Article
Medicine, Research & Experimental
Qianyun Lin, Zitong Li, Lei Lu, Hua Xu, Eddie Lou, Alyssa Chen, Dustin Sun, Wuyi Zhang, Weishu Zhu, Eric U. Yee, Pamela Suzanne Sears, Xinhua Chen, Ciaran P. Kelly
Summary: Anti-inflammatory drugs may worsen the incidence and severity of Clostridioides difficile infection (CDI). These studies have important clinical implications for understanding the role of anti-inflammatory/ corticosteroid therapy in CDI and inflammatory bowel disease management.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Nutrition & Dietetics
Victor Serrano Fernandez, Marta Seldas Palomino, Jose Alberto Laredo-Aguilera, Diana Patricia Pozuelo-Carrascosa, Juan Manuel Carmona-Torres
Summary: Crohn's disease (CD), a subtype of inflammatory bowel disease (IBD), is prevalent in Western countries and has been associated with intestinal dysbiosis. A systematic review and meta-analysis evaluated the efficacy of a high fiber diet in improving CD remission rates, with or without other treatments. Eleven studies involving 2389 CD patients were included. The results showed that a high fiber diet, in conjunction with routine therapies, can enhance CD remission rates. This study provides evidence that dietary fiber intake can effectively improve remission rates in CD patients, regardless of additional treatment.
Review
Gastroenterology & Hepatology
Achuthan Aruljothy, Siddharth Singh, Neeraj Narula, Gordon W. Moran, Sudheer K. Vuyyuru, Malcolm Hogan, Alexa Zayadi, John K. MacDonald, Benedicte Caron, Silvio Danese, Laurent Peyrin Biroulet, Christopher Ma, Vipul Jairath
Summary: This study assessed the efficacy of medical treatments for ulcerative proctitis (UP). The results showed that topical application of 5-aminosalicylic acid and corticosteroids were effective for active UP. They may also be effective for maintenance of remission. Tacrolimus may be effective for induction of remission.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Maximilian Thormann, Bohdan Melekh, Caroline Baer, Maciej Pech, Jazan Omari, Andreas Wienke, Hans-Jonas Meyer, Alexey Surov
Summary: Based on published data, this study analyzed the relationships between apparent diffusion coefficient (ADC) and activity parameters of Crohn's disease. The results showed that ADC had strong inverse correlations with CDAI, MaRIA, and SES-CD scores. However, its role in assessing fibrotic changes in the bowel wall is limited.
EUROPEAN RADIOLOGY
(2023)
Review
Medicine, General & Internal
Qiang Han, Daming Liu, Peng Zhang
Summary: This study aims to evaluate the efficacy and safety of acupuncture for Crohn's disease. Relevant databases will be searched, and randomized controlled trials evaluating the effects of acupuncture on patients with Crohn's disease will be included. The results will be screened and extracted by two independent reviewers, and bias risk assessment, subgroup analysis, and sensitivity analysis will be conducted.
Review
Medicine, General & Internal
Xiaopei Liu, Xue Xiao, Dan Liu, Cong'e Tan
Summary: This study updated the clinical efficacy and safety of budesonide in the treatment of eosinophilic esophagitis using high-quality randomized controlled trial results, showing that oral budesonide is superior to placebo in terms of efficacy. Additionally, it was found that the efficacy of budesonide in patients is not dose-dependent.
ANNALS OF MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Bing Han, Daiyuan Tang, Xiaodan Lv, Shiquan Li, Junhua Fan, Xiaofang Xu, Jiatong Zhang, Shang Xu, Weizheng Ye, Ziqian Huang, Lingling Zhan, Xiaoping Lv
Summary: Using a network meta-analysis and systematic review, this study evaluated the efficacy and safety of combination therapy and infliximab monotherapy in Crohn's disease patients. The results showed that there was no statistical difference between different combination therapies in inducing and maintaining remission. For inducing remission, infliximab + enteral nutrition ranked highest; for maintaining remission, infliximab + azathioprine ranked highest. There was no treatment that was significantly safer than the others.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Review
Cell & Tissue Engineering
Ruo Wang, Qigu Yao, Wenyi Chen, Feiqiong Gao, Pan Li, Jian Wu, Jiong Yu, Hongcui Cao
Summary: Stem cell transplantation is a valuable supplementary therapy for Crohn's disease, as it can reduce disease activity and improve symptoms in patients.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Rani Ahmad, Amr M. Ajlan, Ayman A. Eskander, Turki A. Alhazmi, Khalid Khashoggi, Mohammad A. Wazzan, Ahmed H. Abduljabbar
Summary: This study conducted a systematic review and meta-analysis of magnetic resonance enterography in the prediction of Crohn's disease activity. It found that MRI has a high sensitivity of 90% and specificity of 89%, making it an effective alternative to CT enterography for assessing disease activity in CD patients.
INSIGHTS INTO IMAGING
(2021)
Review
Immunology
Boran Yu, Libo Zhao, Siyao Jin, Huan He, Jing Zhang, Xiaoling Wang
Summary: Information on the comparative efficacy of biologics and small targeted molecules for Crohn's disease (CD) remains unclear. This study aimed to quantify the relative efficacy of investigational and approved biological treatments for CD. Mathematical models were developed to describe the time course and dose-response of efficacy measures, and simulations were performed to compare efficacies across different drugs. The most effective biologics were tumor necrosis factor (TNF)-alpha inhibitors, while the highest efficacy of small targeted molecules was observed in janus kinase (JAK) inhibitors. These findings have important implications for clinical practice in CD.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Kristine Paridaens, John R. Fullarton, Simon P. L. Travis
Summary: A systematic literature review and meta-analysis confirmed the efficacy and safety of oral Pentasa in treating active UC and maintaining remission. Pentasa demonstrated superiority over placebo in inducing and maintaining remission, and had similar efficacy to other 5-ASAs. Additionally, Pentasa was found to be better tolerated than sulfasalazine in maintaining remission.
CURRENT MEDICAL RESEARCH AND OPINION
(2021)
Review
Gastroenterology & Hepatology
Kevin Chin Koon Siw, Jake Engel, Samantha Visva, Ranjeeta Mallick, Ailsa Hart, Anthony de Buck van Overstraeten, Jeffrey D. McCurdy
Summary: Differentiating between perianal fistulas related to cryptoglandular disease and Crohn's disease can be achieved through various diagnostic strategies. MRI and ultrasound characteristics are the most reliable methods, but they have relatively low sensitivity. Further research is needed to confirm these findings and explore whether combining multiple diagnostic tests can improve diagnostic sensitivity.
INFLAMMATORY BOWEL DISEASES
(2022)
Review
Medicine, General & Internal
Richard Beasley, Tim Harrison, Stefan Peterson, Per Gustafson, Angus Hamblin, Thomas Bengtsson, Malin Fageras
Summary: This study found that switching to SMART treatment was associated with a longer time to the first severe asthma exacerbation for patients with poorly controlled asthma. Compared to escalating or continuing GINA treatment with inhaled corticosteroid-long-acting beta(2)-agonist plus short-acting beta(2)-agonist reliever, the SMART regimen was preferred.
Article
Genetics & Heredity
Antonio Di Narzo, Itziar Frades, Heidi M. Crane, Paul K. Crane, Jean-Sebastian Hulot, Andrew Kasarskis, Amy Hart, Carmen Argmann, Marla Dubinsky, Inga Peter, Ke Hao
Summary: The study identified shared genetic determinants between Crohn's Disease (CD) and height, shedding light on the pathogenesis of the disease. This research demonstrates the value of using individual-level data from dbGaP in exploring shared genetic factors and could potentially impact novel therapies and drug repurposing.
Article
Gastroenterology & Hepatology
Patrick Hamilton, Katherine Buhler, John K. MacDonald, Gilaad G. Kaplan, Cynthia H. Seow, Cathy Lu, Kerri L. Novak, Christopher N. Andrews, Siddharth Singh, Vipul Jairath, Remo Panaccione, Christopher Ma
Summary: This study aimed to estimate the placebo response rates in patients with microscopic colitis (MC) and identify factors associated with placebo response. The analysis showed that approximately one-quarter of patients in MC trials responded to placebo, but with significant heterogeneity.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Letter
Gastroenterology & Hepatology
Joshua Quan, Christopher Ma, Remo Panaccione, Lindsay Hracs, Nastaran Sharifi, Michelle Herauf, Ante Makovinovic, Stephanie Coward, Joseph W. Windsor, Lea Caplan, Richard J. M. Ingram, Jamil N. Kanji, Graham Tipples, Jessalyn K. Holodinsky, Charles N. Bernstein, Douglas J. Mahoney, Sasha Bernatsky, Eric Benchimol, Gilaad G. Kaplan
Article
Gastroenterology & Hepatology
Bradley G. Goodyear, Faranak Heidari, Richard J. M. Ingram, Filomeno Cortese, Nastaran Sharifi, Gilaad G. Kaplan, Christopher Ma, Remo Panaccione, Keith A. Sharkey, Mark G. Swain
Summary: Magnetic resonance imaging revealed structural and functional changes within the brains of inflammatory bowel disease patients, in regions known to be involved in processing brain signals associated with behavioral symptoms, anxiety, pain, stress, and cognitive deficits.
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Gastroenterology & Hepatology
Julia J. Liu, Bincy P. Abraham, Paula Adamson, Edward L. Barnes, Kelly A. Brister, Oriana M. Damas, Sarah C. Glover, Kimberly Hooks, Ana Ingram, Gilaad G. Kaplan, Edward V. Loftus, Dermot P. B. McGovern, Melodie Narain-Blackwell, Florence-Damilola Odufalu, Sandra Quezada, Vonda Reeves, Bo Shen, Thaddeus S. Stappenbeck, Latonia Ward
Summary: This comprehensive review examines the epidemiology, clinical presentations, disease phenotypes, treatment outcomes, social determinants of health, and genetic and environmental factors in the pathogenesis of IBD in Black and Hispanic patients in the United States. To improve health equity for underserved minorities with IBD, researchers identified priority areas for further investigation.
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Obstetrics & Gynecology
Sarvee Moosavi, Yang Won Min, Melissa Wong, Ali Rezaie
Summary: Gastroparesis is a functional gastrointestinal disorder that primarily affects women during childbearing age, but there is a lack of data and guidelines for managing it during pregnancy. Despite the absence of approved therapies, healthcare providers must navigate the challenge of counseling and managing gastroparesis patients. This systematic review aims to fill the knowledge gaps regarding the impact of pregnancy on gastroparesis and vice versa, while highlighting the available therapies and safe dietary approaches during pregnancy.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Rheumatology
Claire E. H. Barber, Diane Lacaille, Ruth Croxford, Cheryl Barnabe, Deborah A. Marshall, Michal Abrahamowicz, Hui Xie, J. Antonio Avina-Zubieta, John M. Esdaile, Glen S. Hazlewood, Peter Faris, Steven Katz, Paul MacMullan, Dianne Mosher, Jessica Widdifield
Summary: This study examines the association between rheumatologist access, early treatment, and ongoing care of older-onset rheumatoid arthritis (RA) and healthcare utilization and costs following diagnosis. The results show that access to rheumatologists, timely treatment, and ongoing care are associated with lower total healthcare costs at 5 years. Investments in improving access to care may lead to long-term health system savings.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Marietta Iacucci, Tommaso Lorenzo Parigi, Rocio Del Amor, Pablo Meseguer, Giulio Mandelli, Anna Bozzola, Alina Bazarova, Pradeep Bhandari, Raf Bisschops, Silvio Danese, Gert De Hertogh, Jose G. Ferraz, Martin Goetz, Enrico Grisan, Xianyong Gui, Bu Hayee, Ralf Kiesslich, Mark Lazarey, Remo Panaccione, Adolfo Parra-Blanco, Luca Pastorelli, Timo Rath, Elin S. Royset, Gian Eugenio Tontini, Michael Vieth, Davide Zardo, Subrata Ghosh, Valery Naranjo, Vincenzo Villanacci
Summary: An artificial intelligence computer-aided diagnosis system was developed and validated to evaluate UC biopsies and predict prognosis. The system showed high accuracy and sensitivity in assessing biopsy results and predicting outcomes.
Review
Rheumatology
Gurjeet Bhangu, Nicole M. S. Hartfeld, Diane Lacaille, Elena Lopatina, Alison M. Hoens, Megan R. W. Barber, Karen L. Then, Saania Zafar, Aurore Fifi -Mah, Glen Hazlewood, Claire E. H. Barber
Summary: Shared care models with patient-initiated follow-up show comparable outcomes for rheumatoid arthritis, including disease activity, radiographic damage, and quality of life. However, further research is needed to understand patient preferences, health equity considerations, and long-term outcomes for such models of care.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Letter
Gastroenterology & Hepatology
Will Takakura, Ali Rezaie
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Simon Travis, Alison Potts Bleakman, Marla C. Dubinsky, Stefan Schreiber, Remo Panaccione, Toshifumi Hibi, Theresa Hunter Gibble, Cem Kayhan, Christian Atkinson, Christophe Sapin, Eoin J. Flynn, David T. Rubin
Summary: Bowel urgency has a significant impact on the lives of patients from the United States and Europe, and there are disparities between patient and healthcare professional perceptions on the experience and impact of ulcerative colitis symptoms. The CONFIDE study aimed to evaluate these symptoms and communication gaps between patients and healthcare professionals in the US and Europe.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Sangmin Lee, Cynthia H. Seow, Kara Nerenberg, Stefania Bertazzon, Yvette Leung, Vivian Huang, Tara Whitten, Stephanie Coward, Remo Panaccione, Gilaad G. Kaplan, Amy Metcalfe
Summary: Attendance at a dedicated IBD-pregnancy clinic improves disease-specific pregnancy knowledge and does not affect perinatal outcomes in pregnant women with IBD.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Tommaso L. Parigi, Rosanna Cannatelli, Olga M. Nardone, Irene Zammarchi, Uday Shivaji, Federica Furfaro, Davide Zardo, Paola Spaggiari, Rachele Del Sordo, Orsola Setti, Snehali Majumder, Samuel C. L. Smith, Silvio Danese, Alessandro Armuzzi, Vincenzo Villanacci, Subrata Ghosh, Marietta Iacucci
Summary: This study evaluated the correlation and predictive value of a new and established index in ulcerative colitis. The results showed that PHRI had a similar correlation with endoscopy and was able to effectively stratify the risk of relapse. This study demonstrates that a neutrophil-only assessment is a simple and viable alternative.
JOURNAL OF CROHNS & COLITIS
(2023)
Letter
Rheumatology
Glen S. Hazlewood, Pooneh Akhavan, Jordi Pardo Pardo, Arnav Agarwal, Orit Schieir, Claire E. H. Barber, Laurie Proulx, Dawn P. Richards, Claire Bombardier, Janet E. Pope, Cheryl Barnabe, Peter Tugwell, Shahin Jamal, J. Carter Thorne, Roko P. A. Nikolic, Majed Khraishi, Nick Bansback, Alexandra Legge, Vivian Bykerk, Regina Taylor-Gjevre
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Medicine, General & Internal
Ferdinando D'Amico, Virginia Solitano, Fernando Magro, Pablo A. Olivera, Jonas Halfvarson, David Rubin, Axel Dignass, Sameer Al Awadhi, Taku Kobayashi, Natalia Sousa Freitas Queiroz, Marta Calvo, Paulo Gustavo Kotze, Subrata Ghosh, Laurent Peyrin-Biroulet, Silvio Danese
Summary: As the patents for biologic originator drugs expire, biosimilars are emerging as cost-effective alternatives within healthcare systems. A global survey was conducted to shed light on physicians' knowledge, beliefs, practical approaches, and concerns related to biosimilar adoption. Based on the survey results, a consensus was reached on key statements covering biosimilar effectiveness, safety, indications, rationale, multiple switches, therapeutic drug monitoring, non-medical switching, and future perspectives. The consensus affirmed that biosimilars are equally effective and safe compared to originator drugs.
JOURNAL OF CLINICAL MEDICINE
(2023)
Meeting Abstract
Gastroenterology & Hepatology
R. Atreya, P. Irving, M. Fujiya, J. F. Colombel, S. Danese, L. Peyrin-Biroulet, T. Bessissow, R. Panaccione, G. D'Haens, S. van Haaren, E. Neimark, J. Zambrano, Y. Zhang, K. Kligys, M. Ferrante
JOURNAL OF CROHNS & COLITIS
(2023)
Letter
Gastroenterology & Hepatology
Amrit K. Kamboj, Yin Chan, Jason Nasser, Jane E. Lim, Bianca W. Chang, Ali Rezaie
