Article
Medicine, General & Internal
Yimei Ding, Luan Xue
Summary: This study compared the clinical manifestations, imaging features, and laboratory inspection between HLA-B27 negative and HLA-B27 positive patients with Reactive arthritis (ReA). It found no significant difference in imaging features or laboratory inspection between the two groups, but there was a difference in the joints involved.
Article
Medicine, General & Internal
Tsutomu Takeda, Daisuke Asaoka, Sakiko Ogiya, Ken Akashi, Daiki Abe, Maiko Suzuki, Yoichi Akazawa, Kumiko Ueda, Hiroya Ueyama, Tomoyoshi Shibuya, Taro Osada, Mariko Hojo, Shu Hirai, Rie Ueki, Akihito Nagahara
Summary: We present a rare case of Yersinia enterocolitica enteritis with initial symptoms of fever and abdominal pain followed by erythema nodosum. The diagnosis was confirmed through colonoscopy, computed tomography, pathology, and mucosal culture. Yersinia enteritis can be cured with proper diagnosis and treatment. Erythema nodosum, although uncommon, should still be considered as a possible differential diagnosis.
Article
Multidisciplinary Sciences
Xinbo Yang, Lee I. I. Garner, Ivan V. V. Zvyagin, Michael A. A. Paley, Ekaterina A. A. Komech, Kevin M. M. Jude, Xiang Zhao, Ricardo A. A. Fernandes, Lynn M. M. Hassman, Grace L. L. Paley, Christina S. S. Savvides, Simon Brackenridge, Max N. N. Quastel, M. M. Chudakov, Paul Bowness, Wayne M. M. Yokoyama, Andrew J. J. McMichael, Geraldine M. M. Gillespie, K. Christopher Garcia
Summary: The human leucocyte antigen B*27 (HLA-B*27) is strongly associated with inflammatory diseases of the spine and pelvis and the eye. The mechanism by which HLA-B*27 facilitates disease remains unknown, but it may involve the presentation of pathogenic peptides to CD8(+) T cells. In this study, orphan T cell receptors (TCRs) expressing a disease-associated public beta-chain variable region-complementary-determining region 3 beta (BV9-CDR3 beta) motif were isolated from blood and synovial fluid T cells from individuals with ankylosing spondylitis (AS) and from the eye in individuals with acute anterior uveitis (AAU). These TCRs showed consistent alpha-chain variable region (AV21) chain pairing and were clonally expanded in the joint and eye. Using peptide libraries, self-peptides and microbial peptides that activated the AS- and AAU-derived TCRs were identified. Structural analysis revealed that TCR cross-reactivity for peptide-MHC was rooted in a shared binding motif present in both self-antigens and microbial antigens that engages the BV9-CDR3 beta TCRs. These findings suggest that both microbial antigens and self-antigens could play a pathogenic role in HLA-B*27-associated disease.
Article
Biochemistry & Molecular Biology
Marta Nieckarz, Karolina Jaworska, Adrianna Raczkowska, Katarzyna Brzostek
Summary: This study investigates the role of the transcriptional regulator OmpR in membrane protein expression and secretion in Yersinia enterocolitica. The findings show that OmpR negatively affects the levels of Ysc-Yop proteins, particularly YopD, and represses the expression of yopD. OmpR also has a positive role in the expression of the master regulator of the flagellar-associated T3SS, flhDC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Douglas A. Jabs, Nisha R. Acharya, Soon-Phaik Chee, Debra Goldstein, Peter McCluskey, Philip Murray, Neal Oden, Alan G. Palestine, James T. Rosenbaum, Jennifer E. Thorne, Brett E. Trusko
Summary: This study aimed to establish classification criteria for spondyloarthritis/HLA-B27-associated anterior uveitis using machine learning, achieving high accuracy in both training and validation sets. Key criteria for this condition were identified, with a low misclassification rate, indicating their potential utility in clinical and translational research.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Rohit Parthasarathy, Fernando Santiago, Peter McCluskey, Nadeem O. Kaakoush, Nicodemus Tedla, Denis Wake
Summary: Though the pathogenesis of HLA-B27-associated diseases such as AAU and AS is not well understood, evidence suggests a link to Gram-negative bacteria and subclinical bowel inflammation. The existing literature lacks adequate studies on causation and the role of viruses and fungi, and the unique disease model of AAU to study the gut microbiota has been neglected.
TRENDS IN MICROBIOLOGY
(2023)
Review
Medicine, General & Internal
Shi Huan Tay, Joo Guan Yeo, Jing Yao Leong, Salvatore Albani, Thaschawee Arkachaisri
Summary: Juvenile spondyloarthritis (JSpA) is a diverse spectrum of immune-mediated inflammatory arthritides that typically onset in late childhood and adolescence. It is characterized by a strong association with HLA-B27, enthesitis, and bone resorption.
FRONTIERS IN MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Bruna Torres Furtado Martins, Everton Cruz de Azevedo, Ricardo Seiti Yamatogi, Douglas Ruben Call, Luis Augusto Nero
Summary: The study identified the persistence of a clonal Yersinia enterocolitica bio-serotype 4/O:3 in a particular pork production chain in Brazil, with isolates carrying various virulence genes and multidrug resistance related genes.
Article
Biochemistry & Molecular Biology
Amit Kumar, Shruti Ahlawat, Hari Mohan, Krishna Kant Sharma
Summary: Laccases are polyphenol multicopper oxidases known for their structural and functional diversity in various life forms. The study compared the molecular and physico-chemical properties of fungal laccase isoforms from Ganoderma lucidum with recombinant bacterial laccases from Yersinia enterocolitica strains. Results showed differences in the conserved residues and stability of FLIs compared to rLac under different conditions. These findings provide insights into the evolution of catalytic efficiency and redox properties of FLIs.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Jens A. Hammerl, Andrea Barac, Philipp Erben, Julius Fuhrmann, Ashish Gadicherla, Franziska Kumsteller, Anne Lauckner, Felix Mueller, Stefan Hertwig
Summary: Researchers isolated and characterized two phages from game animals, which showed a broad host range and effectively lysed various serotypes of Yersinia enterocolitica. These phages also demonstrated lytic activity against different strains of Yersinia pseudotuberculosis under specific conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Tejpal Gill, James T. Rosenbaum
Summary: Spondyloarthritis (SpA) is a group of immune mediated inflammatory diseases strongly associated with the MHC class I molecule, HLA-B27. Although various hypotheses have been proposed to explain the HLA-B27 and disease association, the exact mechanisms underlying disease pathogenesis remain unclear. Evidence suggests that diseases related to HLA-B27 may have a microbial pathogenesis, and the influence of microbes on disease development is significant.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Denis Wakefield, Daniel Clarke, Peter McCluskey
Summary: Over the past 5 years, there has been steady progress in understanding the pathogenesis, clinical features, and treatment of acute anterior uveitis (AU). Large gene wide association studies have confirmed AU as a polygenic disease with overlaps with other conditions. Recent research has shown the importance of the microbiome in AU, with evidence suggesting that HLA B27 may influence gut microbiome composition. Clinical investigations have confirmed the typical features of AU and the value of immunosuppressive treatments.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Philip A. Karlsson, Eva Tano, Cecilia Jernberg, Rachel A. Hickman, Lionel Guy, Josef D. Jarhult, Helen Wang
Summary: The study reveals that the Y. enterocolitica outbreak strains in Sweden possess multi-antibiotic and metal-resistance genes acquired through horizontal gene transfer. Additionally, the bacteria were found to carry Tn2670 and Pasteurellaceae plasmids. These findings suggest a potential reservoir of intraspecies dissemination of multidrug-resistance genes among foodborne pathogens.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jens Andre Hammerl, Sabrin El-Mustapha, Michelle Boelcke, Hannah Trampert, Andrea Barac, Claudia Jaeckel, Ashish K. Gadicherla, Stefan Hertwig
Summary: The study identified three groups of temperate phages in pathogenic Y. enterocolitica strains, each with different lytic activity against different strains.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Aleksandra Platt-Samoraj, Klaudia Konczyk-Kmiecik, Tadeusz Bakula
Summary: The study found a high prevalence of Y. enterocolitica among commensal rodents, with all isolates classified as biotype 1A and sporadic isolation of Y. pseudotuberculosis, indicating no high epidemiological risk.
