Article
Engineering, Biomedical
Sahil Inamdar, Tina Tylek, Abhirami Thumsi, Abhirami P. Suresh, Madhan Mohan Chandra Sekhar Jaggarapu, Michelle Halim, Shivani Mantri, Arezoo Esrafili, Nathan D. Ng, Elizabeth Schmitzer, Kelly Lintecum, Camila de Avila, John D. Fryer, Ying Xu, Kara L. Spiller, Abhinav P. Acharya
Summary: In this study, microparticles based on polymerization of alpha-ketoglutarate were developed to modulate macrophage phenotype. These microparticles encapsulated and released spermine, which induced a complex and non-typical phenotypic profile in bone marrow-derived macrophages. The results suggest that spermine encapsulated microparticles have potential applications in inflammation-associated diseases.
Review
Chemistry, Multidisciplinary
Sisini Sasidharan, Daniel M. Davis, Iain E. Dunlop
Summary: Researchers are developing bioinspired materials for immunoengineering by utilizing the biophysical characteristics of the immune synapse and the immune cell surface. These materials include mechanically-controlled biomaterials, micro- and nanopatterned materials, and technologies for externally modulating biophysical variables. These bioinspired materials enhance the understanding of immunology, but there are challenges in translating them to clinical applications.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Mohsen Nami, Patrick Han, Douglas Hanlon, Kazuki Tatsuno, Brian Wei, Olga Sobolev, Mary Pitruzzello, Aaron Vassall, Shari Yosinski, Richard Edelson, Mark Reed
Summary: The ability to assess and monitor patient immune responses is crucial for clinical diagnostics, vaccine design, and understanding protective immunity against infectious diseases. However, there is a lack of low-cost and point-of-care tools for detecting T-cell immune responses in patients. This study developed a device for rapid and label-free detection of human T-cell immune responses, providing a platform for optimizing vaccine formulations and assessing T-cell immunity against various pathogens.
ADVANCED MATERIALS
(2022)
Review
Pharmacology & Pharmacy
Samin Abbaszadeh, Vahideh Nosrati-Siahmazgi, Kiyan Musaie, Saman Rezaei, Mostafa Qahremani, Bo Xiao, Helder A. Santos, Mohammad-Ali Shahbazi
Summary: Novel transplantation techniques are being developed to preserve the function of impaired tissues or organs. However, current technologies face challenges such as graft rejection by the immune system and the need for long-term immunosuppression. Thus, the development of biomaterial-based immunoengineering strategies has gained attention as a potential solution.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Chemistry, Physical
Kat M. Lazar, Shamitha Shetty, Ashutosh Chilkoti, Joel H. Collier
Summary: In recent years, there have been significant advances in the development of biomaterial therapeutics for the treatment and prevention of autoimmune and autoinflammatory diseases, thanks to a better understanding of their underlying mechanisms. Polymeric materials that are drug-free or immune-active have attracted attention due to their versatility, tunability, and potential as alternatives to conventional treatments. This review examines the relationships between polymer properties and immune processes and discusses their application in designing anti-inflammatory materials.
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE
(2023)
Review
Pharmacology & Pharmacy
Theodora Katopodi, Savvas Petanidis, Doxakis Anestakis, Charalampos Charalampidis, Ioanna Chatziprodromidou, George Floros, Panagiotis Eskitzis, Paul Zarogoulidis, Charilaos Koulouris, Christina Sevva, Konstantinos Papadopoulos, Marios Dagher, Nikolaos Varsamis, Vasiliki Theodorou, Chrysi Maria Mystakidou, Nikolaos Iason Katsios, Konstantinos Farmakis, Christoforos Kosmidis
Summary: CAR-T cell therapy has shown promising therapeutic effects in hematological metastasis, but faces challenges such as toxicities, limited tumor access, inadequate persistence, and manufacturing problems. The use of nanotechnology may enhance the efficacy of CAR-T cell treatment by facilitating CAR production, administration, and monitoring. This study highlights the drawbacks of CAR-T immunotherapy and explores the potential benefits of nanotechnology in improving various aspects of CAR-T cell treatment.
Article
Engineering, Biomedical
Joslyn L. Mangal, Sahil Inamdar, Tien Le, Xiaojian Shi, Marion Curtis, Haiwei Gu, Abhinav P. Acharya
Summary: Delivery of glycolytic inhibitor PFK15 using paKG MPs induces anti-inflammatory DCs, which can generate antigen-specific immune responses and be applicable for treating autoimmune diseases.
Article
Multidisciplinary Sciences
Morteza Aramesh, Diana Stoycheva, Ioana Sandu, Stephan J. Ihle, Tamara Zund, Jau-Ye Shiu, Csaba Forro, Mohammad Asghari, Margherita Bernero, Sebastian Lickert, Annette Oxenius, Viola Vogel, Enrico Klotzsch
Summary: Through promoting the formation of microvilli on nanoporous surfaces, gene expression in T cells can be significantly altered, leading to cell activation. The confinement of microvilli inside 200-nm pores results in the formation of TCR nanoclustered hotspots, facilitating sustained and augmented signaling that prompts T cell activation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Chemistry, Multidisciplinary
Jinhua Li, Xinquan Jiang, Hongjun Li, Michael Gelinsky, Zhen Gu
Summary: This review focuses on the design strategies and principles of immunomodulatory biomaterials to regulate macrophage fate, as well as their potential applications in various immunengineering fields. The tunability of material designs, including physical, chemical, biological, and dynamic cues, plays a crucial role in modulating macrophage immune response. The selected immunoengineering applications demonstrate how macrophage-immunomodulating biomaterials are being utilized for cancer immunotherapy, infection immunotherapy, tissue regeneration, inflammation resolution, and vaccination.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Jeongsoo Hur, Hyelee Kim, Uijin Kim, Gi-Beom Kim, Jinho Kim, Byeongju Joo, Duck Cho, Dong-Sung Lee, Aram J. Chung
Summary: In this study, a nonviral T cell nanoengineering system was developed for highly efficient delivery of functional nanomaterials into primary human T cells. The system utilizes cell deformation and restoration induced by inertial flow in a microchannel, creating nanopores in the cellular membrane for effective transfection. This approach shows potential as an alternative technique for improving CAR-T cell manufacturing.
Review
Biotechnology & Applied Microbiology
Lingzhu Zhao, Guoqing Zhao, Jinteng Feng, Zheng Zhang, Jiayu Zhang, Hui Guo, Min Lin
Summary: T cell immune responses play a crucial role in both physiological and pathological processes. Mechanosensitive receptors in the microenvironment are found to regulate various T cell immune responses, including activation, cytokine production, metabolism, proliferation, and migration, in addition to biochemical cues. These mechanical cues are converted into biochemical signals by force-sensitive receptors in the immune synapse, a phenomenon widely accepted in the emerging field of immunomechanobiology. This review provides insights into immunomechanobiology, specifically focusing on the binding and triggering of mechanosensitive receptors and resulting T cell immune responses.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Engineering, Biomedical
Jordan J. Green
Summary: Immunoengineering is a rapidly developing field that applies engineering tools and principles to investigate and modulate the immune system. It has the potential to revolutionize technologies in tissue engineering, drug delivery, and medical devices, and can provide new tools for biomedical discovery and innovation in novel ways to treat various diseases. Additionally, there is a growing focus on creating immunoengineering centers and educational programs in leading universities, with major investments from grant agencies and the development of high-impact research and translational biotechnologies.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Engineering, Biomedical
Olivia M. Saouaf, Gillie A. Roth, Ben S. Ou, Anton A. A. Smith, Anthony C. Yu, Emily C. Gale, Abigail K. Grosskopf, Vittoria C. T. M. Picece, Eric A. Appel
Summary: The research team designed an easily administered slow-delivery influenza vaccine platform using a polymer-nanoparticle hydrogel to prolong the co-delivery of vaccine components to the immune system. They demonstrated a relationship between the physical and chemical properties of the hydrogels and the resulting immune response. Compared to alum, hydrogel-based vaccines showed enhanced antibody response in mice.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Review
Engineering, Biomedical
Fang-Yi Su, Quoc D. Mac, Anirudh Sivakumar, Gabriel A. Kwong
Summary: The clinical success of cancer immunotherapy is driving the development of new methods to detect and treat cancer more effectively. Engineered T cell therapy has the potential to cure disease in subsets of patients, but challenges remain in improving response rates, safety, and lowering costs. Research efforts in biomaterials are focusing on improving cell manufacturing, noninvasive diagnostics, and strategies for in vivo control to enhance anti-tumor immunity and address challenges in T cell immunotherapy.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Engineering, Biomedical
Kenneth M. Adusei, Tran B. Ngo, Kaitlyn Sadtler
Summary: T cells play a crucial role in modulating the immune response to biomaterial implants, maintaining a balance between tissue repair and fibrosis through interactions with innate immune cells.
ACTA BIOMATERIALIA
(2021)
Review
Pharmacology & Pharmacy
Derfogail Delcassian, Asha K. Patel, Abel B. Cortinas, Robert Langer
JOURNAL OF DRUG TARGETING
(2019)
Article
Nanoscience & Nanotechnology
Daniel A. Gonzalez-Carter, Zhan Yuin Ong, Catriona M. McGilvery, Iain E. Dunlop, David T. Dexter, Alexandra E. Porter
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2019)
Article
Biotechnology & Applied Microbiology
Yulia Rybakova, Piotr S. Kowalski, Yuxuan Huang, John T. Gonzalez, Michael W. Heartlein, Frank DeRosa, Derfogail Delcassian, Daniel G. Anderson
Article
Biotechnology & Applied Microbiology
Lei Miao, Linxian Li, Yuxuan Huang, Derfogail Delcassian, Jasdave Chahal, Jinsong Han, Yunhua Shi, Kaitlyn Sadtler, Wenting Gao, Jiaqi Lin, Joshua C. Doloff, Robert Langer, Daniel G. Anderson
NATURE BIOTECHNOLOGY
(2019)
Article
Chemistry, Multidisciplinary
Derfogail Delcassian, Igor Luzhansky, Virginia Spanoudaki, Matthew Bochenek, Collin McGladrigan, Amy Nguyen, Samuel Norcross, Yuhan Zhu, Crystal Shuo Shan, Reed Hausser, Kevin M. Shakesheff, Robert Langer, Daniel G. Anderson
ADVANCED MATERIALS
(2020)
Article
Multidisciplinary Sciences
Lei Miao, Jiaqi Lin, Yuxuan Huang, Linxian Li, Derfogail Delcassian, Yifan Ge, Yunhua Shi, Daniel G. Anderson
NATURE COMMUNICATIONS
(2020)
Article
Nanoscience & Nanotechnology
Sami Ramadan, Richard Lobo, Yuanzhou Zhang, Lizhou Xu, Olena Shaforost, Deana Kwong Hong Tsang, Jingyu Feng, Tianyi Yin, Mo Qiao, Anvesh Rajeshirke, Long R. Jiao, Peter K. Petrov, Iain E. Dunlop, Maria-Magdalena Titirici, Norbert Klein
Summary: Graphene field-effect transistors (GFETs) are ideal building blocks for high-performance electrical biosensors due to the strong response to charged biomolecules. By decorating the graphene sensor area with carbon dots (CDs), the detection limit of GFET biosensors can be significantly improved, resulting in higher sensitivity, faster response, and three orders of magnitude improvements in LoD.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Letter
Cardiac & Cardiovascular Systems
Elvira Forte, Susanne Sattler
Editorial Material
Cardiac & Cardiovascular Systems
Susanne Sattler
Article
Multidisciplinary Sciences
Tankut G. Gueney, Alfonso Muinelo Herranz, Sharon Mumby, Iain E. Dunlop, Ian M. Adcock
Summary: This study explored the impact of stromal cells on basal epithelial cell-derived bronchosphere structure and function through a triple culture of human bronchial epithelial, lung fibroblast, and airway smooth muscle cells. The epithelial-stromal cross-talk led to the formation of branching tubules called bronchotubules, with a mechanically tuneable ECM supporting long-term survival. These bronchotubule models offer insights into how epithelial-stromal cell and cell-ECM communication drive tissue patterning, repair, and disease development.
Article
Engineering, Biomedical
Thomas I. R. Hopkins, Victoria L. Bemmer, Stephen Franks, Carina Dunlop, Kate Hardy, Iain E. Dunlop
Summary: Follicle development in the ovary is tightly regulated and mechanically influenced, with significant variations in tissue stiffness across different regions. Large developmentally-advanced follicles are found to be mechanically dominant structures in the ovary. This study provides new insights for ovarian biomechanics and follicle tissue engineering.
Article
Immunology
Elaine Kouame, Justine C. Noel, Madina Wane, Joel Babdor, Heather L. Caslin, Amy Fan, Berenice Mbiribindi, Susanne Sattler, Alexis S. Mobley
Summary: The organization Black in Immuno was formed to celebrate and support Black voices in immunology, culminating in the global event Black in Immuno Week, which aimed to highlight Black excellence, advocate for diversity in immunology, and create a supportive community for Black immunologists.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Christoph Kuppe, Ricardo O. Ramirez Flores, Zhijian Li, Sikander Hayat, Rebecca T. Levinson, Xian Liao, Monica T. Hannani, Jovan Tanevski, Florian Wuennemann, James S. Nagai, Maurice Halder, David Schumacher, Sylvia Menzel, Gideon Schaefer, Konrad Hoeft, Mingbo Cheng, Susanne Ziegler, Xiaoting Zhang, Fabian Peisker, Nadine Kaesler, Turgay Saritas, Yaoxian Xu, Astrid Kassner, Jan Gummert, Michiel Morshuis, Junedh Amrute, Rogier J. A. Veltrop, Peter Boor, Karin Klingel, Linda W. Van Laake, Aryan Vink, Remco M. Hoogenboezem, Eric M. J. Bindels, Leon Schurgers, Susanne Sattler, Denis Schapiro, Rebekka K. Schneider, Kory Lavine, Hendrik Milting, Ivan G. Costa, Julio Saez-Rodriguez, Rafael Kramann
Summary: In this study, an integrative molecular map of human myocardial infarction was generated using multiple analysis methods. The results elucidated the molecular principles of cardiac tissue organization and provided an important reference for mechanistic and therapeutic studies of cardiac disease.
Editorial Material
Cardiac & Cardiovascular Systems
Susanne Sattler, Gustavo Campos Ramos, Burkhard Ludewig, Peter P. Rainer
EUROPEAN HEART JOURNAL
(2023)
Article
Polymer Science
Anna P. Constantlnou, Uriel Marie-Sainte, Lihui Peng, Dean R. Carroll, Catriona M. McGilvery, Iain E. Dunlop, Theoni K. Georgiou