Article
Biochemistry & Molecular Biology
Donghui Peng, Yuchan Chen, Yanping Sun, Zhihong Zhang, Na Cui, Wensen Zhang, Ying Qi, Yuanning Zeng, Bin Hu, Bingyou Yang, Qiuhong Wang, Haixue Kuang
Summary: The purpose of this study was to investigate the effect of vinegar processing on saikosaponins of Bupleurum chinense DC. (BC) and the protective effects of saikosaponin A (SSA), saikosaponin b1 (SSb1), saikosaponin b2 (SSb2), and saikosaponin D (SSD) in lipopolysaccharide (LPS)-induced acute lung injury (ALI) mice. The results showed that SSA, SSb1, SSb2, and SSD effectively reduced pulmonary edema, inflammatory markers, and lung pathology in the ALI model. Furthermore, SSb2 had a better anti-inflammatory effect compared to the other saikosaponins at the same dose. These findings suggest that the evaluation of BC quality should consider not only SSA and SSD, but also the increased content of SSb1 and SSb2 after vinegar processing.
Article
Immunology
Wenhua Sang, Sha Chen, Lidan Lin, Nan Wang, Xiaoxia Kong, Jinyan Ye
Summary: Chronic ethanol abuse is a risk factor for acute respiratory distress syndrome (ARDS) and chronic obstructive pulmonary disease (COPD). Ethanol produces reactive oxygen species (ROS) and disrupts the balance of mitochondria, leading to pro-injury environment. This study investigated the effects of mitochondria-targeted antioxidant MitoQ on LPS-induced ethanol-sensitized lung injury. MitoQ attenuated lung injury by reducing mitophagy and protecting mitochondria, thus inhibiting NLRP3 inflammasome activation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Junmei Li, Yang Bai, Yiting Tang, Xiangyu Wang, Maria Jose Cavagnaro, Ling Li, Zhaozheng Li, Yi Zhang, Jian Shi
Summary: Acute lung injury (ALI) is a common complication of critical illness, with sepsis being a major cause. Current measures to improve prognosis include protective ventilation strategy, restrictive fluid management, and antibiotics application, with no pharmacological treatment available. This research discovered that a 4-benzene-indol derivative targets the NLRP3 inflammasome signaling, alleviating sepsis-related ALI and potentially serving as a therapeutic drug.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Wenhui Huang, Yue Zhang, Bojun Zheng, Xuguang Ling, Guozhen Wang, Lijuan Li, Wei Wang, Miaoxia Pan, Xu Li, Ying Meng
Summary: Macrophages infiltration plays a crucial role in Sepsis-associated acute lung injury (ALI). This study reveals that Lipopolysaccharides-induced macrophages-derived exosomes (L-Exo) can induce ALI and damage alveolar epithelial cells. It is found that GBP2 in L-Exo targets NLRP3 inflammasomes and promotes inflammation. These findings provide new insights into the prevention and treatment of ALI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Jia-Ying Kang, Meng-Meng Xu, Ying Sun, Zhen-Xing Ding, Yuan-Yuan Wei, Da-Wei Zhang, Yue-Guo Wang, Ji-Long Shen, Hui-Mei Wu, Guang-He Fei
Summary: The study found that melatonin can alleviate LPS-induced acute lung injury by activating the Nrf2/HO-1 signaling axis and inhibiting pyroptosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Tian-qi Xuan, Guohua Gong, Huanhuan Du, Chunyan Liu, Yun Wu, Guilan Bao, Qianqian Ma, Dong Zhen
Summary: This study aimed to investigate the potential of pteryxin in alleviating LPS-induced lung injury and explore the underlying mechanism. The results indicated that pteryxin effectively reduced the severity of lung injury by suppressing the MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Tangjia Li, Chu Zhang, Yuke Wei, Haijing Zhong, Luchen Shan, Pei Yu, Yuqiang Wang, Lipeng Xu
Summary: This study demonstrates that AL-1 effectively alleviates LPS-induced lung injury by reducing proinflammatory cytokine levels, inflammatory responses, and infiltration of inflammatory cells, thereby improving pathological changes in lung tissue.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Biochemistry & Molecular Biology
Rana Dhar, Mohammad Nasiruddin Rana, Lejun Zhang, Yajun Li, Ning Li, Zhengqiang Hu, Chungunag Yan, Xuefeng Wang, Xuyang Zheng, Hongyun Liu, Huashun Cui, Zigang Li, Huifang Tang
Summary: The deficiency of PDE4B can attenuate inflammation and pyroptosis by modulating ROS/Nrf2/NLRP3 pathway, while overexpression of Nrf2 and PDE4B can enhance their expression levels.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Cai Zhang, Xinran Wang, Chunguo Wang, Cheng He, Quantao Ma, Jialin Li, Weiling Wang, Yan-Tong Xu, Ting Wang
Summary: This study identified the chemical compositions of QWZK and demonstrated its protective effects on LPS-induced ALI, potentially through inhibiting the TLR4/NF-kB signaling pathway and NLRP3 inflammasome activation. It suggested that QWZK is a potential therapeutic candidate for the treatments of ALI and pulmonary inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Wang Shuhui, Lei Pan, Feng Ying, Jiang Mingzhu, Liu Zegan, Shen Ting, Ma Shinan, Wang Libo, Guo Xingrong, Du Shiming
Summary: Acute lung injury (ALI) is a severe clinical condition characterized by inflammatory damage to lung barriers, with limited treatment options available. In this study, the researchers investigated the therapeutic effects and molecular mechanisms of Jinyinqingre oral liquid (JYQR), a Traditional Chinese Medicine formulation, in ALI. They found that JYQR significantly improved lung tissue histology and reduced protein levels and pleural thickness in a mouse model of ALI. Mechanistic investigations revealed that JYQR inhibited the NF-κB/NLRP3/GSDMD pathway, thus alleviating LPS-induced ALI.
CHINESE JOURNAL OF NATURAL MEDICINES
(2023)
Article
Chemistry, Medicinal
Shanshan Dai, Bozhi Ye, Longwang Chen, Guangliang Hong, Guangju Zhao, Zhongqiu Lu
Summary: The study revealed that emodin has a protective effect on septic myocardial injury by alleviating the inflammatory response and cardiomyocyte pyroptosis.
PHYTOTHERAPY RESEARCH
(2021)
Article
Integrative & Complementary Medicine
Yuhan Liu, Jiabin Zhou, Yingying Luo, Jinxiao Li, Luorui Shang, Fangyuan Zhou, Shenglan Yang
Summary: The study demonstrated that Honokiol (HKL) could alleviate lipopolysaccharide (LPS)-induced acute lung injury (ALI) by reducing oxidative stress and inhibiting NLRP3 inflammasome-mediated pyroptosis. Both in vivo and in vitro experiments showed that HKL activated Nrf2 to suppress the expression of NLRP3 inflammasome components. Furthermore, HKL exhibited protective effects in LPS-induced ALI rats by attenuating pathological injury.
Article
Plant Sciences
Xiaohui Wang, Lu Wang, Renchao Dong, Kai Huang, Changyuan Wang, Jiangning Gu, Haifeng Luo, Kexin Liu, Jingjing Wu, Huijun Sun, Qiang Meng
Summary: Luteolin effectively protects against acute liver injury induced by LPS through inhibiting the TXNIP-NLRP3 axis, thereby reducing NLRP3 inflammasome activation and liver inflammation, as well as alleviating oxidative stress and hepatocyte injury.
Article
Respiratory System
Zhiling Fu, Xiuying Wu, Fushuang Zheng, Yan Zhang
Summary: This study identified the role of sevoflurane in the regulation of the LINC00839/miR-223/NLRP3 axis, which ameliorates LPS-induced acute lung injury (ALI). This finding offers a promising candidate for the prevention and treatment of ALI.
BMC PULMONARY MEDICINE
(2022)
Article
Cell Biology
Yuhan Liu, Luorui Shang, Jiabin Zhou, Guangtao Pan, Fangyuan Zhou, Shenglan Yang
Summary: This study found that emodin has protective effects on LPS-induced ALI by modulating the NLRP3 inflammasome-related signaling pathway and inhibiting the occurrence of inflammatory responses.
