Exploiting the yeast stress-activated signaling network to inform on stress biology and disease signaling

Regulation of rDNA transcription in response to growth factors, nutrients and energy

(2015) Eric P. Kusnadi et al.   GENE

Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA

(2015) Nicolas Léveillé et al.   Nature Communications

Pathway connectivity and signaling coordination in the yeast stress-activated signaling network

(2014) D. Chasman et al.   Molecular Systems Biology

COSMIC: exploring the world's knowledge of somatic mutations in human cancer

(2014) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

The BioGRID interaction database: 2015 update

(2014) Andrew Chatr-aryamontri et al.   NUCLEIC ACIDS RESEARCH

p53 suppresses carcinoma progression by inhibiting mTOR pathway activation

(2014) N Akeno et al.   ONCOGENE

Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway

(2014) Matthias Drosten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging

(2013) Valentina Gambino et al.   AGING CELL

Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1

(2013) Chuan Wu et al.   NATURE

Stress-induced changes in gene interactions in human cells

(2013) Renuka R. Nayak et al.   NUCLEIC ACIDS RESEARCH

Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program

(2013) C Chauvin et al.   ONCOGENE

Hog1 Controls Global Reallocation of RNA Pol II upon Osmotic Shock in Saccharomyces cerevisiae

(2013) Kristen E. Cook et al.   G3-Genes Genomes Genetics

Characterization of the p53 Cistrome – DNA Binding Cooperativity Dissects p53's Tumor Suppressor Functions

(2013) Katharina Schlereth et al.   PLoS Genetics

Translational reprogramming in cellular stress response

(2013) Botao Liu et al.   Wiley Interdisciplinary Reviews-RNA

mTORC1 and p53

(2012) Paul Hasty et al.   CELL CYCLE

Insights into p53 transcriptional function via genome-wide chromatin occupancy and gene expression analysis

(2012) F Nikulenkov et al.   CELL DEATH AND DIFFERENTIATION

Response to Hyperosmotic Stress

(2012) H. Saito et al.   GENETICS

Nutritional Control of Growth and Development in Yeast

(2012) J. R. Broach   GENETICS

Linking the signaling cascades and dynamic regulatory networks controlling stress responses

(2012) A. Gitter et al.   GENOME RESEARCH

Bet Hedging in Yeast by Heterogeneous, Age-Correlated Expression of a Stress Protectant

(2012) Sasha F. Levy et al.   PLOS BIOLOGY

Checkpoints in a Yeast Differentiation Pathway Coordinate Signaling during Hyperosmotic Stress

(2012) Michal J. Nagiec et al.   PLoS Genetics

Hog1 bypasses stress-mediated down-regulation of transcription by RNA polymerase II redistribution and chromatin remodeling

(2012) Mariona Nadal-Ribelles et al.   GENOME BIOLOGY

Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

(2011) Brian Magnuson et al.   BIOCHEMICAL JOURNAL

The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth, and chemosensitivity under hypoxic conditions

(2011) Elizabeth M. Matthew et al.   CELL CYCLE

Sch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L

(2011) Alexandre Huber et al.   EMBO JOURNAL

Signaling to the ribosome in cancer-It is more than just mTORC1

(2011) Katherine M. Hannan et al.   IUBMB LIFE

Genome-wide analysis of yeast stress survival and tolerance acquisition to analyze the central trade-off between growth rate and cellular robustness

(2011) Anna Zakrzewska et al.   MOLECULAR BIOLOGY OF THE CELL

Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1

(2011) Min Zheng et al.   NATURE CELL BIOLOGY

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

(2011) Michelle C. Mendoza et al.   TRENDS IN BIOCHEMICAL SCIENCES

Multiple Means to the Same End: The Genetic Basis of Acquired Stress Resistance in Yeast

(2011) David B. Berry et al.   PLoS Genetics

A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response

(2010) Maite Huarte et al.   CELL

Antagonistic Interactions Between the cAMP-Dependent Protein Kinase and Tor Signaling Pathways Modulate Cell Growth in Saccharomyces cerevisiae

(2010) V. Ramachandran et al.   GENETICS

The Rapamycin-sensitive Phosphoproteome Reveals That TOR Controls Protein Kinase A Toward Some But Not All Substrates

(2010) Alexandre Soulard et al.   MOLECULAR BIOLOGY OF THE CELL

Translational Regulation of Gene Expression during Conditions of Cell Stress

(2010) Keith A. Spriggs et al.   MOLECULAR CELL

TOR-dependent reduction in the expression level of Rrn3p lowers the activity of the yeast RNA Pol I machinery, but does not account for the strong inhibition of rRNA production

(2010) Anja Philippi et al.   NUCLEIC ACIDS RESEARCH

mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1

(2010) T. Kantidakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein

(2010) Zhaohui Feng et al.   TRENDS IN CELL BIOLOGY

Transcriptional Regulation by P53

(2010) R. Beckerman et al.   Cold Spring Harbor Perspectives in Biology

Coordination of Ribosomal Protein and Ribosomal RNA Gene Expression in Response to TOR Signaling

(2009) LiJuan Xiao et al.   CURRENT GENOMICS

Tumor suppressors and cell metabolism: a recipe for cancer growth

(2009) R. G. Jones et al.   GENES & DEVELOPMENT

Regulation of RNA Polymerase III Transcription InvolvesSCH9-dependent andSCH9-independent Branches of the Target of Rapamycin (TOR) Pathway

(2009) JaeHoon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Stress-activated Protein Kinase Hog1 Mediates S Phase Delay in Response to Osmostress

(2009) Gilad Yaakov et al.   MOLECULAR BIOLOGY OF THE CELL

Adaptive prediction of environmental changes by microorganisms

(2009) Amir Mitchell et al.   NATURE

Protein kinase A and TORC1 activate genes for ribosomal biogenesis by inactivating repressors encoded by Dot6 and its homolog Tod6

(2009) S. I. Lippman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A quantitative estimation of the global translational activity in logarithmically growing yeast cells

(2008) Tobias von der Haar   BMC Systems Biology

New paradigms for the function of JNKK1/MKK4 in controlling growth of disseminated cancer cells

(2008) Jennifer L. Taylor et al.   CANCER LETTERS

Stress-activated Genomic Expression Changes Serve a Preparative Role for Impending Stress in Yeast

(2008) David B. Berry et al.   MOLECULAR BIOLOGY OF THE CELL

Slow Growth Induces Heat-Shock Resistance in Normal and Respiratory-deficient Yeast

(2008) Charles Lu et al.   MOLECULAR BIOLOGY OF THE CELL

Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation

(2008) Luis López-Maury et al.   NATURE REVIEWS GENETICS

Stress resistance and signal fidelity independent of nuclear MAPK function

(2008) P. J. Westfall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coordination of Growth Rate, Cell Cycle, Stress Response, and Metabolic Activity in Yeast

(2007) Matthew J. Brauer et al.   MOLECULAR BIOLOGY OF THE CELL