T Cell Epitopes and Post-Translationally Modified Epitopes in Type 1 Diabetes

Identification of autoreactive CD8+ T cell responses targeting chromogranin A in humanized NOD mice and type 1 diabetes patients

(2015) Yi Li et al.   CLINICAL IMMUNOLOGY

A distinct immunogenic region of glutamic acid decarboxylase 65 is naturally processed and presented by human islet cells to cytotoxic CD8 T cells

(2014) R. R. Knight et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Role of B Lymphocytes in the Pathogenesis of Type 1 Diabetes

(2014) Rochelle M. Hinman et al.   Current Diabetes Reports

β-Cell–Specific CD8 T Cell Phenotype in Type 1 Diabetes Reflects Chronic Autoantigen Exposure

(2014) Ania Skowera et al.   DIABETES

Recognition of Posttranslationally Modified GAD65 Epitopes in Subjects With Type 1 Diabetes

(2014) J. W. McGinty et al.   DIABETES

Citrullinated Glucose-Regulated Protein 78 Is an Autoantigen in Type 1 Diabetes

(2014) Dieter Rondas et al.   DIABETES

Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes

(2014) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Citrulline-Specific Th1 Cells Are Increased in Rheumatoid Arthritis and Their Frequency Is Influenced by Disease Duration and Therapy

(2014) Eddie A. James et al.   Arthritis & Rheumatology

Posttranslational Modification of HLA-DQ Binding Islet Autoantigens in Type 1 Diabetes

(2013) M. van Lummel et al.   DIABETES

Proinsulin/Insulin Autoantibodies Measured With Electrochemiluminescent Assay Are the Earliest Indicator of Prediabetic Islet Autoimmunity

(2013) L. Yu et al.   DIABETES CARE

Chromogranin A is a T cell antigen in human type 1 diabetes

(2013) Peter A. Gottlieb et al.   JOURNAL OF AUTOIMMUNITY

A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis

(2013) Stephen W. Scally et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Diabetogenic T-Cell Clones Recognize an Altered Peptide of Chromogranin A

(2012) T. Delong et al.   DIABETES

Zinc transporter (ZnT)8186–194 is an immunodominant CD8+ T cell epitope in HLA-A2+ type 1 diabetic patients

(2012) M. Scotto et al.   DIABETOLOGIA

Endoplasmic Reticulum Stress and Insulin Biosynthesis: A Review

(2012) Mi-Kyung Kim et al.   Experimental Diabetes Research

CD4+T cells recognize diverse epitopes within GAD65: implications for repertoire development and diabetes monitoring

(2012) Junbao Yang et al.   IMMUNOLOGY

Pancreatic β-cells depend on basal expression of active ATF6α-p50 for cell survival even under nonstress conditions

(2011) Tracy Teodoro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Genetics of the HLA Region in the Prediction of Type 1 Diabetes

(2011) Janelle A. Noble et al.   Current Diabetes Reports

Autoantigenesis: the evolution of protein modifications in autoimmune disease

(2011) Hester A Doyle et al.   CURRENT OPINION IN IMMUNOLOGY

Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated  -Cell Death

(2011) S. Arif et al.   DIABETES

Islet Amyloid Polypeptide Is a Target Antigen for Diabetogenic CD4+ T Cells

(2011) T. Delong et al.   DIABETES

Induction of Cross-Linking and Silencing of Sp1 by Transglutaminase during Liver Injury in ASH and NASH via Different ER Stress Pathways

(2011) Soichi Kojima et al.   DIGESTIVE DISEASES

Free fatty acids induce transglutaminase 2-dependent apoptosis in hepatocytes via ER stress-stimulated PERK pathways

(2011) Ting-Fang Kuo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Human Type 1 Diabetes Is Associated with T Cell Autoimmunity to Zinc Transporter 8

(2011) M. Dang et al.   JOURNAL OF IMMUNOLOGY

Increase in endoplasmic reticulum-associated tissue transglutaminase and enzymatic activation in a cellular model of Parkinson's disease

(2011) Robin Verhaar et al.   NEUROBIOLOGY OF DISEASE

Endoplasmic Reticulum Stress-Induced JNK Activation Is a Critical Event Leading to Mitochondria-Mediated Cell Death Caused by β-Lapachone Treatment

(2011) Hyemi Lee et al.   PLoS One

HLA-DR1001 presents “altered-self” peptides derived from joint-associated proteins by accepting citrulline in three of its binding pockets

(2010) Eddie A. James et al.   ARTHRITIS AND RHEUMATISM

Presence of Tissue Transglutaminase in Granular Endoplasmic Reticulum is Characteristic of Melanized Neurons in Parkinson's Disease Brain

(2010) Micha M. M. Wilhelmus et al.   BRAIN PATHOLOGY

Simultaneous Detection of Circulating Autoreactive CD8+ T-Cells Specific for Different Islet Cell-Associated Epitopes Using Combinatorial MHC Multimers

(2010) J. H. Velthuis et al.   DIABETES

HLA Class I and Genetic Susceptibility to Type 1 Diabetes: Results From the Type 1 Diabetes Genetics Consortium

(2010) J. A. Noble et al.   DIABETES

Naturally Arising Human CD4 T-Cells That Recognize Islet Autoantigens and Secrete Interleukin-10 Regulate Proinflammatory T-Cell Responses via Linked Suppression

(2010) T. I. M. Tree et al.   DIABETES

The endoplasmic reticulum stress response in the pancreatic β-cell

(2010) A. Volchuk et al.   DIABETES OBESITY & METABOLISM

Chromogranin A is an autoantigen in type 1 diabetes

(2010) Brian D Stadinski et al.   NATURE IMMUNOLOGY

The Environmental Determinants of Diabetes in the Young (TEDDY) Study

(2009)   Annals of the New York Academy of Sciences

Pancreatic Islet Autoantibodies as Predictors of Type 1 Diabetes in the Diabetes Prevention Trial-Type 1

(2009) T. Orban et al.   DIABETES CARE

IL-1β caused pancreatic β-cells apoptosis is mediated in part by endoplasmic reticulum stress via the induction of endoplasmic reticulum Ca2+ release through the c-Jun N-terminal kinase pathway

(2009) Q. Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Multiple antibody reactivities to citrullinated antigens in sera from patients with rheumatoid arthritis: association with HLA-DRB1 alleles

(2008) O Snir et al.   ANNALS OF THE RHEUMATIC DISEASES

The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus

(2008) Décio L. Eizirik et al.   ENDOCRINE REVIEWS

The Unfolded Protein Response: A Pathway That Links Insulin Demand with β-Cell Failure and Diabetes

(2008) Donalyn Scheuner et al.   ENDOCRINE REVIEWS

Selective CD4+ T Cell Help for Antibody Responses to a Large Viral Pathogen: Deterministic Linkage of Specificities

(2008) Alessandro Sette et al.   IMMUNITY

CD4+ T cells from type 1 diabetic and healthy subjects exhibit different thresholds of activation to a naturally processed proinsulin epitope

(2008) Junbao Yang et al.   JOURNAL OF AUTOIMMUNITY

The role of HLA-DQ8 β57 polymorphism in the anti-gluten T-cell response in coeliac disease

(2008) Zaruhi Hovhannisyan et al.   NATURE