Development of a strategy and computational application to select candidate protein analogues with reduced HLA binding and immunogenicity

Post hoc assessment of the immunogenicity of bioengineered factor VIIa demonstrates the use of preclinical tools

(2017) Kasper Lamberth et al.   Science Translational Medicine

The Immune Epitope Database and Analysis Resource in Epitope Discovery and Synthetic Vaccine Design

(2017) Ward Fleri et al.   Frontiers in Immunology

A humanized mouse model identifies key amino acids for low immunogenicity of H7N9 vaccines

(2017) Yamato Wada et al.   Scientific Reports

Engineering less immunogenic and antigenic FVIII proteins

(2016) Kathleen P. Pratt   CELLULAR IMMUNOLOGY

UMD-Predictor: A High-Throughput Sequencing Compliant System for Pathogenicity Prediction of any Human cDNA Substitution

(2016) David Salgado et al.   HUMAN MUTATION

HLA-DRB1 Alleles Are Associated With Different Magnitudes of Dengue Virus–Specific CD4+T-Cell Responses

(2016) Daniela Weiskopf et al.   JOURNAL OF INFECTIOUS DISEASES

Rational design of stable and functional hirudin III mutants with lower antigenicity

(2015) Saeme Asgari et al.   BIOLOGICALS

Protein deimmunization via structure-based design enables efficient epitope deletion at high mutational loads

(2015) Regina S. Salvat et al.   BIOTECHNOLOGY AND BIOENGINEERING

Depletion of T Cell Epitopes in Lysostaphin Mitigates Anti-Drug Antibody Response and Enhances Antibacterial Efficacy In Vivo

(2015) Hongliang Zhao et al.   CHEMISTRY & BIOLOGY

Definition of a pool of epitopes that recapitulates the T cell reactivity against major house dust mite allergens

(2015) D. Hinz et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Development and validation of a broad scheme for prediction of HLA class II restricted T cell epitopes

(2015) Sinu Paul et al.   JOURNAL OF IMMUNOLOGICAL METHODS

A Population Response Analysis Approach To Assign Class II HLA-Epitope Restrictions

(2015) Sinu Paul et al.   JOURNAL OF IMMUNOLOGY

Changes in the amino acid sequence of the recombinant human factor VIIa analog, vatreptacog alfa, are associated with clinical immunogenicity

(2015) J. N. Mahlangu et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Studies on Deimmunization of Antileukaemic L-Asparaginase to have Reduced Clinical Immunogenicity- An in silico Approach

(2015) L. N. Ramya et al.   PATHOLOGY & ONCOLOGY RESEARCH

Mutagenic Deimmunization of Diphtheria Toxin for Use in Biologic Drug Development

(2015) Joerg U. Schmohl et al.   Toxins

HLA class II peptide tetramersvsallergen-induced proliferation for identification of allergen-specific CD4 T cells

(2014) D. Van Hemelen et al.   ALLERGY

Computationally driven deletion of broadly distributed T cell epitopes in a biotherapeutic candidate

(2014) Regina S. Salvat et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Recombinant factor VIIa analog in the management of hemophilia with inhibitors: results from a multicenter, randomized, controlled trial of vatreptacog alfa

(2014) S. R. Lentz et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Humanized cobra venom factor: Structure, activity, and therapeutic efficacy in preclinical disease models

(2014) Carl-Wilhelm Vogel et al.   MOLECULAR IMMUNOLOGY

The immune epitope database (IEDB) 3.0

(2014) Randi Vita et al.   NUCLEIC ACIDS RESEARCH

Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations

(2014) Faviel F. González-Galarza et al.   NUCLEIC ACIDS RESEARCH

Removing T-cell epitopes with computational protein design

(2014) C. King et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes

(2014) R. Mazor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune camouflage: Relevance to vaccines and human immunology

(2014) Anne S De Groot et al.   Human Vaccines & Immunotherapeutics

Evaluating the Immunogenicity of Protein Drugs by ApplyingIn VitroMHC Binding Data and the Immune Epitope Database and Analysis Resource

(2013) Sinu Paul et al.   Clinical & Developmental Immunology

T-cell dependent immunogenicity of protein therapeutics: Preclinical assessment and mitigation

(2013) Vibha Jawa et al.   CLINICAL IMMUNOLOGY

A strategy to determine HLA class II restriction broadly covering the DR, DP, and DQ allelic variants most commonly expressed in the general population

(2013) Denise M. McKinney et al.   IMMUNOGENETICS

Previously undescribed grass pollen antigens are the major inducers of T helper 2 cytokine-producing T cells in allergic individuals

(2013) Véronique Schulten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beyond humanization and de-immunization: tolerization as a method for reducing the immunogenicity of biologics

(2013) Anne S De Groot et al.   Expert Review of Clinical Pharmacology

Dissecting Mechanisms of Immunodominance to the Common Tuberculosis Antigens ESAT-6, CFP10, Rv2031c (hspX), Rv2654c (TB7.7), and Rv1038c (EsxJ)

(2012) C. S. Lindestam Arlehamn et al.   JOURNAL OF IMMUNOLOGY

T Cell Responses to Known Allergen Proteins Are Differently Polarized and Account for a Variable Fraction of Total Response to Allergen Extracts

(2012) C. Oseroff et al.   JOURNAL OF IMMUNOLOGY

Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A

(2012) R. Mazor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of HLA DR epitope de-immunization of Factor VIII in vitro and in vivo

(2011) Leonard Moise et al.   CLINICAL IMMUNOLOGY

Functional classification of class II human leukocyte antigen (HLA) molecules reveals seven different supertypes and a surprising degree of repertoire sharing across supertypes

(2011) Jason Greenbaum et al.   IMMUNOGENETICS

Recombinant factor VIIa analog (vatreptacog alfa [activated]) for treatment of joint bleeds in hemophilia patients with inhibitors: a randomized controlled trial

(2011) ERICH V. DE PAULA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Therapeutic enzyme deimmunization by combinatorial T-cell epitope removal using neutral drift

(2011) J. R. Cantor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes

(2011) M. Onda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Construction of a humanized antibody to hepatitis B surface antigen by specificity-determining residues (SDR)-grafting and de-immunization

(2010) Keun-Soo Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MHC Class II epitope predictive algorithms

(2010) Morten Nielsen et al.   IMMUNOLOGY

Divergent Motifs but Overlapping Binding Repertoires of Six HLA-DQ Molecules Frequently Expressed in the Worldwide Human Population

(2010) J. Sidney et al.   JOURNAL OF IMMUNOLOGY

Five HLA-DP Molecules Frequently Expressed in the Worldwide Human Population Share a Common HLA Supertypic Binding Specificity

(2010) John Sidney et al.   JOURNAL OF IMMUNOLOGY

Molecular Determinants of T Cell Epitope Recognition to the Common Timothy Grass Allergen

(2010) C. Oseroff et al.   JOURNAL OF IMMUNOLOGY

Bioengineering a Unique Deimmunized Bispecific Targeted Toxin That Simultaneously Recognizes Human CD22 and CD19 Receptors in a Mouse Model of B-Cell Metastases

(2010) D. A. Vallera et al.   MOLECULAR CANCER THERAPEUTICS

Design and modification of EGF4KDEL 7Mut, a novel bispecific ligand-directed toxin, with decreased immunogenicity and potent anti-mesothelioma activity

(2009) B J Stish et al.   BRITISH JOURNAL OF CANCER

Immune epitope database analysis resource (IEDB-AR)

(2008) Q. Zhang et al.   NUCLEIC ACIDS RESEARCH

An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes

(2008) M. Onda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Systematic Assessment of MHC Class II Peptide Binding Predictions and Evaluation of a Consensus Approach

(2008) Peng Wang et al.   PLoS Computational Biology