期刊
IMMUNOLOGY
卷 151, 期 4, 页码 375-384出版社
WILEY
DOI: 10.1111/imm.12764
关键词
cancer; T cells; infection; inflammation; lung; tissue-resident
类别
资金
- National Natural Science Foundation of China [81471552]
- Anhui Provincial Natural Science Foundation [1408085MH156]
gamma delta T cells are greatly enriched in mucosal and epithelial sites, such as the skin, respiratory, digestive and reproductive tracts, and they are defined as tissue-resident immune cells. In these tissues, the characteristics and biological roles of T cells are distinguished from each other. The lungs represent the most challenging immunological dilemma for the host, and they have their own effective immune system. The abundance of T cells, an estimated 8-20% of resident pulmonary lymphocytes in the lung, maintains lung tissue homeostasis. In this review, we summarize the recent research progress regarding lung-resident T cells, including their development, residency and immune characteristics, and discuss the involvement of T cells in infectious diseases of the lung, including bacterial, viral and fungal infections; lung allergic disease; lung inflammation and fibrosis; and lung cancer.
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