期刊
CURRENT DRUG TARGETS
卷 16, 期 13, 页码 1429-1437出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389450115666140804220441
关键词
alpha(IIb)beta(3)-integrins; alpha(IIb)beta(3)-inhibitors; abciximab; eptifibatide; MCF-7 breast cancer cells; apoptosis
资金
- Medical University in Bialystok, Poland [113-27636F]
Integrin receptors are considered to be the key factors in carcinogenesis. alpha(IIb)beta(3)-Integrin (GP IIb/IIIa) is the main glycoprotein of the surface of platelets, its presence has also been noted on the certain cancer cell lines. The molecular mechanism of its action in cancer cells remains unknown. This study presents effects of two alpha(IIb)beta(3)-inhibitors: Abciximab and Eptifibatide on apoptosis, expression of proline oxidase (POX), signaling molecules ERK 1/2, transcription factor NF-kappa B and HIF-1 alpha, vascular endothelial growth factor (VEGF) as well as DNA biosynthesis, collagen biosynthesis and prolidase activity in MCF-7 breast cancer cells. Both ligands induced apoptosis, however we found significant differences in molecular mechanism of action between tested alpha(IIb)beta(3)-inhibitors. These differences include expression of POX, HIF-1 alpha, NF-kappa B, VEGF and collagen biosynthesis. Eptifibatide presented stronger proapoptotic activity in MCF-7 cells than Abciximab. Results of this study suggest that Eptifibatide may be considered as a novel candidate for development of new anticancer therapy.
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