Article
Immunology
Sophie Strasser, Christa Relly, Christoph Berger, Johannes Truck
Summary: A retrospective analysis found that a substantial proportion of children with severe bacterial infections (SBIs) had immune function impairments. Routine immunological testing can help identify these abnormalities and optimize preventive measures to avoid future SBI episodes.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Celine Aerts, Shannon Leahy, Humberto Mucasse, Sanjay Lala, Justina Bramugy, Cally J. Tann, Shabir A. Madhi, Azucena Bardaji, Quique Bassat, Ziyaad Dangor, Joy E. Lawn, Mark Jit, Simon R. Procter
Summary: This study investigated the acute costs of neonatal sepsis and meningitis in sub-Saharan Africa and found significant expenses associated with these conditions. The findings will contribute to the economic evaluations of interventions aiming to prevent neonatal invasive bacterial infections.
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Microbiology
Anna Furuta, Alyssa Brokaw, Gygeria Manuel, Matthew Dacanay, Lauren Marcell, Ravin Seepersaud, Lakshmi Rajagopal, Kristina Adams Waldorf
Summary: Group B streptococci (GBS) are bacteria that can cause serious infections in newborns, leading to significant neurodevelopmental injury and disability.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Louisa Nitsch, Stefan Felix Ehrentraut, Marcus Grobe-Einsler, Felix J. Bode, Mohammed Banat, Matthias Schneider, Felix Lehmann, Julian Zimmermann, Johannes Weller
Summary: Community-acquired bacterial meningitis is a serious disease that can lead to severe complications and death. This study investigated the diagnostic performance of cerebrospinal fluid (CSF) parameters for sepsis in patients with community-acquired bacterial meningitis.
Review
Pediatrics
Maite Van Hentenryck, Alan R. Schroeder, Russell J. McCulloh, Christopher D. Stave, Marie E. Wang
Summary: There is currently a lack of rigorous clinical trial data to determine the optimal duration of parenteral antibiotic therapy for bacterial meningitis in young infants. High-quality comparative effectiveness research is urgently needed to further study this question.
Article
Infectious Diseases
Tuula Pelkonen, Suvi Urtti, Ondina Cardoso, Moe H. Kyaw, Irmeli Roine, Heikki Peltola
Summary: This study aimed to identify risk factors for death among young infants with possible serious bacterial infection at hospital admission and found that tachycardia and seizures were independent predictors of death.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Jane E. Brumbaugh, Edward F. Bell, Barbara T. Do, Rachel G. Greenberg, Barbara J. Stoll, Sara B. DeMauro, Heidi M. Harmon, Susan R. Hintz, Abhik Das, Karen M. Puopolo
Summary: This study aimed to report the incidence of late-onset meningitis (LOM) during birth hospitalization and the neurodevelopmental outcomes at 18 to 26 months' corrected age in children born extremely preterm. The results showed a decreasing incidence of LOM, and both LOM and late-onset sepsis (LOS) were associated with an increased risk of death or neurodevelopmental impairment (NDI), with varying risk depending on the LOM pathogen.
Article
Emergency Medicine
Emanuele Castagno, Sonia Aguzzi, Lorenza Rossi, Rachele Gallo, Andrea Carpino, Fulvio Ricceri, Antonio F. Urbino, Claudia Bondone
Summary: The study aimed to determine the prognostic value of clinical features and biomarkers in children with sepsis and bacterial meningitis in the emergency department. The results showed that age older than 12 months, capillary refill time greater than 3 seconds, and oxygen blood saturation lower than 90% were significantly associated with unfavorable outcomes. Furthermore, procalcitonin was an accurate and early prognostic biomarker that could guide the identification of high-risk children.
PEDIATRIC EMERGENCY CARE
(2023)
Article
Immunology
Edward W. Green, Malick Ndiaye, Ilias M. Hossain, Yekini A. Olatunji, Shah M. Sahito, Rasheed Salaudeen, Henry Badji, Ahmed Manjang, Lamin Ceesay, Philip C. Hill, Brian Greenwood, Grant A. Mackenzie
Summary: This article highlights the incidence, outcome, and burden of pneumonia, sepsis, and meningitis in older children and adults in rural Gambia. The diseases are responsible for significant morbidity and mortality, with many deaths occurring after hospital discharge and most cases being culture negative. Improvements in prevention, diagnosis, inpatient, and follow-up management are urgently needed.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Lene Fogt Lundbo, Zitta Barrella Harboe, Hakon Sandholdt, Lars Smith-Hansen, Palle Valentiner-Branth, Steen Hoffmann, Thomas Benfield
Summary: A Danish case-control study found that certain comorbidities increased the risk of invasive meningococcal disease ranging from 2- to 40-fold. These comorbidities included renal disease, immunological disorders, liver disease, cancer, and solid organ transplantation. Vaccination and appropriate medical care may be necessary for these populations with increased risk.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Chung Pham Van, The Trong Nguyen, Sy Tien Bui, Trong Van Nguyen, Huyen Thi Thanh Tran, Dong Trac Pham, Long Phi Trieu, Manh Dang Nguyen
Summary: This study described the prevalence, clinical features, and treatment outcomes of IMD among young soldiers of the Vietnam People's Army, and identified ceftriaxone resistance in Neisseria meningitidis. New recruits were found to be at higher risk of IMD, with prognostic factors for severity including petechial rash, septicemia, and meningococcemia.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Immunology
Ying Luo, Ying Xue, Qun Lin, Liyan Mao, Guoxing Tang, Huijuan Song, Wei Liu, Shiji Wu, Weiyong Liu, Yu Zhou, Lingqing Xu, Zhigang Xiong, Ting Wang, Xu Yuan, Yong Gan, Ziyong Sun, Feng Wang
Summary: The study established a diagnostic model based on a combination of CSF chlorine, CSF nucleated cell count, CSF lymphocyte proportion, and the tuberculosis-specific antigen/phytohemagglutinin (TBAg/PHA) ratio, which showed excellent utility in discriminating between TBM and BM, with high sensitivity and specificity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Infectious Diseases
Rami H. Jaber, Nathan P. Beahm
Summary: This review evaluated the clinical evidence for the use of daptomycin in acute bacterial meningitis in both pediatric and adult patients. The results suggest that daptomycin could be a safe and effective alternative for the treatment of meningitis caused by Gram-positive bacteria. However, further research is needed to establish the optimal dosing regimen, duration of therapy, and place in therapy for the management of meningitis.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Medicine, General & Internal
Virginia Pomar, Natividad Benito, Pol Duch, Marc Colome, Alba Rivera, Pere Domingo
Summary: A long-term observational study of adult BM patients in Barcelona has found that in recent years, patients without underlying conditions who develop BM are older and more likely to have pneumococcal or listerial infections and systemic complications, although the in-hospital mortality has decreased compared to the first period.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Clinical Neurology
Tatiana Barichello, Carlos Henrique Rocha Catalao, Ursula K. Rohlwink, Martijn van der Kuip, Dan Zaharie, Regan S. Solomons, Ronald van Toorn, Marceline Tutu van Furth, Rodrigo Hasbun, Federico Iovino, Vivian Ssonko Namale
Summary: Bacterial meningitis varies globally in terms of incidence, case fatality rates, and etiological agents. Africa has the highest prevalence of bacterial meningitis, particularly in the meningitis belt of sub-Saharan Africa. Streptococcus pneumoniae and Neisseria meningitidis are the main pathogens in adults and children over one year old, while Streptococcus agalactiae, Escherichia coli, and Staphylococcus aureus are common in neonatal meningitis.
FRONTIERS IN NEUROLOGY
(2023)
Article
Obstetrics & Gynecology
Y. Iwasaki, H. Ohbe, D. Shigemi, K. Fushimi, H. Yasunaga
Summary: This study aimed to investigate the effect of antithrombin III (ATIII) for disseminated intravascular coagulation (DIC) in obstetrics using a national inpatient database in Japan. The study found that ATIII may have a beneficial effect in reducing the rate of hysterectomy in obstetric patients with DIC.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Infectious Diseases
Yoshifumi Morita, Makoto Kurano, Daisuke Jubishi, Mahoko Ikeda, Koh Okamoto, Masami Tanaka, Sohei Harada, Shu Okugawa, Kyoji Moriya, Yutaka Yatomi
Summary: This study compared urine sediment findings between COVID-19 patients and non-COVID-19 patients with acute renal injuries, and found that certain urine sediment particles and biochemical markers were associated with the severity of COVID-19.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Microbiology
Hiroaki Baba, Hajime Kanamori, Issei Seike, Ikumi Niitsuma-Sugaya, Kentaro Takei, Kengo Oshima, Yudai Iwasaki, Yuko Ogata, Hirona Nishimaki, Daisuke Konno, Takuya Shiga, Koji Saito, Koichi Tokuda, Tetsuji Aoyagi
Summary: Patients with severe COVID-19 are at high risk for secondary infection with multidrug-resistant organisms, which contribute to a more severe clinical course and longer ICU stays. This case highlights the challenges of preventing, diagnosing, and treating multidrug-resistant organisms and healthcare-associated infections in the critical care management of severe COVID-19.
Editorial Material
Dentistry, Oral Surgery & Medicine
Kazuto Hoshi, Tetsuro Ikebe, Yoshihide Ota, Hiromitsu Kishimoto, Takeshi Kurata, Hiroshi Kurita, Kentaro Sakamaki, Toshihiko Takenobu, Sohei Harada, Toru Ogasawara, Kanchu Tei, Tadaaki Kirita
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY
(2022)
Article
Surgery
Takaki Hirano, Yudai Iwasaki, Yuko Ono, Tokiya Ishida, Kazuaki Shinohara
Summary: The incidence and timing of delayed formation of splenic pseudoaneurysm (SPA) after blunt splenic injury in patients treated with nonoperative management (NOM) were investigated in this study. Among 49 patients treated with NOM, 10.2% had delayed formation of SPA, all occurring within 15 days of injury. The incidence of SPA formation was not significantly different between patients who received transcatheter arterial embolization (TAE) and those who did not.
ANNALS OF VASCULAR SURGERY
(2023)
Article
Critical Care Medicine
Neha Gupta, Lisa Settle, Brent R. Brown, Donna L. Armaignac, Michael Baram, Nicholas E. Perkins, Margit Kaufman, Roman R. Melamed, Amy B. Christie, Valerie C. Danesh, Joshua L. Denson, Sreekanth R. Cheruku, Karen Boman, Vikas Bansal, Vishakha K. Kumar, Allan J. Walkey, Juan P. Domecq, Rahul Kashyap, Christopher E. Aston
Summary: In hospitalized COVID-19 patients, prior use of a combination of renin-angiotensin-aldosterone system inhibitors (RAASIs) was associated with higher in-hospital mortality compared to the use of RAASIs alone. Compared to ARBs, ACEIs were associated with significantly higher mortality in hospitalized COVID-19 patients.
CRITICAL CARE MEDICINE
(2022)
Article
Microbiology
Kosuke Hoashi, Brian Hayama, Masahiro Suzuki, Aki Sakurai, Kazumi Takehana, Taisuke Enokida, Koichi Takeda, Daisuke Ohkushi, Yohei Doi, Sohei Harada
Summary: Piperacillin-tazobactam may be an effective option for treating ESBL-producing Escherichia coli bacteremia in areas with low frequency of OXA-1 co-production.
MICROBIOLOGY SPECTRUM
(2022)
Article
Critical Care Medicine
Sadatomo Tasaka, Shinichiro Ohshimo, Muneyuki Takeuchi, Hideto Yasuda, Kazuya Ichikado, Kenji Tsushima, Moritoki Egi, Satoru Hashimoto, Nobuaki Shime, Osamu Saito, Shotaro Matsumoto, Eishu Nango, Yohei Okada, Kenichiro Hayashi, Masaaki Sakuraya, Mikio Nakajima, Satoshi Okamori, Shinya Miura, Tatsuma Fukuda, Tadashi Ishihara, Tetsuro Kamo, Tomoaki Yatabe, Yasuhiro Norisue, Yoshitaka Aoki, Yusuke Iizuka, Yutaka Kondo, Chihiro Narita, Daisuke Kawakami, Hiromu Okano, Jun Takeshita, Keisuke Anan, Satoru Robert Okazaki, Shunsuke Taito, Takuya Hayashi, Takuya Mayumi, Takero Terayama, Yoshifumi Kubota, Yoshinobu Abe, Yudai Iwasaki, Yuki Kishihara, Jun Kataoka, Tetsuro Nishimura, Hiroshi Yonekura, Koichi Ando, Takuo Yoshida, Tomoyuki Masuyama, Masamitsu Sanui
Summary: This study summarizes the recommendations for the clinical practice of ARDS in adults and children, providing specific guidelines on diagnosis, treatment, and management.
JOURNAL OF INTENSIVE CARE
(2022)
Article
Respiratory System
Sadatomo Tasaka, Shinichiro Ohshimo, Muneyuki Takeuchi, Hideto Yasuda, Kazuya Ichikado, Kenji Tsushima, Moritoki Egi, Satoru Hashimoto, Nobuaki Shime, Osamu Saito, Shotaro Matsumoto, Eishu Nango, Yohei Okada, Kenichiro Hayashi, Masaaki Sakuraya, Mikio Nakajima, Satoshi Okamori, Shinya Miura, Tatsuma Fukuda, Tadashi Ishihara, Tetsuro Kamo, Tomoaki Yatabe, Yasuhiro Norisue, Yoshitaka Aoki, Yusuke Iizuka, Yutaka Kondo, Chihiro Narita, Daisuke Kawakami, Hiromu Okano, Jun Takeshita, Keisuke Anan, Satoru Robert Okazaki, Shunsuke Taito, Takuya Hayashi, Takuya Mayumi, Takero Terayama, Yoshifumi Kubota, Yoshinobu Abe, Yudai Iwasaki, Yuki Kishihara, Jun Kataoka, Tetsuro Nishimura, Hiroshi Yonekura, Koichi Ando, Takuo Yoshida, Tomoyuki Masuyama, Masamitsu Sanui
Summary: This study translated the 2021 ARDS Clinical Practice Guideline and provided recommendations for different clinical questions for adults and children.
RESPIRATORY INVESTIGATION
(2022)
Article
Endocrinology & Metabolism
Yudai Iwasaki, Yusuke Sasabuchi, Sho Horikita, Taku Furukawa, Junji Shiotsuka, Alan Kawarai Lefor, Masamitsu Sanui
Summary: This study found a significant association between the use of sodium-glucose cotransporter 2 inhibitors and the incidence of metabolic acidosis with euglycemia. Patients receiving these inhibitors should be closely monitored for the development of euglycemic diabetic ketoacidosis, especially those scheduled for invasive surgical procedures.
BMC ENDOCRINE DISORDERS
(2022)
Article
Microbiology
Yuki Ohama, Yusuke Nomura, Miyuki Mizoguchi, Yoshimi Higurashi, Koh Okamoto, Sohei Harada
Summary: Recent use of bacterial whole-genome sequencing has led to the discovery of new bacterial species and reclassification of taxonomy. Accurate identification methods for bacterial species in clinical microbiology laboratories are limited. This study found that matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry can accurately identify Klebsiella variicola. Accurate identification will help in studying the clinical characteristics of K. variicola.
MICROBIOLOGY SPECTRUM
(2022)
Article
Infectious Diseases
Ryo Yamaguchi, Takehito Yamamoto, Koh Okamoto, Sohei Harada, Miho Echizenya, Takeya Tsutsumi, Tappei Takada
Summary: This study assessed the effectiveness and safety of teicoplanin compared with vancomycin for treating glycopeptide-susceptible Enterococcus faecium (GSEF) bacteraemia. The results showed that teicoplanin is non-inferior to vancomycin in treating GSEF bacteraemia and significantly reduces the risk of acute kidney injury.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Medicine, General & Internal
Yudai Iwasaki, Yusuke Takei, Mitsuhiro Yamada, Shigekazu Sugino, Koji Saito, Tetsuji Aoyagi, Kengo Oshima, Hajime Kanamori, Hiroaki Baba, Kentarou Takei, Koichi Tokuda, Eichi N. Kodama, Tetsuro Kamo, Tadashi Kamio, Takehiko Kasai, Satoru Ogawa, Masanori Yamauchi
Summary: This study aimed to evaluate the association between COVID-19 coagulopathy and extracellular vesicle (EV) levels. No significant difference was found in EV levels between COVID-19 coagulopathy patients and non-coagulopathy patients. However, CD41+ EV levels were significantly higher in COVID-19 coagulopathy patients and might play an essential role in the development of COVID-19 coagulopathy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Critical Care Medicine
Takaki Hirano, Mikio Nakajima, Hiroyuki Ohbe, Richard H. Kaszynski, Yudai Iwasaki, Yuki Arakawa, Yusuke Sasabuchi, Kiyohide Fushimi, Hiroki Matsui, Hideo Yasunaga
Summary: The aim of this study was to examine the effectiveness of corticosteroids in OHCA patients administered ECPR. The results of propensity score matching analysis showed that corticosteroid administration was associated with increased in-hospital mortality in OHCA patients receiving ECPR.
RESUSCITATION PLUS
(2022)
Article
Critical Care Medicine
Gianluigi Li Bassi, Kristen Gibbons, Jacky Y. Suen, Heidi J. Dalton, Nicole White, Amanda Corley, Sally Shrapnel, Samuel Hinton, Simon Forsyth, John G. Laffey, Eddy Fan, Jonathon P. Fanning, Mauro Panigada, Robert Bartlett, Daniel Brodie, Aidan Burrell, Davide Chiumello, Alyaa Elhazmi, Mariano Esperatti, Giacomo Grasselli, Carol Hodgson, Shingo Ichiba, Carlos Luna, Eva Marwali, Laura Merson, Srinivas Murthy, Alistair Nichol, Mark Ogino, Paolo Pelosi, Antoni Torres, Pauline Yeung Ng, John F. Fraser
