Review
Biochemistry & Molecular Biology
Akaash Mundra, Aram Yegiazaryan, Haig Karsian, Dijla Alsaigh, Victor Bonavida, Mitchell Frame, Nicole May, Areg Gargaloyan, Arbi Abnousian, Vishwanath Venketaraman
Summary: Tuberculosis (TB) is a leading cause of mortality, and its rates have increased during the emergence of COVID-19. This review explores the detrimental effects of high levels of type I interferons (IFNs) on the host fighting TB infection. The findings suggest that increased type I IFNs can affect immune cell functions, promote inflammation, and inhibit production of protective substances.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Holger Loerchner, Laia Canes Esteve, Maria Elisa Goes, Roxanne Harzenetter, Nathalie Brachmann, Praveen Gajawada, Stefan Guenther, Nicolas Doll, Jochen Poeling, Thomas Braun
Summary: This study reveals that TNF alpha recruits VEGFA-expressing neutrophils for muscle tissue revascularization through the CCL20-CCR6 axis. This finding provides a promising approach for revascularization, especially in diabetic conditions.
CIRCULATION RESEARCH
(2023)
Article
Immunology
Wenxi Xu, Laura M. Snell, Mengdi Guo, Giselle Boukhaled, Bethany L. Macleod, Ming Li, Michael Tullius, Cynthia J. Guidos, Ming-Sound Tsao, Maziar Divangahi, Marcus A. Horwitz, Jun Liu, David G. Brooks
Summary: Chronic viral infections exacerbate the severity of Mycobacterium tuberculosis (Mtb) coinfection by increasing Mtb burden, disrupting immune surveillance, and worsening disease mortality. The study demonstrates the impact of viral infections on coinfection and highlights the mechanisms involved in disease progression.
Article
Immunology
Iwona Niemietz, Kelly L. Brown
Summary: This study found that hyaluronan (HA) can prime neutrophils to produce a stronger oxidative burst in response to different stimuli, when combined with TNF alpha. Additionally, HA can enhance intracellular reactive oxygen species (ROS) production induced by TNF alpha, as well as activate p38 MAPK and apoptosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Cheldon Ann Alcantara, Ira Glassman, Kevin H. Nguyen, Arpitha Parthasarathy, Vishwanath Venketaraman
Summary: Mycobacterium tuberculosis (M. tb) remains a major cause of death in developing countries. The BCG vaccine is widely used in developing countries but its efficacy is still uncertain. Neutrophils play a crucial role in the immune response against M. tb, promoting clearance of the bacteria and regulating the inflammatory response. This review highlights the role of neutrophils during M. tb infection and emphasizes the need for more research on effective vaccination.
Article
Hematology
Yajing Zhao, Pengcheng Xu, Li Guo, Haoyi Wang, Yanan Min, Qi Feng, Yu Hou, Tao Sun, Guosheng Li, Xuebin Ji, Jihua Qiu, Jun Peng, Xinguang Liu, Ming Hou
Summary: The study found increased proinflammatory CD16(+) monocytes in peripheral blood of ITP patients and elevated TNF-alpha-expressing macrophages in the spleen. TNF-alpha blockade reduced the number and function of proinflammatory subsets of monocytes and macrophages, leading to remarkable attenuation of antibody-mediated platelet destruction.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Microbiology
Tesia L. Cleverley, Siri Peddineni, Jeannette Guarner, Francesca Cingolani, Pamela K. Garcia, Heather Koehler, Edward S. Mocarski, Daniel Kalman
Summary: Infections caused by MTC and NTM can lead to widespread morbidity and mortality. Imatinib mesylate may be a new therapeutic approach for mycobacterial infections, reducing lesion size and inflammation, accelerating immune response, and inhibiting granuloma formation and growth, thereby mitigating lung damage and morbidity.
Article
Immunology
Ana Carolina Matias Dinelly Pinto, Rodolfo de Melo Nunes, Igor Albuquerque Nogueira, Bernhard Fischer, Rudolf Lucas, Virginia Claudia Carneiro Girao-Carmona, Vivian Louise Soares de Oliveira, Flavio Almeida Amaral, Georg Schett, Francisco Airton Castro Rocha
Summary: TNF inhibitors are commonly used for the treatment of arthropathies like rheumatoid arthritis (RA), but not all patients achieve remission and there is a risk of infection. This study found that the lectin-like domain of TNF has anti-inflammatory effects and can mitigate the development of immune-mediated arthritis in mice.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biophysics
Sandra Montalvo-Quiros, Sergio Gomez-Grana, Maria Vallet-Regi, Rafael C. Prados-Rosales, Blanca Gonzalez, Jose L. Luque-Garcia
Summary: Tuberculosis remains a major public health issue with a lack of effective vaccine and the emergence of highly antibiotic-resistant strains of Mycobacterium tuberculosis. Silver nanoparticles show high bactericidal efficacy, but their relatively high toxicity calls for the design of nanocarriers for safe delivery. Mesoporous silica nanoparticles have been used as carriers for silver nanoparticles as antimycobacterial agents, demonstrating good capability against Mtb with different synthetic approaches.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biology
Ines Lahmann, Joscha Griger, Jie-Shin Chen, Yao Zhang, Markus Schuelke, Carmen Birchmeier
Summary: MET and CXCR4 cooperate to protect muscle stem cells against the harsh inflammatory environment encountered in acute muscle injury. Lack of these factors leads to severe apoptosis in early stages of regeneration.
Article
Medicine, Research & Experimental
Yoann Rombouts, Olivier Neyrolles
Summary: This study reveals that Mycobacterium tuberculosis produces a virulence factor called 1-tuberculosinyladenosine, which leads to lysosomal dysfunction and lipid accumulation in macrophages similar to lysosomal storage diseases. These findings provide insights into how the bacteria manipulates host lipid metabolism for its survival and suggest new strategies for host-directed therapy against tuberculosis.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Aline de Oliveira Rezende, Rafaella Santos Saboia, Adeliane Castro da Costa, Diana Messala Pinheiro da Silva Monteiro, Adrielle Zagmignan, Luis Angelo Macedo Santiago, Rafael Cardoso Carvalho, Paulo Vitor Soeiro Pereira, Ana Paula Junqueira-Kipnis, Eduardo Martins de Sousa
Summary: This study investigated the association of HIF-1 alpha expression and related mechanisms with latent or active tuberculosis infection. The results showed that IL-15 expression was higher in individuals with LTBI, while IL-18 and TNF-alpha expression were similar between LTBI and TB groups. Additionally, patients with active TB had higher serum 25(OH)D3 levels and expression of IL-6, HIF1A, and A20. The study also found that PBMCs from individuals with LTBI showed decreased NF-kappa B phosphorylation and increased TNF-alpha production after HIF-1 alpha blockade.
Article
Microbiology
Khushboo Borah Slater, Luana Moraes, Ye Xu, Daniel Kim
Summary: In this study, the authors used C-13 metabolic flux analysis to measure intracellular carbon metabolic fluxes in Mtb-infected macrophages and found that glycolytic fluxes were significantly increased and pentose phosphate pathway fluxes were reduced in infected macrophages.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
M. E. F. A. G. Oliveira, Y. J. A. Silva, L. A. Azevedo, L. A. Linhares, L. M. L. Montenegro, S. Alves Jr, R. V. S. Amorim
Summary: The study investigated the adjuvant effect of chitosan with the drug ethambutol as a compound, demonstrating a promising composite against strains Mtb H37Rv and multidrug resistant tuberculosis. The CS-EMB compound showed increased antibacterial activity and cytotoxicity compared to the isolated EMB, making it a potential therapeutic option for drug-resistant tuberculosis.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Katy Diallo, Numa Simons, Souraya Sayegh, Michel Baron, Yannick Degboe, Jean-Frederic Boyer, Andrey Kruglov, Sergei Nedospasov, Julien Novarino, Meryem Aloulou, Nicolas Fazilleau, Arnaud Constantin, Alain Cantagrel, Jean-Luc Davignon, Benjamin Rauwel
Summary: The study shows that the binding of anti-TNF biologics to tmTNF can reduce the severity of arthritis by increasing the expression of anti-inflammatory markers and decreasing inflammation. This suggests a complementary explanation for the effects of anti-TNF biologics in treating inflammatory diseases and opens the door to studies on new arginase-1-dependent therapeutic targets.
Article
Infectious Diseases
Rosa Polo, Xabier Garcia-Albeniz, Carolina Teran, Miguel Morales, David Rial-Crestelo, M. Angeles Garcinuno, Miguel Garcia del Toro, Cesar Hita, Juan Luis Gomez-Sirvent, Luis Buzon, Alberto Diaz de Santiago, Jose Perez Arellano, Jesus Sanz, Pablo Bachiller, Elisa Martinez Alfaro, Vicente Diaz-Brito, Mar Masia, Alicia Hernandez-Torres, Jose M. Guerra, Jesus Santos, Piedad Arazo, Leopoldo Munoz, Jose Ramon Arribas, Pablo Martinez de Salazar, Santiago Moreno, Miguel A. Hernan, Julia Del Amo
Summary: This study evaluated the effectiveness of hydroxychloroquine (HCQ) and Tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) as pre-exposure prophylaxis for COVID-19. The results suggest that the use of TDF/FTC and HCQ may have both benefits and risks in preventing COVID-19.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Medicine, Research & Experimental
Veronica Jimenez-Sabado, Sergi Casabella-Ramon, Anna Llach, Ignasi Gich, Sandra Casellas, Francisco Ciruela, S. R. Wayne Chen, Jose M. Guerra, Antonino Ginel, Raul Benitez, Juan Cinca, Carmen Tarifa, Leif Hove-Madsen
Summary: This study aimed to examine the impact of I3-blocker treatment on spontaneous calcium release events or transient inward currents (ITI) in patients with atrial fibrillation (AF). The results showed that I3-blocker treatment did not affect calcium current density, but it reduced ITI frequency and calcium spark frequency, as well as the levels of phosphorylated RyR2 and phospholamban.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Ana Carolina Schwab, Ante Anic, Michal M. Farkowski, Jose Guerra, Konstantinos E. Iliodromitis, Kristine Jubele, Rui Providencia, Julian K. R. Chun, Serge Boveda
Summary: This study conducted a survey to show how clinicians currently approach the knowledge gap in dealing with recurrences after a failed ablation for atrial fibrillation (AF). The majority of respondents perform routine monitoring for AF recurrences after ablation and prefer a long-term monitoring strategy. The combination of absence of symptoms and recorded AF is considered as the definition of success by most respondents.
Article
Environmental Sciences
Jose M. Guerra-Garcia, Sandra Calero-Cano, Inigo Donazar-Aramendia, Inmaculada Giraldez, Emilio Morales, Pablo Arechavala-Lopez, J. Lucas Cervera-Currado
Summary: The assessment of trace metal content in our fish diet is important due to the adverse effect on human health. Little information is available for Southern Spain, a region characterized by high seafood intake. Nine species from the Bay of Cádiz with high commercial value were selected and found to be generally safe for consumption according to health limits provided by World, European and Spanish legislations.
MARINE POLLUTION BULLETIN
(2023)
Article
Environmental Sciences
Juan Sempere-Valverde, Patricio Ramalhosa, Sahar Chebaane, Free Espinosa, Joao Gama Monteiro, Alejandro Bernal-Ibanez, Eva Cacabelos, Ignacio Gestoso, Jose Manuel Guerra-Garcia, Joao Canning-Clode
Summary: Marinas serve as hubs for non-indigenous species and are part of a network of highly modified water bodies connected by recreational maritime traffic. Floating structures, particularly pontoons, have higher abundance of non-indigenous species within marinas and pose a risk for their introduction, establishment, and spread. This study investigated the influence of marina location and substratum type on fouling assemblages recruitment, exploring water parameters and substratum chemical composition. The findings highlight the importance of marina differences and structural morphology in shaping assemblages, with variations observed in species composition, biomass, and structure. Understanding these factors can contribute to better management of urban ecosystems and mitigating coastal ecosystems degradation.
MARINE POLLUTION BULLETIN
(2023)
Article
Physiology
Gerard Amoros-Figueras, Sergi Casabella-Ramon, Georgina Company-Se, Dabit Arzamendi, Esther Jorge, Alvaro Garcia-Osuna, Yolanda Macias, Damian Sanchez-Quintana, Javier Rosell-Ferrer, Jose M. Guerra, Juan Cinca
Summary: A model of atrial infarction was established by selective occlusion of atrial coronary branches. Multifrequency impedance mapping can recognize atrial infarct scarring with lower data variability, which has potential application in the study of atrial arrhythmia mechanisms.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Ethics
Ines Galende-Dominguez, Octavio M. Rivero-Lezcano
Summary: Progress in precision medicine is achieved through clinical trials using genetic biomarkers to guide patient stratification and assign treatment or control groups. Genetic analysis of biomarkers is essential, involving the study of biological samples from donor patients. However, it is common to introduce purposes beyond the trial's objectives, leading to potential risks of data misuse and re-identification of sample donors. Therefore, genetic analysis should be restricted to the trial's main objectives or well-justified goals.
Review
Cardiac & Cardiovascular Systems
Lukasz Januszkiewicz, Sergio Barra, Rui Providencia, Julian K. R. Chun, Giulio Conte, Michal M. Farkowski, Jose M. Guerra, Eloi Marijon, Carlo de Asmundis, Serge Boveda
Summary: The aim of this study was to identify potential regional disparities in characteristics of ICD recipients, patient perceptions and perspectives after implantation and level of information provided to patients. The study found that patients in Western Europe reported higher satisfaction after ICD placement, while patients in Central/Eastern Europe felt more optimally informed at the time of device implantation. Therefore, novel strategies are needed to address regional differences in patients' quality of life and provision of information.
Article
Biochemistry & Molecular Biology
Carmen Tarifa, Veronica Jimenez-Sabado, Rafael Franco, Jose Montiel, Jose Guerra, Francisco Ciruela, Leif Hove-Madsen
Summary: Increased activation of adenosine A(2A) receptors (A(2A)Rs) leads to higher incidence of spontaneous calcium release in atrial fibrillation (AF). Adenosine A(3) receptors (A(3)Rs) can counteract excessive A(2A)R activation, but their role in the atrium is not well understood. This study found that A(3)Rs inhibit spontaneous calcium release in human atrial myocytes and can attenuate pathological elevations in calcium release events, suggesting their potential therapeutic importance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Valerie Samouillan, Eduardo Garcia, Aleyda Benitez-Amaro, Maria Teresa La Chica Lhoest, Jany Dandurand, Virginia Actis Dato, Jose Maria Guerra, Joan Carles Escola-Gil, Gustavo Chiabrando, Carlos Enrich, Vicenta Llorente-Cortes
Summary: The accumulation of lipids in cardiomyocytes leads to cardiac dysfunction. Blocking cardiomyocyte cholesteryl ester (CE) loading specifically with antibodies against the P3 sequence of the LRP1 receptor improves cardiac insulin sensitivity. The impact of anti-P3 antibodies on biophysical alterations was analyzed.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Medicine, General & Internal
Leslie P. Zuniga-Macias, Ricardo E. Ramirez-Orozco, Francisco J. Avelar-Gonzalez, Rosalba Perez-Villalva, Norma A. Bobadilla, Jose M. Arreola-Guerra
Summary: The state of Aguascalientes, Mexico has a high prevalence of chronic kidney disease, particularly persistent albuminuria (pA). This study aimed to identify potential biomarkers of early renal injury in pA patients. The results showed that SerpinA3 was significantly associated with pA and could be a biomarker for early kidney injury.
REVISTA DE INVESTIGACION CLINICA-CLINICAL AND TRANSLATIONAL INVESTIGATION
(2023)
Article
Medicine, General & Internal
Carolina C. Barajas-Garcia, Alma L. Guerrero-Barrera, Jose M. Arreola-Guerra, Francisco J. Avelar-Gonzalez, Flor Y. Ramirez-Castillo
Summary: We present two cases of postrenal transplant patients with large biofilm structures covering the double-J stents, without urinary tract infections. The biofilms consisted of cocci integrated in a net structure and overlapping bacilli cells. This is the first time high-quality images of noncrystalline biofilms in renal transplant recipients with long-term stenting have been reported.
JOURNAL OF MEDICAL CASE REPORTS
(2023)
Article
Fisheries
M. Castilla-Gavilan, J. M. Guerra-Garcia, J. M. Moreno-Oliva, I. Hachero-Cruzado
Summary: Marine amphipods, specifically Gammarus insensibilis, have shown potential as a live feed resource for Integrated Multi-Trophic Aquaculture. This study examined the waste removal capabilities of G. insensibilis at different densities and fed on dry or wet detritus. The species exhibited high survival rates and showed the highest tolerance for nitrate, followed by nitrite and ammonium. Low-density individuals were found to remove significantly higher amounts of detritus, regardless of its dry or wet state. Wet detritus is recommended for better handling and scaled-up trials in aquaculture systems.
Article
Cardiac & Cardiovascular Systems
Gerard Amoros-Figueras, Sergi Casabella-Ramon, Zoraida Moreno-Weidmann, Antoni Ivorra, Jose M. Guerra, Tomas Garcia-Sanchez
Summary: This study characterizes the dynamics of electrograms after pulsed field ablation (PFA) in areas of irreversible electroporation (IRE) and reversible electroporation. The results show that electrograms can differentiate between reversible electroporation and IRE areas during the first 30 minutes post ablation, and provide valuable information for immediate lesion assessment after PFA.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2023)
Article
Mathematics, Applied
Osmin Ferrer, Jose Guerra, Alberto Reyes
Summary: This paper studies a multiparametric nonlinear system with a transcritical bifurcation in a region of points in R-3. The boundaries of the parametric regions where important qualitative changes occur in the dynamics of the system are determined. Equilibrium points in each region are also established and classified. Finally, the stability of the equilibrium points at infinity of the system obtained from Poincare compactification is classified, and the global phase portrait of the system is made.
