Article
Endocrinology & Metabolism
Ann A. Coulter, Frank L. Greenway, Dachuan Zhang, Sujoy Ghosh, Cathryn R. Coulter, Sarah L. James, Yanlin He, Luke A. Cusimano, Candida J. Rebello
Summary: Naringenin, an activator found in citrus fruits, has beneficial effects on thermogenesis and insulin sensitivity. Our study investigated if carotenoids can enhance the metabolic effects of naringenin on adipocytes. Results showed that beta-carotene acts synergistically with naringenin to improve thermogenesis and glucose metabolism genes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Haoshen Feng, Yan Yin, Rui Zheng, Jian Kang
Summary: The study demonstrated that Rosiglitazone significantly alleviated lung inflammation and emphysema induced by cigarette smoke exposure by inhibiting M1 macrophage polarization, mainly through the activation of PPAR gamma and RXR alpha.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Miao Miao, Xue Wang, Tian Liu, Yan-Jie Li, Wen-Qian Yu, Tong-Mei Yang, Shou-Dong Guo
Summary: Atherosclerosis, a major factor of cardiovascular disease, is influenced by inflammation, dyslipidemia, and oxidative stress. Peroxisome proliferator-activated receptors (PPARs), as nuclear receptors, have tissue- and cell-specific expression and regulate genes involved in lipid metabolism, inflammation, and redox homeostasis. Despite controversies, accumulating evidence supports the role of PPAR activation in attenuating atherosclerosis. Recent advances provide valuable insights into the mechanisms of PPAR activation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Neurosciences
Chaoran Xu, Huaijun Chen, Shengjun Zhou, Chenjun Sun, Xiaolong Xia, Yucong Peng, Jianfeng Zhuang, Xiongjie Fu, Hanhai Zeng, Hang Zhou, Yang Cao, Qian Yu, Yin Li, Libin Hu, Guoyang Zhou, Feng Yan, Gao Chen, Jianru Li
Summary: The pharmacological activation of RXR-alpha accelerates hematoma clearance, alleviates neurological dysfunction after ICH, and reduces neuroinflammation by repolarizing microglia/macrophages, indicating a promising therapeutic target for ICH.
NEUROSCIENCE BULLETIN
(2021)
Article
Gastroenterology & Hepatology
Maria Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodriguez, Luis Leiva-Vega, Aranzazu Pintor-Chocano, Daniel Horrillo, Lourdes Hernandez-Cosido, Jorge L. Torres, Eva Novoa, Ruben Nogueiras, Gema Medina-Gomez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio
Summary: Obesity leads to chronic low-grade inflammation, causing diabetes, steatosis, and insulin resistance. Activation of the p38 pathway in macrophages plays a crucial role in this inflammation, suggesting p38 inhibition as a potential treatment for obesity comorbidities. However, lack of p38 activation in myeloid cells worsens high-fat diet-induced obesity, diabetes, and steatosis. Deficient p38 activation increases macrophage IL-12 production, leading to inhibition of hepatic FGF21 and reduction of thermogenesis in the brown fat.
Article
Biochemistry & Molecular Biology
Faizul Azam, Martiniano Bello
Summary: In this study, the structural and energetic mechanism of RXRα-PPARγ heterodimer in bound or unbound state to DNA and in complex with co-crystallized ligands was explored through simulations and analysis. The results suggest that DNA binding alters the correlated motions and conformational mobility within the system, affecting the dimerization and binding affinity of RXRα-PPARγ complex. Additionally, PPARγ plays a greater role in regulating the free and bound DNA state.
Article
Cell Biology
Szu-Yu Liu, Chia-Chang Huang, Shiang-Fen Huang, Tsai-Ling Liao, Nai-Rong Kuo, Ying-Ying Yang, Tzu-Hao Li, Chih-Wei Liu, Ming-Chih Hou, Han-Chieh Lin
Summary: Activation of systemic, renal vessel and renal tissue levels of PPAR gamma by chronic pioglitazone treatment has beneficial effects on endotoxemia-related TNF alpha/NF kappa B-mediated acute and chronic renal inflammation in cirrhosis. This study revealed that normalization of renal and renal arterial levels of PPAR gamma effectively prevented LPS-induced acute and chronic renal dysfunction in cirrhotic ascitic rats.
Article
Biotechnology & Applied Microbiology
Zhuo Zhang, Yuhua Yang, Xiaomei Lv, Hongyuan Liu
Summary: This study found that the expression levels of IL-17 were significantly increased in pregnant women with preeclampsia (PE), and IL-17 may serve as a sensitive biomarker for PE. Overexpression of IL-17 promoted the viability, migration, and invasion of trophoblast cells, while knockdown of IL-17 inhibited these effects. Furthermore, IL-17 activated the PPAR-gamma/RXR-alpha/Wnt signaling pathway to promote proliferation, migration, and invasion of trophoblast cells.
Article
Nutrition & Dietetics
Olga Kaczmarczyk, Agnieszka Dabek-Drobny, Agnieszka Piatek-Guziewicz, Michal Wozniakiewicz, Pawel Pasko, Justyna Dobrowolska-Iwanek, Aneta Wozniakiewicz, Aneta Targosz, Agata Ptak-Belowska, Urszula Szczyrk, Malgorzata Strzalka, Pawel Zagrodzki, Malgorzata Zwolinska-Wcislo
Summary: There is a close relationship between intestinal inflammation and nutrition in patients with inflammatory bowel disease (IBD). Patients with active IBD have poor nutritional status, reduced levels of short-chain fatty acids, and altered expression of tight junction proteins in the intestine.
Article
Environmental Sciences
Yupeng Zhu, Li Jing, Xiangyang Li, Dan Zheng, Guiqing Zhou, Yue Zhang, Yujian Sang, Zhixiong Shi, Zhiwei Sun, Xianqing Zhou
Summary: This study revealed that BDE-209 disrupts glycolipid metabolism by inhibiting the Pl3K/AKT/GLUT4 pathway and activating the mTOR/PPAR gamma/RXR alpha pathway.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Cardiac & Cardiovascular Systems
Fatemeh Yarmohammadi, A. Wallace Hayes, Gholamreza Karimi
Summary: Cardiotoxicity can be a complication caused by drugs and chemicals, affecting morbidity, quality of life, and mortality. The role of peroxisome proliferator-activated receptors (PPARs) in controlling gene expression related to lipid metabolism and inflammation in the heart has been identified. Natural chemicals can protect against cardiotoxicity by targeting PPARs.
CARDIOVASCULAR TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Wael A. A. Alanazi, Turki Alharbi, Doaa M. M. El-Nagar, Abdullah M. M. Albogami, Mohammed Alswayyed
Summary: In this study, it was found that the SGLT2 inhibitor dapagliflozin attenuated lipopolysaccharide-induced hypotension by inhibiting vasodilation and reducing cytokine levels. This protective effect was independent of glycemic control and applicable to patients with different glucose levels.
Article
Biochemistry & Molecular Biology
Hyo-Shin Kwon, Gil-Saeng Jeong, Byeong-Churl Jang
Summary: CTXA from Cudrania tricuspidata Bureau exhibits strong anti-adipogenic and anti-inflammatory effects on 3T3-L1 cells by regulating the expression and phosphorylation levels of C/EBP-alpha, PPAR-gamma, FAS, ACC, perilipin A, STAT-3/5, AMPK, and iNOS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Otorhinolaryngology
Rolando R. Rosas, Kristine M. Nachbor, Nathan Handley, Grant Mathison, Beverly R. Wuertz, Fadlullah Ba'th, Frank G. Ondrey
Summary: The study demonstrates that targeting the PPAR gamma/RXR alpha heterodimer with pioglitazone and bexarotene is effective in reducing cell proliferation in head and neck squamous cell carcinoma. There is potential for clinical application, but further research is needed to fully explore the chemopreventive potential of these medications.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Cell Biology
Wanting Shao, Melitta B. Koepke, Theresa Vilsmaier, Alaleh Zati Zehni, Mirjana Kessler, Sophie Sixou, Mariella Schneider, Nina Ditsch, Vincent Cavailles, Udo Jeschke
Summary: The cytoplasmic co-expression of RXR alpha and PPAR gamma in breast cancer patients is associated with shorter survival and tumor aggressiveness markers. This finding is clinically relevant for identifying high-risk breast cancer patients, especially those with early and node-negative disease.
Article
Immunology
Merve Biliktu, Sefika Pinar Senol, Meryem Temiz-Resitoglu, Demet Sinem Guden, Mehmet Furkan Horat, Seyhan Sahan-Firat, Serhan Sevim, Bahar Tunctan
INFLAMMOPHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Sefika Pinar Senol, Meryem Temiz-Resitoglu, Demet Sinem Guden, Ayse Nihal Sari, Seyhan Sahan-Firat, Bahar Tunctan
Summary: Bexarotene, a selective RXR agonist, has shown protective effects against hyperalgesia induced by LPS in a mouse model of inflammatory pain. It is possible that these effects are mediated by decreased activity of the TLR4/MyD88/TAK1/NF-kappa B/COX-2 signaling pathway in the central nervous system, as well as increased formation of pro-inflammatory cytokines.
NEUROCHEMICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Demet Sinem Guden, Meryem Temiz-Resitoglu, Sefika Pinar Senol, Deniz Kibar, Sakir Necat Yilmaz, Bahar Tunctan, Kafait U. Malik, Seyhan Sahan-Firat
Summary: This study investigated the effects of mTOR inhibition by rapamycin on inflammation, microglial activation, oxidative stress, and apoptosis associated with a systemic challenge with LPS, revealing its regulation of the inflammatory response via the IKB-alpha/NF-kappa B/HIF-1 alpha signaling pathway.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Ali Cagli, Sefika Pinar Senol, Meryem Temiz-Resitoglu, Demet Sinem Guden, Ayse Nihal Sari, Seyhan Sahan-Firat, Bahar Tunctan
Summary: This study investigated the effects of sEH inhibitor TPPU in preventing hyperalgesia in an LPS-induced pain mouse model. The results suggest that TPPU may alleviate pain sensitivity by modulating signaling pathways and protein expression.
DRUG DEVELOPMENT RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Rukiye Nalan Tiftik, Meryem Temiz-Resitoglu, Demet Sinem Guden, Gulsen Bayrak, Ismail Un, Sakir Necat Yilmaz, Seyhan Sahan-Firat
Summary: The study indicated that ROCK/I kappa B-alpha/NF-kappa B p65 pathway activation plays a role in IL-1 beta-induced inflammatory response and oxidative stress. ROCK inhibition might be a beneficial treatment option for OA patients due to its anti-inflammatory and antioxidant effects.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2021)
Review
Psychiatry
Erensu Baysak, Demet Sinem Guden, Feyza Aricioglu, Angelos Halaris
Summary: The review evaluates the potential of using CRP as a biomarker for psychiatric disorders, based on accumulating evidence from large studies and meta-analyses. CRP may serve as a 'psychiatric biomarker' to inform clinicians about neuroinflammation, medication effects, cardiometabolic status, comorbidities, and potentially guide treatment selection based on clinical outcomes.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2022)
Article
Cardiac & Cardiovascular Systems
Meryem Temiz-Resitoglu, Demet S. Guden, Sefika P. Senol, Ozden Vezir, Nehir Sucu, Deniz Kibar, Sakir N. Yilmaz, Bahar Tunctan, Kafait U. Malik, Seyhan Sahan-Firat
Summary: The present study aimed to explore the contribution of mammalian target of rapamycin (mTOR) in DOCA salt-induced hypertension and related pathophysiological changes in cardiovascular and renal tissues. The results showed that mTOR played an important role in regulating blood pressure and the development of cardiovascular and renal pathophysiological changes. Pharmacological inhibition of mTOR could serve as a novel target for the treatment of hypertension.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Cagla Akinci-Uysal, Meryem Temiz-Resitoglu, Demet Sinem Guden, Sefika Pinar Senol, Ozden Vezir, Nehir Sucu, Bahar Tunctan, Kafait U. Malik, Seyhan Sahan-Firat
Summary: This study demonstrates that activation of the MEK1/ERK1/2 pathway contributes to mTOR-mediated target and remote organ injury in hind limb ischemia/reperfusion.
CUKUROVA MEDICAL JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Bahar Tunctan, Sefika Pinar Senol, Meryem Temiz-Resitoglu, Dilsah Ezgi Yilmaz, Demet Sinem Guden, Omer Bahceli, Mehmet Furkan Horat, Seyhan Sahan-Firat, Ayse Nihal Sari, John R. Falck, Raghunath Reddy Anugu, Kafait U. Malik
Summary: By activating the GPR75 signaling pathway, 5,14-HEDGE exerts its protective effects against LPS-induced hypotension and tachycardia in arterial tissues.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Meeting Abstract
Pharmacology & Pharmacy
Bahar Tunctan, Sefika Pinar Senol, Meryem Temiz-Resitoglu, Demet Sinem Guden, Omer Bahceli, Mehmet Furkan Horat, Seyhan Sahan-Firat, Ayse Nihal Sari, John R. Falck, Kafait U. Malik
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Demet Sinem Guden, Feyza Aricioglu
PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
(2020)
Meeting Abstract
Pharmacology & Pharmacy
D. S. Guden, M. Temiz-Resitoglu, S. P. Senol, D. Kibar, S. N. Yilmaz, B. Tunctan, S. Sahan-Firat
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2019)
