Jian Dong, Zhihui Wang, Tingting Liu, Peng Zhang, Michael Pyne, Guixin Dong, Shining Guo
Summary: This study creates the largest koala gut microbiota data set in China and explores the factors that may impact gut microbiota and the immune system in captive koalas, with a focus on the role of age. It is also the first study to investigate the correlation between gut microbiota and cytokines in koalas.
MICROBIOLOGY SPECTRUM
(2023)
Article
Environmental Sciences
Hong-Yun Zhang, Ya-Li Wang, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Lu Zhang, Hai-Feng Mi, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Lin Feng
Summary: The study discussed the effects of zearalenone on intestinal immune components, cytokines and molecular mechanisms of juvenile grass carp, pointing out that zearalenone inhibits immune components in the intestines and may increase the risk of mucosal exposure and associated diseases.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Immunology
Maria Botia-Sanchez, Georgina Galicia, Lorena Albaladejo-Marico, Daniel Toro-Dominguez, Maria Morell, Raquel Marcos-Fernandez, Abelardo Margolles, Marta E. Alarcon-Riquelme
Summary: Systemic lupus erythematosus is an autoimmune disease that can cause intestinal inflammation, leading to changes in the intestinal barrier and gut microbiota composition, which can in turn affect the interaction between the host immune system and gut microbiota.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Huan Zhang, Zhilin Zhang, Yiqun Liao, Wenjie Zhang, Dong Tang
Summary: The human gut microbiome plays a crucial role in human health, especially in the early development of host immunity. It is closely linked to the immune system and can influence the development of various diseases in infants and young children. The composition of the infant gut microbiome can predict disease risk and can be modulated to prevent and treat diseases. Maternal influences, including food delivery and feeding, have the most significant impact on the infant gut microbiota.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Yuki Maruyama, Yuichiro Nishimoto, Kouta Umezawa, Ryosuke Kawamata, Yuko Ichiba, Kota Tsutsumi, Mitsuo Kimura, Shinnosuke Murakami, Yasushi Kakizawa, Takashi Kumagai, Takuji Yamada, Shinji Fukuda
Summary: Saliva contains a wealth of biological information, but collecting saliva is time-consuming. This study found that mouth-rinsed water can be used as an alternative to saliva in oral metabolome analysis, as they have similar types and amounts of metabolites.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Aditi Jangid, Shinji Fukuda, Tamotsu Kato, Masahide Seki, Yutaka Suzuki, Todd D. Taylor, Hiroshi Ohno, Tulika Prakash
Summary: Fructooligosaccharides (FOS) are prebiotics with health-promoting properties. They modulate the gut microbial composition and influence the production of secretary Immunoglobulin A (SIgA). Certain bacterial species are involved in FOS metabolization and their abundance decreases over time.
Article
Oncology
Akimasa Kure, Tomoya Tsukimi, Chiharu Ishii, Wanping Aw, Nozomu Obana, Gaku Nakato, Akiyoshi Hirayama, Haruna Kawano, Toshiyuki China, Fumitaka Shimizu, Masayoshi Nagata, Shinji Isotani, Satoru Muto, Shigeo Horie, Shinji Fukuda
Summary: This study found that androgen deprivation therapy (ADT) leads to detrimental changes in gut microbiota in patients with prostate cancer, potentially increasing their frailty and risk of adverse outcomes.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Multidisciplinary Sciences
Aditi Jangid, Shinji Fukuda, Yutaka Suzuki, Todd D. Taylor, Hiroshi Ohno, Tulika Prakash
Summary: This study elucidated the effect of a grain-based diet on the gut microbiome of mice. The presence of soluble fiber in the grain-based diet led to a higher enrichment of probiotic Lactobacilli compared to a purified ingredients-based diet. The grain-based diet also enhanced energy-expensive cellular processes. In contrast, the purified ingredients-based diet showed a higher abundance of cellulolytic bacterial community and host-derived oligosaccharide metabolism functions.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Yuichiro Nishimoto, Yoshinori Mizuguchi, Yuka Mori, Masaki Ito, Shoko Miyazato, Yuka Kishimoto, Takuji Yamada, Shinji Fukuda
Summary: In recent years, there have been many reports on the effects of prebiotics on intestinal health. This study aimed to quantify the effects of resistant maltodextrin (RMD) on the intestine, particularly the intestinal microbiome and metabolome profiles. A randomized, double-blind, and controlled trial was conducted in 29 Japanese subjects with high hemoglobin A1c (HbA1c) levels. The results showed that the intake of RMD had beneficial effects on the gut environment, including modulation of commensal microbiota and reduction of virulence metabolites, which are known to be causative factors in metabolic disorders.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Hirotsugu Shiroma, Satoshi Shiba, Pande Putu Erawijantari, Hiroyuki Takamaru, Masayoshi Yamada, Taku Sakamoto, Yukihide Kanemitsu, Sayaka Mizutani, Tomoyoshi Soga, Yutaka Saito, Tatsuhiro Shibata, Shinji Fukuda, Shinichi Yachida, Takuji Yamada
Summary: This study investigated the influence of surgical CRC treatment on the gut microbiome and metabolites. The results showed that CRC-associated species, such as Fusobacterium nucleatum, decreased post-surgery, while carcinogenesis-associated deoxycholate (DCA) and its producing species and genes increased. Methods to estimate postoperative CRC risk based on the gut microbiome and metabolomic compositions were developed. The study is the first report on differences between pre- and post-surgery using metagenomics and metabolomics data analysis and may contribute to CRC risk assessment in postoperative patients.
Article
Nutrition & Dietetics
Yuka Goto, Yuichiro Nishimoto, Shinnosuke Murakami, Tatsuhiro Nomaguchi, Yuka Mori, Masaki Ito, Ryohei Nakaguro, Toru Kudo, Tsubasa Matsuoka, Takuji Yamada, Toshiki Kobayashi, Shinji Fukuda
Summary: This study aimed to investigate the relationship between the intestinal environment and glucose tolerance, and found that the consumption of barley has beneficial effects on glucose tolerance. The increase in specific metabolites and the increase in the abundance of certain gut bacteria were correlated with the improvement in glucose tolerance.
Article
Multidisciplinary Sciences
Yohko Yoshida, Ippei Shimizu, Atsuhiro Shimada, Keita Nakahara, Sachiko Yanagisawa, Minoru Kubo, Shinji Fukuda, Chiharu Ishii, Hiromitsu Yamamoto, Takamasa Ishikawa, Kuniyuki Kano, Junken Aoki, Goro Katsuumi, Masayoshi Suda, Kazuyuki Ozaki, Yutaka Yoshida, Shujiro Okuda, Shigeo Ohta, Shiki Okamoto, Yasuhiko Minokoshi, Kanako Oda, Toshikuni Sasaoka, Manabu Abe, Kenji Sakimura, Yoshiaki Kubota, Norihiko Yoshimura, Shingo Kajimura, Maria Zuriaga, Kenneth Walsh, Tomoyoshi Soga, Tohru Minamino
Summary: This study demonstrates that dysfunction of brown adipose tissue (BAT) is involved in the development of heart failure through choline metabolism disorientation. The research shows that BAT thermogenic capacity is reduced in mice with thoracic aortic constriction or myocardial infarction, leading to decreased body temperature. Moreover, hypoxia induces apoptosis of brown adipocytes. Enhancement of BAT function improves cardiac function, while genetic BAT dysfunction impairs systolic function.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Kyosuke Yakabe, Seiichiro Higashi, Masahiro Akiyama, Hiroshi Mori, Takumi Murakami, Atsushi Toyoda, Yuta Sugiyama, Shigenobu Kishino, Kenji Okano, Akiyoshi Hirayama, Aina Gotoh, Shunyi Li, Takeshi Mori, Takane Katayama, Jun Ogawa, Shinji Fukuda, Koji Hase, Yun-Gi Kim
Summary: A soy protein diet increases the mortality rate of antibiotic-treated, C. difficile-infected mice and enhances the levels of amino acids and abundance of Lactobacillus genus in the intestines. The fermentation of soy protein by Ligilactobacillus murinus generates amino acids that promote the growth of C. difficile, and this process involves the anchored cell wall proteinase PrtP. Thus, the interaction between dietary protein and the gut microbiota is a critical factor affecting host susceptibility to CDI, suggesting that dietary protein sources play an important role in controlling the disease.
Article
Health Care Sciences & Services
Katsuma Miyaho, Kenji Sanada, Shunya Kurokawa, Arisa Tanaka, Tomoyuki Tachibana, Chiharu Ishii, Yoshihiro Noda, Shinichiro Nakajima, Shinji Fukuda, Masaru Mimura, Taishiro Kishimoto, Akira Iwanami
Summary: This study aimed to investigate the impact of aging on the relationship among gut microbiota composition, gastrointestinal symptoms, and treatment course for MDD. The findings revealed that several gut microbes had higher relative abundances in the late-life group, along with higher diversity in the Chao1 index at baseline, compared to the middle-aged group. Additionally, possible microbial taxa related to GI symptoms in late-life depression were identified.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Pathology
Lauren Shuman, Jonathan Pham, Thomas Wildermuth, Xue-Ru Wu, Vonn Walter, Joshua I. Warrick, David J. DeGraffy
Summary: Although noninvasive bladder cancers have high recurrence rates, early-stage disease is not well-studied and there is a lack of models to validate the contribution of molecular drivers of bladder tumorigenesis. In this study, a Pik3ca1047R mouse model was generated to understand the role of PIK3CA mutations in bladder tumorigenesis. It was found that Pik3ca1047R can elicit early tumorigenic changes in the urothelium, but progression to invasion may require additional genetic alterations.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yuxin Wang, Tatsuya Morishima, Maiko Sezaki, Ryo Sato, Gaku Nakato, Shinji Fukuda, Kouji Kobiyama, Ken J. Ishii, Yuhua Li, Hitoshi Takizawa
Summary: Bacterial infections can activate hematopoietic stem and progenitor cells to migrate from the bone marrow to the spleen, a process known as extramedullary hematopoiesis. Recent studies have shown that gut commensal bacteria not only regulate the host immune system, but also hematopoietic homeostasis. This study reveals that Akkermansia muciniphila, a mucin-degrading bacterium, can rapidly activate bone marrow myelopoiesis and induce delayed extramedullary hematopoiesis through the MYD88/TRIF innate immune signaling pathway.
Article
Microbiology
Kota Oshibuchi, Jiayue Yang, Nozomu Obana, Shinji Fukuda, Kazuharu Arakawa
Summary: In this study, the complete genome sequence of Solobacterium moorei JCM 10645(T), a Gram-positive bacterium associated with sepsis, bacteremia, halitosis, and periodontal disease, was reported.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)
Article
Gastroenterology & Hepatology
Yoshimi Yukawa-Muto, Tomonori Kamiya, Hideki Fujii, Hiroshi Mori, Atsushi Toyoda, Ikuya Sato, Yusuke Konishi, Akiyoshi Hirayama, Eiji Hara, Shinji Fukuda, Norifumi Kawada, Naoko Ohtani
Summary: This study identified specific gut bacterial species abundant in patients with HE and verified their functions linked to HE pathophysiology. Targeting these bacteria could be a potentially effective strategy to treat HE.
HEPATOLOGY COMMUNICATIONS
(2022)
Article
Biotechnology & Applied Microbiology
Yongshou Yang, Thanutchaporn Kumrungsee, Norihisa Kato, Shinji Fukuda, Manabu Kuroda, Shotaro Yamaguchi
Summary: This study investigates the effects of Aspergillus-derived cellulase on the gut microbiota of rats fed a high-fat diet. The results demonstrate that cellulase can significantly increase the abundance of Bifidobacterium and Lactobacillus, showing prebiotic-like effects.
FERMENTATION-BASEL
(2022)