Article
Neurosciences
Kseniia Prokofeva, Yuki C. Saito, Yasutaka Niwa, Seiya Mizuno, Satoru Takahashi, Arisa Hirano, Takeshi Sakurai
Summary: To understand the regulation of sleep-wakefulness cycles, it is important to study the relationship between the preoptic area (POA) and lateral hypothalamic area (LHA), which have opposing roles in sleep-wakefulness regulation. This study revealed the direct connection between GABA- and galanin-producing neurons in the ventrolateral preoptic nucleus (VLPO) and orexin-producing neurons in the LHA. It also discovered that the VLPOGABA-LHA pathway plays a previously unknown role in the regulation of sleep and wakefulness.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Cell Biology
Huiliang Xue, Jinhui Xu, Lei Chen, Lei Zhao, Ming Wu, Laixiang Xu
Summary: The study investigates the regulating effect of RFRP-3 synchronized with photoperiods on the seasonal reproduction of striped hamsters. The results reveal the correlation between RFRP-3 and reproductive hormones as well as MLT, and the higher expression of RFRP-3 in the hypothalamus compared to the ovaries or testis.
Article
Neurosciences
Masahiro Morishita, Arisa Kamada, Shinji Tsukahara
Summary: The study revealed that CALB-SDN neurons are activated during copulation in both male and female rats, but the patterns of neuronal activation in the CALB-SDN during copulation may differ between sexes.
NEUROSCIENCE LETTERS
(2021)
Article
Cell Biology
Giulia Cencelli, Laura Pacini, Anastasia De Luca, Ilenia Messia, Antonietta Gentile, Yunhee Kang, Veronica Nobile, Elisabetta Tabolacci, Peng Jin, Maria Giulia Farace, Claudia Bagni
Summary: Fragile X syndrome (FXS) is characterized by the absence of the fragile X messenger ribonucleoprotein 1 (FMRP), resulting in increased protein synthesis and altered amyloid precursor protein (APP) processing. This study demonstrates an age-dependent dysregulation of APP processing in fibroblasts, neural precursor cells, and organoids derived from FXS individuals. Treatment with a cell-permeable peptide restores protein synthesis levels, suggesting potential therapeutic applications for FXS during a specific developmental window.
Article
Engineering, Electrical & Electronic
Mihai Coca, Mihai Datcu
Summary: Optical remote sensing instruments are essential for understanding climate change and managing ground-level events. The paper presents a solution for natural anomaly detection in multispectral imagery using FPGA-based deep convolutional neural networks. The implemented algorithm on the FPGA accelerator achieved remarkable speedup and lower power consumption compared to the Tesla K80 GPU.
IEEE JOURNAL OF SELECTED TOPICS IN APPLIED EARTH OBSERVATIONS AND REMOTE SENSING
(2023)
Article
Environmental Sciences
Francesco Pasciucco, Isabella Pecorini, Renato Iannelli
Summary: Nowadays, the importance of environmental protection and the interest in wastewater treatment plants (WWTPs) have increased due to the shift towards a circular economy. This study investigates the environmental impacts of centralized wastewater treatment in a tourist area in central Italy using simulation software and life cycle assessment methodology. The results show that connecting a small decentralized WWTP to a medium-size centralized facility is the best management option in terms of pollutant emissions during the high tourist season, while the decentralized system is less penalized in the low season with lower energy consumption. Site-specific conditions and seasonal variations should be considered when determining the level of centralization in tourist areas.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Neurosciences
Sumei Fan, Xinqi Cheng, Pingping Zhang, Yuanyin Wang, Liecheng Wang, Juan Cheng
Summary: The sedative effects of dexmedetomidine are not completely understood, but it has been found to activate NA(-) and NA(+) neurons in the VLPO, which may explain its unique sedative properties with rapid arousal.
Article
Ophthalmology
Luisa Frizziero, Raffaele Parrozzani, Davide Londei, Elisabetta Pilotto, Edoardo Midena
Summary: The study found that peripapillary capillaries VAD and VLF were reduced in eyes with NPDR, while VDI was significantly decreased in mild and moderate NPDR eyes but not in severe NPDR. Larger peripapillary vessels showed increased VAD and VDI in NPDR eyes, and pRNFL and GCC thickness decreased in NPDR eyes, with significant changes mainly in GCC.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Multidisciplinary Sciences
Alessandra Porcu, Anna Nilsson, Sathwik Booreddy, Samuel A. Barnes, David K. Welsh, Davide Dulcis
Summary: Seasonal changes in day length affect physiological functions, and the SCN-PVN axis plays a crucial role in processing photoperiod-related information. This study found that NMS and VIP neurons in the SCN exhibit neurotransmitter plasticity in response to altered photoperiod in mice. NMS neurons are able to adjust PVN network activity to winter-like photoperiod and influence behavior through multisynaptic neurotransmitter switching.
Article
Biochemistry & Molecular Biology
Somayeh Mousavi, Haowen Qiu, Matthew T. Andrews, James W. Checco
Summary: During winter, hibernating mammals undergo extreme physiological changes, such as decreased metabolism, near-freezing body temperatures, and reduced heart rate, allowing them to survive without food for several months. The neurochemical basis of this regulation is largely unknown. This study used a peptidomics approach to examine the changes in endogenous peptides in the hypothalamus and pituitary of a hibernating mammal, the thirteen-lined ground squirrel. The results provide critical insight into the molecular basis of hibernation and have potential implications for organ preservation, obesity treatment, and stroke treatment.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Sergio Hidalgo, Maribel Anguiano, Christine A. Tabuloc, Joanna C. Chiu
Summary: Organisms adapt to seasonal changes in photoperiod and temperature to survive, but the mechanisms by which these signals are integrated in the brain to alter seasonal biology are poorly understood. In this study, the researchers investigated the role of the EYES ABSENT (EYA) gene and the neuropeptide Pigment-dispersing factor (PDF) in mediating seasonal adaptations. They found that PDF negatively modulated EYA levels and influenced seasonal physiology through the circadian clock. The results provide insights into the regulation of seasonal biology by integrating photoperiod and temperature signals.
Article
Plant Sciences
Sayaka Takahashi, Erina Takahashi
Summary: The study focused on clarifying the functional relationship between leaf expansion and vessel formation in trees of different species. It was found that the timing of vessel formation after leaf appearance varied among tree species, reflecting differences in vessel porosities and connected to their different life strategies.
Article
Biotechnology & Applied Microbiology
Meng Wang, Mengyao Sun, Yue Zhao, Yuying Shi, Shuo Sun, Shen Wang, Yiping Zhou, Lei Chen
Summary: The seasonal changes have an impact on soil microbial diversity in coal mining subsidence areas. Temperature, total phosphorus, available phosphorus, total organic carbon, and dry matter content are the key factors for the seasonal change of soil microbial community in the wetland of the coal mining subsidence area in Jining.
Article
Multidisciplinary Sciences
Kalpana D. D. Acharya, Madeline Graham, Harshini Raman, Abigail E. R. Parakoyi, Alexis Corcoran, Merzu Belete, Bharath Ramaswamy, Shashikant Koul, Ishneet Sachar, Kevin Derendorf, Jeremy B. B. Wilmer, Srikanth Gottipati, Marc J. J. Tetel
Summary: Decreased estrogens during menopause increase the risk of anxiety, depression, type 2 diabetes, and obesity. Depleting estrogens and having a high-fat diet in rodents also lead to anxiety and adiposity. The interaction between estrogens, diet, anxiety, and metabolism is poorly understood, but evidence suggests that gut microbiota play a role.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
Kyoochul Ha, Eunhee Lee, Hyowon An, Sunghyun Kim, Changhui Park, Gyoo-Bum Kim, Kyung-Seok Ko
Summary: This study evaluated seasonal groundwater quality in an agricultural area in Korea due to groundwater pumping, finding that irrigation water is one of the important factors contributing to groundwater quality changes. Hydrochemical analysis results showed that groundwater quality was influenced by dilution, with variations depending on well depth and location.
Article
Agriculture, Dairy & Animal Science
M. Chasles, D. Chesneau, C. Moussu, J. A. Abecia, J. A. Delgadillo, P. Chemineau, M. Keller
DOMESTIC ANIMAL ENDOCRINOLOGY
(2019)
Article
Multidisciplinary Sciences
Anne-Charlotte Trouillet, Matthieu Keller, Jan Weiss, Trese Leinders-Zufall, Lutz Birnbaumer, Frank Zufall, Pablo Chamero
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Environmental Sciences
Daphne Capela, Kevin Poissenot, Carlos Dombret, Matthieu Keller, Isabelle Franceschini, Sakina Mhaouty-Kodja
Article
Agriculture, Dairy & Animal Science
S. Ramirez, D. Chesneau, E. Grimaldo-Viesca, J. Vielma, H. Hernandez, J. Santiago-Moreno, P. Chemineau, M. Keller, J. A. Delgadillo
DOMESTIC ANIMAL ENDOCRINOLOGY
(2019)
Review
Endocrinology & Metabolism
Matthieu Keller, Laura N. Vandenberg, Thierry D. Charlier
FRONTIERS IN NEUROENDOCRINOLOGY
(2019)
Article
Veterinary Sciences
Arsene Ella, Gilles Gomot, Isabelle Levy, Claudia Dominici, Hans Adriaensen, Fabrice Reigner, Matthieu Keller, Daniel Guillaume
JOURNAL OF EQUINE VETERINARY SCIENCE
(2019)
Article
Reproductive Biology
J. A. Abecia, M. Keller, C. Palacios, P. Chemineau, J. A. Delgadillo
Review
Endocrinology & Metabolism
Kimberly J. Jennings, Luis de Lecea
Review
Neurosciences
Alanna Dorsey, Luis de Lecea, Kimberly J. Jennings
Summary: Sleep plays a crucial role in women's health, and sex differences in sleep quality have significant implications. Ovarian hormones are shown to regulate female sleep by acting on various brain regions and neurochemicals. Future research is needed to focus on these gender differences to improve overall health.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Environmental Sciences
Rami Abi Khalil, Brigitte Barbier, Ambre Fafournoux, Ali Barka Mahamat, Aurelie Marquez, Kevin Poissenot, Matthieu Keller, Amelie Desvars-Larrive, Javier Fernandez-De-Simon, Michael Coeurdassier, Etienne Benoit, Sebastien Lefebvre, Adrien Pinot, Virginie Lattard
Summary: The study found that there is no genetic basis for anticoagulant rodenticides resistance in fossorial water voles, but rather a diet-based resistance mechanism. Only two coding mutations were detected in the Vkorc1 gene in a small percentage of the voles, which did not alter their sensitivity to anticoagulant rodenticides. Instead, the seasonal variation in vitamin K1 concentration in the voles' liver was found to be responsible for their increased resistance.
ENVIRONMENTAL RESEARCH
(2021)
Article
Anthropology
Marie Balasse, Philippe Chemineau, Sara Parisot, Denis Fiorillo, Matthieu Keller
Summary: In temperate Europe, sheep mate in autumn and lamb in the spring. However, current Mediterranean husbandries practice autumn lambing, which has advantages in terms of resource use and seasonal availability. This is made possible by the breeding capabilities of Mediterranean breeds, planning by herders, and the availability of forage resources during autumnal rains. Further research is needed to understand the emergence of autumn and winter sheep births in the western Mediterranean.
JOURNAL OF ARCHAEOLOGICAL METHOD AND THEORY
(2023)
Article
Multidisciplinary Sciences
Plotine Jardat, Alexandra Destrez, Fabrice Damon, Zoe Menard-Peroy, Celine Parias, Philippe Barriere, Matthieu Keller, Ludovic Calandreau, Lea Lansade
Summary: Animals can sense human emotions through smell, as chemoreception is a primitive and widespread sense. A study on horses showed that they can discriminate between human odors produced during fear and joy contexts, suggesting the involvement of chemosignals in interspecies communication.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Kevin Poissenot, Chantal Moussu, Morgane Brachet, Didier Chesneau, Philippe Chemineau, Anne-Lyse Laine, Martine Migaud, Nathalie Charbonnel, Matthieu Keller
Summary: Small rodent species display cyclic fluctuations in population density, and the mechanisms behind these variations are not well understood. This study found that season and inter-annual factors have an effect on male reproductive physiology in water voles, but population density does not modulate these parameters, suggesting a weak role of population density in population dynamics.
Meeting Abstract
Behavioral Sciences
Pablo Chamero, Anne-Charlotte Trouillet, Matthieu Keller, Trese Leinders-Zufall, Frank Zufall
Article
Environmental Sciences
Kevin Poissenot, Chantal Moussu, Alain Reymond, Pierre Dorfman, Matthieu Keller
Summary: This study reveals that early postnatal exposure to 1μg/kg·bw/d dose of 17 alpha-Ethinylestradiol (EE2) can lead to precocious puberty and reproductive organ dysfunction in female rats.
TOXICOLOGY AND ENVIRONMENTAL HEALTH SCIENCES
(2021)