Review
Pharmacology & Pharmacy
Bo Qi, Yang Yu, Yaoqi Wang, Yuzun Wang, Yonghao Yu, Keliang Xie
Summary: Sepsis is a major cause of death in critically ill patients with no effective treatment, but molecular hydrogen shows potential therapeutic effects in sepsis. However, the specific treatment mechanism of molecular hydrogen remains unclear. Molecular hydrogen treatment can help improve organ injuries caused by sepsis.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Review
Nutrition & Dietetics
Aynaz Velayati, Mohamad Reza Vafa, Nadia Sani'ee, Zahra Darabi
Summary: Ginger has potential therapeutic effects in sepsis due to its anti-inflammatory, antioxidant, antimicrobial, and antitumor properties.
Review
Pharmacology & Pharmacy
Clive N. May, Rinaldo Bellomo, Yugeesh R. Lankadeva
Summary: Vitamin C has various beneficial effects and may be helpful in treating sepsis and COVID-19. Experimental evidence shows that high-dose vitamin C can significantly improve clinical symptoms and promote organ function recovery.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yanhong Wu, Meiling Zhao, Zhaoheng Lin
Summary: The study showed that PQQ can alleviate acute liver injury, inflammation, oxidative stress damage, and apoptosis in sepsis rats, as well as reduce inflammation, oxidative stress, and apoptosis in LPS-induced Kupffer cells. It was also found that PQQ could suppress CUL3 expression in Kupffer cells exposed to LPS, which in turn weakened the protective effects of PQQ on inflammatory and oxidative damage as well as apoptosis.
Article
Cell Biology
Meng Ning, Yingwu Liu, Donglian Wang, Jin Wei, Guoyong Hu, Pengcheng Xing
Summary: The study highlights the significance of TRIM27 in sepsis-induced lung injury. Knockdown of TRIM27 alleviates inflammation, oxidative stress, and apoptosis by suppressing ubiquitination of PPAR gamma and reducing NOX4 expression.
INFLAMMATION RESEARCH
(2022)
Article
Immunology
Fangfang Yu, Wenxia Tian, Jie Dong
Summary: This study explored the role of anagliptin in sepsis treatment. It was found that anagliptin alleviated the oxidative stress induced by LPS stimulation and inhibited the release of inflammatory factors and activation of the NF-kappa B pathway by repressing the expression level of RIP1. These findings suggest that anagliptin has potential pharmacological properties for the treatment of sepsis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Guo-wei Tu, Yi Zhang, Jie-fei Ma, Jun-yi Hou, Guang-wei Hao, Ying Su, Jing-chao Luo, Lulu Sheng, Zhe Luo
Summary: This study reveals the central role of T cell-derived extracellular vesicles (EVs) in sepsis-induced lung injury, and their ability to trigger alveolar epithelial cell apoptosis, oxidative stress, inflammation, and tissue damage through the DAG/PKC/NOX4 pathway. These findings suggest that T cell-derived EVs and the elevated distribution of DGKK could be potential targets for therapeutic strategies in sepsis-induced lung injury.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Article
Immunology
Yuan-yuan Xu, Cheng-zhu Xu, You-feng Liang, Dan-qun Jin, Jie Ding, Yao Sheng, Le Zhang, Fang Deng
Summary: The combination of ascorbic acid and hydrocortisone has a synergistic effect in protecting against septic organ injury by inhibiting the inflammatory response and oxidative stress, with the antioxidative effect of ascorbic acid contributing to the anti-inflammatory action.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2022)
Article
Critical Care Medicine
Zhanqin Zhang, Chaoying Yan, Jiwen Miao, Kairui Pu, Hongli Ma, Qiang Wang
Summary: The study showed that mitochondrial transplantation can reduce systemic inflammation and organ injury, enhance bacterial clearance, and improve survival rate in sepsis. Microarray analysis revealed significant changes in gene expression related to inflammatory response, complement and coagulation cascades, and rejection reaction in polymicrobial sepsis.
Article
Urology & Nephrology
Lu Li, Xiaoxi Liu, Shasha Li, Qingyan Wang, Hongru Wang, Menglu Xu, Yanxin An
Summary: The study demonstrates that THC can prevent Sepsis-induced AKI by suppressing inflammation and oxidative stress, and activating the SIRT1 signaling pathway. THC not only increased the survival rate and improved kidney function in mice, but also inhibited inflammatory response and prevented cell apoptosis in renal tissues.
Article
Medicine, Research & Experimental
Ilknur Esen Yildiz, Atilla Topcu, Ilkay Bahceci, Medeni Arpa, Levent Tumkaya, Tolga Mercantepe, Sule Batcik, Yasin Yildiz
Summary: This study investigated the antioxidant and anti-inflammatory effects of fosfomycin in sepsis, showing promising results in reducing lung injury associated with sepsis.
Review
Chemistry, Medicinal
Mahdi Vajdi, Pouria Sefidmooye Azar, Ata Mahmoodpoor, Farzaneh Dashti, Sarvin Sanaie, Fateme Kiani Chalmardi, Arash Karimi
Summary: This article systematically reviews the effects and mechanisms of resveratrol in the treatment of septic shock, and the results show that resveratrol can reduce the complications of sepsis by affecting inflammatory pathways, oxidative stress, and modulating immune responses. Future human randomized clinical trials are necessary due to the promising therapeutic effects of resveratrol on sepsis complications and the lack of clinical trials in this regard.
PHYTOTHERAPY RESEARCH
(2023)
Article
Chemistry, Medicinal
Yinyan Yin, Nuo Xu, Tao Qin, Bangyue Zhou, Yi Shi, Xinyi Zhao, Bixia Ma, Zhengzhong Xu, Chunmei Li
Summary: The study showed that astaxanthin exhibits strong antioxidant properties by increasing cellular reductive status, upregulating antioxidant enzyme activities, and inhibiting cytokine secretions, which could potentially alleviate DC-related inflammatory responses and serve as a promising approach for sepsis treatment.
Article
Biochemistry & Molecular Biology
Meagan S. Kingren, Marlene E. Starr, Hiroshi Saito
Summary: The incidence and mortality rates of sepsis increase significantly with age, especially in older adults. However, there is currently a lack of effective therapeutic strategies targeting older patients with severe sepsis, despite ongoing research efforts. Further research using aged animal models with clinically relevant treatments is essential for future progress in this area.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Cell Biology
Zhang Wei, Kang Pinfang, Zhou Jing, Yao Zhuoya, Qian Shaohuan, Shi Chao
Summary: This study investigates the effects of curcumin on diabetic cardiomyopathy by regulating the AKT pathway and promoting the transfer of Nrf2 into the nucleus. Curcumin was found to inhibit cell pyroptosis by reducing reactive oxygen species accumulation and mitochondrial damage in diabetic myocardium. The protective effects of curcumin were diminished when the Nrf2 pathway was blocked. These findings suggest that curcumin has potential therapeutic effects in treating diabetic cardiomyopathy.
MEDIATORS OF INFLAMMATION
(2023)
Article
Neurosciences
Sandra Bonfante, Larissa Joaquim, Maria Eduarda Fileti, Amanda Della Giustina, Mariana Pereira de Souza Goldim, Lucineia Gainski Danielski, Evandro Cittadin, Raquel Jaconi De Carli, Bianca Xavier de Farias, Nicole Alessandra Engel, Naiana Rosa, Jucelia Jeremias Fortunato, Vijayasree Giridharan, Giselli Scaini, Gislaine Tezza Rezin, Jaqueline Generoso, Rafael Mariano de Bitencourt, Silvia Terra, Tatiana Barichello, Fabricia Petronilho
Summary: STC-1 has been shown to have a protective role by inhibiting the inflammatory response, reducing oxidative stress, and improving mitochondrial function, thereby providing neuroprotection against sepsis-associated encephalopathy.
NEUROTOXICITY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jean Wu, Colin Carlock, Junbo Shim, Ines Moreno-Gonzalez, William Glass, April Ross, Tatiana Barichello, Joao Quevedo, Yahuan Lou
Summary: IL33 is essential for regulating the expression of AQP4 in astrocytes, with its deficiency leading to abnormal tau accumulation in neurons and impaired drainage. This study suggests that different forms of AQP4 play distinct roles in glymphatic drainage, with p-AQP4 driving flow toward perivenous space while n-AQP4 may help remove neuronal wastes. Defects in IL33-related mechanisms may contribute to chronic neurodegeneration and tauopathy in aging mice.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Larissa Silva Joaquim, Lucineia Gainski Danielski, Sandra Bonfante, Erica Biehl, Khiany Mathias, Tais Denicol, Erick Bagio, Everton Venicius Lanzzarin, Richard Simon Machado, Gabriela Costa Bernades, Jaqueline Generoso, Amanda Della Giustina, Tatiana Barichello, Fabricia Petronilho
Summary: The study demonstrates that inhibiting NLRP3 activation with MCC950 can reduce brain oxidative damage after cerebral ischemia/reperfusion in rats.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Helena M. Abelaira, Thayse Rosa, Airam B. de Moura, Natalia M. Andrade, Nicoly S. Martinello, Larissa R. Maciel, Maria Eduarda M. Botelho, Laura A. Borba, Beatriz C. Chede, Camila O. Arent, Larissa Joaquim, Sandra Bonfante, Lucineia G. Danielski, Talita Tuon, Fabricia Petronilho, Joao Quevedo, Gislaine Z. Reus
Summary: This study evaluated the treatment effects of ketamine, electroconvulsive stimulation (ECS), escitalopram, alone or in combination, in adult male and female rats subjected to maternal deprivation (MD) animal model. The findings showed that the treatments were able to reverse depressive and anhedonic behavior in females, while elicited different responses in males. Furthermore, the study highlights the importance of considering gender differences in MDD related to early stress and therapeutic strategies.
MOLECULAR NEUROBIOLOGY
(2022)
Editorial Material
Psychiatry
Tatiana Barichello, Vijayasree V. Giridharan, Clarissa M. Comim, Rodrigo Morales
BRAZILIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Immunology
Vijayasree V. Giridharan, Jaqueline S. Generoso, Leonardo Lence, Gabriela Candiotto, Emilio Streck, Fabricia Petronilho, Anilkumar Pillai, Tarek Sharshar, Felipe Dal-Pizzol, Tatiana Barichello
Summary: Sepsis disrupts the microbiota-gut-brain axis homeostasis and leads to cognitive impairment. Survivors of sepsis show significant decline in memory and learning. Understanding the function of glial cells and gut microbiota can provide new approaches for treating sepsis patients.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Neurosciences
Amanda Della Giustina, Judite Filgueiras Rodrigues, Erick Bagio, Sandra Bonfante, Larissa Joaquim, Graciela Zarbato, Solange Stork, Richard Simon Machado, Mariana Pereira de Souza Goldim, Lucineia Gainski Danielski, Khiany Mathias, Carlos Dacoregio, Taise Cardoso, Giulia S. Predroso, Ligia Milanez Venturini, Rubya Pereira Zaccaron, Paulo Cesar Lock Silveira, Ricardo Aurino Pinho, Fabricia Petronilho
Summary: Sepsis is a life-threatening condition caused by a dysregulated response to infection, which leads to organ dysfunction. Inflammation and oxidative stress play major roles in the damage to the lungs and brain in sepsis. A physical exercise program has protective effects against inflammation and oxidative stress in the lungs and brain of septic rats.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Lucineia Gainski Danielski, Amanda Della Giustina, Fernanda Frederico Gava, Tatiana Barichello, Fabricia Petronilho
Summary: Sepsis is a life-threatening condition that can lead to cognitive and memory damage, which may be associated with astrocytic activation and the release of inflammatory mediators.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Endocrinology & Metabolism
Larissa Joaquim, Amanda Della Giustina, Richard Simon Machado, Kiuanne Lino Lobo Metzker, Sandra Bonfante, Lucineia Gainski Danielski, Mariana Pereira de Souza Goldim, Fabricia Petronilho
Summary: Recovered COVID-19 patients may experience neurological, psychiatric, and cognitive problems, although the exact prevalence and outcome of cognitive sequelae are unclear. The mechanisms behind COVID-19-induced cognitive dysfunction may involve neuroinflammation mediated by sustained systemic inflammation, disrupted brain barrier, and glial reactiveness.
NEUROIMMUNOMODULATION
(2022)
Article
Biochemistry & Molecular Biology
Vijayasree V. Giridharan, Celso S. G. Catumbela, Carlos Henrique R. Catalao, Juneyoung Lee, Bhanu P. Ganesh, Fabricia Petronilho, Felipe Dal-Pizzol, Rodrigo Morales, Tatiana Barichello
Summary: In this study, it was found that peripheral infection may be a risk factor for Alzheimer's disease pathology, and infection can accelerate cognitive decline and AD pathology. By inducing a polymicrobial infection in APP/PS1 mice through cecal ligation and puncture surgery, the study showed that sepsis led to increased Aβ deposition and activation of microglia around Aβ plaques in the brain. Furthermore, sepsis affected gut microbiome composition and structure, as well as short-chain fatty acid levels.
MOLECULAR PSYCHIATRY
(2023)
Review
Critical Care Medicine
Tatiana Barichello, Jaqueline S. Generoso, Mervyn Singer, Felipe Dal-Pizzol
Summary: A biomarker is a measurable indicator of a patient's clinical condition that can be measured accurately and reproducibly. In sepsis patients, there are various biomarkers such as PRMs, complement system, and cytokines. However, further research is needed to identify the optimal combinations of biomarkers.
